WO2014079573A1 - Multi-day patch for the transdermal administration of rotigotine - Google Patents
Multi-day patch for the transdermal administration of rotigotine Download PDFInfo
- Publication number
- WO2014079573A1 WO2014079573A1 PCT/EP2013/003515 EP2013003515W WO2014079573A1 WO 2014079573 A1 WO2014079573 A1 WO 2014079573A1 EP 2013003515 W EP2013003515 W EP 2013003515W WO 2014079573 A1 WO2014079573 A1 WO 2014079573A1
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- WO
- WIPO (PCT)
- Prior art keywords
- rotigotine
- layer
- transdermal therapeutic
- therapeutic system
- self
- Prior art date
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- 239000004005 microsphere Substances 0.000 description 1
- 229940020452 neupro Drugs 0.000 description 1
- 230000000324 neuroprotective effect Effects 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- NZIDBRBFGPQCRY-UHFFFAOYSA-N octyl 2-methylprop-2-enoate Chemical compound CCCCCCCCOC(=O)C(C)=C NZIDBRBFGPQCRY-UHFFFAOYSA-N 0.000 description 1
- 229940065472 octyl acrylate Drugs 0.000 description 1
- ANISOHQJBAQUQP-UHFFFAOYSA-N octyl prop-2-enoate Chemical compound CCCCCCCCOC(=O)C=C ANISOHQJBAQUQP-UHFFFAOYSA-N 0.000 description 1
- RPQRDASANLAFCM-UHFFFAOYSA-N oxiran-2-ylmethyl prop-2-enoate Chemical compound C=CC(=O)OCC1CO1 RPQRDASANLAFCM-UHFFFAOYSA-N 0.000 description 1
- 239000003961 penetration enhancing agent Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- 230000001235 sensitizing effect Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 231100000444 skin lesion Toxicity 0.000 description 1
- 206010040882 skin lesion Diseases 0.000 description 1
- 231100000245 skin permeability Toxicity 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000011115 styrene butadiene Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 229940116411 terpineol Drugs 0.000 description 1
- 125000001302 tertiary amino group Chemical group 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- 229920000428 triblock copolymer Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B37/00—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding
- B32B37/12—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by using adhesives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2556/00—Patches, e.g. medical patches, repair patches
Abstract
Description
Claims
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
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MX2015006357A MX354502B (en) | 2012-11-22 | 2013-11-21 | Multi-day patch for the transdermal administration of rotigotine. |
BR112015011729-5A BR112015011729B1 (en) | 2012-11-22 | 2013-11-21 | TRANSDERMAL THERAPEUTIC SYSTEM, KIT COMPRISING IT AND METHOD FOR PREPARING IT |
EA201500553A EA201500553A1 (en) | 2012-11-22 | 2013-11-21 | MULTI-DAY PLASTER FOR INTERCUTABLE ROTIGOTIN INTRODUCTION |
IN2488DEN2015 IN2015DN02488A (en) | 2012-11-22 | 2013-11-21 | |
CN201380054953.XA CN104736146B9 (en) | 2012-11-22 | 2013-11-21 | Multi-day patch for transdermal administration of rotigotine |
EP13795432.7A EP2922533B1 (en) | 2012-11-22 | 2013-11-21 | Multi-day patch for the transdermal administration of rotigotine |
CN201910246426.8A CN110200950B (en) | 2012-11-22 | 2013-11-21 | Multi-day patch for transdermal administration of rotigotine |
ES13795432.7T ES2639294T3 (en) | 2012-11-22 | 2013-11-21 | Multi-day patch for transdermal administration of rotigotine |
JP2015543338A JP6301356B2 (en) | 2012-11-22 | 2013-11-21 | Multi-day patch for transdermal administration of rotigotine |
CA2887085A CA2887085C (en) | 2012-11-22 | 2013-11-21 | Multi-day patch for the transdermal administration of rotigotine |
US14/443,210 US11389410B2 (en) | 2012-11-22 | 2013-11-21 | Multi-day patch for the transdermal administration of rotigotine |
KR1020157008077A KR20150094588A (en) | 2012-11-22 | 2013-11-21 | Multi-day patch for the transdermal administration of rotigotine |
AU2013350037A AU2013350037B2 (en) | 2012-11-22 | 2013-11-21 | Multi-day patch for the transdermal administration of rotigotine |
US17/589,262 US20220151949A1 (en) | 2012-11-22 | 2022-01-31 | Multi-Day Patch for the Transdermal Administration of Rotigotine |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12193808 | 2012-11-22 | ||
EP12193808.8 | 2012-11-22 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
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US14/443,210 A-371-Of-International US11389410B2 (en) | 2012-11-22 | 2013-11-21 | Multi-day patch for the transdermal administration of rotigotine |
US17/589,262 Division US20220151949A1 (en) | 2012-11-22 | 2022-01-31 | Multi-Day Patch for the Transdermal Administration of Rotigotine |
Publications (1)
Publication Number | Publication Date |
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WO2014079573A1 true WO2014079573A1 (en) | 2014-05-30 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2013/003515 WO2014079573A1 (en) | 2012-11-22 | 2013-11-21 | Multi-day patch for the transdermal administration of rotigotine |
Country Status (15)
Country | Link |
---|---|
US (2) | US11389410B2 (en) |
EP (1) | EP2922533B1 (en) |
JP (1) | JP6301356B2 (en) |
KR (1) | KR20150094588A (en) |
CN (2) | CN104736146B9 (en) |
AR (1) | AR093481A1 (en) |
AU (1) | AU2013350037B2 (en) |
BR (1) | BR112015011729B1 (en) |
CA (1) | CA2887085C (en) |
EA (1) | EA201500553A1 (en) |
ES (1) | ES2639294T3 (en) |
IN (1) | IN2015DN02488A (en) |
MX (1) | MX354502B (en) |
TW (1) | TW201431570A (en) |
WO (1) | WO2014079573A1 (en) |
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WO2015177204A1 (en) * | 2014-05-20 | 2015-11-26 | Lts Lohmann Therapie-Systeme Ag | Transdermal delivery system containing rotigotine |
WO2015177212A1 (en) * | 2014-05-20 | 2015-11-26 | Lts Lohmann Therapie-Systeme Ag | Transdermal delivery system including an interface mediator |
WO2016096840A1 (en) * | 2014-12-16 | 2016-06-23 | Amarin Technologies S.A. | A device for the transdermal delivery of rotigotine |
EP2922533B1 (en) | 2012-11-22 | 2017-06-14 | UCB Biopharma SPRL | Multi-day patch for the transdermal administration of rotigotine |
WO2019043172A1 (en) * | 2017-09-04 | 2019-03-07 | Lts Lohmann Therapie-Systeme Ag | Transdermal delivery system including an emulsifier |
WO2019077118A1 (en) * | 2017-10-20 | 2019-04-25 | Amw Gmbh | Stabilized transdermal delivery system |
US11033723B2 (en) | 2013-07-03 | 2021-06-15 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system comprising an electronic component |
EP3854388A1 (en) * | 2020-01-24 | 2021-07-28 | Luye Pharma Switzerland AG | Transdermal therapeutic system comprising rotigotine and at least one non-amine-resistant silicone adhesive |
US11426359B2 (en) | 2014-05-20 | 2022-08-30 | Lts Lohmann Therapie-Systeme Ag | Method for adjusting the release of active agent in a transdermal delivery system |
US11648213B2 (en) | 2018-06-20 | 2023-05-16 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
RU2798017C2 (en) * | 2018-06-20 | 2023-06-14 | Лтс Ломанн Терапи-Систем Аг | Transdermal therapeutic system containing asenapine |
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WO2018199018A1 (en) * | 2017-04-26 | 2018-11-01 | ニプロ株式会社 | Transdermally absorbable preparation and method for producing same |
JPWO2018199015A1 (en) * | 2017-04-26 | 2020-03-12 | ニプロ株式会社 | Transdermal preparation and method for producing the same |
EP3861999A4 (en) * | 2018-10-01 | 2022-06-22 | Hisamitsu Pharmaceutical Co., Inc. | Asenapine-containing adhesive patch |
KR20200046461A (en) * | 2018-10-24 | 2020-05-07 | 에스케이케미칼 주식회사 | Composition comprising non-crystalline rotigotine and manufacturing method thereof |
US20220117934A1 (en) * | 2019-02-15 | 2022-04-21 | Hisamitsu Pharmaceutical Co., Inc. | Rotigotine stabilization method |
JP6872675B1 (en) * | 2019-06-14 | 2021-05-19 | 久光製薬株式会社 | Rotigotine-containing patch |
KR102260202B1 (en) * | 2019-10-30 | 2021-06-03 | 에바바이오 주식회사 | Ionic Mixture for Rotigotine and Uses thereof |
CA3162229A1 (en) * | 2019-12-20 | 2020-12-30 | Patrick Mohr | Transdermal therapeutic system containing agomelatine |
CN113384560A (en) * | 2021-07-07 | 2021-09-14 | 华健医疗(深圳)有限公司 | Compound transdermal patch of rotigotine and nicotine for treating or preventing nervous system diseases and preparation method thereof |
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Also Published As
Publication number | Publication date |
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JP2016500086A (en) | 2016-01-07 |
US20220151949A1 (en) | 2022-05-19 |
AU2013350037B2 (en) | 2016-03-03 |
CN110200950A (en) | 2019-09-06 |
CN104736146B (en) | 2019-03-01 |
EP2922533A1 (en) | 2015-09-30 |
IN2015DN02488A (en) | 2015-09-11 |
CA2887085A1 (en) | 2014-05-30 |
AU2013350037A1 (en) | 2015-06-11 |
ES2639294T3 (en) | 2017-10-26 |
AR093481A1 (en) | 2015-06-10 |
US11389410B2 (en) | 2022-07-19 |
JP6301356B2 (en) | 2018-03-28 |
CA2887085C (en) | 2020-12-22 |
MX2015006357A (en) | 2016-02-10 |
EA201500553A1 (en) | 2015-12-30 |
BR112015011729A2 (en) | 2017-07-11 |
KR20150094588A (en) | 2015-08-19 |
EP2922533B1 (en) | 2017-06-14 |
CN110200950B (en) | 2023-03-10 |
US20150290142A1 (en) | 2015-10-15 |
BR112015011729B1 (en) | 2022-08-16 |
MX354502B (en) | 2018-03-08 |
CN104736146A (en) | 2015-06-24 |
TW201431570A (en) | 2014-08-16 |
CN104736146B9 (en) | 2019-04-12 |
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