WO2014070993A1 - Nouveau système de détection des embolies dans le cerveau utilisant un dispositif photoacoustique doppler transcrânien capable de mesurer la vascularisation et la perfusion - Google Patents

Nouveau système de détection des embolies dans le cerveau utilisant un dispositif photoacoustique doppler transcrânien capable de mesurer la vascularisation et la perfusion Download PDF

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Publication number
WO2014070993A1
WO2014070993A1 PCT/US2013/067713 US2013067713W WO2014070993A1 WO 2014070993 A1 WO2014070993 A1 WO 2014070993A1 US 2013067713 W US2013067713 W US 2013067713W WO 2014070993 A1 WO2014070993 A1 WO 2014070993A1
Authority
WO
WIPO (PCT)
Prior art keywords
array
brain
transducer elements
vasculature
ultrasound
Prior art date
Application number
PCT/US2013/067713
Other languages
English (en)
Inventor
Stuart STEIN
Pennypacker CARL
Original Assignee
Cerebrosonics, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cerebrosonics, Llc filed Critical Cerebrosonics, Llc
Priority to CA2890157A priority Critical patent/CA2890157A1/fr
Priority to US14/070,264 priority patent/US20140194740A1/en
Publication of WO2014070993A1 publication Critical patent/WO2014070993A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
    • A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
    • A61B5/004—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
    • A61B5/0042—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6814—Head
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/06—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A61B8/0808—Detecting organic movements or changes, e.g. tumours, cysts, swellings for diagnosis of the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/42—Details of probe positioning or probe attachment to the patient
    • A61B8/4209—Details of probe positioning or probe attachment to the patient by using holders, e.g. positioning frames
    • A61B8/4227—Details of probe positioning or probe attachment to the patient by using holders, e.g. positioning frames characterised by straps, belts, cuffs or braces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/488—Diagnostic techniques involving Doppler signals

Definitions

  • An ischemic stroke is the result of neuronal death due to lack of oxygen, a deficit that produces focal brain injury. This event is accompanied by tissue changes consistent with an infarction (tissue death caused by an obstruction to blood supply) that can be identified with neuroimaging of the brain. Strokes are usually accompanied by symptoms, but they also may occur without producing clinical findings and be considered clinically silent. Additionally, many current transcranial imaging devices are severely limited by the aberrations caused by the skull or intervening tissues. A strong need to address these matters exists.
  • mini-strokes At the time of stroke, mini-strokes, suspected strokes, or TIAs, magnetic resonance (MRI) and computed tomography (CT) of the brain (intracranial) and neck are the most employed techniques/devices used to look for blood vessel abnormalities, including stenosis, as a basis for stroke.
  • MRI magnetic resonance
  • CT computed tomography
  • Such thicknesses is recorded and put into an array in computer memory, or a file on disc, or other media that then describes skull thicknesses. This helps establish an absolute reference frame for all work and in addition, alerts the operator as to where the thinnest parts of the skull are for easier insonification.
  • the device consists of a rigid base shell or helmet 133 that is either placed around the patient's 112 head or the head is placed into the base shell 133 while the base shell 133 is affixed to the supporting surface upon which the patient 112 is laying.
  • the main material for the base shell (base shell number) is a plastic, metal, or other like material that can be produced by thermoforming, injection molding, casting or other like means.
  • the base shell 133 creates the framework for the helmet.
  • silicone for example, as disclosed in U.S. Letters Patent 8,449,565, may be used, said patent being incorporated expressly herein by this reference, as if the contents of the same were set forth herein in their entirety.
  • the helmet apparatus holds an array of seven custom Doppler transducers in lateral symmetry of the head, of which the two Carotid ultrasound transducers 208 and two temporal bone window ultrasound transducers 204 are bilateral, and of which the two eye ultrasound transducers 202, two temporal bone window ultrasound transducers 204, and basilar artery and vertebral artery ultrasound transducer 206 are remotely controlled in X-Y translation across the surface of the skull, pressured against the patient's 112 head in the Z direction at an appropriate pressure, pitch, and yaw angle rotation to aim the Doppler beam. These movements are carried out by a set of motor actuators 250, specified schematically in the drawing as TCD/Actuator Motor modules 250.
  • the two carotid artery transducers 208 do not contain this translational control.
  • the two eye transducers 202 and two carotid transducers 208 may be located on a more flexible substrate of the modules they are attached to, in order to prevent harmful levels of pressure applied to the eyes and the carotid arteries. In another exemplary embodiment, the two eye transducers 202 and two carotid transducers 208 may also be attached with adhesive.
  • the wiring for the motor modules 250 and the transducers 300 is routed through the helmet to the base of the shell, where the connection interface to the power supply and data output modem 400 is located.
  • the separate helmet members have electronic connections in the snap interface to route power and data through the helmet's wiring.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Acoustics & Sound (AREA)
  • Hematology (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)

Abstract

La présente invention concerne un casque commandé et surveillé depuis un centre de données distant qui permet un classement et un triage rapide d'individus ayant des troubles cérébraux de type accident vasculaire cérébral, basé sur de nouvelles utilisations et l'enregistrement de différents processus de signal. L'imagerie photo-acoustique Doppler transcrânienne (DTC) et d'autres modalités générant rapidement des données médicales résultantes sont décrites, pour la prise en charge de patients présentant un trouble cérébral aigu de façon plus rapide.
PCT/US2013/067713 2012-10-31 2013-10-31 Nouveau système de détection des embolies dans le cerveau utilisant un dispositif photoacoustique doppler transcrânien capable de mesurer la vascularisation et la perfusion WO2014070993A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA2890157A CA2890157A1 (fr) 2012-10-31 2013-10-31 Nouveau systeme de detection des embolies dans le cerveau utilisant un dispositif photoacoustique doppler transcranien capable de mesurer la vascularisation et la perfusion
US14/070,264 US20140194740A1 (en) 2013-01-07 2013-11-01 Emboli detection in the brain using a transcranial doppler photoacoustic device capable of vasculature and perfusion measurement

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201261720992P 2012-10-31 2012-10-31
US61/720,992 2012-10-31
US201361749618P 2013-01-07 2013-01-07
US61/749,618 2013-01-07
US201361833802P 2013-06-11 2013-06-11
US61/833,802 2013-06-11

Publications (1)

Publication Number Publication Date
WO2014070993A1 true WO2014070993A1 (fr) 2014-05-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/067713 WO2014070993A1 (fr) 2012-10-31 2013-10-31 Nouveau système de détection des embolies dans le cerveau utilisant un dispositif photoacoustique doppler transcrânien capable de mesurer la vascularisation et la perfusion

Country Status (2)

Country Link
CA (1) CA2890157A1 (fr)
WO (1) WO2014070993A1 (fr)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140194740A1 (en) * 2013-01-07 2014-07-10 Cerebrosonics, Llc Emboli detection in the brain using a transcranial doppler photoacoustic device capable of vasculature and perfusion measurement
EP3146902A1 (fr) * 2015-09-28 2017-03-29 Michael Zhadkevich Dispositif de détection, monitorage et préventions simultanés d'embolie cérébrale
US9808260B2 (en) 2014-05-04 2017-11-07 Zhadkevich Medical, Inc. Noninvasive protection from emboli
US20180214124A1 (en) * 2016-01-05 2018-08-02 Neural Analytics, Inc. Systems and methods for detecting neurological conditions
US10130374B2 (en) 2012-05-11 2018-11-20 Michael Zhadkevich Anti-embolic device and method
EP3415097A4 (fr) * 2016-02-08 2019-01-23 FUJIFILM Corporation Dispositif de génération d'image d'onde acoustique et procédé de génération d'image d'onde acoustique
US10258348B2 (en) 2015-01-27 2019-04-16 Michael Zhadkevich Devices and techniques for vascular compression
US10534894B2 (en) 2016-04-15 2020-01-14 BR Invention Holding, LLC Mobile medicine communication platform and methods and uses thereof
US10617388B2 (en) 2016-01-05 2020-04-14 Neural Analytics, Inc. Integrated probe structure
CN111110193A (zh) * 2019-12-27 2020-05-08 华南师范大学 基于光声流速测量评估管径狭窄分数的装置及方法
US11090026B2 (en) 2016-01-05 2021-08-17 Novasignal Corp. Systems and methods for determining clinical indications
US11116515B2 (en) 2012-05-11 2021-09-14 Michael Zhadkevich Anti-embolic device and method
US11207054B2 (en) 2015-06-19 2021-12-28 Novasignal Corp. Transcranial doppler probe

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040019278A1 (en) * 2000-05-26 2004-01-29 Kenneth Abend Device and method for mapping and tracking blood flow and determining parameters of blood flow
WO2006102511A2 (fr) * 2005-03-23 2006-09-28 New Health Sciences, Inc. Systemes et procedes pour l'utilisation d'evaluation vasculaire dynamique pour distinguer entre des etats vasculaires et pour l'examen de la pression intracranienne
WO2009101618A1 (fr) * 2008-02-12 2009-08-20 Newval-Tech Knowledge Services And Investments Ltd Casque téléphonique sans fil pour réduire l'exposition à un rayonnement nocif sur la base d'une distance estimée par rapport à un dispositif sans fil
US20120083717A1 (en) * 2010-10-05 2012-04-05 Cerevast Therapeutics Non-Invasive Transcranial Ultrasound Apparatus
US20120165676A1 (en) * 2010-12-22 2012-06-28 Philip Chidi Njemanze Neuravionic System for Life Support in High Performance Avionics

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040019278A1 (en) * 2000-05-26 2004-01-29 Kenneth Abend Device and method for mapping and tracking blood flow and determining parameters of blood flow
WO2006102511A2 (fr) * 2005-03-23 2006-09-28 New Health Sciences, Inc. Systemes et procedes pour l'utilisation d'evaluation vasculaire dynamique pour distinguer entre des etats vasculaires et pour l'examen de la pression intracranienne
WO2009101618A1 (fr) * 2008-02-12 2009-08-20 Newval-Tech Knowledge Services And Investments Ltd Casque téléphonique sans fil pour réduire l'exposition à un rayonnement nocif sur la base d'une distance estimée par rapport à un dispositif sans fil
US20120083717A1 (en) * 2010-10-05 2012-04-05 Cerevast Therapeutics Non-Invasive Transcranial Ultrasound Apparatus
US20120165676A1 (en) * 2010-12-22 2012-06-28 Philip Chidi Njemanze Neuravionic System for Life Support in High Performance Avionics

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11701126B2 (en) 2012-05-11 2023-07-18 Michael Zhadkevich Anti-embolic device and method
US10130374B2 (en) 2012-05-11 2018-11-20 Michael Zhadkevich Anti-embolic device and method
US11116515B2 (en) 2012-05-11 2021-09-14 Michael Zhadkevich Anti-embolic device and method
US11116517B2 (en) 2012-05-11 2021-09-14 Michael Zhadkevich Anti-embolic device and method
US20140194740A1 (en) * 2013-01-07 2014-07-10 Cerebrosonics, Llc Emboli detection in the brain using a transcranial doppler photoacoustic device capable of vasculature and perfusion measurement
US9808260B2 (en) 2014-05-04 2017-11-07 Zhadkevich Medical, Inc. Noninvasive protection from emboli
US11026697B2 (en) 2015-01-27 2021-06-08 Michael Zhadkevich Devices and techniques for vascular compression
US11759212B2 (en) 2015-01-27 2023-09-19 Michael Zhadkevich Devices and techniques for vascular compression
US10258348B2 (en) 2015-01-27 2019-04-16 Michael Zhadkevich Devices and techniques for vascular compression
US11207054B2 (en) 2015-06-19 2021-12-28 Novasignal Corp. Transcranial doppler probe
US11103416B2 (en) 2015-09-28 2021-08-31 Michael Zhadkevich Device and method for simultaneous detection, monitoring and prevention of cerebral emboli
EP3146902A1 (fr) * 2015-09-28 2017-03-29 Michael Zhadkevich Dispositif de détection, monitorage et préventions simultanés d'embolie cérébrale
US11452500B2 (en) 2016-01-05 2022-09-27 Novasignal Corp. Integrated probe structure
US11090026B2 (en) 2016-01-05 2021-08-17 Novasignal Corp. Systems and methods for determining clinical indications
US10617388B2 (en) 2016-01-05 2020-04-14 Neural Analytics, Inc. Integrated probe structure
US20180220991A1 (en) * 2016-01-05 2018-08-09 Neural Analytics, Inc. Systems and methods for detecting neurological conditions
US11589836B2 (en) 2016-01-05 2023-02-28 Novasignal Corp. Systems and methods for detecting neurological conditions
US20180214124A1 (en) * 2016-01-05 2018-08-02 Neural Analytics, Inc. Systems and methods for detecting neurological conditions
US10709417B2 (en) * 2016-01-05 2020-07-14 Neural Analytics, Inc. Systems and methods for detecting neurological conditions
EP3415097A4 (fr) * 2016-02-08 2019-01-23 FUJIFILM Corporation Dispositif de génération d'image d'onde acoustique et procédé de génération d'image d'onde acoustique
US11119199B2 (en) 2016-02-08 2021-09-14 Fujifilm Sonosite, Inc. Acoustic wave image generation apparatus and acoustic wave image generation method
US10534894B2 (en) 2016-04-15 2020-01-14 BR Invention Holding, LLC Mobile medicine communication platform and methods and uses thereof
US11677134B2 (en) 2016-04-15 2023-06-13 BR Invention Holding, LLC Mobile medicine communication platform and methods and uses thereof
CN111110193A (zh) * 2019-12-27 2020-05-08 华南师范大学 基于光声流速测量评估管径狭窄分数的装置及方法

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Publication number Publication date
CA2890157A1 (fr) 2014-05-08

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