WO2014072342A1 - An ophthalmic marking unit, a method and a computer program product - Google Patents

An ophthalmic marking unit, a method and a computer program product Download PDF

Info

Publication number
WO2014072342A1
WO2014072342A1 PCT/EP2013/073168 EP2013073168W WO2014072342A1 WO 2014072342 A1 WO2014072342 A1 WO 2014072342A1 EP 2013073168 W EP2013073168 W EP 2013073168W WO 2014072342 A1 WO2014072342 A1 WO 2014072342A1
Authority
WO
WIPO (PCT)
Prior art keywords
electronic device
portable electronic
marking unit
angular orientation
cornea
Prior art date
Application number
PCT/EP2013/073168
Other languages
French (fr)
Inventor
Andreas Christoph KÜHNEL
Martin Charles
Original Assignee
Eye Technology Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eye Technology Ltd. filed Critical Eye Technology Ltd.
Publication of WO2014072342A1 publication Critical patent/WO2014072342A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/013Instruments for compensation of ocular refraction ; Instruments for use in cornea removal, for reshaping or performing incisions in the cornea
    • A61F9/0136Mechanical markers

Definitions

  • the invention relates to an ophthalmic marking unit for mapping an axis on the cornea for aligning an intraocular lens.
  • Such marking units are known, e.g. as a pendulum marker or a level instrument designed to mark a zero degrees orientation, to be used in combination with a further angular orientation device such as a Mendez ring to actually determine a specific aligning axis.
  • marking units determine the specific aligning axis directly, e.g. by integrating a Mendez ring on a level instrument.
  • the alignment axis on the cornea is marked so that a toric intraocular lens (IOL) can be placed correctly to compensate for a corneal astigmatism of a patient.
  • IOL intraocular lens
  • the accuracy of the known marking units is low.
  • the accuracy of a pendulum marker is typically in a range of 5° - 10°.
  • the invention aims at obtaining an ophthalmic marking unit that has, during use, an improved accuracy.
  • the marking unit comprises an elongate element having a distal end for touching the cornea and a proximal end attached to a coupling module for rigidly coupling the elongate element to a portable electronic device capable of determining an angular orientation.
  • a very convenient marking unit is obtained that is potentially very accurate since the desired angle can be preselected and the determination of the angle can be performed automatically. Then, the user of the marking unit may concentrate on the other operations such as turning the marker around the pupil, and performing the actual marking process on the cornea, thereby improving accuracy, reliability and risk of errors.
  • the invention also relates to a method for mapping an axis on the cornea for aligning an intraocular lens.
  • a computer program product may comprise a set of computer executable instructions stored on a data carrier, such as a flash memory, a CD or a DVD.
  • the set of computer executable instructions which allow a
  • programmable computer to carry out the method as defined above may also be available for downloading from a remote server, for example via the Internet, e.g. as an app.
  • Fig. 1 shows a schematic perspective view of an ophthalmic marking unit according to the invention
  • Fig. 2 shows a schematic view of a distal end of the marking unit shown in Fig. 1, and
  • Fig. 3 shows a flow chart of an embodiment of a method according to the invention.
  • FIG. 1 shows a schematic perspective view of an ophthalmic marking unit 1 according to the invention.
  • the marking unit 1 comprises a curved elongate element 2 with a distal end 3 and a proximal end 4.
  • the distal end 3 is intended for touching the cornea of the eye for mapping a placement axis A of a toric intraocular lens (IOL) for aligning the IOL in the eye.
  • the marking unit 1 also comprises a coupling element to which the distal end 4 of the elongate element 2 is attached.
  • the coupling element includes a sleeve 5 clamping a portable electronic device 20 such as a mobile phone, a smart phone or a tablet.
  • the proximal end 4 of the elongate element 2 is detachably attached to the coupling module 5. Then, the elongate element 2 can be sterilized for repeated use.
  • the portable electronic device 20 includes a display 6, an accelerometer 7 and a processor 8.
  • the processor 8 of the device 6 is able to determine an angular orientation, e.g. in a vertical plane.
  • the distal end 3 of the elongate element 2 includes two tips 9, 10 to contact the cornea at mutual opposite positions PI, P2 with respect to the pupil.
  • Figure 2 shows a schematic view of the distal end 3 of the marking unit 1, including the two tips 9, 10 placed at opposite positions PI, P2 with respect to the pupil 11, on the cornea 12.
  • the tips 9, 10 are provided with marking ink to mark the cornea 12.
  • the distal end 3 of the marking unit 1 is located near the cornea 12. Then, the angle of the elongate element 2 is modified with respect to the pupil 11. In this process, the tips 9, 10 turn around the pupil 11 until the portable electronic device 20 determines that a pre- determined angular orientation of the elongate element 2 with respect to the pupil 11 orientation has been reached.
  • the portable electronic device 20 may provide a signal indicating an actual angular orientation of the elongate element 2, e.g. by displaying the angle in a digital format and/or by controlling a synthesized speaker.
  • the pre- determined angular orientation is input in a digital manner in the portable electronic device 20 as a pre-selected angle, before locating the distal end 3 of the marking unit 1 adjacent to the cornea 12. Then, upon reaching a range of the pre-selected angular orientation, the portable electronic device 6 activates a detection signal, e.g. an audible and/or visible signals such as beeps and/or colours on the display 6 of the device 20.
  • a detection signal e.g. an audible and/or visible signals such as beeps and/or colours on the display 6 of the device 20.
  • a parameter of the detection signal depends on the offset between the actual determined angular orientation and the preselected angular orientation, so that the user of the marking unit 1 is guided to the pre-selected angular orientation.
  • the cornea 12 is marked by touching the cornea 12 with the tips 9, 10.
  • Figure 6 shows a flow chart of an embodiment of the method according to the invention.
  • the method is used for mapping an axis on the cornea for aligning an intraocular lens.
  • the method comprises a step of providing 110 a portable electronic device capable of determining an angular orientation, a step of providing 120 a marking unit including an elongate element having a distal end and a proximal end, the proximal end being rigidly coupled to the portable electronic device, a step of locating 130 the distal end of the marking unit adjacent to the cornea, and a step of modifying 140 the angle of the elongate element until a pre-determined angular orientation is determined by the portable electronic device.
  • the method for mapping an axis on the cornea for aligning an intraocular lens can be performed using, in the portable electronic device, dedicated hardware structures, such as FPGA and/or ASIC components. Otherwise, the method can also at least partially be performed using a computer program product comprising instructions for causing a processor in the portable electronic device to perform the process of determining the pre-determined angular orientation. Said process, and optionally any sub- steps, can in principle be performed on a single processor. However, it is noted that at least one (sub)step can be performed on a separate processor.
  • a processor can be loaded with a specific software module. Dedicated software modules can be provided, e.g. from the Internet.
  • the set of computer executable instructions which allow a programmable computer to carry out the process of determining the pre-determined angular
  • orientation may be stored on a data carrier, such as a flash memory, a CD or a DVD, or may be available for downloading from a remote server, for example via the Internet, e.g. as an app.
  • a data carrier such as a flash memory, a CD or a DVD
  • a remote server for example via the Internet, e.g. as an app.
  • the coupling module for rigidly coupling the elongate element to the portable electronic device can be implemented as a sleeve as described above.
  • other implementations of the coupling module are also possible, e.g. using a screwing connection.
  • the portable electronic device can also be used for making a picture during subsequent steps in the above-mentioned processes, e.g. for documentation.

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

The invention relates to an ophthalmic marking unit (1) for mapping an axis on the cornea for aligning an intraocular lens. The marking unit comprises an elongate element (2) having a distal end (3) for touching the cornea. The elongate element also has a proximal end (4) provided with a coupling module for rigidly coupling the elongate element to a portable electronic device (20). The portable electronic device is capable of determining an angular orientation by using an included accelerometer (7).

Description

Title: An ophthalmic marking unit, a method and a computer program product
The invention relates to an ophthalmic marking unit for mapping an axis on the cornea for aligning an intraocular lens.
Such marking units are known, e.g. as a pendulum marker or a level instrument designed to mark a zero degrees orientation, to be used in combination with a further angular orientation device such as a Mendez ring to actually determine a specific aligning axis.
Other marking units determine the specific aligning axis directly, e.g. by integrating a Mendez ring on a level instrument.
The alignment axis on the cornea is marked so that a toric intraocular lens (IOL) can be placed correctly to compensate for a corneal astigmatism of a patient.
However, it appears that the accuracy of the known marking units is low. As an indication, the accuracy of a pendulum marker is typically in a range of 5° - 10°.
It is an object of the invention to provide an ophthalmic marking unit, wherein the above-mentioned disadvantage is reduced. In particular, the invention aims at obtaining an ophthalmic marking unit that has, during use, an improved accuracy. Thereto, according to an aspect of the invention, the marking unit comprises an elongate element having a distal end for touching the cornea and a proximal end attached to a coupling module for rigidly coupling the elongate element to a portable electronic device capable of determining an angular orientation.
By applying the functionality of a portable electronic device of determining an angular orientation, a very convenient marking unit is obtained that is potentially very accurate since the desired angle can be preselected and the determination of the angle can be performed automatically. Then, the user of the marking unit may concentrate on the other operations such as turning the marker around the pupil, and performing the actual marking process on the cornea, thereby improving accuracy, reliability and risk of errors.
The invention also relates to a method for mapping an axis on the cornea for aligning an intraocular lens.
Further, the invention relates to a computer program product. A computer program product may comprise a set of computer executable instructions stored on a data carrier, such as a flash memory, a CD or a DVD. The set of computer executable instructions, which allow a
programmable computer to carry out the method as defined above, may also be available for downloading from a remote server, for example via the Internet, e.g. as an app.
Other advantageous embodiments according to the invention are described in the following claims.
By way of example only, embodiments of the present invention will now be described with reference to the accompanying figures in which
Fig. 1 shows a schematic perspective view of an ophthalmic marking unit according to the invention;
Fig. 2 shows a schematic view of a distal end of the marking unit shown in Fig. 1, and
Fig. 3 shows a flow chart of an embodiment of a method according to the invention.
The figures are merely schematic views of a preferred
embodiment according to the invention. In the figures, the same reference numbers refer to equal or corresponding parts.
Figure 1 shows a schematic perspective view of an ophthalmic marking unit 1 according to the invention. The marking unit 1 comprises a curved elongate element 2 with a distal end 3 and a proximal end 4. The distal end 3 is intended for touching the cornea of the eye for mapping a placement axis A of a toric intraocular lens (IOL) for aligning the IOL in the eye. The marking unit 1 also comprises a coupling element to which the distal end 4 of the elongate element 2 is attached. The coupling element includes a sleeve 5 clamping a portable electronic device 20 such as a mobile phone, a smart phone or a tablet. Optionally, the proximal end 4 of the elongate element 2 is detachably attached to the coupling module 5. Then, the elongate element 2 can be sterilized for repeated use.
The portable electronic device 20 includes a display 6, an accelerometer 7 and a processor 8. By using the accelerometer 7, the processor 8 of the device 6 is able to determine an angular orientation, e.g. in a vertical plane.
In the shown embodiment, the distal end 3 of the elongate element 2 includes two tips 9, 10 to contact the cornea at mutual opposite positions PI, P2 with respect to the pupil.
Figure 2 shows a schematic view of the distal end 3 of the marking unit 1, including the two tips 9, 10 placed at opposite positions PI, P2 with respect to the pupil 11, on the cornea 12. During use of the marking unit 1, the tips 9, 10 are provided with marking ink to mark the cornea 12.
In applying the marking unit 1, the distal end 3 of the marking unit 1 is located near the cornea 12. Then, the angle of the elongate element 2 is modified with respect to the pupil 11. In this process, the tips 9, 10 turn around the pupil 11 until the portable electronic device 20 determines that a pre- determined angular orientation of the elongate element 2 with respect to the pupil 11 orientation has been reached.
The portable electronic device 20 may provide a signal indicating an actual angular orientation of the elongate element 2, e.g. by displaying the angle in a digital format and/or by controlling a synthesized speaker.
In a preferred embodiment, the pre- determined angular orientation is input in a digital manner in the portable electronic device 20 as a pre-selected angle, before locating the distal end 3 of the marking unit 1 adjacent to the cornea 12. Then, upon reaching a range of the pre-selected angular orientation, the portable electronic device 6 activates a detection signal, e.g. an audible and/or visible signals such as beeps and/or colours on the display 6 of the device 20.
Optionally, a parameter of the detection signal depends on the offset between the actual determined angular orientation and the preselected angular orientation, so that the user of the marking unit 1 is guided to the pre-selected angular orientation.
When, the correct pre-determined angular orientation has been determined by the device 20, the cornea 12 is marked by touching the cornea 12 with the tips 9, 10.
Figure 6 shows a flow chart of an embodiment of the method according to the invention. The method is used for mapping an axis on the cornea for aligning an intraocular lens. The method comprises a step of providing 110 a portable electronic device capable of determining an angular orientation, a step of providing 120 a marking unit including an elongate element having a distal end and a proximal end, the proximal end being rigidly coupled to the portable electronic device, a step of locating 130 the distal end of the marking unit adjacent to the cornea, and a step of modifying 140 the angle of the elongate element until a pre-determined angular orientation is determined by the portable electronic device.
The method for mapping an axis on the cornea for aligning an intraocular lens can be performed using, in the portable electronic device, dedicated hardware structures, such as FPGA and/or ASIC components. Otherwise, the method can also at least partially be performed using a computer program product comprising instructions for causing a processor in the portable electronic device to perform the process of determining the pre-determined angular orientation. Said process, and optionally any sub- steps, can in principle be performed on a single processor. However, it is noted that at least one (sub)step can be performed on a separate processor. A processor can be loaded with a specific software module. Dedicated software modules can be provided, e.g. from the Internet. The set of computer executable instructions, which allow a programmable computer to carry out the process of determining the pre-determined angular
orientation, may be stored on a data carrier, such as a flash memory, a CD or a DVD, or may be available for downloading from a remote server, for example via the Internet, e.g. as an app.
The invention is not restricted to the embodiments described herein. It will be understood that many variants are possible.
As an example, the coupling module for rigidly coupling the elongate element to the portable electronic device can be implemented as a sleeve as described above. However, other implementations of the coupling module are also possible, e.g. using a screwing connection.
Further, the portable electronic device can also be used for making a picture during subsequent steps in the above-mentioned processes, e.g. for documentation.
Other such variants will be apparent for the person skilled in the art and are considered to fall within the scope of the invention as defined in the following claims.

Claims

Claims
1. An ophthalmic marking unit for mapping an axis on the cornea for aligning an intraocular lens, the marking unit comprising an elongate element having a distal end for touching the cornea and a proximal end attached to a coupling module for rigidly coupling the elongate element to a portable electronic device, the device being capable of determining an angular orientation and comprising an accelerometer.
2. An ophthalmic marking unit according to claim 1, wherein the portable electronic device is a mobile phone, a smart phone or a tablet.
3. An ophthalmic marking unit according to claim 1 or 2, wherein the coupling module includes a sleeve clamping the portable electronic device.
4. An ophthalmic marking unit according to any of the preceding claims, wherein the distal end includes two tips to contact the cornea at mutual opposite positions with respect to the pupil.
5. An ophthalmic marking unit according to claim 4, wherein the tips are provided with marking ink.
6. An ophthalmic marking unit according to any of the preceding claims, wherein the elongate element is curved.
7. An ophthalmic marking unit according to any of the preceding claims, wherein the proximal end of the elongate element is detachably attached to the coupling module.
8. A portable electronic device, comprising an ophthalmic marking unit according to any of the preceding claims 1-7, wherein the device is capable of determining an angular orientation and comprises an
accelerometer.
9. A portable electronic device according to claim 7 or 8, capable of determining an angular orientation in a vertical plane.
10. A method for mapping an axis on the cornea for aligning an intraocular lens, the method comprising the steps of: - providing a portable electronic device capable of determining an angular orientation,
- providing a marking unit including an elongate element having a distal end and a proximal end, the proximal end being rigidly coupled to the portable electronic device,
- locating the distal end of the marking unit adjacent to the cornea, and
- modifying the angle of the elongate element until a pre-determined angular orientation is determined by the portable electronic device.
11. A method according to claim 10, further comprising the steps of: - pre-selecting the pre-determined angular orientation in the portable electronic device before locating the distal end of the marking unit adjacent to the cornea, and
- activating a detection signal, via the portable electronic device, when an actual determined angular orientation is within a range of the pre- selected angular orientation.
12. A method according to claim 11, wherein the detection signal is audible and/or visible.
13. A method according to claim 11 or 12, wherein a parameter of the detection signal depends on the offset between the actual determined angular orientation and the pre-selected angular orientation.
14. A method according to any of the preceding claims 10-13, further including the step of marking the cornea with the distal end of the elongate element when the pre-determined angular orientation is determined by the portable electronic device.
15. A computer program product for mapping an axis on the cornea for aligning an intraocular lens, the computer program product comprising computer readable code for causing a processor in a portable electronic device to perform the step of determining whether a pre-determined angular orientation of an elongate element is reached, the elongate element being comprised by a marking element and having a distal end and a proximal end, the proximal end being rigidly coupled to the portable electronic device, wherein the distal end of the marking unit is located adjacent to the cornea, and the angle of the elongate element is modified until the pre-determined angular orientation is determined by the processor of the portable electronic device.
PCT/EP2013/073168 2012-11-07 2013-11-06 An ophthalmic marking unit, a method and a computer program product WO2014072342A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL2009770A NL2009770C2 (en) 2012-11-07 2012-11-07 An ophthalmic marking unit, a method and a computer program product.
NL2009770 2012-11-07

Publications (1)

Publication Number Publication Date
WO2014072342A1 true WO2014072342A1 (en) 2014-05-15

Family

ID=47844429

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2013/073168 WO2014072342A1 (en) 2012-11-07 2013-11-06 An ophthalmic marking unit, a method and a computer program product

Country Status (2)

Country Link
NL (1) NL2009770C2 (en)
WO (1) WO2014072342A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015200142A1 (en) * 2014-06-24 2015-12-30 Oasis Medical, Inc. Electronic eye marking device
WO2016004131A1 (en) * 2014-07-01 2016-01-07 Amo Wavefront Sciences, Llc System and method for corneal topography with flat panel display
US9962077B2 (en) 2014-07-01 2018-05-08 Amo Wavefront Sciences, Llc System and method for corneal topography with flat panel display
ES2678271A1 (en) * 2018-05-31 2018-08-09 Salvador NEBRO COBO Ocular goniometer (Machine-translation by Google Translate, not legally binding)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002094144A1 (en) * 2001-05-18 2002-11-28 Georg Gerten Marking instrument
DE202010012367U1 (en) * 2010-01-27 2010-11-18 Geuder Ag Device for applying a marking to the human eye
US20110251630A1 (en) * 2010-04-08 2011-10-13 Richardson Gary A Corneal marking apparatus
WO2012050622A2 (en) * 2010-10-15 2012-04-19 Tracey Technologies, Corp Tools and methods for the surgical placement of intraocular implants

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002094144A1 (en) * 2001-05-18 2002-11-28 Georg Gerten Marking instrument
DE202010012367U1 (en) * 2010-01-27 2010-11-18 Geuder Ag Device for applying a marking to the human eye
US20110251630A1 (en) * 2010-04-08 2011-10-13 Richardson Gary A Corneal marking apparatus
WO2012050622A2 (en) * 2010-10-15 2012-04-19 Tracey Technologies, Corp Tools and methods for the surgical placement of intraocular implants

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015200142A1 (en) * 2014-06-24 2015-12-30 Oasis Medical, Inc. Electronic eye marking device
WO2016004131A1 (en) * 2014-07-01 2016-01-07 Amo Wavefront Sciences, Llc System and method for corneal topography with flat panel display
US9615739B2 (en) 2014-07-01 2017-04-11 Amo Wavefront Sciences, Llc System and method for corneal topography with flat panel display
US9962077B2 (en) 2014-07-01 2018-05-08 Amo Wavefront Sciences, Llc System and method for corneal topography with flat panel display
AU2015284130B2 (en) * 2014-07-01 2019-07-25 Amo Wavefront Sciences, Llc. System and method for corneal topography with flat panel display
AU2015284130B9 (en) * 2014-07-01 2019-08-01 Amo Wavefront Sciences, Llc. System and method for corneal topography with flat panel display
US10492680B2 (en) 2014-07-01 2019-12-03 Amo Wavefront Sciences, Llc System and method for corneal topography with flat panel display
ES2678271A1 (en) * 2018-05-31 2018-08-09 Salvador NEBRO COBO Ocular goniometer (Machine-translation by Google Translate, not legally binding)
WO2019229287A1 (en) * 2018-05-31 2019-12-05 Universidad De Málaga Ocular goniometer
US11918301B2 (en) 2018-05-31 2024-03-05 Universidad De Malag Ocular goniometer

Also Published As

Publication number Publication date
NL2009770C2 (en) 2014-05-08

Similar Documents

Publication Publication Date Title
CN107454834B (en) System and method for placing a medical device in a bone
US11241319B2 (en) Method and device for ordering a custom orthopedic device
US11712546B2 (en) Electronic valve reader having orientation sensing mechanism
US9119565B2 (en) Intraocular lens alignment
JP2012518472A5 (en)
WO2014072342A1 (en) An ophthalmic marking unit, a method and a computer program product
RU2013158108A (en) SURGICAL ALIGNMENT USING GUIDELINES
CN111212609A (en) System and method for using augmented reality with shape alignment for placement of medical devices in bone
US10156740B2 (en) Spectacle wearing parameter measurement device, spectacle wearing parameter measurement program, and position specifying method
US20150366714A1 (en) Electronic eye marking device
CA3033576C (en) Automated fine adjustment of an ophthalmic surgery support
JP5570673B2 (en) Ophthalmic equipment
CN103082988A (en) Human vision parameter automatic testing method and device thereof
US11559435B2 (en) Systems and methods for femtosecond laser ophthalmic surgery docking
EP3159760B1 (en) Terminal device and terminal control program
US20080123054A1 (en) Phoropter aligner
US11717354B1 (en) Device and method for displaying the axis of astigmatism of an eye
CN104042183A (en) Interpupillary distance measuring instrument
JP2021058666A (en) Automated fine adjustment of ophthalmic surgery support
JP2013111090A (en) Instrument for positioning intraocular lens
CN116392245A (en) Surgical navigation system and surgical navigation method
Sivagnanam et al. A New System of Axis Marking for Toric Intraocular Lenses-The Toric Max System

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 13786282

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 13786282

Country of ref document: EP

Kind code of ref document: A1