WO2014089313A1 - PCSK9 iRNA COMPOSITIONS AND METHODS OF USE THEREOF - Google Patents
PCSK9 iRNA COMPOSITIONS AND METHODS OF USE THEREOF Download PDFInfo
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- WO2014089313A1 WO2014089313A1 PCT/US2013/073349 US2013073349W WO2014089313A1 WO 2014089313 A1 WO2014089313 A1 WO 2014089313A1 US 2013073349 W US2013073349 W US 2013073349W WO 2014089313 A1 WO2014089313 A1 WO 2014089313A1
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- WIPO (PCT)
- Prior art keywords
- rnai agent
- double stranded
- nucleotides
- stranded rnai
- strand
- Prior art date
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Classifications
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- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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- C12Y—ENZYMES
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2310/30—Chemical structure
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- C12N2310/35—Nature of the modification
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Abstract
Description
Claims
Priority Applications (34)
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NZ709013A NZ709013A (en) | 2012-12-05 | 2013-12-05 | Pcsk9 irna compositions and methods of use thereof |
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SI201330931T SI2929031T1 (en) | 2012-12-05 | 2013-12-05 | Pcsk9 irna compositions and methods of use thereof |
BR112015013105-0A BR112015013105B1 (en) | 2012-12-05 | 2013-12-05 | DOUBLE-STRAND RNAI AGENT CAPABLE OF INHIBITING PCSK9 EXPRESSION, ITS USES, PHARMACEUTICAL COMPOSITION AND METHOD OF INHIBITING PCSK9 EXPRESSION IN A CELL IN VITRO |
DK13811327.9T DK2929031T5 (en) | 2012-12-05 | 2013-12-05 | PCSK9-IRNA COMPOSITIONS AND METHODS OF USING IT |
CN201810143112.0A CN108220295B (en) | 2012-12-05 | 2013-12-05 | PCSK9 iRNA compositions and methods of use thereof |
AU2013355237A AU2013355237C1 (en) | 2012-12-05 | 2013-12-05 | PCSK9 iRNA compositions and methods of use thereof |
KR1020157016265A KR102096014B1 (en) | 2012-12-05 | 2013-12-05 | PCSK9 iRNA COMPOSITIONS AND METHODS OF USE THEREOF |
KR1020207008808A KR20200035490A (en) | 2012-12-05 | 2013-12-05 | PCSK9 iRNA COMPOSITIONS AND METHODS OF USE THEREOF |
EA201591075A EA037110B9 (en) | 2013-10-17 | 2013-12-05 | PCSK9 iRNA COMPOSITIONS AND METHODS OF USE THEREOF |
EP13811327.9A EP2929031B9 (en) | 2012-12-05 | 2013-12-05 | Pcsk9 irna compositions and methods of use thereof |
ES13811327.9T ES2657608T3 (en) | 2012-12-05 | 2013-12-05 | Compositions of pcsk9 arni and methods of use thereof |
CN201380063930.5A CN104854242B (en) | 2012-12-05 | 2013-12-05 | PCSK9 iRNA compositions and its application method |
LTEP13811327.9T LT2929031T (en) | 2012-12-05 | 2013-12-05 | Pcsk9 irna compositions and methods of use thereof |
MX2015007035A MX367076B (en) | 2012-12-05 | 2013-12-05 | PCSK9 iRNA COMPOSITIONS AND METHODS OF USE THEREOF. |
JP2015545846A JP6574383B2 (en) | 2012-12-05 | 2013-12-05 | PCSK9 iRNA composition and method of use thereof |
CA2892160A CA2892160C (en) | 2012-12-05 | 2013-12-05 | Pcsk9 irna compositions and methods of use thereof |
RS20180075A RS56783B9 (en) | 2012-12-05 | 2013-12-05 | Pcsk9 irna compositions and methods of use thereof |
IL238917A IL238917B (en) | 2012-12-05 | 2015-05-20 | Pcsk9 irna compositions and methods of use thereof |
ZA2015/03829A ZA201503829B (en) | 2012-12-05 | 2015-05-28 | Pcsk9 irna compositions and methods of use thereof |
HK16101596.8A HK1213598A1 (en) | 2012-12-05 | 2016-02-15 | Pcsk9 irna compositions and methods of use thereof pcsk9 irna |
HRP20180126TT HRP20180126T2 (en) | 2012-12-05 | 2018-01-23 | PCSK9 iRNA COMPOSITIONS AND METHODS OF USE THEREOF |
CY20181100085T CY1120195T1 (en) | 2012-12-05 | 2018-01-23 | IRNA TOY PCSK9 COMPOSITIONS AND METHODS OF USE |
AU2020201441A AU2020201441A1 (en) | 2012-12-05 | 2020-02-27 | PCSK9 iRNA compositions and methods of use thereof |
NL301107C NL301107I2 (en) | 2012-12-05 | 2021-06-04 | inclisiran |
FR21C1021C FR21C1021I2 (en) | 2012-12-05 | 2021-06-04 | ARNI COMPOSITIONS OF PCSK9 AND RELATED METHODS OF USE |
LTPA2021510C LTC2929031I2 (en) | 2012-12-05 | 2021-06-04 | |
LU00209C LUC00209I2 (en) | 2012-12-05 | 2021-06-04 | |
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IL292159A IL292159A (en) | 2012-12-05 | 2022-04-11 | Pcsk9 irna compositions and methods of use thereof |
AU2022224712A AU2022224712A1 (en) | 2012-12-05 | 2022-08-29 | PCSK9 iRNA compositions and methods of use thereof |
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EP (3) | EP3336187A1 (en) |
JP (4) | JP6574383B2 (en) |
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CN (2) | CN108220295B (en) |
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ES (1) | ES2657608T3 (en) |
FR (1) | FR21C1021I2 (en) |
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HR (1) | HRP20180126T2 (en) |
HU (2) | HUE035887T2 (en) |
IL (2) | IL238917B (en) |
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NO (1) | NO2021024I1 (en) |
NZ (1) | NZ709013A (en) |
PL (1) | PL2929031T4 (en) |
PT (1) | PT2929031T (en) |
RS (1) | RS56783B9 (en) |
SI (1) | SI2929031T1 (en) |
WO (1) | WO2014089313A1 (en) |
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