WO2014061349A1

WO2014061349A1 - Method for maintaining pen-shaped injection drug at room temperature

Info

Publication number: WO2014061349A1
Application number: PCT/JP2013/072813
Authority: WO
Inventors: 宣治屋宜
Original assignee: YAGI Noriharu
Priority date: 2012-10-16
Filing date: 2013-08-27
Publication date: 2014-04-24

Abstract

The present invention can reliably maintain a drug such as insulin in a pen-shaped syringe at room temperature, and moreover can be easily realized merely by means of storage in a vacuum flask that is commercially available or in a household. A buffer tube is produced from a foamed resin and has an outer tube, which can be inserted into a cylindrical portable vacuum flask, and a cylindrical hole, which is such that the drug side of the pen-shaped syringe arrives at the center of a holder, the buffer tube is inserted into the portable vacuum flask, so the pen-shaped syringe is not damaged by impacting the hard inner wall of the vacuum flask, and the space is cooled by a refrigerant, so the insulin within is also cooled. Also, by disposing the refrigerant to the outside of an insulated tube having a cylindrical hole into which the injection button side of the pen-shaped syringe is inserted, the problem of the pen-shaped syringe directly contacting the refrigerant and being excessively cooled also does not arise.

Description

How to maintain pen-type injection solution at room temperature

The present invention relates to a simple pen-type syringe holder in which a drug solution such as insulin contained in a pen-type syringe is maintained at room temperature.

Insulin is an important drug for the treatment of diabetes. Injecting insulin is a heavy burden on the patient. However, the widespread use of pen-type insulin syringes has made insulin familiar to diabetes treatment. Currently, frequent injections of insulin are also common for better glycemic control. This has increased the opportunity to use insulin outdoors.
However, insulin is susceptible to heat. The storage temperature of insulin is as follows: 1. “If unused, avoid freezing and store at 2-8 ° C. protected from light”. 2. It is stipulated that "Do not put in the refrigerator during use, but store at room temperature."
Exceeding this temperature greatly loses the insulin effect, and even if injected, there is a risk of increasing blood sugar.

Therefore, in the summer, it is difficult to control the temperature of the diabetic patient for taking out insulin during outdoor work, outdoor sports, and seamount leisure, and cold storage is required. However, the conventional cooling method is a special product or a combination of uncertain materials that are inconvenient to carry and constant temperature.
On the other hand, as in Patent Document 1, a drug such as insulin that is unstable to heat can be kept cool and well at a temperature suitable for storage, and can be easily carried anywhere. In order to provide an epoch-making cold container for medicine, a cold container for storing medicine, the container body having an upper opening, and the container body in a state of concealing the upper opening of the container body The container body is composed of an inner cylinder body and an outer cylinder body, and a vacuum heat insulating portion is provided between the inner cylinder body and the outer cylinder body. A structure has been proposed.

JP2003-180797

However, the structure as disclosed in Patent Document 1 is not only expensive because it has a special structure, but is not suitable for a pen-type insulin syringe that has become popular in recent years. In addition, since the cold insulator and the side wall of the insulin container are in contact with each other, the insulin drug solution may freeze and deteriorate.
The technical problem of the present invention pays attention to such a problem, and it is possible to reliably maintain a medical solution such as insulin contained in a pen-type syringe, which has been popular in recent years, at room temperature, and to be stored in a thermos bottle on the market or at home. It is simply possible to realize it.

The present invention is characterized in that it can be used simply as an insulin cooler by using a wide-mouth thermos bottle, which is widely used, and inserting the holder unit of the present invention into the inside.
Specifically, Claim 1 has an outer diameter that can be inserted into a cylindrical portable thermos bottle, a buffer cylinder having a cylindrical hole in which the liquid side of the pen-type syringe comes to the center of the holder, and the pen-type syringe A pen-type syringe holder unit comprising a heat insulating cylinder having a cylindrical hole into which an injection button side is inserted, and a region in which a cooling agent is disposed on the outer periphery of the heat insulating cylinder.

According to a second aspect of the present invention, the cylindrical holes of the heat insulating cylinder and the buffer cylinder are directly connected to each other, or the heat insulating cylinder is partially inserted into the buffer cylinder or to the inner bottom position. A holder unit for a pen-type syringe according to Item 1.

According to a third aspect of the present invention, the shock-absorbing cylinder and / or the heat-insulating cylinder has a stretchability, and has a structure in which the lower end and / or the upper end of the pen-type syringe is packed with an elastic material or a cotton-like body. It is the holder unit of the pen-type syringe of Claim 1 or Claim 2.

A fourth aspect of the present invention is characterized in that the cold insulating agent is exposed or hidden by a sheet, and has an open / close lid that closes an outer end of the heat insulating cylinder, and has a stopper that prevents the cold insulating agent from being detached. A holder unit for a pen-type injector according to claim 2 or claim 3.

The present invention has a heat insulating cylinder in which a buffer cylinder having an outer diameter that can be inserted into a cylindrical portable thermos bottle and a cylindrical hole are directly connected to each other, or are inserted into the buffer cylinder partially or to the inner bottom position. The pen-type syringe is inserted into the cylindrical hole so that the drug solution side is located on the buffer cylinder side and the injection button side is located on the heat insulation cylinder side,
A pen-type syringe characterized by inserting a buffer tube, a heat insulating tube, and a cooling agent into the thermos bottle in a state where a cooling agent is disposed so as to surround the heat insulating tube, and then tightening the cap of the thermos bottle. It is a method of storing in a thermos.

According to a sixth aspect of the present invention, the cold insulating material is inserted into the inner wall of the cylindrical body, and the cold insulating material is bent by a method in which the heat insulating cylinder is inserted into a central portion of the cold insulating agent and then stored in the freezing portion to freeze the cold insulating agent. Mold the agent,
Alternatively, the cryogen is frozen by being stored in the freezing portion in a state where the cryogen is inserted into a ring-shaped space formed by closing the bottom of the outer cylinder and the bottom of the inner cylinder with a bottom plate made of a donut-shaped disk. 6. The method of storing a pen-type syringe according to claim 5 in a thermos bottle, wherein the shape of the cryogen that is curved by the method is shaped.

Claim 7 has an outer diameter that can be inserted into a cylindrical portable thermos bottle, and inserts a buffer cylinder having a cylindrical hole in which the drug solution side of the pen type syringe is in the center, and an injection button side of the pen type syringe, And the buffer cylinder and the cylindrical hole are directly connected to each other, or have a cylindrical hole inserted into the buffer cylinder partially or up to the inner bottom position, and a coolant is provided on the outer periphery on the side where the injection button side is inserted. A heat insulating cylinder to be disposed;
At least the cold-retaining agent is put in a freezing room or a refrigerating room and cooled, and then the heat-insulating tube with the cold-retaining agent and a buffer tube are connected and inserted into the thermos with the pen-type syringe stored. This is a method for cooling a liquid medicine in a pen-type syringe.

According to the holder unit of the pen-type syringe according to claim 1, the buffer cylinder having an outer diameter that can be inserted into the cylindrical portable thermos bottle and having a cylindrical hole in which the drug solution side of the pen-type syringe comes to the center of the holder is foamed resin. Since the pen-type syringe does not collide with the hard inner wall of the thermos and is not damaged, and the space is cooled with the cold insulation agent, the insulin inside is also kept cold.
In addition, since the heat insulating cylinder having a cylindrical hole for inserting the other part of the pen type syringe, that is, the injection button side, and the cold insulation agent are disposed on the outer periphery of the thermal insulation cylinder, the pen type syringe is in direct contact with the cold insulation agent. Therefore, the problem of being too cold does not occur. If the thermos cap is tightened via a sponge-like elastic material, there is no play and there is no risk of the pen-type syringe rattling.

When the cylindrical hole of the said heat insulation cylinder and the said buffer cylinder is directly connected like Claim 2, or the said heat insulation cylinder is made into the structure inserted in the said buffer cylinder partially or to an inner bottom position, insulin drug solution etc. Since heat is not deteriorated by heat and is surely insulated, the problem that insulin is in contact with the cryogen and cooled too much is solved. Moreover, even if it is taken outdoors, there is no fear that the pen-type syringe will be damaged by impact.

As in claim 3, since the buffer cylinder and / or the heat insulation cylinder have elasticity, when the holder unit is inserted into the thermos and the cap is tightened, the pen-type syringe is stably stored in the thermos, It is safe to take it outdoors in the hot summer.
In addition, since the lower end and / or the upper end of the pen-type syringe are packed with an elastic material such as sponge or a cotton-like body, the pen-type syringe stored in the holder unit does not rattle.

Since the open / close lid for closing the outer end of the heat insulating cylinder is provided as in the fourth aspect, the pen-type syringe can be inserted simply by opening the open / close lid, which is convenient. In addition, since it has a stopper that prevents refrigeration of the cold insulation agent wound around the heat insulation cylinder, there is no risk of the refrigeration agent coming off, and the patient does not have to worry about the refrigeration agent by himself or herself. There is no fear of bothering you. If an opaque sheet is put on the cold insulation agent or the buffer cylinder as shown by a chain line in FIG. 4, the user cannot see the cold insulation agent and need not be aware of it.

A heat-insulating cylinder in which a buffer cylinder having an outer diameter that can be inserted into a cylindrical portable thermos bottle and a cylindrical hole are directly connected to each other or inserted into the buffer cylinder partially or up to the inner bottom position as in claim 5. The pen-type syringe is inserted into the cylindrical hole so that the chemical solution side is located on the buffer cylinder side and the injection button side is located on the heat insulation cylinder side, and a cooling agent is disposed so as to surround the heat insulation cylinder In this state, the buffer tube, the heat insulating tube, and the cold insulation agent are inserted into the thermos bottle and then the thermoseal cap is tightened. Can be maintained. In addition, since the pen-type syringe is buffered by the buffering action of the foamed resin formed in a cylindrical shape, there is no risk of damage.

As in claim 6, the cold insulation agent is inserted into the inner wall of the cylindrical body, and the cold insulation agent is frozen by being housed in the freezing section with the cylindrical heat insulation cylinder inserted in the center of the cold insulation agent. Therefore, when inserting into a thermos bottle, it can be frozen in advance so that it can be wound around the outer periphery of a cylindrical heat-insulating cylinder, and commercially available general-purpose cryogens can also be used. Alternatively, the cryogen is frozen by storing it in a freezing section in a ring-shaped space formed by closing the bottom of the outer cylinder and the bottom of the inner cylinder with a bottom plate made of a donut disk. According to this method, the inner diameter dimension of the cold-retaining agent is shaped with high accuracy in the same manner as the outer diameter dimension, so that the operation is simple.

As in claim 7, the cryogen is put in a freezer compartment or a refrigerator compartment and cooled, and then a heat insulating cylinder with a cryogen and a buffer cylinder are connected and inserted into the thermos bottle with a pen-type syringe stored. The method facilitates the spread of the pen-type syringe holder of the present invention because the patient can easily do the work himself. Moreover, the chemical | medical solution side of a pen type syringe is positioned by the cylindrical hole in the center position of a buffer cylinder, and is buffered.

It is sectional drawing which shows the room temperature maintenance holder unit of the pen type insulin syringe by this invention. In the embodiment of a cooling agent molding jig (molding apparatus), (1) is a perspective view showing an exploded mold, and (2) is a sectional view showing an integrated mold. It is sectional drawing which illustrates the holder unit without the troublesome shaping of a cold insulating agent. It is sectional drawing which shows the example which covered the opaque sheet | seat so that a cold insulating agent might not be visible. It is sectional drawing which shows the improved type | mold of FIG.

Next, an embodiment of how the method for maintaining room temperature of pen-type injection insulin according to the present invention is practically described will be described. FIG. 1 is a cross-sectional view showing a first embodiment of a room temperature maintaining holder unit of a pen-type syringe according to the present invention, which is an example using a commercially available small-diameter cylindrical thermos.
In FIG. 1, a cylindrical thermos has a space 3 between an inner bottle 1 and an outer bottle 2 in a vacuum state, and the thermos is closed with a cap 4. In the cylindrical inner bottle 1, a foamed resin body (styrene foam) 5 is inserted as a buffer cylinder for a holder, and a pen-type insulin syringe P is positioned at the center thereof. A cylindrical and elastic heat insulating cylinder 7 is disposed so that the drug solution of the pen-type syringe P, that is, insulin i does not contact the frozen cryogen 6 and the heat insulating cylinder is tightened when the cap 4 is tightened. 7 is compressed by the cap 4.
In addition, if the

extensible bodies

8 and 9 such as a sponge and a cotton-like body are packed so as to be in contact with the lower end and / or the upper end of the pen-type injector P, play in which the pen-type injector P rattles can be eliminated. The upper and lower sides of the

fillings

8 and 9 are closed with a cover plate or a bottom plate.

The buffer cylinder 5 is formed in a cylindrical shape so that the pen-type injector P can be held in the center. However, when the expansion and contraction body 8 is packed, the buffer cylinder 5 does not necessarily have a bottom and may have no bottom. In this case, since the expansion / contraction body 8 also serves as the bottom portion, it is better to stuff it into the tight.
The buffer cylinder 5 for containing the pen-type syringe P is for preventing the pen-type syringe P from colliding with the inner wall of the cylindrical thermos bottle and damaging it. is there. Thus, although the buffering action is the purpose, when the heat insulation cylinder 7 is an elastic material, the elasticity is not necessarily required. When the heat insulation cylinder 7 does not have elasticity, the buffer cylinder 5 is given elasticity instead. Both of them may have stretchability, and in the case of a foamed resin body such as polystyrene foam, both may not have so much stretchability.

The outer diameter of the heat insulating cylinder 7 is reduced, and the cooling agent 6 is disposed in a curved state on the outer periphery thereof and placed on the buffer cylinder 5. In this manner, the heat insulating cylinder 7 that insulates the cold insulating agent 6 is positioned on the side opposite to the liquid medicine i side of the pen-type injector P. At this time, the size of the heat insulating cylinder 7 is set so as not to fall into the buffer cylinder 5. When both cylindrical holes are connected to each other and the pen-type syringe P is housed therein, the drug solution i is positioned at the central position, so that the thermal uniformity is achieved.
As indicated by a chain line 71, a heat insulating cylinder 7 having a small outer diameter may be partially inserted into the upper end of the buffer cylinder 5 so as to be centerable. Alternatively, it can be inserted until it reaches the inner bottom position of the buffer cylinder 5 as indicated by a chain line 72 or can be partially inserted into the buffer cylinder 5 as indicated by a chain line 73.

As described above, when the pen-type injector P is inserted into the cylindrical buffer cylinder 5 and the small-diameter heat insulating cylinder 7 and inserted into the thermos bottle, the action of the cold insulating agent 6 causes the inner surface of the inner bottle 1 and the buffer. The space between the inner and outer surfaces of the cylinder 5 and the heat insulating cylinder 7, the inner and outer surfaces of the cryogen 6 and the outer surface of the pen-type syringe P is filled with cold air, and as a result, the insulin stored in the container portion of the pen-type syringe P The chemical solution i is kept cold and maintained at room temperature. The pen type syringe P has a cross section of the cap with the clip C so that a scale indicating the amount of insulin i can be seen, but the holder of the present invention with the scale side of insulin i facing down. Since the cryogen 6 is kept away by storing in the unit, it is possible to effectively prevent the insulin i from being too cold. That is, the cold-retaining agent 6 is positioned on the side opposite to the chemical solution i side, that is, on the side where the injection button B is located at the end.
Further, as described above, since the position of the insulin i of the pen-type syringe is positioned at the center, the thermal and impact forces become uniform.

Although it is possible to cool the cold insulating agent 6 together with the heat insulating cylinder 7 and the buffer cylinder 5 in the refrigerator, FIG. 2 (1) shows an embodiment in which the cold insulating agent 6 curved in a cylindrical shape is shaped. It is a perspective view to show, and around the outer periphery of the small-diameter heat insulating cylinder 7 is inserted into the guide cylinder G in a state where about 40 g of the melted refrigerant 6 'is wound, and then put into the freezer of the refrigerator. Freeze.
It is desirable to arrange the heat insulating cylinder 7 at the center of the guide cylinder G. For this purpose, a donut-shaped disk having a size that allows the upper and lower ends of the heat insulating cylinder 7 to be inserted can be inserted into the inner periphery of the guide cylinder G.
In this way, after freezing into a C shape, semicircular shape, or circularly curved shape, it is inserted into a cylindrical thermos. If the cooling time is short or the cooling requirement is not strict as in the case of using indoors in accordance with the expected cooling effect, it is not always necessary to freeze in the cooling state. Conversely, when used in hot weather, freeze the cryogen.

(2) is a cross-sectional view illustrating an integral type, and a ring-shaped space S is formed by closing the space between the lower end of the guide cylinder G and the lower end of the inner cylinder 7 'with a donut-shaped bottom plate 10. It is integrated.
In order to shape the shape of the cooling agent into a C shape, a semicircular shape, or a circularly curved shape, the molten cooling agent is packed in the ring-shaped space S, and then stored in the freezer of the refrigerator. It is enough to freeze it.
After the cryogen 6 'freezes, it is taken out from the ring-shaped space S, arranged on the outer periphery of the heat insulating cylinder 7, and inserted into the thermos bottle together with the pen-type syringe. In addition, if it is set as the dimension which the heat insulation pipe | tube 7 enters in inner cylinder 7 ', the heat insulation pipe | tube 7 can be inserted as it is, without taking out a cold insulating agent from the space S, and can be accommodated in a thermos.
Further, it is possible to use only the frozen cryogen 6 after being frozen by wrapping the cryogen 6 around a jig cylinder having an outer diameter equivalent to that of the heat insulating cylinder 7 and freezing. If the jig cylinder is thin and strong, the jig cylinder may be disposed on the outer periphery of the heat insulating cylinder 7.

FIG. 3 shows a configuration in which the heat insulating cylinder 7 of FIG. 1 is partially inserted into the buffer cylinder 5 as indicated by a chain line 73 and a donut-shaped stopper 11 is wound around the outer end of the heat insulating cylinder 7. . In addition, a cellophane tape or the like is wound around the outer periphery so as not to be thicker than the outer diameter of the buffer cylinder 5 as much as possible. In addition, when the cooling agent 6 is inserted into the guide cylinder G of FIG. 2 (1), it can be prevented from protruding from the outer diameter of the buffer cylinder 5. The reason for hating such protrusion is to enable smooth insertion into the thermos.

When the cooling agent 6 is cooled, it is only necessary to put it in the freezer or refrigeration room together with the buffer cylinder 5, so that the work of shaping the cooling agent is unnecessary as shown in FIG. Take out the heat insulation cylinder 7 from the refrigerator. Then, after removing the opening / closing lid 12 and storing the pen-type injector P, it is sufficient to insert the pen-type syringe P into the thermos bottle with the opening / closing lid 12 closed. If the buffer cylinder 5 and the heat insulating cylinder 7 are bonded and fixed at the position of the chain line 73, the patient only needs to put in and out the pen-type syringe P and open and close the open / close lid 12, and the operation is simple.

When commercializing, it is preferable that the cold insulation agent 6 is not visible in terms of design, so an opaque thin sheet 13 (which may be partially transparent) is pasted as shown by a chain line in FIG. When a warning message or a warning is displayed, the patient does not need to be aware of the cryogen 6 and need not be aware of it. Since it is only necessary to put the buffer cylinder 5 in and out of the refrigerator, the patient's convenience is improved and the product is patient-friendly.
The heat insulating cylinder 7 in FIG. 1 is inserted and fixed in the buffer cylinder 5 until it reaches the inner bottom position as indicated by a chain line 72. Although only a part of the buffer cylinder 5 is indicated by a chain line, the entire buffer cylinder 5 may be covered with the sheet 13 so that it looks beautiful.

When the embodiment other than the above is illustrated, as shown in FIG. 3, in the case where the cap portion with the clip C is thicker than the injection button B side, the inner diameter of the cylindrical hole for storing the pen-type syringe P is also the injection button. The B side has a small diameter and the cap side has a large diameter. If the opening / closing lid 12 is provided on the cap side, even if it is inserted from the cap side, it enters only partway due to the small diameter hole, and if it is inserted from the injection button B side, it is completely entered. In this case, as shown in FIG. 5, the opening / closing lid 12 is provided on the cap side, and the up and down directions are reversed. With this structure, even if the insertion direction is wrong, the chemical solution i does not come to the cryogen 6 side.
In FIG. 4, when the opening / closing lid 12 is bonded and fixed, and instead the heat insulating cylinder 7 itself is removed, the pen-shaped syringe P is inserted from the bottom in the pulled-out state, and the lower end is left open. 7 may be inserted into the buffer cylinder 5 and the cold-retaining agent 6 may be attached.

In order not to insert the pen-type syringe P in the reverse direction, a photograph of the pen-type syringe P can be pasted on the outer surface of each cylindrical body.
In the above embodiment, it is described that insulin i is contained in the pen-type syringe P assuming a diabetic patient, but other chemicals may be contained in the pen-type syringe P instead of the insulin i. Absent.

As described above, a buffer cylinder having an outer diameter that can be inserted into a cylindrical portable thermos bottle and a cylindrical hole are directly connected to each other, or a heat insulating cylinder is inserted into the buffer cylinder partially or up to the inner bottom position. In addition, since the liquid side of the pen-type syringe is located on the buffer cylinder side and the injection button side is located on the side of the heat insulating cylinder wrapped with the cryogen, the liquid medicine contained in the pen-type syringe can be reliably maintained at room temperature, and Because it is housed in a thermos at home, it can maintain light shielding properties. As a result, diabetics can easily go out in the summer and enjoy leisure activities. In addition, since the chemical solution dislikes the refrigerator, even when the cooler is not used for the purpose of power saving, the method of using the cryogen together will be useful even when stored indoors.

P Pen-type insulin syringe B Injection button i Drug solution (insulin)
3 Vacuum Space 4 Thermos Cap 5 Styrofoam Buffer Cylinder 6 Coolant 7 Heat Insulating Cylinder 8/9 Stretchable Body C Clip G Guide Cylinder
10 Donut-shaped bottom plate S Ring-shaped space
11 Stopper
12 Opening / closing lid
13 Opaque sheet

Claims

A heat insulating cylinder having an outer diameter that can be inserted into a cylindrical portable thermos bottle and having a cylindrical hole in which the liquid side of the pen-type syringe comes to the center and a cylindrical hole for inserting the injection button side of the pen-type syringe A holder unit for a pen-type syringe, comprising a cylinder and a region for arranging a cold insulation agent on the outer periphery of the heat insulation cylinder.
The cylindrical hole of the said heat insulation cylinder and the said buffer cylinder is directly connected, or the said heat insulation cylinder is a structure inserted in the said buffer cylinder partially or to an inner bottom position, The structure of Claim 1 characterized by the above-mentioned. Pen-type syringe holder unit.
The said buffer cylinder and / or a heat insulation cylinder have a stretching property, It has the structure packed with an elastic material or a cotton-like body in the lower end and / or upper end of the said pen type syringe. A pen-type syringe holder unit as described in 1.
The said heat insulating agent is exposed or concealed by a sheet, and has a lid portion that closes an outer end of the heat insulating cylinder, and has a stopper that prevents the cold insulating agent from detaching. The holder unit of the pen type syringe according to claim 3.
A buffer cylinder having an outer diameter that can be inserted into a cylindrical portable thermos bottle and a cylindrical hole are directly connected to each other, or have a heat insulating cylinder that is partially inserted into the buffer cylinder or to the inner bottom position. Inserted into the cylindrical hole so that the chemical solution side is located on the buffer cylinder side and the injection button side is located on the heat insulation cylinder side,
A pen-type syringe characterized by inserting a buffer tube, a heat insulating tube, and a cooling agent into the thermos bottle in a state where a cooling agent is disposed so as to surround the heat insulating tube, and then tightening the cap of the thermos bottle. How to store in a thermos.
Insert the cold-retaining agent into the inner wall of the cylindrical body, and store the heat-insulating cylinder in the center of the cold-retaining agent and store it in the freezing part to form the curved cold-retaining agent by freezing the cold-retaining agent. Or
Alternatively, the cryogen is frozen by being stored in the freezing portion in a state where the cryogen is inserted into a ring-shaped space formed by closing the bottom of the outer cylinder and the bottom of the inner cylinder with a bottom plate made of a donut-shaped disk. 6. A method of storing a pen-type syringe according to claim 5 in a thermos, wherein the method is to form a cryogen that is curved by the method.
A buffer cylinder having an outer diameter that can be inserted into a cylindrical portable thermos bottle and having a cylindrical hole in which the liquid side of the pen-type syringe comes to the center; an injection button side of the pen-type syringe; and the buffer cylinder; A heat insulating cylinder in which cylindrical holes are directly connected to each other or have a cylindrical hole inserted into the buffer cylinder partially or up to the inner bottom position, and a cooling agent is disposed on the outer periphery on the side where the injection button side is inserted. And
At least the cold-retaining agent is put in a freezing room or a refrigerating room and cooled, and then the heat-insulating tube with the cold-retaining agent and a buffer tube are connected and inserted into the thermos with the pen-type syringe stored. A method for cooling a liquid medicine in a pen-type syringe.