WO2014053449A3 - Method and device for the continuous production of pulverulent pharmaceutical lyophilisates - Google Patents

Method and device for the continuous production of pulverulent pharmaceutical lyophilisates Download PDF

Info

Publication number
WO2014053449A3
WO2014053449A3 PCT/EP2013/070370 EP2013070370W WO2014053449A3 WO 2014053449 A3 WO2014053449 A3 WO 2014053449A3 EP 2013070370 W EP2013070370 W EP 2013070370W WO 2014053449 A3 WO2014053449 A3 WO 2014053449A3
Authority
WO
WIPO (PCT)
Prior art keywords
lyophilisates
continuous production
pulverulent
pharmaceutical
pulverulent pharmaceutical
Prior art date
Application number
PCT/EP2013/070370
Other languages
German (de)
French (fr)
Other versions
WO2014053449A2 (en
Inventor
Richard Süverkrüp
Original Assignee
Richard Süverkrüp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richard Süverkrüp filed Critical Richard Süverkrüp
Publication of WO2014053449A2 publication Critical patent/WO2014053449A2/en
Publication of WO2014053449A3 publication Critical patent/WO2014053449A3/en

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/042—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum for drying articles or discrete batches of material in a continuous or semi-continuous operation, e.g. with locks or other air tight arrangements for charging/discharging
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
    • F26B5/065—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing the product to be freeze-dried being sprayed, dispersed or pulverised

Abstract

Disclosed are a method and an installation for the rapid, energy-efficient, feedback-controlled, continuous production of pulverulent pharmaceutical lyophilisates in the form of a free-flowing powder consisting of spherical particles of uniform size (spherolyophilisates).
PCT/EP2013/070370 2012-10-02 2013-09-30 Method and device for the continuous production of pulverulent pharmaceutical lyophilisates WO2014053449A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102012109406.3A DE102012109406B4 (en) 2012-10-02 2012-10-02 Process and plant for the continuous production of pharmaceutical lyophilisates
DE102012109406.3 2012-10-02

Publications (2)

Publication Number Publication Date
WO2014053449A2 WO2014053449A2 (en) 2014-04-10
WO2014053449A3 true WO2014053449A3 (en) 2014-11-27

Family

ID=49354634

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2013/070370 WO2014053449A2 (en) 2012-10-02 2013-09-30 Method and device for the continuous production of pulverulent pharmaceutical lyophilisates

Country Status (2)

Country Link
DE (1) DE102012109406B4 (en)
WO (1) WO2014053449A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102015105375B4 (en) * 2015-01-07 2016-11-03 Richard Süverkrüp Apparatus and method for producing monodisperse frozen drops
EP4204751A1 (en) * 2020-08-31 2023-07-05 Massachusetts Institute of Technology Lyophilization systems and methods

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2016600A1 (en) * 1968-08-29 1970-05-08 Leybold Heraeus Verwaltung Frozen granules for freeze drying
DE1922491A1 (en) * 1969-05-02 1970-11-05 Otto Suwelack Nachf Fa Dr Device for sucking off granulated or powdery products from individual trays
US3670520A (en) * 1969-04-02 1972-06-20 Procedes Pour L Ind Alimentair Installation for freezing a liquid or semi-liquid product
US20040231184A1 (en) * 1998-02-04 2004-11-25 Michael Wefers Dried food product
US20080060213A1 (en) * 2004-07-23 2008-03-13 Bayer Technology Services Gmbh Sterile Freezing, Drying, Storing, Assaying and Filling Process

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004018666B3 (en) * 2004-04-17 2005-06-30 Deckert Maschinenbau Gmbh Continually-operated food freeze-drying tunnel has a heating station separated from the discharge station by a vapor release chamber
WO2009006891A1 (en) * 2007-07-10 2009-01-15 Niro A/S Method for freeze-drying a product and freeze-drying apparatus for carrying out the method

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2016600A1 (en) * 1968-08-29 1970-05-08 Leybold Heraeus Verwaltung Frozen granules for freeze drying
US3670520A (en) * 1969-04-02 1972-06-20 Procedes Pour L Ind Alimentair Installation for freezing a liquid or semi-liquid product
DE1922491A1 (en) * 1969-05-02 1970-11-05 Otto Suwelack Nachf Fa Dr Device for sucking off granulated or powdery products from individual trays
US20040231184A1 (en) * 1998-02-04 2004-11-25 Michael Wefers Dried food product
US20080060213A1 (en) * 2004-07-23 2008-03-13 Bayer Technology Services Gmbh Sterile Freezing, Drying, Storing, Assaying and Filling Process

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"Microdrop Generation", vol. 5, 10 December 2002, CRC PRESS, ISBN: 978-1-42-003998-6, ISSN: 2154-7254, article ERIC LEE: "Methods of Generating Monodisperse Microdrops", XP055097024, DOI: 10.1201/9781420039986.ch2 *
SÖREN N. EGGERSTEDT ET AL: "Protein spheres prepared by drop jet freeze drying", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 438, no. 1-2, 30 August 2012 (2012-08-30), pages 160 - 166, XP055097057, ISSN: 0378-5173, DOI: 10.1016/j.ijpharm.2012.08.035 *
WANG Z L ET AL: "Powder formation by atmospheric spray-freeze-drying", POWDER TECHNOLOGY, ELSEVIER SEQUOIA, LAUSANNE, CH, vol. 170, no. 1, 30 November 2006 (2006-11-30), pages 45 - 52, XP027983827, ISSN: 0032-5910, [retrieved on 20061130] *

Also Published As

Publication number Publication date
WO2014053449A2 (en) 2014-04-10
DE102012109406A1 (en) 2014-04-03
DE102012109406B4 (en) 2016-04-28

Similar Documents

Publication Publication Date Title
PL2766682T3 (en) Process, process line and use of the process line for the production of freeze-dried particles
PT3013571T (en) Method for continuous production of tablets, tabletting system for carrying out the method, and use of the tabletting system for the production of tablets of at least two ingredients containing particles with a significant difference in particle size
EP3013526A4 (en) Abrasive particles, method of making abrasive particles, and abrasive articles
EP3009210A4 (en) Ta POWDER, PRODUCTION METHOD THEREFOR, AND Ta GRANULATED POWDER
EP3264504A4 (en) Polyimide-coated active material particles, slurry for electrode material, negative electrode, battery, and method for producing polyimide-coated active material particles
EP2984590A4 (en) Methods, systems, apparatus, products, articles and data structures for cross-platform digital content
EP2710074B8 (en) Water redispersible epoxy polymer powder and method for making the same
EP3129135A4 (en) Reactors, systems, and methods for forming solid products
HK1223360A1 (en) Novel indolizine derivatives, method for the production thereof and pharmaceutical compositions containing same
EP2868641A4 (en) Sintered spherical bn particles with concave part, method for producing same, and polymer material
EP2905313A4 (en) Metal particle dispersion, article and sintered film using metal particle dispersion, and method for producing sintered film
EP3020733A4 (en) Core-shell crosslinked hyaluronic acid gel particles, production method for same, and medical material
ZA201204441B (en) Granules for pharmaceutical preparations,methods and apparatus for their production
EP2826765A4 (en) Production method for 2,3,3,3-tetra-fluoropropene and 1,1-difluoroethylene
EP2883855A4 (en) Method for preparing inorganic particles, and inorganic particles obtained thereby
EP3375808A4 (en) Particles, particle material, connecting material, and connection structure
EP2995299A4 (en) Functional polymer film-coated particle having high drug content, tablet containing same, and methods for production thereof
WO2013009585A3 (en) Systems and methods for product configuration
EP2906616A4 (en) Particle manufacturing method, particles, and particle manufacturing apparatus
EP2631252A4 (en) Method for producing ethylene-based polymer particles, and stretch-molded article obtained from ethylene-based polymer particles
EP2579973A4 (en) Apparatus and method for the production of particles
EP2796513A4 (en) Oligomer-modified fine particles, method for producing same, and coating material
EP3042883A4 (en) Granulated body, production method therefor, and production method for glass article
PT2835413T (en) Particles of a coal-like solid, uses and method for manufacturing the same
WO2014053449A3 (en) Method and device for the continuous production of pulverulent pharmaceutical lyophilisates

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 13776440

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 13776440

Country of ref document: EP

Kind code of ref document: A2