WO2014108795A8 - An improved process for the preparation of chiral diol sulfones and statins - Google Patents
An improved process for the preparation of chiral diol sulfones and statins Download PDFInfo
- Publication number
- WO2014108795A8 WO2014108795A8 PCT/IB2014/000017 IB2014000017W WO2014108795A8 WO 2014108795 A8 WO2014108795 A8 WO 2014108795A8 IB 2014000017 W IB2014000017 W IB 2014000017W WO 2014108795 A8 WO2014108795 A8 WO 2014108795A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- improved process
- statins
- preparation
- chiral diol
- diol sulfones
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to an improved process to prepare chiral diol sulfones of formula (I), wherein R1 and R2 each independently represent group selected from C1-4 alkyl, C1-4 alkenyl, C3-6 cycloalkyl, C6-10 aryl or C7-12 aralkyl, each of R1 and R2 may be substituted and wherein R1 and R2 may form a ring together with the C-atom; R3 represents group selected from C1-5 alkyl, aryl or aralkyl.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN158CH2013 | 2013-01-10 | ||
IN158/CHE/2013 | 2013-01-10 | ||
IN2489/CHE/2013 | 2013-06-06 | ||
IN2489CH2013 | 2013-06-06 |
Publications (4)
Publication Number | Publication Date |
---|---|
WO2014108795A2 WO2014108795A2 (en) | 2014-07-17 |
WO2014108795A3 WO2014108795A3 (en) | 2014-10-30 |
WO2014108795A8 true WO2014108795A8 (en) | 2015-02-19 |
WO2014108795A9 WO2014108795A9 (en) | 2015-10-29 |
Family
ID=50114433
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2014/000017 WO2014108795A2 (en) | 2013-01-10 | 2014-01-06 | An improved process for the preparation of chiral diol sulfones and statins |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2014108795A2 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104513232A (en) * | 2015-01-08 | 2015-04-15 | 苏州莱克施德药业有限公司 | Preparation process for rosuvastatin ethyl ester |
CN105037331B (en) * | 2015-06-17 | 2018-02-09 | 浙江科技学院 | The preparation method of Rosuvastatin intermediate |
CN107298675B (en) * | 2017-06-19 | 2020-08-11 | 浙江美诺华药物化学有限公司 | Preparation method of rosuvastatin calcium intermediate |
CN109574939B (en) * | 2017-09-28 | 2022-05-27 | 安徽省庆云医药股份有限公司 | Preparation method of rosuvastatin sodium |
CN108358868B (en) * | 2018-04-17 | 2021-10-29 | 同济大学 | Preparation method of 2-substituted benzothiazole compound |
CN110724133B (en) * | 2019-10-30 | 2022-09-13 | 江苏阿尔法药业股份有限公司 | Preparation method of pitavastatin calcium intermediate |
CN112028881B (en) * | 2020-09-02 | 2023-08-15 | 能特科技有限公司 | Synthesis method of rosuvastatin calcium higher intermediate R-1 |
CN112159403B (en) * | 2020-09-30 | 2022-04-15 | 复旦大学 | Preparation method of key intermediate for synthesizing statins |
CN112679490A (en) * | 2021-01-28 | 2021-04-20 | 安徽美诺华药物化学有限公司 | Chiral side chain of rosuvastatin calcium containing sulfone structure and preparation method and application thereof |
CN113754650B (en) * | 2021-08-06 | 2023-10-20 | 湖北宇阳药业有限公司 | High-selectivity synthesis method of rosuvastatin calcium intermediate |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2648897B2 (en) | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | Pyrimidine derivatives |
GB9903472D0 (en) | 1999-02-17 | 1999-04-07 | Zeneca Ltd | Chemical process |
PL367133A1 (en) | 2001-06-06 | 2005-02-21 | Bristol-Myers Squibb Company | Process for preparing chiral diol sulfones and dihydroxy acid hmg coa reductase inhibitors |
CZ304171B6 (en) * | 2011-12-16 | 2013-12-04 | Zentiva, K.S. | Process for preparing protected chiral sulfone-diols |
-
2014
- 2014-01-06 WO PCT/IB2014/000017 patent/WO2014108795A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2014108795A2 (en) | 2014-07-17 |
WO2014108795A9 (en) | 2015-10-29 |
WO2014108795A3 (en) | 2014-10-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2014108795A3 (en) | An improved process for the preparation of chiral diol sulfones and statins | |
CY1119060T1 (en) | METHODS OF METHODOLOGICAL MODIFICATION, COMPOSITIONS AND USES OF THESE | |
PH12019502286A1 (en) | Process for preparing an optically active pyrimidinium compounds | |
PH12016501192B1 (en) | Tetrahydropyridopyrazines modulators of gpr6 | |
WO2014100764A3 (en) | Methods of inhibiting prmt5 | |
WO2014144545A3 (en) | Substituted benzoxazoles and methods of use thereof | |
WO2014121040A8 (en) | Flap modulators | |
WO2018029711A3 (en) | Process for the preparation of venetoclax | |
MY194307A (en) | Pyridone derivative having tetrahydropyranylmethyl group | |
WO2015142903A3 (en) | Method of controlling lactate production with piperdine-dione derivatives | |
EP3504185A4 (en) | Novel substituted n'-hydroxycarbamimidoyl-1,2,5-oxadiazole compounds as indoleamine 2,3-dioxygenase (ido) inhibitors | |
WO2012101011A3 (en) | New aryl-benzocycloalkyl amide derivatives | |
WO2015197534A3 (en) | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds | |
MX2018007219A (en) | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds. | |
MX2014014838A (en) | Novel cyclic depsipeptide derivative and pest control agent comprising same. | |
WO2016013030A3 (en) | Hydroxysteroid compounds, their intermediates, process of preparation, composition and uses thereof | |
WO2016071361A3 (en) | Herbicidal compounds | |
WO2016038628A3 (en) | A process for preparing olodaterol and intermediates thereof | |
MX2019001465A (en) | Method for producing spiroketal-substituted cyclic ketoenols. | |
WO2016071364A3 (en) | Herbicidal compounds | |
WO2014121055A3 (en) | Flap modulators | |
SA518390788B1 (en) | Compound targeting interleukin-23a and b-cell activating factor and uses thereof | |
WO2016071362A3 (en) | Herbicidal compounds | |
WO2016142819A3 (en) | Novel process for the preparation of ranolazine | |
WO2016014864A8 (en) | Hydroxy-(r),(r)-2,2'-bismethylnaltrexones and uses thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 14704886 Country of ref document: EP Kind code of ref document: A2 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 14704886 Country of ref document: EP Kind code of ref document: A2 |