WO2014036314A3 - Diagnosis of rheumatoid arthritis (ra) using differentially methylated loci identified in peripheral blood mononuclear cells, t-cells, b-cells and monocytes - Google Patents

Diagnosis of rheumatoid arthritis (ra) using differentially methylated loci identified in peripheral blood mononuclear cells, t-cells, b-cells and monocytes Download PDF

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Publication number
WO2014036314A3
WO2014036314A3 PCT/US2013/057375 US2013057375W WO2014036314A3 WO 2014036314 A3 WO2014036314 A3 WO 2014036314A3 US 2013057375 W US2013057375 W US 2013057375W WO 2014036314 A3 WO2014036314 A3 WO 2014036314A3
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WIPO (PCT)
Prior art keywords
cells
diagnosis
monocytes
rheumatoid arthritis
peripheral blood
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PCT/US2013/057375
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French (fr)
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WO2014036314A2 (en
Inventor
Jonathan Lim
Robert Shoemaker
Louis Bookbinder
David Anderson
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Ignyta, Inc.
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Publication of WO2014036314A2 publication Critical patent/WO2014036314A2/en
Publication of WO2014036314A3 publication Critical patent/WO2014036314A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Differentially methylated loci relevant to the diagnosis of autoimmune disorders such as RA, as well as related methods and reagents, are disclosed.
PCT/US2013/057375 2012-08-31 2013-08-29 Diagnosis of rheumatoid arthritis (ra) using differentially methylated loci identified in peripheral blood mononuclear cells, t-cells, b-cells and monocytes WO2014036314A2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201261695685P 2012-08-31 2012-08-31
US201261695703P 2012-08-31 2012-08-31
US61/695,703 2012-08-31
US61/695,685 2012-08-31
US201361776731P 2013-03-11 2013-03-11
US61/776,731 2013-03-11
US201361777680P 2013-03-12 2013-03-12
US61/777,680 2013-03-12

Publications (2)

Publication Number Publication Date
WO2014036314A2 WO2014036314A2 (en) 2014-03-06
WO2014036314A3 true WO2014036314A3 (en) 2014-05-01

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PCT/US2013/057375 WO2014036314A2 (en) 2012-08-31 2013-08-29 Diagnosis of rheumatoid arthritis (ra) using differentially methylated loci identified in peripheral blood mononuclear cells, t-cells, b-cells and monocytes

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WO (1) WO2014036314A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE054225T2 (en) * 2016-01-29 2021-08-30 Epigenomics Ag Methods for detecting cpg methylation of tumor-derived dna in blood samples
EP3978624A1 (en) * 2016-07-19 2022-04-06 Exact Sciences Corporation Methylated control dna
WO2018195522A1 (en) * 2017-04-21 2018-10-25 Wake Forest University Health Sciences Arid5b overexpression in inflammatory diseases
CN109425743B (en) * 2017-08-29 2020-12-18 北京大学 Microsphere double-antibody sandwich detection method and kit for detecting soluble FAM19A4 protein
CN111826433B (en) * 2019-04-23 2023-08-18 清华大学深圳研究生院 Application of LncRNA in prognosis evaluation of diabetes and early warning of recurrent abortion
WO2020241770A1 (en) * 2019-05-31 2020-12-03 国立大学法人東北大学 Method for testing for sensitivity of chemotherapy against colorectal cancer
CN110687285B (en) * 2019-10-29 2023-03-21 安徽医科大学 Diagnostic kit and application of MAK16 in preparation of early diagnosis reagent for systemic lupus erythematosus
CA3161720A1 (en) * 2019-12-16 2021-06-24 Jorn Lewin Methods for detecting colorectal cancer
CN113355411B (en) * 2020-03-02 2022-05-10 中山大学孙逸仙纪念医院 Tumor immunotyping method based on lncRNA marker
CN111850108B (en) * 2020-06-05 2023-09-05 广东省人民医院 DNA methylation composition related to death risk of coronary heart disease patient, screening method and application thereof
CN111455045B (en) * 2020-06-18 2020-09-29 中南大学湘雅二医院 Diagnostic reagent for systemic lupus erythematosus and platform and application thereof
WO2023057467A1 (en) * 2021-10-04 2023-04-13 Age Labs As Screening method for rheumatoid arthritis
CN113913522B (en) * 2021-11-18 2023-03-10 武汉艾米森生命科技有限公司 Reagent and kit for detecting endometrial cancer
WO2023102539A1 (en) * 2021-12-03 2023-06-08 Washington State University Dna methylation biomarkers for rheumatoid arthritis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090018031A1 (en) * 2006-12-07 2009-01-15 Switchgear Genomics Transcriptional regulatory elements of biological pathways tools, and methods

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090018031A1 (en) * 2006-12-07 2009-01-15 Switchgear Genomics Transcriptional regulatory elements of biological pathways tools, and methods

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
"Human Gene AFAP1L2 (uc0011bn.3) Description and Page Index. Homo Sapiens Actin Filament Associated Protein 1-Like 2 (AFAP1L2), transcript variant 1, mRNA. Transcript (Including UTRs) Position: chr10:116,054,583-116,164,515.", 14 June 2013 (2013-06-14), Retrieved from the Internet <URL:http://genome.ucsc.edu/index.html.> [retrieved on 20140219] *
"Human Gene HSPA12A (uc0011cu.3) Description and Page Index. Homo Sapiens Heat Shock 70kDa Protein 12A (HSPA12A), mRNA. Transcript (Including UTRs) Position: chr10:118,430,703-118,609,716.", 14 June 2013 (2013-06-14), Retrieved from the Internet <URL:http://genome.ucsc.edu/index.html.> [retrieved on 20140219] *
"Human Gene LBX1 (uc001ksx.3) Description and Page Index. Homo Sapiens Ladybird Homeobox 1 (LBX1), mRNA. Transcript (Including UTRs) Position: chr10:102,986,733-102,988,717.", 14 June 2013 (2013-06-14), Retrieved from the Internet <URL:http://genome.ucsc.edu/index.html.> [retrieved on 20140219] *
BROCCHIERI, L ET AL.: "hsp70 Genes In The Human Genome: Conservation And Differentiation Patterns Predict A Wide Array Of Overlapping And Specialized Functions.", BMC EVOLUTIONARY BIOLOGY, vol. 8, no. 19, 2008, pages 1 - 20 *
CUNHA, I ET AL.: "Identification Of Genes Associated With Local Aggressiveness And Metastatic Behavior In Soft Tissue Tumors.", TRANSLATIONAL ONCOLOGY., vol. 3, no. 1, February 2010 (2010-02-01), pages 23 - 32 *
RAUCH, T ET AL.: "MIRA-Assisted Microarray Analysis, A New Technology For The Determination Of DNA Methylation Patterns, Identifies Frequent Methylation of Homeodomain-Containing Genes in Lung Cancer Cells.", CANCER RESEARCH., vol. 66, no. 16, 15 August 2006 (2006-08-15), pages 7939 - 7947 *

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