WO2014074528A3 - Combination therapies using anti-pseudomonas psl and pcrv binding molecules - Google Patents

Combination therapies using anti-pseudomonas psl and pcrv binding molecules Download PDF

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Publication number
WO2014074528A3
WO2014074528A3 PCT/US2013/068609 US2013068609W WO2014074528A3 WO 2014074528 A3 WO2014074528 A3 WO 2014074528A3 US 2013068609 W US2013068609 W US 2013068609W WO 2014074528 A3 WO2014074528 A3 WO 2014074528A3
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WO
WIPO (PCT)
Prior art keywords
pseudomonas
binding molecules
pcrv
combination therapies
pseudomonas psl
Prior art date
Application number
PCT/US2013/068609
Other languages
French (fr)
Other versions
WO2014074528A8 (en
WO2014074528A2 (en
Inventor
Antonio Digiandomenico
Paul Warrener
Charles STOVER
Bret SELLMAN
Ralph Minter
Sandrine GUILLARD
Steven RUST
Miaden TOMICH
Vignesh Venkatraman
Reena VARKEY
Li Peng
Melissa Damschroder
Partha Chowdhury
Nazzareno Dimasi
Ryan FLEMING
Binyam Bezabeh
Changshou Gao
Original Assignee
Medimmune, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune, Llc filed Critical Medimmune, Llc
Priority to MX2015005719A priority Critical patent/MX2015005719A/en
Priority to KR1020157014108A priority patent/KR20150082367A/en
Priority to AU2013341349A priority patent/AU2013341349A1/en
Priority to CN201380058109.4A priority patent/CN104995209A/en
Priority to SG11201502937PA priority patent/SG11201502937PA/en
Priority to EP13853854.1A priority patent/EP2917236A2/en
Priority to CA2888211A priority patent/CA2888211A1/en
Priority to US14/440,215 priority patent/US20150284450A1/en
Priority to JP2015540877A priority patent/JP2015535005A/en
Priority to BR112015010240A priority patent/BR112015010240A2/en
Publication of WO2014074528A2 publication Critical patent/WO2014074528A2/en
Publication of WO2014074528A3 publication Critical patent/WO2014074528A3/en
Publication of WO2014074528A8 publication Critical patent/WO2014074528A8/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Using anti-Pseudomonas PsI and PcrV binding molecules and related compositions in prevention and treatment of Pseudomonas infection are disclosed. Further provided are isolated binding molecules which specifically bind to Pseudomonas PcrV or Pseudomonas PsI, and bispecific antibodies that specifically bind to Pseudomonas PcrV and Pseudomonas PsI. The sequences of heavy chain and light chain as well as sequences of complementarity determining regions (CDRs) of these binding molecules are further disclosed.
PCT/US2013/068609 2012-11-06 2013-11-06 Combination therapies using anti-pseudomonas psl and pcrv binding molecules WO2014074528A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
MX2015005719A MX2015005719A (en) 2012-11-06 2013-11-06 Combination therapies using anti-pseudomonas psl and pcrv binding molecules.
KR1020157014108A KR20150082367A (en) 2012-11-06 2013-11-06 Combination therapies using anti-pseudomonas psl and pcrv binding molecules
AU2013341349A AU2013341349A1 (en) 2012-11-06 2013-11-06 Combination therapies using anti-Pseudomonas Psl and PcrV binding molecules
CN201380058109.4A CN104995209A (en) 2012-11-06 2013-11-06 Combination therapies using anti-pseudomonas psl and pcrv binding molecules
SG11201502937PA SG11201502937PA (en) 2012-11-06 2013-11-06 COMBINATION THERAPIES USING ANTI-<i>PSEUDOMONAS</i> PSL AND PCRV BINDING MOLECULES
EP13853854.1A EP2917236A2 (en) 2012-11-06 2013-11-06 Combination therapies using anti-pseudomonas psl and pcrv binding molecules
CA2888211A CA2888211A1 (en) 2012-11-06 2013-11-06 Combination therapies using anti-pseudomonas psl and pcrv binding molecules
US14/440,215 US20150284450A1 (en) 2012-11-06 2013-11-06 Combination therapies using anti-pseudomonas psl and pcrv binding molecules
JP2015540877A JP2015535005A (en) 2012-11-06 2013-11-06 Combination therapy with anti-Pseudomonas Psl and PcrV binding molecules
BR112015010240A BR112015010240A2 (en) 2012-11-06 2013-11-06 COMBINATION THERAPIES THROUGH THE USE OF PSL-BINDING MOLECULES AND ANTI-PSEUDOMONAL PCRV

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261723192P 2012-11-06 2012-11-06
US61/723,192 2012-11-06

Publications (3)

Publication Number Publication Date
WO2014074528A2 WO2014074528A2 (en) 2014-05-15
WO2014074528A3 true WO2014074528A3 (en) 2014-07-03
WO2014074528A8 WO2014074528A8 (en) 2015-05-21

Family

ID=50685302

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/068609 WO2014074528A2 (en) 2012-11-06 2013-11-06 Combination therapies using anti-pseudomonas psl and pcrv binding molecules

Country Status (11)

Country Link
US (1) US20150284450A1 (en)
EP (1) EP2917236A2 (en)
JP (1) JP2015535005A (en)
KR (1) KR20150082367A (en)
CN (1) CN104995209A (en)
AU (1) AU2013341349A1 (en)
BR (1) BR112015010240A2 (en)
CA (1) CA2888211A1 (en)
MX (1) MX2015005719A (en)
SG (1) SG11201502937PA (en)
WO (1) WO2014074528A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE038509T2 (en) 2011-06-10 2018-10-29 Medimmune Ltd Anti-pseudomonas psl binding molecules and uses thereof
JP6182152B2 (en) * 2011-11-07 2017-08-16 メディミューン，エルエルシー Combination therapy with anti-Pseudomonas Psl and PcrV binding molecules
TWI719938B (en) * 2014-06-19 2021-03-01 美商麥迪紐有限責任公司 Treatment of polybacterial infections
MX2017014002A (en) 2015-05-01 2018-08-01 Inhibrx Lp Type iii secretion system targeting molecules.
PL3322734T3 (en) 2015-07-16 2021-05-04 Inhibrx, Inc. Multivalent and multispecific dr5-binding fusion proteins
CN108368149A (en) * 2015-11-30 2018-08-03 免疫医疗有限公司 Method for preventing or treating nosocomial pneumonia
SG11201809778TA (en) * 2016-05-05 2018-12-28 Univ Pennsylvania Dna antibody constructs for use against pseudomonas aeruginosa
RU2020112725A (en) * 2017-10-02 2021-11-08 Аридис Фармасьютикалс, Инк. COMPOSITIONS AND METHODS FOR COMBATING INFECTIONS CAUSED BY BLUE STICK (PSEUDOMONAS AERUGINOSA)
GB201816553D0 (en) 2018-10-10 2018-11-28 Centauri Therapeutics Ltd Novel compounds and therapeutic uses thereof
GB201816554D0 (en) 2018-10-10 2018-11-28 Centauri Therapeutics Ltd Novel compounds and therapeutic uses thereof
US11655302B2 (en) 2019-06-10 2023-05-23 Sanofi Anti-CD38 antibodies and formulations
KR20220019755A (en) * 2019-06-11 2022-02-17 리제너론 파마슈티칼스 인코포레이티드 Anti-PcrV Antibodies that Bind to PcrV, Compositions Comprising Anti-PcrV Antibodies, and Methods of Using the Same
JP7478807B2 (en) * 2019-07-09 2024-05-07 北京三▲諾▼佳邑生物技▲術▼有限▲責▼任公司 Antibody specifically recognizing Pseudomonas pcrV and use thereof
KR20210095781A (en) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 A multi-specific antibody comprising a fusion construct consisting of a Fab and a bioactive effector moiety
CN114072145B (en) * 2020-06-01 2024-06-11 北京三诺佳邑生物技术有限责任公司 Antibodies specifically recognizing pseudomonas PCRV and uses thereof
CN116693680A (en) * 2020-08-07 2023-09-05 北京三诺佳邑生物技术有限责任公司 Antibodies specifically recognizing pseudomonas PSL and uses thereof
WO2022105818A1 (en) * 2020-11-18 2022-05-27 Staidson (Beijing) Biopharmaceuticals Co., Ltd. Combinations of antibodies and bispecific antibodies comprising antigen-binding specifically recognizing pseudomonas pcrv and psl
TW202417478A (en) 2022-06-29 2024-05-01 瑞典商阿斯特捷利康公司 Anti-pcrv and psl bispecifics for treatment of bronchiectasis

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US20050069539A1 (en) * 2003-08-13 2005-03-31 Pfizer Inc Modified human IGF-IR antibodies
US20050265998A1 (en) * 2003-12-10 2005-12-01 Greg Elson Neutralizing antibodies and methods of use thereof
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US20060165682A1 (en) * 2004-12-15 2006-07-27 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
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Also Published As

Publication number Publication date
AU2013341349A8 (en) 2015-12-03
WO2014074528A8 (en) 2015-05-21
CN104995209A (en) 2015-10-21
AU2013341349A1 (en) 2015-05-21
CA2888211A1 (en) 2014-05-15
SG11201502937PA (en) 2015-06-29
KR20150082367A (en) 2015-07-15
EP2917236A2 (en) 2015-09-16
BR112015010240A2 (en) 2017-08-22
US20150284450A1 (en) 2015-10-08
MX2015005719A (en) 2016-01-12
WO2014074528A2 (en) 2014-05-15
JP2015535005A (en) 2015-12-07

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