WO2014104338A1

WO2014104338A1 - Chemical liquid circuit and chemical liquid system using same

Info

Publication number: WO2014104338A1
Application number: PCT/JP2013/085207
Authority: WO
Inventors: 根本　茂; 増田　和正; 宗仁栗本
Original assignee: 株式会社根本杏林堂
Priority date: 2012-12-28
Filing date: 2013-12-27
Publication date: 2014-07-03
Also published as: JPWO2014104338A1; JP2018167058A; JP2020073119A

Abstract

In the present invention, a chemical liquid circuit (601P) is provided with a contrast agent line (605), a physiological saline line (606), a syringe line, a patient line (608) and a base line section (610). The chemical liquid circuit (601P) is further provided with first valve devices (V-1, V-2) and a second value device (V-3). (i) In a case where a liquid is suctioned toward the upstream side of the base line section (610), the first valve devices (V-1, V-2) allow the contrast agent to flow from the inside of the contrast agent line (605) to the inside of the base line section (610). (ii) In a case where the liquid is pushed toward the downstream side of the base line section (610), the first valve devices (V-1, V-2) allow the liquid to flow in the above-described direction but not in the reverse in the contrast agent line (605). The second value device (V-3) allows the liquid to flow from the physiological saline line (606) side to the base line section (610) side, but does not allow the reverse to occur.

Description

Chemical circuit and chemical circuit system using the same

The present invention relates to a chemical circuit and a system for injecting a chemical such as a contrast medium and physiological saline into a patient, and in particular, a chemical circuit and a chemical circuit system that can be suitably used for angiography such as cardiac catheter examination. About.

Medical diagnostic imaging devices include CT (Computed Tomography) scanners and MRI (Magnetic Resonance).
There are an imaging device, a PET (Positron Emission Tomography) device, an angiography device, and an MRA (MR Angio) device. When taking an image of a patient using these devices, a medical solution such as a contrast medium or physiological saline is often injected into the patient.

Patent Document 1 discloses a chemical circuit system used for angiography (for example, FIGS. 7A to 7B). This system draws a contrast agent source solution connected to a solution circuit into a syringe and injects it toward a patient.

JP 2007-222656 A

By the way, when performing angiography, it is necessary to perform aspiration of a contrast medium into a drug solution syringe, injection into a patient, and injection of physiological saline into a patient in a predetermined order (details will be described later). In such chemical injection, if it is necessary to operate, for example, a three-way stopcock in order to change the route of the chemical, if there is an operator's operation mistake, there is a risk that the predetermined chemical cannot be injected in a predetermined procedure. There is.

The present invention has been made in view of such problems, and an object thereof is to provide a chemical circuit and a chemical circuit system capable of injecting a predetermined chemical liquid in a predetermined procedure without requiring a complicated operation by an operator. There is to do.

In order to achieve the above object, a chemical circuit according to one embodiment of the present invention is as follows:
A contrast agent line connected to the contrast agent chamber;
A saline line connected to the saline chamber;
A syringe line connected to the chemical syringe;
A patient line for delivering contrast media or saline to the patient;
A baseline part to which each line is connected;
A liquid medicine circuit that is used for liquid medicine injection for injecting a contrast medium into the liquid medicine syringe and then injecting the contrast medium from the syringe toward a patient,
further,
(I) When the liquid is drawn toward the upstream side of the baseline portion, the contrast medium flows from the contrast agent line into the baseline portion, and (ii) the liquid flows from the upstream side of the baseline portion. A first valve device that allows liquid to flow from the upstream side of the baseline portion to the downstream side without backflowing into the contrast agent line when pushed toward the downstream side;
A second valve device that allows liquid to flow from the saline line side to the baseline portion side but not vice versa;
A chemical circuit.

(Explanation of terms)
“Connected” includes not only a predetermined element directly connected to an object but also a state in which the predetermined element is connected through some other element.
The “(contrast / saline) chamber” is intended to be a container such as a bottle or a bag, and is not limited to a specific shape.
“Line (contrast line / saline line / syringe line / patient line, etc.)” means a liquid flow path, and does not necessarily mean that an independent member such as a tube is required. . For example, when a predetermined connector is provided in the baseline portion and a chemical syringe is directly connected to this connector (no tube is used), a part of the connector corresponds to the syringe line. It will be.

According to the present invention, it is possible to provide a chemical circuit and system capable of injecting a predetermined chemical liquid in a predetermined procedure without requiring a complicated operation by an operator.

It is a figure which shows typically the chemical | medical solution circuit system of one form of this invention. It is a schematic diagram which shows the function of a dual check valve. It is a figure which shows typically the switching machine holding a part of chemical | medical solution circuit. It is a figure which shows typically the chemical | medical solution circuit system of the other form of this invention. It is a figure which shows a part of process of angiography (contrast medium suction | inhalation). It is a figure which shows a part of process of an angiography (extrusion of a contrast agent). It is a figure which shows a part of process of an angiography (air clear). It is a figure which shows a part of process of an angiography (operation of a valve | bulb). It is a figure which shows a part of process of an angiography (extrusion of a contrast agent). It is a figure which shows a part of process of an angiography (flush with the physiological saline). It is a figure which shows a part of process of an angiography (additional flash). It is a figure which shows a part of process of angiography (establishment of a blood route). It is a figure which shows typically the chemical | medical solution circuit system of the other form of this invention. It is a figure which shows an example of a roller type pump typically. It is a figure which shows an example of a piston type pump typically. It is sectional drawing which shows the other example of a release valve. FIG. 14B is a drawing showing a part of the release valve of FIG. 14A. It is sectional drawing which shows an example of a release valve. It is a figure which shows typically the chemical | medical solution circuit and chemical | medical solution circuit system of other one form of this invention. It is sectional drawing which shows typically an example of a dust prevention type syringe. It is the schematic diagram which looked at the 2nd piston from the back side. It is a figure which shows typically the chemical | medical solution circuit and chemical | medical solution circuit system of another one form of this invention. It is a figure which shows typically the structural example of a clamping mechanism. It is a figure which shows typically one of the modifications of the structural example of the clamping mechanism of FIG. 20A. It is a figure which shows typically the other structural example of a clamping mechanism. It is a figure which shows typically another structural example of a clamping mechanism. It is a figure which shows typically another structural example of a clamping mechanism.

Hereinafter, an embodiment of the present invention will be described with reference to the drawings. In the following description, terms indicating directions such as up, down, right, and left are used, but this does not limit the present invention. Further, the contrast agent and the physiological saline may be simply referred to as “medical solution” or “liquid” without being distinguished.

(First embodiment)
A chemical circuit system 200 according to this embodiment shown in FIG. 1 is used for, for example, cardiac catheter examination. The chemical circuit system 200 includes a chemical circuit 201 (detailed below), a contrast medium chamber 221, a physiological saline chamber 223, a pressure transducer 270, and a chemical syringe 251 connected thereto. The chemical circuit system 200 also includes an injection head 260 that holds the syringe 251 and sucks and pushes out the chemical (only a part of the injection circuit 260 is also illustrated).

Specifically, the drug solution circuit 201 of FIG. 1 includes a syringe line 204 connected to the syringe 251, a contrast agent line 205 connected to the contrast agent chamber 221, and physiological saline connected to the physiological saline chamber 223. A line 206, a transducer line 207 connected to the transducer 270, a patient line 208 connected to the patient via a catheter (not shown), and a baseline portion 210 to which these lines are connected. .

The material, length, and diameter of the tubes constituting the lines 204 to 208 may be appropriately selected in consideration of the pressure applied to the tubes. In a cardiac catheter test, since a chemical solution is injected at a relatively high pressure, a portion to which a high pressure is applied is preferably composed of a high pressure resistant tube. Similarly,

dual check valves

215A and 215B and

release valves

202A and 202B, which will be described later, preferably have a high breakdown voltage.

The “baseline part 210” refers to a part to which the above-mentioned lines 204 to 208 are connected as shown in FIG. 1, and is composed of tubes, valves, connectors and the like. In this example, the syringe line 204 is connected to the upstream side of the baseline part 210 and the patient line 208 is connected to the downstream side. A contrast medium line 205, a physiological saline line 206, and a transducer line 207 are connected to an intermediate portion of the base line portion 210 sequentially from the upstream side. Each of these lines 205 to 207 is connected to the base line portion 210 in a T shape.

Note that “connected in a T-shape” is intended to connect so that the flow path branches, and does not limit the angle at which the lines intersect.

In this embodiment, the contrast medium line 205 and the physiological saline line 206 are connected to the base line unit 210 by

dual check valves

215A and 215B, respectively. As an example, the two dual check valves 215A, B (detailed below) may be the same, or different ones having different functions may be used. In FIG. 1, the same thing is utilized as an example.

The

dual check valves

215A and 215B are valves having the following functions (see also FIG. 2A):
(I) When the liquid is drawn toward the upstream side of the baseline portion 210 (that is, the syringe 251 side), the liquid is allowed to flow in that direction.
(Ii) On the other hand, regarding the dual check valve 215A, when the liquid is pushed from the upstream side to the downstream side of the baseline part 210, the liquid flows through the valve 215A to the downstream side. As for the dual check valve 215B, when the liquid is similarly pushed toward the downstream side or when being pushed from the physiological saline line 206 side toward the valve 215B side, the liquid flows in those directions. .

Also, the

dual check valves

215A and 215B restrict the flow from the downstream side to the upstream side and the flow toward the

lines

205 and 206 as shown in FIG. 2A.

In FIG. 1, another valve 215A is arranged upstream of the dual check valve 215B, and the flow of the liquid upstream is restricted by this valve 215A. It is not pulled toward the side.

As shown in FIG. 1, the transducer line 207 is connected to the base line part 210 by a T-shaped connector 217 having no valve function as an example. A three-way cock 213 may be provided between the T-shaped connector 217 and the dual check valve 215B. However, the arrangement position of the three-way cock 213 is not necessarily limited to this. As shown in FIG. 2C, the stopcock 213 may be disposed downstream of the air sensor 232 (detailed below) in the patient line 208.

As an example, the three-way stopcock 213 is one in which one of the three lines connected thereto is closed along the direction of the lever (for example, in the state of FIG. 1, the liquid moves to a line (not shown) that extends downward) May be prevented). Such a three-way cock is used when an operator discharges the liquid in the line to the outside as needed.

Next, the devices connected to the lines 204 to 208 will be described. In addition, since these apparatuses can use a conventionally well-known apparatus, detailed description shall be abbreviate | omitted.

The chemical syringe 251 to which the syringe line 204 is connected may have a capacity of, for example, about several tens to 200 ml. Moreover, it is preferable that the syringe 251 can perform high-pressure injection when performing a cardiac catheter test or the like. If necessary, a protective cover that covers the syringe 251 may be used. The syringe 251 has a cylindrical cylinder member and a piston member (plunger rod) that is slidably inserted into the cylinder member. The piston member may be a so-called rodless type.

The injector (injection head) 260 to which the chemical syringe 251 is detachably mounted is not limited, but is preferably a type that can perform high-pressure injection, for example. The injector 260 includes a motor that is a driving source and a presser member that moves back and forth. By pulling the presser member, the piston member of the syringe is pulled to fill the syringe with the chemical solution, while by pressing the presser member, the liquid in the syringe is pushed out.

The injector 260 may be a one-cylinder type in which only one syringe is mounted, or a two-cylinder type in which only two syringes are mounted. Further, an injector for CT inspection, an injector for MR inspection, an injector for angiography inspection, and the like may be used.

(Chemical injection device)
In addition, although detailed illustration is abbreviate | omitted, a console (control unit) may be connected to the injector (injection head) 260, and a chemical | medical solution injection apparatus may be comprised. The console can be connected to the injector 260 in a wired or wireless manner. The console may have one or a plurality of displays and a control unit (control unit, controller) including a microprocessor or the like. This display may be a touch panel type as an example. Thus, even when the term “injector (injection head)” and the term “console” are properly used, in the present invention, these are configured integrally, for example, the console and the injector are in one housing. It is not impeded to be provided in the body.

(Example of piston drive mechanism)
The piston drive mechanism may have a shaft that receives power from a drive source (not shown) such as a motor and rotates forward and backward on the spot. When this shaft is rotated a predetermined number of times, the presser member (ram member) moves in the front-rear direction by a distance corresponding thereto. A load cell (pressure sensor) for detecting a pressing force applied to the piston may be attached to the pressing surface of the ram member. A method of detecting the pressing force based on the value of the motor current can also be adopted.

(Syringe)
Various syringes can be used. For example, the syringe outer cylinder (cylinder member) may be made of a resin material such as polyethylene or polypropylene, or made of glass. Also good. It is preferable that at least a portion of the syringe outer cylinder in which the chemical solution is stored has a light-transmitting property, that is, is transparent or translucent so that the remaining amount of the chemical solution inside can be visually recognized. And it is preferable to attach the scale (not shown) which can display the residual amount of a chemical | medical solution to the outer peripheral surface of a syringe outer cylinder. The gasket of the syringe (the tip portion of the piston member) slides in a liquid-tight manner in the axial direction within the syringe outer cylinder, and at least the outer peripheral portion thereof may be formed of an elastic seal member.

Return to the explanation of the circuit. As an example, the contrast agent chamber 221 to which the contrast agent line 205 is connected may be a bottle-like container filled with a contrast agent. The contrast agent chamber 221 may be used while being suspended by a suspender (not shown), and the contrast agent line 205 is connected to the lower portion of the contrast agent chamber 221. This connection may be made via a needle.

As shown in FIG. 1, an air sensor 231 (for example, an infrared sensor) for detecting whether air is mixed in the liquid in the contrast medium line 205 is disposed below the contrast medium chamber 221. By detecting the air in the line by the air sensor 231, it can be detected that the chemical liquid in the chamber has run out. A drip chamber 233 is disposed below the air sensor 231 and on the contrast medium line 205, and the contrast medium from the contrast medium chamber 221 once drops into the chamber 233, and the contrast medium from within the chamber 233. It flows into the line 205.

As an example, the physiological saline chamber 223 to which the physiological saline line 206 is connected may be a bag-like container filled with physiological saline, and in this example, further, a pressurizing means 224 for pressurizing the bag. (This type of structure is also referred to as a “pressure bag”). Commercially available pressure bags may be used. The pressurizing means 224 is not limited, and may compress the bag using a fluid such as air as a driving source, or compress the bag using a motor or the like as a driving source. Also good. Similar to the contrast agent line 205, a similar air sensor 231 and drip chamber 233 are also disposed in the physiological saline line 206. The mechanism for pressurizing the physiological saline is not limited to the above, but other configurations will be described later.

The physiological saline line 206 is provided with a release valve 202A for switching opening and closing of the line 206. The release valve 202A has a movable member 203 that moves in response to an external force. By moving the movable member 203, the valve opening / closing state is switched to open and close the physiological saline line 206. In this embodiment, as an example, the valve 202A is opened by pushing the movable member 203, and physiological saline from the pressurized bag flows toward the baseline portion 210 (the direction in which the liquid flows depends on the pressure difference of the liquid). It is configured as follows.

Next, devices and the like connected to the transducer line 207 will be described. For example, the pressure transducer 270 connected to the line 207 detects blood pressure so that the patient's pulse can be monitored. As an example, the pulse waveform is configured to be displayed on a display 271 connected to the transducer 270.

The transducer valve 207 is also provided with a release valve 202B similar to the release valve 202A of the physiological saline line 206. However, the direction is opposite to that of the release valve 202A. In this release valve 202B, the movable member 203 is pushed, so that the chemical liquid can flow to the transducer 270 side.

In the example of FIG. 1, the movable member 203 of one release valve 202A and the movable member 203 of the other release valve 202B are arranged to face each other. Furthermore, the distance (L1, L2) from the base line part 210 to the

movable members

203, 203 of each valve is arranged so as not to be the same so as to correspond to the configuration of the switching machine 300 described later.

A thin tube called a catheter (not shown) is connected to the distal end of the patient line 208, and this catheter is inserted into the patient's blood vessel. In the cardiac catheter test, the catheter tip is transferred to, for example, the coronary artery, and a contrast agent or the like is injected into the blood vessel from the catheter tip.

Subsequently, with reference to FIG. 2B, a switching device 300 for holding a part of the chemical circuit 201 of FIG. 1 and switching the flow thereof as appropriate will be described. The switching machine 300 includes a box-shaped housing 310 as an example. The switching device 300 includes a first holding unit 306 for holding a part of the physiological saline line 206 and a second holding unit 307 for holding a part of the transducer line 207. These holding

portions

306 and 307 are formed in a concave shape, and the

release valves

202A and 202B of each line are set therein.

In the housing 310 of the switching machine 300, for example, driving

units

301 and 301 that push the

movable members

203 and 203 of the

valves

202A and 202B electromechanically using, for example, a motor as a driving source are provided. The driving

units

301 and 301 may be configured to operate in response to a control signal from an external controller 350. The function of the controller 350 is not particularly limited, but the injector 260 may have the function.

The switching machine 300 also includes a third holding unit 308 that holds a part of the patient line 208 and an air sensor 332 that detects the presence or absence of bubbles in the patient line 208. For example, the air sensor 332 may be an ultrasonic sensor. The ultrasonic sensor 332 is advantageous in that, even when bubbles are mixed in the liquid under a high pressure condition, the ultrasonic sensor 332 can be found well.

Hereinafter, a method for using the chemical circuit 200 of the present embodiment configured as described above will be described.

FIG. 3 shows an initial state. In this state, the

movable members

203 and 203 of the

release valves

202A and 202B are not pushed and the liquid does not flow bidirectionally. In the state of FIG. 3, when the operator presses a predetermined button (air clear button) of the injector 206, the piston drive mechanism operates to pull the piston member of the syringe 251. Thereby, the inside of the syringe 251 and the syringe line 204 becomes negative pressure, and the contrast agent in the chamber 221 is drawn into the

syringe lines

205 and 204 and the syringe 251 via the contrast agent line 205 and the dual check valve 215A.

Next, as shown in FIG. 4, this time, the piston member of the syringe 251 is pushed, and the contrast agent is pushed out from the syringe 251. The liquid passes through the syringe line 204 to the baseline part 210 side, passes through the two

dual check valves

215A and 215B, and fills the baseline part 210. This extrusion operation of the contrast agent is continued until the contrast agent is pushed out at least beyond the dual check valve 215B, as shown in FIG.

Next, as shown in FIG. 5, the movable member 203 of the release valve 202A and the movable member 203 of the release valve 202B are pushed to open both

valves

202A and 202B. The opening is automatically performed when the driving

units

301 and 301 of the switching machine 300 press each movable member. At this time, the pressurizing means 224 of the physiological saline chamber 223 is driven, and a predetermined pressure (for example, about 300 mmHg) is applied to the physiological saline. Therefore, when the valve 202A is opened, the physiological saline flows from the chamber 223 side toward the base line part 210, passes through the release valve 202A and the dual check valve 215B, and flows toward the patient line 208 side. The contrast agent further passes through the three-way stopcock 213 and branches at the connector 217, with some flowing into the patient line 208 and the other flowing into the transducer line 207. Here, since the release valve 202B is opened, the physiological saline flows toward the transducer 270 beyond the release valve 202B. In this way, by filling each line with physiological saline, bubbles in the line are removed to the outside.

Next, as shown in FIG. 6, the pressing of the movable member 203 of the release valve 202A of the physiological saline line 206 is released so that the physiological saline does not flow downstream beyond the release valve 202A. In addition, the pressing of the movable member 203 of the release valve 202B of the transducer line 207 is released so that the contrast agent does not flow into the transducer 270 side in the next contrast agent injection step, and the contrast agent or the like exceeds the release valve 202B. Make sure that it does not flow to the transducer side.

Next, by operating the piston drive mechanism of the injector 206 and pushing the piston member of the syringe 251, the contrast medium in the syringe 251 is pushed out toward the patient as shown in FIG. Specifically, the contrast agent passes through the contrast agent line 204, the baseline portion 210, the patient line 208, and a catheter (not shown) to a predetermined imaging site (for example, a coronary artery of the heart) in the patient body. Sent.

Next, after the contrast agent is injected and the residual pressure in the circuit is sufficiently lowered, the movable member 203 of the release valve 202A of the physiological saline line 206 is pushed as shown in FIG. 8 to open the valve again. Similar to the process described above, at this time, a predetermined pressure (for example, about 300 mmHg) is applied to the physiological saline by the pressurizing means 224 of the pressure bag. Is sent to the base line part 210 and the patient line 208, and the contrast medium is flushed.

Next, as shown in FIG. 9, if necessary, the release valve 202B of the transducer line 207 is opened, whereby physiological saline is caused to flow further to the transducer side than the release valve 202B. Do a flash by.

Thereafter, as shown in FIG. 10, the pressing of the movable member 203 of the check valve 202A of the physiological saline line 206 is released, and the physiological saline does not flow to the base line part 210 side beyond the valve 202A. Thereby, the pressurized state of the physiological saline downstream of the baseline part 210 is released. As a result, as shown in FIG. 10, a blood route is established through the patient line 208 and the transducer line 207, and the blood pressure can be detected by the transducer 270.

As described above, the chemical circuit 201 according to the present embodiment includes the contrast medium line 205, the physiological saline line 206, the syringe line 204, the patient line 208, and the base line section 210, and the contrast medium line 205.

Dual check valves

215A and 215B for restricting the flow of the liquid in a predetermined direction are provided at a connection portion between the base line portion 210 and the physiological saline line 206 and the base line portion 206. Therefore, it is possible to satisfactorily perform the suction of the contrast medium into the syringe 251 (FIG. 3) and the subsequent delivery of the contrast medium (FIG. 4) without requiring the operator to manually switch the three-way stopcock. Can do.

Also, the chemical circuit 201 of this embodiment is provided with a release valve 202A in the physiological saline line 206. In particular, since the release valve 202A switches between opening and closing by pressing the movable member 203, for example, the release valve 202A can be easily switched compared to a type in which opening and closing is switched by twisting a lever such as a three-way cock. Specifically, there is an advantage that it is easy to perform automatic switching by a switching machine using an actuator such as a motor. Further, such movement of the movable member 203 can be performed in a short time compared to the case of twisting the lever. Further, in the case of the configuration in which the flow path is closed by the function of the

release valves

202A and 202B itself as in the present embodiment, for example, the closing can be performed more reliably than when the tube is crushed and closed.

Furthermore, in the configuration of the present embodiment, the transducer line 207 can be satisfactorily closed using the release valve 202B, so that a high-pressure liquid transducer 270 can be used even when a high-pressure injection such as a cardiac catheter test is performed. Inflow to the side can be prevented, and as a result, breakage and damage of the transducer 270 can be prevented.

As an example, the drug solution circuit 201 of the present embodiment is used as a disposable with the contrast medium line 205, the physiological saline line 206, the syringe line 204, the transducer line 207, the patient line 208, and the base line unit 210 as one set. It may be a thing. That is, the chemical circuit 201 can be used a plurality of times, but may be replaced with a new one when the use with respect to one patient is completed for the purpose of preventing infection. In this case, it may be disposable including the drip chambers 233 and 233 (only one of them) of the physiological saline line 206 and the contrast medium line 205.

In addition, the chemical circuit system of the present embodiment uses the chemical circuit 201 described above, and includes an injector that mounts the syringe 251 and performs suction and injection (delivery) of liquid, and opening and closing a predetermined line of the chemical circuit 201. And a switching device 300 that automatically switches between. According to such a system, it is possible to appropriately perform a series of injection operations of contrast medium and physiological saline without requiring the operator to switch the three-way stopcock, and if necessary, all steps Can also be performed automatically.

The present invention is not limited to the form described above. For example, as a configuration for extruding physiological saline, a tube pump that continuously crushes the tube and flows physiological saline in the tube in a predetermined direction may be used instead of the pressure bag. Alternatively, a device that repeatedly sucks and pushes physiological saline by reciprocating the piston member of a small syringe can be used. This device uses a cam mechanism and a biasing member (for example, a spring). May be.

(Second Embodiment-1-)
In the chemical circuit system according to the present invention, a pump device 226 as shown in FIG. 11 may be used in place of the pressurizing means 224 for physiological saline (FIG. 1). FIG. 11 shows only a part of the chemical circuit system. About the structure downstream from the three-way cock 213, the thing similar to FIG. 1 can be used.

The pump device 226 is of the type disclosed in Japanese Patent No. 3626264, for example. The pump device 226 includes a main body 227 on which a small syringe 226a is mounted, and a piston drive mechanism (not shown) that moves the piston member of the syringe 226a back and forth.

In order to realize the transportation of the physiological saline by the pump device 226, in the configuration of FIG. 11, a part of the circuit is changed from that of FIG. Specifically, T-shaped

connectors

215C and 215D are used instead of the

dual check valves

215A and 215B, and one valve V-1 is disposed between the two connectors. The one-way valve V-1 is arranged so as to allow the flow to the downstream side and not to allow the flow in the opposite direction, as indicated by the triangular mark in FIG. The flow restriction directions of the other one-way valves V-2 to V4 also follow the direction of the triangular mark in FIG.

On the line 205 connecting the T-shaped connector 215C and the contrast medium chamber 221, a connector 234, an infusion chamber 233, an air sensor 231 and a one-way valve V-2 are arranged in this order from the side close to the chamber 221. The arrangement of these

components

234, 233, 231 can be changed as appropriate.

The physiological saline line 206 connecting the connector 215D and the physiological saline chamber 223 is divided into two on the way, and the branched line 209 extends to the pump device 226. As an example, the line 209 is connected to the line 206 by a T-shaped connector. As shown in FIG. 11, two one-way valves V-3 and V-4 are arranged on the line 206.

One one-way valve V-5 is also provided between the connector 215D and the three-way cock 213. The one-way valve V-5 may be omitted. When there is one valve V-5, a circuit downstream from the one valve may be made disposable. Alternatively, a circuit downstream from the connector 215D may be used as the disposal regardless of the presence or absence of the one-way valve V-5.
Further, a chemical liquid tube (not shown) may be connected to the three-way cock 213, and the chemical liquid may be injected toward the patient via the chemical liquid tube.

In the chemical circuit system of FIG. 11 configured as described above, by operating the pump device 226 to move the piston member of the small syringe 226a forward and backward, (i) physiological saline from the chamber 223 into the syringe 226a Suction and (ii) discharge of physiological saline from the small syringe 226a are repeated. Thereby, physiological saline is inject | poured toward a patient.

In the configuration of FIG. 11, as an example, a load sensor 223 </ b> S that measures the weight of the physiological saline chamber 223 is provided. The control device (not shown) is based on the output value of the load sensor 223S or a value obtained by converting the load sensor 223S into a load. Whether or not) When it is determined that the value is equal to or less than a predetermined set value, a predetermined warning (for example, lighting of a lamp, display of a message, output of sound or sound, etc.) is issued to the surgeon.

Of course, the load sensor 223S as described above can also be used in the chemical circuit system of the embodiment of FIG.

For example, in order to omit the air sensor 231 in the chemical circuit system of FIG. 11, a connector having a floating valve body as disclosed in Japanese Patent Application Laid-Open No. 9-117505 can be used as an example for the drip chamber. , Air contamination on the patient line side is prevented. Further, it may be determined based on the position of the valve body whether or not it is empty, and if it is empty, control such as stopping injection may be performed.

The chemical circuit system of FIG. 11 includes the following chemical circuit:
A medical chemical circuit used for angiography,
A contrast agent line connected to the contrast agent chamber;
A saline line connected to the saline chamber;
A syringe line connected to the syringe;
A patient line for delivering contrast media or saline to the patient;
A baseline part to which each line is connected, wherein the contrast medium line and the physiological saline line are each connected in a T-shape; and
In addition,
a: (i) When the liquid is drawn toward the upstream side of the baseline portion, the contrast medium flows from the line into the baseline portion, and (ii) the liquid flows from the upstream side of the baseline portion. A first valve means (V-1, V-2) configured to pass through the valve means and flow liquid in that direction when pushed toward the downstream side;
b: Second valve means (V-1) which allows the liquid to flow in the direction when the liquid is pushed from the upstream side to the downstream side of the baseline portion but does not allow the reverse flow. When,
c: When the physiological saline is sent from the physiological saline chamber by the physiological saline feeding means, the physiological saline is allowed to flow to the patient line side, and the flow to the syringe line side is not allowed. Valve means (V-3, V-1);
A medical chemical circuit comprising:

(Second Embodiment-2-)
FIG. 16 shows a chemical circuit and a chemical circuit system according to another embodiment of the present invention. The circuit configuration of FIG. 16 may be basically the same as that of FIG. 11, and is the same as or corresponds to the structural part having the same function as that of FIG. 11 (shown by replacing the 200 series with the 600 series). Are attached).

In FIG. 16, reference numeral 605 is a contrast medium line, reference numeral 606 is a physiological saline line, reference numeral 607 is a transducer line, reference numeral 609 is a line branched from the physiological saline line 606, reference numeral 608 is a patient line, and reference numeral 610 is a baseline. Part. Reference numeral 621 is a contrast medium chamber, and reference numeral 623 is a physiological saline chamber. Reference numeral 633 denotes an infusion chamber, and the infusion chamber 633 may be a conventionally known one in which an insertion needle is integrally formed thereon. Reference numerals V-1 to V4 denote one-way valves having the same structure and the same arrangement as those in FIG. Reference numerals 615C to 615F denote T-shaped connectors, and

reference numerals

641, 642, and 643 denote connection members. For example, at least one of the

connectors

615C and 615D may be a dual check valve as described above.

The main differences between the circuit configuration of FIG. 16 and the circuit of FIG. 11 are as follows:
The syringe pump 500 has a double packing type syringe 550 (detailed below).
The one-way valve V-5 (see FIG. 11) is omitted.
A release valve 401A (details below) is arranged on the transducer line 607;

It should be noted that the contents already described with reference to FIG. 11 or the contents already described with reference to FIG. 1 can be applied to matters not specifically described below.

A syringe 550 used in the syringe pump 500 (FIG. 16) will be described with reference to FIG. The syringe 550 is a dust-proof syringe as disclosed in, for example, Japanese Patent No. 3639095:
A hollow cylinder member 551;
A piston member 557 formed with two-

stage pistons

553 and 554 that slide in the axial direction in the cylinder member 551;
Having
Annular seal members R1 and R2 for ensuring watertightness are provided on the outer periphery of the first and

second pistons

553 and 554. For example, the distance between the seal members R1 and R2 may be set to a distance equal to the stroke amount of the first-stage piston 553 necessary for sucking a predetermined injection amount. The material of the seal member is an example, and may be an elastic member such as an elastomer.

Specifically, the piston member 557 sucks a predetermined injection amount at a position (before suction) where the front surface of the first-stage piston 553 contacts or substantially contacts the inner surface of the front end of the cylinder member 551. It is configured to reciprocate between a position moved by a predetermined stroke (after suction). The second-stage piston 554 is disposed behind the first-stage piston 553. The cross-sectional shape of the seal rings R1 and R2 is not particularly limited. For example, various cross-sections such as a circle, an ellipse, a rectangle, a polygon, and a D-shape can be used.

A concave portion 577 a that is gripped by a gripping member (not shown) of the syringe pump is formed at the base end portion of the piston member 557. The piston member 557 reciprocates with respect to the cylinder member 551 in response to a force from a drive mechanism (not shown) of the syringe pump. As a result, the suction of the chemical liquid to the syringe 550 and the delivery of the chemical liquid from the syringe 550 are repeated to act as a pump.

For example, the piston member may be reciprocated using a pump system as disclosed in Japanese Patent No. 4367911. In this case, a syringe having a position restriction piece on the cylinder member may be attached to the pump system.

In the piston member 557 in FIG. 17, the distance between the seal members R1 and R2 is approximately equal to the stroke required for the first-stage piston 553 to suck a predetermined injection amount. With this configuration, unsanitary things such as dust in the outside air are prevented from entering the inside of the seal member R2 of the second piston 554, and the space S between the

pistons

553 and 554 is maintained in a sterilized state. Therefore, the chemical liquid sucked into the syringe 550 can be kept hygienic.

For example, the syringe 550 may be modified as follows.
The sealing member R1 and / or R2 is provided integrally with the piston, for example by integral molding.
-The sealing member R2 is not fitted. In this case, although the sealing performance of the outer periphery of the second-stage piston is not ensured, it is also preferable that the piston prevents foreign matter (such as dust) from entering the inside of the piston. .
The range from the front surface portion to the outer peripheral portion of the first-stage piston is constituted by an elastic member.
The entire at least one piston is made of an elastic member;
The space between the

pistons

553, 554 is filled with a gas having a sterilizing effect.
The distance between the sealing members R1, R2 is set longer or shorter than the stroke of the first stage piston.

Further, as the syringe 550, a wing-like member for preventing rotation may be formed on the outer peripheral surface of the cylindrical cylinder member 551.

In the chemical circuit system 600 of FIG. 16 configured as described above, as in the configuration of FIG. 1, (i) the injector is operated to suck the contrast agent from the contrast agent chamber 621 into the chemical syringe 651, and An injection operation of pushing the contrast agent toward the patient, and (ii) an operation of operating the syringe pump 500 to inject the physiological saline in the physiological saline chamber 623 toward the patient, such as a stopcock switching operation by an operator Can be carried out correctly without any special requirements.

In the system shown in FIG. 16, instead of the chemical syringe 651 (having a cylindrical cylinder member and a piston member slidably inserted therein), a syringe having a structure like the above-described syringe 550 is used. Also good.

Further, the second piston may be configured as shown in FIG. In the second piston 554, a seal member R2 is attached to the outer periphery of the piston, and a gas passage 558 is formed between a groove 554a formed from the outer periphery of the piston toward the center and the seal member R2. Sterile gas may be sealed between the first piston and the second piston through the gas passage 558. The size of the gas passage 558 can be changed as appropriate, but as an example, it is also preferable that the gas passage 558 has a size that allows gas to be sealed and that foreign matters such as dust hardly pass through.

18 may be formed with a small hole 554b for enclosing a sterilizing gas. Although only one is shown in FIG. 18, the small hole 554b may be one or more. Both the groove 554a and the small hole 554b may be provided, or only one of them may be provided.

(Release valve)
14A is a cross-sectional view of a release valve used in the configuration of FIG. FIG. 14B is a front view and a bottom view showing the shaft member of the release valve.

The release valve 401A includes a hollow main body member 411, a tube connection member 412 connected to a lower portion thereof, and a cap member 413 that closes an upper end opening of the main body member 411 as members constituting the casing 410. ing. In addition, a shaft member 425 is disposed inside the main body member 411 so as to be movable upward and downward. The shaft member 425 is provided with two

seal members

428 and 429, and a flange portion 425f is formed on a part of the shaft member 425. As an example, each of the sealing

members

428 and 429 may be a disk-shaped member made of an elastic member.

The shaft member 425 is biased upward by the coil spring S1 (FIG. 14), and in this state, the flange portion 425f presses against the seal member 429. In this state, liquid does not flow from the lower end opening 412a of the connection member 412 toward the side opening 411a of the main body member 411 (or in the opposite direction).

On the other hand, when the end portion of the shaft member 425 protruding upward from the center portion of the cap member 413 is pushed, the flange portion 425f moves downward, so that the liquid flow path (not shown in detail) is opened. The liquid can flow from the lower end opening 412a of the connection member 412 toward the side opening 411a of the main body member 411 (or in the opposite direction). Regarding the liquid flow path, for example, a part of the flow path may be formed by a groove formed along the longitudinal direction of the outer periphery of the shaft member 425. In the present embodiment, as shown in FIG. 14B, the lower end side 425a of the shaft member 425 has a cross-shaped cross section as an example. The shape is not necessarily limited to a cross shape, and may be changed to various shapes.

For the release valve 401A, the shaft member 425 may be pressed / released by using a device such as the automatic switching machine 300 (FIG. 2B) described in the first embodiment. The operation of the switching machine may be controlled by an injection device, or may be manually operated by an operator.

Alternatively, a release valve 401B as shown in FIG. 15 may be used. The release valve 401B of FIG. 15 includes a hollow main body member 411 and a cap member 413 that closes the upper end opening as members constituting the casing 410. A shaft member 425 is arranged inside the main body member 411 so as to be movable upward and downward. The shaft member 425 is provided with one seal member 429 and an O-ring R1. A pressing member 416 having a flow path formed therein is attached to the upper end of the shaft member 425 protruding upward from the cap member 413. The pressing member 416 has a side opening 416a serving as a liquid inlet / outlet.

Even in the release valve 401B configured as described above, when the shaft member 425 is not pressed, the flange portion 425f is pressed against the seal member 429 by the urging force of the coil spring S1, and as a result, the pressing member is pressed from the lower end opening 411a. The liquid is prevented from flowing toward the side opening 416a of 416 (or the opposite direction). On the other hand, when the cap member shaft member 425 is pushed, the liquid flow path (not shown in detail) is opened, thereby allowing the liquid to flow.

(Circuit configuration according to another embodiment)
The circuit configuration of FIG. 19 will be described. This chemical circuit 601P is partially similar to that of FIG. 11 and FIG. 16 described above, but a part of the circuit is a disposable circuit and a clamping mechanism for closing the tube (line). Is different (details below).

In addition, about the structure similar to the said form, the overlapping description is abbreviate | omitted. It should be noted that the contents described below can be used in combination with other technical matters in this specification as appropriate. The present invention is not limited to the specific configurations illustrated in the drawings and / or the specification, and other configurations, components, and the like may be used as needed.

The chemical circuit (601P) in the chemical circuit system of FIG. 19 can be expressed as follows as an example:
A contrast agent line (605) connected to the contrast agent chamber (621);
A saline line (606) connected to a saline chamber (623);
A liquid flow path connected to the chemical syringe (651);
A patient line (608) for delivering contrast agent or saline to the patient;
A baseline portion (610) to which each line is connected;
A chemical circuit (601P) used for injecting a contrast medium into the chemical syringe (651) and then injecting the contrast medium from the syringe toward the patient,
In addition, it is structured as follows:
(I) When the liquid is drawn toward the upstream side of the baseline portion, the contrast agent flows from the contrast agent line into the baseline portion, and (ii) the liquid flows from the upstream side to the downstream side of the baseline portion. The first valve device (V-1, V-2) that allows the liquid to flow from the upstream side to the downstream side of the baseline portion without flowing back into the contrast agent line when pushed )When,
A second valve device (V-3) that allows liquid to flow from the saline line to the base line side but not vice versa:
The disposable circuit portion (601P-1) on the downstream side of the connection portion between the base line portion (610) and the physiological saline line (606) is preferably detachable via a one-way valve (V-5). It is configured.

Even in such a circuit configuration, (i) in one example, by driving a piston drive mechanism of an injector (not shown) and pulling the piston, the contrast agent is transferred from the contrast agent chamber (621) into the drug solution syringe (651). And / or (ii) a syringe pump (pump means) (500) to cause the saline in the saline chamber (623) to be syringed by the action of pushing the contrast medium toward the patient and / or It is possible to perform the operation of injecting toward the patient without backflowing to the side. That is, according to such a circuit configuration, it is possible to correctly perform the suction and injection of the contrast agent without requiring a stopcock switching operation by the operator.

(Specific description of circuit configuration)
In the chemical circuit 601P of FIG. 19, the disposable circuit portion 601P-1 is configured to be detachable with respect to the end of a line 608 extending downstream from the connector 615D via a one-way valve V-5, a connector, or the like. . In this example, the one-way valve V-5 is used, but it may be detachable by a simple connector or the like.

In this example, the disposable circuit portion 601P-1 has a line 608 extending from the one-way valve V-5 toward the patient, and a line 607 branched from the midway position toward the transducer 670. One clamping mechanism 660 is provided at the line 607 and the line 608 of the disposal circuit portion 601P-1.

The clamping mechanism 660 may include a drive source (not shown) and one or more clamp members 668 that press the tube. The clamp member 668 is moved by a driving force from a driving source (not shown), and the flexible tube is crushed to close the flow path. The driving source (not shown) is not particularly limited, but various actuators such as a motor and a fluid cylinder can be used.

The operation control of the drive source (not shown) may be automatically performed by a controller (not shown). Such a controller may be a microcomputer including a processor unit, a memory, and the like, and its arrangement position is not limited at all.

In the example of FIG. 19, the two clamping mechanisms 660 are drawn apart from each other, but these may be driven by different driving sources or driven by a common driving source. There may be.

Further, in the case of the circuit configuration as shown in FIG. 19, one, plural, or all of the following may be adopted:
An air sensor 631 is provided in the middle or at the end of the contrast medium line 605,
An air sensor 631 is provided in the middle or at the end of the physiological saline line 606;
-At least one of the connectors 615C to 615F has the function of a one-way valve (check valve), etc.

The air sensor 631 may use infrared rays as exemplified in the above embodiment, but may also be an optical sensor that uses ultraviolet rays, a sensor that uses ultrasonic waves, or the like. . In particular, in the case of an ultraviolet sensor, there is an advantage that it is possible to better distinguish between blood and a chemical solution and to detect a foreign substance in the liquid as compared with an infrared sensor.

Subsequently, some examples of the clamping mechanism 660 will be described.

In the clamping mechanism of FIG. 20A (a), a pair of

clamp members

668a and 668a arranged to face each other with the tube T interposed therebetween are provided. Each clamp member 668 has a corner portion on the side in contact with the tube, and presses the tube at the corner portion.

However, it is not necessary that both the clamp members 668a have corners, only one of the clamp members 668a is as shown in the figure, and the other is a clamp member (not shown) that abuts on a flat surface. Also good. Alternatively, the clamp member 668a ′ (FIG. 20B) may have a facing surface having a shape substantially complementary to the corner of the clamp member 668a (in this example, a V-shaped groove as an example).

In the clamping mechanism shown in FIG. 20A (b), each clamp member 668b protrudes in a curved shape on the side in contact with the tube, and the tube T is pressed by this protruding portion. As described above, only one clamp member 668b is as shown in the figure, and the other is a flat clamp member (not shown) or a substantially complementary shape (curved concave surface in this example) as described above. It is good also as a clamp member (not shown) which has an opposing surface.

In the clamping mechanism of FIG. 20A (c), each clamp member 668c is formed in a circular shape. The other may be a flat clamp member (not shown), a clamp member (not shown) having a curved concave surface, or the like.

The clamp member may have any shape or material as long as it can firmly close the tube. For example, a rod-shaped member (for example, a pin clamp; one end of the rod-shaped member serves as an abutting portion for the tube. Alternatively, the tube may be pressed by a part of the outer peripheral surface of the rod-shaped member), a plate-shaped member. Various members such as a block member and a spherical member can be used. The clamp member may be metallic or made of resin. In the case of metallicity, either a magnetic material or a nonmagnetic material may be used.

As for the opening / closing operation of the pair of clamp members as illustrated in FIGS. 20A and 20B, each clamp member may advance toward the center of the tube and sandwich the tube, or may be configured to be movable. Only one of them may advance with respect to the other and sandwich the tube. When each clamp member is configured to be movable, the mechanism may be a mechanism in which the operation of one clamp member and the operation of the other clamp member are linked with each other.

Note that this description of the material can be applied to any member constituting the clamping mechanism 660 and / or its accessories, etc., without departing from the scope of the present invention.

In the clamping mechanism of FIG. 21, a pair of clamp members are not used, but only one member is movable clamp members 668a to 668c, and the fixed receiving surface 668s on which the clamp members 668a to 668c do not move. It is configured to be able to move forward and backward. The shape of each of the clamp members 668a to 668c is the same as that in FIG.

Furthermore, a clamping mechanism configured as shown in FIG. 22 may be used. The clamping mechanism has a slide member 669 that can move in the lateral direction. When the slide member 669 is slid in a predetermined direction (rightward in the drawing), a part of the slide member 669 is clamped. The clamp member 668 is moved toward the tube T side in contact with 668, and finally the tube T is closed. On the other hand, when the slide member 669 is slid in the opposite direction, the clamp member 668 moves backward from the tube T, and the tube T is opened.

The slide member 669 may have an inclined surface (cam surface) 669a that contacts the clamp member 688 as a specific example. The slide member 669 may be slid by a user's finger, for example, or may be configured to be automatically slid by a drive mechanism (actuator) (not shown).

The moving direction of the slide member 669 is not necessarily limited to the horizontal direction (that is, the direction along the tube in this case). Although illustration is omitted, for example, by rotating in the circumferential direction with respect to the tube, the cam surface formed in a part of the member gradually becomes an internal clamp member (in this case, a sphere may be used as an example). You may press against the tube side.

For example, an anti-slip rib and / or a protrusion (both not shown) may be formed on a part of the slide member 669, for example, at a portion where the finger abuts. Further, a receiving part (or engaging part to be engaged) with which a part of the drive mechanism for moving the slide member 669 comes into contact may be formed.

Regarding the configuration having the slide member 669, the following changes may be made. In other words, when the slide member 669 is moved to a predetermined fixed position, a part of the slide member 669 may be engaged or fitted with another member to obtain a click feeling. For example, a part of the slide member 669 may be fitted into a recess (not shown) formed on another member, or may be configured to get over a protrusion formed on the other member. In addition, when the slide member 669 is moved from the fixed position, in other words, it is more preferable that a click feeling is obtained even when the slide member 669 is removed from the fixed position. It goes without saying that such a change can be similarly applied to the configuration of FIG. 23 described below.

As the clamping mechanism, the one shown in FIG. 23 can also be used. The clamping mechanism of FIG. 23 has the same principle as that of FIG. 22 for opening and closing the tube, but a relatively soft tube T ′ disposed in the connector housing (662, detailed below) is provided. The difference is that the clamp member 668 is pressed. One reason for this configuration is as follows.

That is, for example, when a chemical solution is injected at a very high pressure (for example, 500 psi or more, specifically 800 psi or more, more specifically 1000 psi or more), the normal chemical solution tube T (tube T It is envisaged that it will be very difficult to crush the portion that is harder than ′. Therefore, in the clamping mechanism shown in FIG. 23, a tube T ′ that is relatively softer than the other chemical solution tubes T in the chemical circuit is arranged in the casing, and the soft tube T ′ is pressed and closed. .

When the soft tube T ′ is configured, (i) the tube T ′ may be more easily deformed by making the material of the tube softer than that of other tubes of the chemical circuit, or (ii) The material is the same, but the tube T ′ may be more easily deformed by reducing the thickness of the tube T ′, reducing the warp, and / or combinations thereof.

However, since the soft tube T ′ may expand due to the pressure of the chemical solution, the protective cover 662 is provided so as to surround the soft tube T ′. The protective cover 662 may have any shape, but may be a cylindrical shape having an inner diameter that is slightly larger than the diameter of the tube. The cross-sectional shape is preferably circular, but may be, for example, an ellipse, a rectangle, or a polygon. An opening 662a is formed in a part of the protective cover 662, and the clamp member 668 is configured to move forward and backward through the opening 662a.

The protective cover 662 may be made of any material, but as an example, the protective cover 662 may be a resin molded product.

According to the configuration illustrated in FIG. 23, since the soft tube T ′ is crushed, the tube is crushed well compared to the case of directly pressing a part of the chemical liquid tube T, that is, The line can be closed, which is particularly advantageous in the case of high-pressure chemical solution injection.

As described above, various examples of the chemical circuit and some specific examples of the clamping mechanism have been described. However, the arrangement position of the clamping mechanism can be variously changed. 19 will be described as an example. The chemical solution circuit may be arranged at one or a plurality of locations selected from positions indicated by symbols A to E.

When a plurality of clamping mechanisms are arranged, each clamping mechanism may be the same or different. For example, according to the pressure of the chemical solution assumed in the line, a higher-pressure clamping mechanism is arranged at a high pressure, and a normal clamping mechanism is arranged at a low pressure. You can also.

(Other configurations)
-Roller type pump device-
Note that a roller-type pump 470 as shown in FIG. 12 can be used as means for pressurizing the chemical chamber and delivering the chemical. As an example, the pump 470 includes a pair of pressing

members

471 and 472 arranged so as to sandwich the chamber 223 therebetween. When one of the

pressing members

471 and 472 comes close to the other, the chamber 223 between both the

members

471 and 472 is pressed, and thereby the chemical solution inside the chamber 223 is pushed out.

Although the specific structure can be appropriately designed or changed, as an example, both members may be connected by a hinge portion 474 so that one of the members rotates with respect to the other. A roller 476 may be provided to bring one member close toward the other. The roller 476 rotates around the rotation center 476a (there may or may not be a drive source) and moves downward as indicated by an arrow in the figure, and the pressing member 471 is directed toward the other member 472. You may be comprised so that it may press.

-Piston type pump device-
Furthermore, a piston type pump 480 as shown in FIG. 13 can be used. The pump 480 includes two

syringes

481 and 486 connected in series, and the front end portion of the front syringe 481 is connected to the line 209 (see FIG. 11). A short gasket 482a is slidably disposed in the front syringe 481, and a protrusion 485 is formed on the back surface of the gasket 482a. The protrusion 485 is not necessarily formed, but plays a role of defining a movable range when the gasket 482a moves rearward.

The tip of the rear syringe 486 is formed to be thin and inserted into a through hole formed in the sealing member 482b of the front syringe 481. Thus, the liquid or gas in the rear syringe 486 is sent into the front syringe 481 and sucked from the syringe 481. The pump 480 is also provided with driving means (not shown) for moving the piston member of the rear syringe 486 back and forth.

In the chemical circuit system according to the present invention, it is possible to suck and inject physiological saline using the pump device 480 of the type as shown in FIG.

-Octopus tube-
Various conventionally known structures, devices, and equipment can be applied to the circuit system of the present invention. For example, a structure called an octopus tube may be provided at an arbitrary position of the circuit in order to prevent air bubbles from being injected into the patient. As an example, an octopus pipe may be provided between the connector 217 and the air sensor 232 in the configuration of FIG. The “octopus tube” is a protruding part (the outer shape may be any shape) such as the head of a spear that is formed in a hollow inside, and traps bubbles flowing through the circuit. Is to do. Therefore, it is preferable that the octopus pipe is arranged so as to protrude vertically upward. Moreover, it is preferable to provide in the location where the direction of a line (tube) is stable among circuit systems so that the attitude | position may not fluctuate.

This application discloses the following invention.
1. A contrast agent line (605) connected to the contrast agent chamber;
A saline line (606) connected to the saline chamber;
A syringe line (604) connected to the chemical syringe (651);
A patient line (608) for delivering contrast agent or saline to the patient;
A baseline portion (610) to which the lines are connected;
A chemical liquid circuit (601) used for injecting a contrast medium into the chemical liquid syringe (651) and then injecting the contrast medium from the syringe toward the patient,
further,
(I) When the liquid is drawn toward the upstream side of the baseline part (610), the contrast agent flows from the contrast medium line (605) into the baseline part (610), and (ii) When the liquid is pushed from the upstream side to the downstream side of the baseline part (610), the liquid flows from the upstream side to the downstream side of the baseline part (610) without flowing back into the contrast agent line. A first valve device (V-1, V-2) that allows the flow of
A second valve device (V-3, V-4) that allows liquid to flow from the saline line (606) side to the base line part (610) side but not vice versa;
A chemical circuit.

2. further,
A transducer line (607) having one end connected to the pressure transducer and the other end connected to the baseline portion (610);
A release valve (401A) having a movable member (425) and disposed on the transducer line (607) and opening and closing the line by moving the movable member (425);
A chemical circuit as described above, comprising:

3. As the first valve device (V-1, V-2),
A one-way valve (V-2) provided in the contrast medium line (605);
A one-way valve (V-1) provided in the baseline portion (610);
The chemical circuit according to the above, comprising:

3-1. The circuit part (601P-1) on the downstream side of the connection part between the base line part and the physiological saline line is preferably configured to be exchangeable via a one-way valve (V-5). Chemical circuit (601P).

4). A chemical circuit (601) as described above;
A pump unit (500) that draws physiological saline from the physiological saline chamber and feeds the physiological saline from the physiological saline line (606) side to the baseline part (610) side;
A chemical circuit system (600) comprising:

5. The pump unit is
A syringe pump (500) for transferring a liquid by repeating an operation of sucking a liquid into a syringe and an operation of pushing out the liquid.
The chemical circuit system described above.

6). The syringe (550) of the syringe pump is
A hollow cylinder member (551);
A piston member (557) formed with two-stage pistons (553, 554) sliding in the axial direction in the cylinder member (551);
The above-described chemical circuit system, which is a dust-proof syringe (550) having

7. Seal members (R1, R2) for ensuring water-tightness are provided on the outer periphery of the first-stage and second-stage pistons (553, 554), and between the seal members (R1, R2). The chemical circuit system according to the above, wherein the distance is set to a distance corresponding to a stroke amount of the first stage piston necessary for sucking a predetermined injection amount.

The following changes may be made.
(1) The saline line is connected to the saline delivery device, not the chamber. The “physiological saline delivery device” has a certain housing member that contains physiological saline and a mechanism that pushes out the physiological saline. For example,
-Aspirate saline from chamber 623 into a generic syringe only once and push saline out of the syringe.
A device that does not include the chamber 623 or the syringe pump 500 and simply pushes the physiological saline from a physiological saline containing member (for example, a syringe). In this case, the syringe may be a prefilled type pre-filled with physiological saline, or may be one in which physiological saline is sucked into the syringe by a suction device (not shown).
(2) Similarly, the contrast medium line and the syringe 651 can be appropriately changed. That is,
-Aspirate the contrast agent from the chamber 621 into the syringe 651 only once and push the contrast agent out of the syringe.
-Repeat the operation of sucking and extruding the contrast agent from the chamber 621 into a reciprocating syringe (such as the syringe 550).
-The connector 615C, the valve V-2, the line 605, etc. are omitted, and a device that pushes out the contrast agent from the contrast agent accommodating member (for example, a syringe) is simply connected to the baseline portion 610. In this case, the syringe may be a prefilled type in which a contrast medium is pre-filled, or may be one in which the contrast medium is sucked into the syringe by a suction device (not shown).

200 Chemical liquid circuit system 201 Chemical

liquid circuit

202A, 202B Release valve 203 Movable member 205 Contrast medium line 206 Saline line 207 Transducer line 208 Patient line 209 Line 210 Base line part 213 Three-

way stopcock

215A, 215B

Dual check valve

215C, 215D Connector 221 Contrast medium chamber 223 Saline chamber 223S Sensor 226 Pump device 226a Syringe 227

Main body part

231, 232 Air sensor 251 Syringe 260 Injector 270 Pressure transducer 300 Switching machine 301 Drive part 332

Air sensor

401A, 401B Release valve 410 Casing 411 Main body member 412 Tube connection Member 413 Cap member 425

Movable member

428, 429 Seal member 4 0 Roller type pump 476 Roller 480

Piston type pump

481, 486 Syringe 500 Syringe 551 Cylinder member 551a

End pipe

553, 554 Piston 557 Piston member 600 Liquid circuit system 601P Chemical liquid circuit 601P-1 Disposable circuit 604 Syringe line 605 Contrast medium line 606 Physiology Saline line 607 Transducer line 608 Patient line 610 Base line portion 615C to 615F T connector 621 Contrast medium chamber 623 Saline chamber 651 Drug syringe 660 Clamping mechanism 662 Protective cover 662a Openings 668a to 668c, 668a ′ Clamp member 668s Receiving surface 669 Slide member T Tube T 'Soft tube V-1 to V-5 One-way valve (valve device)

Claims

A contrast agent line connected to the contrast agent chamber;
A saline line connected to the saline chamber;
A syringe line connected to the chemical syringe;
A patient line for delivering contrast media or saline to the patient;
A baseline part to which each line is connected;
A liquid medicine circuit that is used for liquid medicine injection for injecting a contrast medium into the liquid medicine syringe and then injecting the contrast medium from the syringe toward a patient,
further,
(I) When the liquid is drawn toward the upstream side of the baseline portion, the contrast medium flows from the contrast agent line into the baseline portion, and (ii) the liquid flows from the upstream side of the baseline portion. A first valve device that allows liquid to flow from the upstream side of the baseline portion to the downstream side without backflowing into the contrast agent line when pushed toward the downstream side;
A second valve device that allows liquid to flow from the saline line to the baseline portion but not vice versa;
A chemical circuit.
further,
A transducer line having one end connected to the pressure transducer and the other end connected to the baseline portion;
A release valve that has a movable member and is disposed on the transducer line and opens and closes the line by moving the movable member;
The chemical circuit according to claim 1, comprising:
As the first valve device,
A one-way valve provided in the contrast medium line;
A one-way valve provided in the baseline portion;
The chemical | medical solution circuit of Claim 1 or 2 which has these.
The chemical circuit according to any one of claims 1 to 3, wherein a circuit portion downstream of a connection portion between the base line portion and the physiological saline line is configured to be replaceable.
The chemical circuit according to any one of claims 1 to 4,
A pump unit that draws physiological saline from the physiological saline chamber and feeds the physiological saline from the physiological saline line side to the baseline portion side;
A chemical circuit system comprising:
The pump unit is
A syringe pump that transfers liquid by repeating the operation of sucking the liquid into the syringe and the operation of pushing out the liquid.
The chemical circuit system according to claim 5.
The syringe of the syringe pump is
A hollow cylinder member;
A piston member formed with a two-stage piston that slides in the axial direction in the cylinder member;
The chemical circuit system according to claim 6, which is a dust-proof syringe having
A seal member for ensuring water tightness is provided on the outer periphery of the first and second stage pistons, and the distance between the seal members is the first stage required for sucking a predetermined injection amount. Set to the distance corresponding to the stroke amount of the eye piston,
The chemical circuit system according to claim 7.