WO2014057444A1 - Orthotopic artificial bladder endoprosthesis - Google Patents

Orthotopic artificial bladder endoprosthesis Download PDF

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Publication number
WO2014057444A1
WO2014057444A1 PCT/IB2013/059253 IB2013059253W WO2014057444A1 WO 2014057444 A1 WO2014057444 A1 WO 2014057444A1 IB 2013059253 W IB2013059253 W IB 2013059253W WO 2014057444 A1 WO2014057444 A1 WO 2014057444A1
Authority
WO
WIPO (PCT)
Prior art keywords
casing
coating
endoprosthesis
fabric
endoprosthesis according
Prior art date
Application number
PCT/IB2013/059253
Other languages
French (fr)
Inventor
Antonio Sambusseti
Gianni Cancarini
Original Assignee
Antonio Sambusseti
Gianni Cancarini
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antonio Sambusseti, Gianni Cancarini filed Critical Antonio Sambusseti
Publication of WO2014057444A1 publication Critical patent/WO2014057444A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/042—Urinary bladders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/003—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time
    • A61F2250/0031—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time made from both resorbable and non-resorbable prosthetic parts, e.g. adjacent parts

Definitions

  • the present invention relates to an orthotopic artificial bladder endoprosthesis.
  • the application of the present invention lies in the replacement of the bladder of a patient, if the latter is suffering from serious incurable diseases such to compromise the correct function thereof.
  • Known bladder endoprostheses comprise a balloon casing made with an impermeable layered silicone membrane.
  • Such casing is sufficiently rigid so as to stably keep its shape and flexible enough to be able to be manually compressed to ensure that it empties.
  • the casing has a connection element located at a lower portion of the casing to connect with the patient's urethra.
  • connection bodies are located at the top to enable connection with the ureters.
  • a musculo-fibrous tissue layer (not impermeable) around the casing.
  • a neobladder is generated around the endoprosthesis.
  • the technical task underlying the present invention is to propose an orthotopic artificial bladder endoprosthesis that overcomes the drawback of the abovementioned prior art.
  • the object of the present invention is to provide an orthotopic artificial bladder endoprosthesis that limits the risks associated with bacterial infections .
  • the specified technical task and the specified object are substantially achieved by an orthotopic artificial bladder endoprosthesis comprising the technical characteristics set forth in one or more of the enclosed claims .
  • FIG. 1 is a schematic side view of an orthotopic artificial bladder endoprosthesis in accordance with the present invention.
  • FIG. 1 is a cross-sectional side view of the endoprosthesis shown in figure 1.
  • reference number 1 indicates an orthotopic artificial bladder endoprosthesis in its entirety in accordance with the present invention.
  • the endoprosthesis 1 comprises a balloon-shaped casing 2 having an internal surface 2a and an external surface 2b.
  • the casing 2 defines, at its interior, a closed enclosure for containing the urine.
  • the enclosure has a volume substantially comprised between 100 cm 3 and 900 cm3 , preferably being 400 cm .
  • the casing 2 is obtained by means of a multi-layered silicone layer membrane.
  • the membrane substantially comprises 20 layers, each approximately 30 pm thick.
  • the membrane with which the casing 2 is obtained has a thickness comprised between 500 pm and 700 pm, and preferably the thickness of the membrane is substantially 600 pm.
  • the casing 2 is therefore sufficiently rigid to maintain its shape, while at the same time sufficiently flexible to be able to be pushed from the outside to facilitate the expulsion of the urine.
  • the membrane is produced by means of a process illustrated in the patent application WO 2007/039159 which is incorporated herein for reference purposes.
  • the silicone used may be constituted by copolymers of dimethyl- and metavinyl-siloxane reinforced with silicon.
  • the silicone can be admixed with radio- opacifiers such as barium sulphate, titanium dioxide or the like, in a manner such that the endoprosthesis 1 can be detected by means of radiological diagnostic techniques.
  • radio- opacifiers such as barium sulphate, titanium dioxide or the like
  • both on the internal surface 2a and on the external surface 2b of the casing 2 respective layers are applied of a highly biocompatible protective material.
  • a highly biocompatible protective material is pyrolytic turbostratic carbon with a thickness comprised between 0.2 pm and 0.3 pm.
  • the application of the carbon layer on the external surface 2b of the casing 2 allows the risk of the forming fibrous capsule adhering to the casing 2 itself to be avoided .
  • the application of the carbon layer on the internal surface 2a of the casing 2 allows protecting the casing 2 itself from the corrosion caused by the urine.
  • the casing 2 also comprises a connector 3 fixed to the casing 2 in order to allow the connection of the patient's urethra to the endoprosthesis 1.
  • the connector 3 has frustoconical shape and is glued to the casing 2 at an opening 4 made in the membrane in order to allow the urine to exit .
  • the connector 3 is glued to the casing 2 at a larger base thereof.
  • the connector 3 has a height of 15 mm and the larger base a height of 24 mm. Furthermore, the diameter of the hole at the smaller base is approximately 6 mm and the thickness approximately 1 mm .
  • the connector 3 is made of silicone internally reinforced with a net or mesh inserted in the thickness. Such net or mesh is preferably made of Dacron® or Goretex®.
  • the connector 3 is made by means of known techniques such as, for example, molding, dipping or the like.
  • the net allows the patient's urethra to be stitched to the connector 3 in a simpler and more stable way.
  • the endoprosthesis 1 further comprises two tubular connection elements 5 that are fixed, e.g. by means of gluing, to the casing 2 and can be connected to the ureters of the patient.
  • the connection elements 5 are arranged in a position substantially opposite the connector 3.
  • the endoprosthesis 1 comprises a coating 6 which at least encloses the casing 2.
  • the coating 6 also encloses the connector 3 and the connection elements 5.
  • the coating 6 is made of a preferably homopolymer PGA (polyglycolide or poylglycolic acid) fiber fabric.
  • PGA is a highly biocompatible and resorbable polymer and is resistant to urine. In detail, the resorption time of PGA is approximately one month.
  • the fabric of the coating 6 can be obtained by weaving the PGA thread in various ways, giving rise to a knitted fabric, a woven fabric or a non-woven fabric.
  • the fabric of the coating 6 is a knitted fabric, and even more preferably a warp knitted fabric.
  • the fabric of the coating 6 has a rougher surface capable of assuming a net configuration with sufficiently small meshes.
  • its weft is such that its interstitial space is less than 200 pm, preferably around 160 pm, corresponding to an average area of the holes equal to approximately 0.02 mm . This ensures impermeability to urine, preventing leaks.
  • the coating is impregnated with blood and in particular with plasma, which allows the antibiotic drugs to be effective.
  • the fabric of the coating 6 is preferably textured so as to give it even greater surface roughness and greater rigidity and impermeability. The greater roughness of the fabric limits the risk of adhesion of the fibrous capsule.
  • the fabric of the coating 6 has a thickness substantially comprised between 0.3 mm and 0.6 mm, more preferably comprised between 0.4 mm and 0.53 mm, still more preferably being substantially 0.45 mm.
  • the thread with which the fabric of the coating 6 is obtained has a density comprised between 50 and 200 denier.
  • the coating 6 is arranged outside the casing 2. In other words, the coating 6 is facing the external surface 2b of the casing 2. Advantageously, the coating 6 does not adhere to the casing 2.
  • the open coating 6 is wound around the casing 2 in a manner such that it is also wound around the connector 3 and the connection elements 5.
  • the coating 6 is then reclosed by means of a stitching made using a resorbable thread.
  • the PGA fiber fabric with which the coating 6 is obtained allows musculo-fibrous tissue to form on the outside of the endoprosthesis 1.
  • a layer of transition epithelium which is also called urothelium, directed internally.
  • the layer of urothelium is impermeable, an essential fact to ensure the correct functioning of the prosthesis and the neobladder that is being formed.
  • the urethra and the ureters of the patient are respectively connected to the connector 3 and to the connection elements 5 in a manner such that they come into contact and are sutured with the coating 6 with a resorbable thread.
  • the urethra and the ureters are merged with the forming biological tissue.
  • a neobladder is formed comprising musculo-fibrous tissue coated with urothelium.
  • the neobladder just formed has structural and impermeability characteristics sufficient for a correct functioning thereof.
  • the silicone casing 2 is therefore not indispensable for the functionality of the neobladder and can be removed by means of a subsequent operation.
  • the endoprosthesis 1 in accordance with the present invention is therefore of temporary nature.
  • the invention achieves the pre-established object.
  • the neobladder of the patient will only be constituted by biological material.

Landscapes

  • Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

An orthotopic artificial bladder endoprosthesis comprises a collapsible casing (2) constituted by a multi-layered silicone membrane having an external surface (2b) and an internal surface (2a) both coated with pyrolytic turbostratic carbon, two tubular connection elements (5) fixed to the casing (2) and connectable to ureters of a patient and a connector (3) fixed to the casing (2) connectable to the urethra of the patient; a coating (6) made of a PGA fiber fabric associated at least with said casing ( 2 ).

Description

ORTHOTOPIC ARTIFICIAL BLADDER ENDOPROSTHESIS"
The present invention relates to an orthotopic artificial bladder endoprosthesis.
The application of the present invention lies in the replacement of the bladder of a patient, if the latter is suffering from serious incurable diseases such to compromise the correct function thereof.
Known bladder endoprostheses comprise a balloon casing made with an impermeable layered silicone membrane.
Such casing is sufficiently rigid so as to stably keep its shape and flexible enough to be able to be manually compressed to ensure that it empties.
The casing has a connection element located at a lower portion of the casing to connect with the patient's urethra. Similarly, two connection bodies are located at the top to enable connection with the ureters.
These connections are achieved by suturing or by simply interlocking.
Following the implant of the endoprosthesis in the patient, there is the formation of a musculo-fibrous tissue layer (not impermeable) around the casing. In such a manner, a neobladder is generated around the endoprosthesis.
Since the endoprotheses of known type are permanent, complications can occur even after the complete rehabilitation of the patient.
Indeed, it may occur that an infection hits the neobladder in an accidental manner or following the use of catheters.
In such case, a suitable antibiotic treatment is necessary. Such drugs are effective in extinguishing the bacterial loads nested in biological tissue and have poor or even zero effect on bacterial loads nested on artificial materials like those that make up the casing. Disadvantageously, therefore, endoprostheses of known type can represent an obstacle in the effectiveness of antibiotic treatments.
In this context, the technical task underlying the present invention is to propose an orthotopic artificial bladder endoprosthesis that overcomes the drawback of the abovementioned prior art.
In particular, the object of the present invention is to provide an orthotopic artificial bladder endoprosthesis that limits the risks associated with bacterial infections .
The specified technical task and the specified object are substantially achieved by an orthotopic artificial bladder endoprosthesis comprising the technical characteristics set forth in one or more of the enclosed claims .
Further characteristics and advantages of the present invention will emerge more clearly from the following non-limiting description of a preferred but not exclusive embodiment of an orthotopic artificial bladder endoprosthesis, as illustrated in the enclosed drawings in which:
- Figure 1 is a schematic side view of an orthotopic artificial bladder endoprosthesis in accordance with the present invention; and
- Figure 2 is a cross-sectional side view of the endoprosthesis shown in figure 1.
With reference to the enclosed figures, reference number 1 indicates an orthotopic artificial bladder endoprosthesis in its entirety in accordance with the present invention.
The endoprosthesis 1 comprises a balloon-shaped casing 2 having an internal surface 2a and an external surface 2b. The casing 2 defines, at its interior, a closed enclosure for containing the urine. The enclosure has a volume substantially comprised between 100 cm 3 and 900 cm3 , preferably being 400 cm .
The casing 2 is obtained by means of a multi-layered silicone layer membrane.
In a preferred embodiment, the membrane substantially comprises 20 layers, each approximately 30 pm thick.
The membrane with which the casing 2 is obtained has a thickness comprised between 500 pm and 700 pm, and preferably the thickness of the membrane is substantially 600 pm.
In such a manner, the casing 2 is therefore sufficiently rigid to maintain its shape, while at the same time sufficiently flexible to be able to be pushed from the outside to facilitate the expulsion of the urine.
The membrane is produced by means of a process illustrated in the patent application WO 2007/039159 which is incorporated herein for reference purposes.
By way of example, the silicone used may be constituted by copolymers of dimethyl- and metavinyl-siloxane reinforced with silicon.
Advantageously, the silicone can be admixed with radio- opacifiers such as barium sulphate, titanium dioxide or the like, in a manner such that the endoprosthesis 1 can be detected by means of radiological diagnostic techniques.
Both on the internal surface 2a and on the external surface 2b of the casing 2, respective layers are applied of a highly biocompatible protective material. By way of example, such material is pyrolytic turbostratic carbon with a thickness comprised between 0.2 pm and 0.3 pm. The application of the carbon layer on the external surface 2b of the casing 2 allows the risk of the forming fibrous capsule adhering to the casing 2 itself to be avoided .
The application of the carbon layer on the internal surface 2a of the casing 2 allows protecting the casing 2 itself from the corrosion caused by the urine.
The casing 2 also comprises a connector 3 fixed to the casing 2 in order to allow the connection of the patient's urethra to the endoprosthesis 1.
In accordance with that illustrated, the connector 3 has frustoconical shape and is glued to the casing 2 at an opening 4 made in the membrane in order to allow the urine to exit .
In particular, the connector 3 is glued to the casing 2 at a larger base thereof.
According to a preferred embodiment, the connector 3 has a height of 15 mm and the larger base a height of 24 mm. Furthermore, the diameter of the hole at the smaller base is approximately 6 mm and the thickness approximately 1 mm .
The connector 3 is made of silicone internally reinforced with a net or mesh inserted in the thickness. Such net or mesh is preferably made of Dacron® or Goretex®. The connector 3 is made by means of known techniques such as, for example, molding, dipping or the like.
The net allows the patient's urethra to be stitched to the connector 3 in a simpler and more stable way.
The endoprosthesis 1 further comprises two tubular connection elements 5 that are fixed, e.g. by means of gluing, to the casing 2 and can be connected to the ureters of the patient. The connection elements 5 are arranged in a position substantially opposite the connector 3.
In accordance with the present invention, the endoprosthesis 1 comprises a coating 6 which at least encloses the casing 2. Preferably, the coating 6 also encloses the connector 3 and the connection elements 5. The coating 6 is made of a preferably homopolymer PGA (polyglycolide or poylglycolic acid) fiber fabric. PGA is a highly biocompatible and resorbable polymer and is resistant to urine. In detail, the resorption time of PGA is approximately one month.
The fabric of the coating 6 can be obtained by weaving the PGA thread in various ways, giving rise to a knitted fabric, a woven fabric or a non-woven fabric.
Preferably, the fabric of the coating 6 is a knitted fabric, and even more preferably a warp knitted fabric.
In this case, the fabric of the coating 6 has a rougher surface capable of assuming a net configuration with sufficiently small meshes.
In detail, its weft is such that its interstitial space is less than 200 pm, preferably around 160 pm, corresponding to an average area of the holes equal to approximately 0.02 mm . This ensures impermeability to urine, preventing leaks.
In addition, once the endoprosthesis is inserted, the coating is impregnated with blood and in particular with plasma, which allows the antibiotic drugs to be effective.
Furthermore, the fabric of the coating 6 is preferably textured so as to give it even greater surface roughness and greater rigidity and impermeability. The greater roughness of the fabric limits the risk of adhesion of the fibrous capsule.
Purely by way of example, the fabric of the coating 6 has a thickness substantially comprised between 0.3 mm and 0.6 mm, more preferably comprised between 0.4 mm and 0.53 mm, still more preferably being substantially 0.45 mm. In addition, the thread with which the fabric of the coating 6 is obtained has a density comprised between 50 and 200 denier.
The coating 6 is arranged outside the casing 2. In other words, the coating 6 is facing the external surface 2b of the casing 2. Advantageously, the coating 6 does not adhere to the casing 2.
During the obtainment of the endoprosthesis 1, the open coating 6 is wound around the casing 2 in a manner such that it is also wound around the connector 3 and the connection elements 5.
The coating 6 is then reclosed by means of a stitching made using a resorbable thread.
Advantageously, the PGA fiber fabric with which the coating 6 is obtained allows musculo-fibrous tissue to form on the outside of the endoprosthesis 1.
Inside - and specifically between the casing 2 and the coating 6 - during resorption, there is the formation of a layer of transition epithelium, which is also called urothelium, directed internally. Advantageously, the layer of urothelium is impermeable, an essential fact to ensure the correct functioning of the prosthesis and the neobladder that is being formed.
During the implant of the endoprosthesis 1, the urethra and the ureters of the patient are respectively connected to the connector 3 and to the connection elements 5 in a manner such that they come into contact and are sutured with the coating 6 with a resorbable thread. In this manner, during resorption the urethra and the ureters are merged with the forming biological tissue. In such a manner, after the coating 6 resorption process has been concluded, a neobladder is formed comprising musculo-fibrous tissue coated with urothelium. In other words, the neobladder just formed has structural and impermeability characteristics sufficient for a correct functioning thereof.
The silicone casing 2 is therefore not indispensable for the functionality of the neobladder and can be removed by means of a subsequent operation.
The endoprosthesis 1 in accordance with the present invention is therefore of temporary nature.
The invention achieves the pre-established object.
Indeed, since the endoprosthesis is temporary and the non-resorbable material casing is removed after the conclusion of the coating resorption process, the neobladder of the patient will only be constituted by biological material.
If the patient is affected by bacterial infections, the use of antibiotic treatments will be fully effective since it will only act on biological and non-artificial tissue .

Claims

1. Orthotopic artificial bladder endoprosthesis comprising a collapsible casing (2) constituted by a multi-layered silicone membrane having an external surface (2b) and an internal surface (2a) both coated with pyrolytic turbostratic carbon, two tubular connection elements (5) fixed to the casing (2) and connectable to ureters of a patient and to a connector (3) fixed to the casing (2) connectable to the urethra of the patient; characterized in that it comprises a coating (6) made of a PGA fiber fabric associated with at least said casing ( 2 ) .
2. Endoprosthesis according to claim 1, characterized in that said coating (6) is further associated with said connection elements (5) and/or said connector (3) .
3. Endoprosthesis according to any one of the preceding claims, characterized in that the fabric of the coating (6) is of warp knitted type.
4. Endoprosthesis according to any one of the preceding claims, characterized in that the fabric of the coating
(6) is textured.
5. Endoprosthesis according to any one of the preceding claims, characterized in that the thickness of the fabric of the coating (6) is comprised between 0.1 mm and 2 mm, preferably between 0.3 mm and 0.6 mm, more preferably between 0.4 mm and 0.53 mm, still more preferably is 0.45 mm .
6. Endoprosthesis according to any one of the preceding claims, characterized in that the fabric of the coating (6) is obtained with a thread having a density comprised between 50 and 200 denier.
7. Endoprosthesis according to any one of the preceding claims, characterized in that the membrane of the casing (2) has a thickness comprised between 500 pm and 700 pm, preferably being approximately 600 pm.
8. Endoprosthesis according to any one of the preceding claims, characterized in that it is at least partly removable after a predetermined time period.
PCT/IB2013/059253 2012-10-11 2013-10-10 Orthotopic artificial bladder endoprosthesis WO2014057444A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001709A ITMI20121709A1 (en) 2012-10-11 2012-10-11 ORTHOTOPIC ENDOPROSTHESIS OF ARTIFICIAL BLADDER
ITMI2012A001709 2012-10-11

Publications (1)

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WO2014057444A1 true WO2014057444A1 (en) 2014-04-17

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WO (1) WO2014057444A1 (en)

Cited By (9)

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Publication number Priority date Publication date Assignee Title
WO2015140251A1 (en) * 2014-03-21 2015-09-24 Antonio Sambusseti Drainage tube for urine in silicone with carbon coating for supporting an absorbable device for tissue reconstruction of urethral segment
WO2015159185A1 (en) * 2014-04-14 2015-10-22 Antonio Sambusseti Orthotopic artificial bladder endoprosthesis
WO2016051330A1 (en) * 2014-09-30 2016-04-07 Antonio Sambusseti Orthotopic artificial bladder endoprosthesis
WO2016051333A1 (en) * 2014-09-30 2016-04-07 Antonio Sambusseti Orthotopic artificial bladder endoprosthesis
CN106388971A (en) * 2016-12-06 2017-02-15 庞希宁 Artificial urinary bladder intelligent control device and control method thereof
CN106580517A (en) * 2017-01-23 2017-04-26 夏生俊 Artificial bladder device
ITUB20161129A1 (en) * 2016-02-26 2017-08-26 Scuola Superiore Di Studi Univ E Di Perfezionamento Santanna ARTIFICIAL BLADDER
JP2017531487A (en) * 2014-10-14 2017-10-26 アントニオ・サンブッセティＡｎｔｏｎｉｏ ＳＡＭＢＵＳＳＥＴＩ Absorbable device for bone regeneration
IT201800006814A1 (en) * 2018-06-29 2019-12-29 EXPANDER FOR ORTHOTOPIC ENDOPROTESIS OF ARTIFICIAL BLADDER

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WO2007039160A1 (en) * 2005-10-03 2007-04-12 Antonio Sambusseti Patch for replacement of a portion of bladder wall following partial cystectomy
WO2011064110A1 (en) * 2009-11-27 2011-06-03 Antonio Sambusseti Absorbable patch in pga for the replacement of a portion of bladder wall following partial cystectomy
WO2011160875A1 (en) * 2010-06-25 2011-12-29 Antonio Sambusseti Orthotopic artificial bladder prosthesis

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Publication number Priority date Publication date Assignee Title
WO2007039159A1 (en) 2005-10-03 2007-04-12 Antonio Sambusseti Orthotopic artificial bladder prosthesis and production method thereof
WO2007039160A1 (en) * 2005-10-03 2007-04-12 Antonio Sambusseti Patch for replacement of a portion of bladder wall following partial cystectomy
WO2011064110A1 (en) * 2009-11-27 2011-06-03 Antonio Sambusseti Absorbable patch in pga for the replacement of a portion of bladder wall following partial cystectomy
WO2011160875A1 (en) * 2010-06-25 2011-12-29 Antonio Sambusseti Orthotopic artificial bladder prosthesis

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015140251A1 (en) * 2014-03-21 2015-09-24 Antonio Sambusseti Drainage tube for urine in silicone with carbon coating for supporting an absorbable device for tissue reconstruction of urethral segment
US10092389B2 (en) 2014-04-14 2018-10-09 Antonio Sambusseti Orthotopic artificial bladder endoprosthesis
WO2015159185A1 (en) * 2014-04-14 2015-10-22 Antonio Sambusseti Orthotopic artificial bladder endoprosthesis
EA032856B1 (en) * 2014-09-30 2019-07-31 Антонио Самбуссети Orthotopic artificial bladder endoprosthesis
WO2016051333A1 (en) * 2014-09-30 2016-04-07 Antonio Sambusseti Orthotopic artificial bladder endoprosthesis
US10441405B2 (en) 2014-09-30 2019-10-15 Antonio Sambusseti Orthotopic artificial bladder endoprosthesis
CN107072771A (en) * 2014-09-30 2017-08-18 安东尼奥·桑布瑟蒂 Prosthese in Orthotopic artificial bladder
CN107072772A (en) * 2014-09-30 2017-08-18 安东尼奥·桑布瑟蒂 Prosthese in Orthotopic artificial bladder
EA033339B1 (en) * 2014-09-30 2019-09-30 Антонио Самбуссети Orthotopic artificial bladder endoprosthesis
WO2016051330A1 (en) * 2014-09-30 2016-04-07 Antonio Sambusseti Orthotopic artificial bladder endoprosthesis
JP2017529927A (en) * 2014-09-30 2017-10-12 アントニオ・サンブッセティＡｎｔｏｎｉｏ ＳＡＭＢＵＳＳＥＴＩ Orthotopic artificial endovesical prosthesis
JP2017529928A (en) * 2014-09-30 2017-10-12 アントニオ・サンブッセティＡｎｔｏｎｉｏ ＳＡＭＢＵＳＳＥＴＩ Orthotopic artificial endovesical prosthesis
US10350051B2 (en) 2014-09-30 2019-07-16 Antonio Sambusseti Orthotopic artificial bladder endoprosthesis
JP2017531487A (en) * 2014-10-14 2017-10-26 アントニオ・サンブッセティＡｎｔｏｎｉｏ ＳＡＭＢＵＳＳＥＴＩ Absorbable device for bone regeneration
WO2017145128A1 (en) * 2016-02-26 2017-08-31 Scuola Superiore Di Studi Universitari E Di Perfezionamento Sant'anna Artificial bladder
ITUB20161129A1 (en) * 2016-02-26 2017-08-26 Scuola Superiore Di Studi Univ E Di Perfezionamento Santanna ARTIFICIAL BLADDER
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