WO2014033588A1 - Stimulation et suivi de la réponse en imagerie par résonance magnétique fonctionnelle - Google Patents

Stimulation et suivi de la réponse en imagerie par résonance magnétique fonctionnelle Download PDF

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Publication number
WO2014033588A1
WO2014033588A1 PCT/IB2013/056757 IB2013056757W WO2014033588A1 WO 2014033588 A1 WO2014033588 A1 WO 2014033588A1 IB 2013056757 W IB2013056757 W IB 2013056757W WO 2014033588 A1 WO2014033588 A1 WO 2014033588A1
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WIPO (PCT)
Prior art keywords
animations
patient
control unit
animation
brain
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PCT/IB2013/056757
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English (en)
Inventor
Sirel KARAKAS
Hakki Muammer KARAKAS
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Norometrika Medikal Tip Teknolojileri Saglik Yazilim Donanim Ve Danismanlik Sanayi Ve Ticaret Limited Sirketi
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Publication of WO2014033588A1 publication Critical patent/WO2014033588A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/4806—Functional imaging of brain activation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/04—Constructional details of apparatus
    • A61B2560/0437—Trolley or cart-type apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2576/00—Medical imaging apparatus involving image processing or analysis
    • A61B2576/02—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part
    • A61B2576/026—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part for the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/16—Devices for psychotechnics; Testing reaction times ; Devices for evaluating the psychological state
    • A61B5/165—Evaluating the state of mind, e.g. depression, anxiety
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/16—Devices for psychotechnics; Testing reaction times ; Devices for evaluating the psychological state
    • A61B5/168—Evaluating attention deficit, hyperactivity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A61B5/377—Electroencephalography [EEG] using evoked responses
    • A61B5/378—Visual stimuli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A61B5/377—Electroencephalography [EEG] using evoked responses
    • A61B5/38—Acoustic or auditory stimuli
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00—ICT specially adapted for the handling or processing of medical images
    • G16H30/40—ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

Definitions

  • the present invention relates to medical devices and methods for the magnetic resonance imaging (MRI) that produces stimulation leading to brain activation on the basis of which neurocognitive assessments can be made for.
  • MRI magnetic resonance imaging
  • the method that we developed includes various software and hardware for stimulating the patient, obtaining patient responses, storing and analyzing these responses and monitoring the brain activity in magnetic resonance imaging.
  • US2007299359 discloses a triggering device which simultaneously sends an auditory signal to the user and a triggering signal to the analysis device.
  • the device is developed for the detection of brainstem disorders.
  • the United States patent document no. 2010194389 discloses a method for presenting moving pictures to the user and, when a movement is made in response to these pictures, for simultaneously mapping the relevant muscular activity and brain activity. The method is developed for analyzing the control of the brain over muscular movements.
  • the objective of the invention is to develop stimulation methods for neuro- cognitive investigations in functional MRI.
  • the methods allow the observation of the brain activity which is produced by standard stimulation methods under the routine clinical conditions of magnetic resonance imaging.
  • Another objective of the invention is to provide an integrated system of devices for functional magnetic resonance imaging that is easy to use and does not include complex controls.
  • Figure 1 is a schematic view of the system.
  • Figure 2 is the side view of the response pad.
  • Figure 3 is the flow chart of the method.
  • the inventive functional MRI system (1) essentially comprises of:
  • control unit (2) which is adapted for controlling initiation and change of visual, auditory and sensory-motor tasks that are used for stimulating the brain.
  • At least one MRI scanner (3) or electroencephalography device for performing brain mapping at least one MRI scanner (3) or electroencephalography device for performing brain mapping
  • At least one triggering unit (33) adapted for starting the stimulus animations in the control unit (2) when it receives a start command from the MR scanner at the initiation of imaging and for ending the stimulus animations from the control unit when the unit receives a stop command from the MR scanner at the termination of imaging,
  • the patient whose neuro-cognitive assessment will be performed and the MRI scanner are in the MR room (the room where magnetic fields and the radio waves exist).
  • the patient holds one response pad (5) with the right or left hand, or holds two response pads (5) with both the right and left hands.
  • the carrier cart (6) on which there is the control unit (2) and the projector (41) is located in the MRI control room that is separate from the MRI scanner room since metallic and electronic devices is not permissible in the MRI room.
  • the connections between the response pads (5) in the MRI room and the control unit (2) are made using cables with magnetic shielding and/or fiber optic cables.
  • the connection between the triggering unit (33) at the MRI scanner (3) and the control unit (2) is also made using cables with magnetic shielding and/or fiber optic cables.
  • the control unit (2) is a medical class touch screen POS (Point of Service) or POC (Point of Care) type computer.
  • the user selects and starts the stimulus animation to be shown to the patient using the computer's touch screen (21).
  • the stimulus animations are stored in the animation database (22).
  • the control unit is an industrial class computer.
  • the user selects and starts the stimulus animation to be shown to the patient on the medical class touch screen (21) of the industrial class computer.
  • the stimulus animations are stored in the animation database (22).
  • the triggering unit (33) sends a command to the control unit (2) to start animation when MR imaging starts.
  • the triggering unit (33) sends a command to the control unit (2) to terminate the animation when MR imaging ends.
  • MR imaging is performed during the interval between the start and end of the stimulus animation; it is thus performed simultaneously with stimulation.
  • the projector (41) which is placed on the carrying cart (6) and is connected to the control unit (2), projects the image of the animation to the rear projection screen (31) and from there on to a mirror that is attached to the head coil.
  • the lens system (long throw lens) used in the projector (41) provides a net image at the distance between the control unit in the control room and the screen in the MRI scanner room.
  • an MR-compatible monitor (LCD or TFT or LED or OLED or plasma screen) (42) which is connected to the control unit (2), projects the image of the animation directly to the patient in the MRI scanner room.
  • the control unit (2) and the projector (41) are connected to the carrying cart (6) with the first holder (61) and the second holder (62), respectively.
  • the holders (61), (62) are connected to connection points (not shown on the figures) on the carrying cart (6) by means of connection units (i.e. screw, clips etc).
  • the holders (61), (62) are connected to connection points (not shown on the figures) on the control unit (2) and the projector (41) by means of connection units.
  • the second holder (62) has a mechanism whereby the projector (41) is moved in the 3- dimensional space.
  • an integrated system (1) whose component parts are compiled and wherein all pieces can be carried all at once, is provided.
  • holders (61), (62) are removable.
  • Drawers are provided on the carrying cart (6) and these are used to store the control unit (2) and the projector (41) when they are not in use.
  • Stimulus animation is provided through various tasks that the patient is required to perform. The different stimulus animations in the tasks produce different activations in the patient's brain.
  • buttons (52) are provided on the response pad (5).
  • the behavioral responses given by the patient by pushing buttons (52) are stored in the response database (24).
  • the information stored in the response database (24) is then analyzed.
  • the design of the response pad (5) incorporates some features.
  • Response pad has a plurality of buttons (52); the handle fits the palm; the protrusions, indentations and slants (51) at the bottom and sides of the handle allows the 4 fingers (index- middle-ring-little fingers) grasp the handle whereby the sliding of the response pad is prevented.
  • the behavioral responses are obtained using two symmetrically designed response pads (5), the one designed for the right-handers is slanted to the right and the one designed for left-handers is slanted to the left. These features lead to a response pad which is more ergonomic and easy-to-use compared to the previous ones in the art.
  • EEG electroencephalography
  • animations sent to the patient over the projector (41) or the monitor (42) and the behavioral responses given by the patient are monitored on the touch screen (21) in real time.
  • a method (100) enabling the production of activations in the brain through MR imaging, to record and store both these activations and the behavioral responses for later analysis is comprised of the following steps:
  • patient performs the tasks. For this, patient either responds behaviorally by using the response pads (5) or responds covertly (108),
  • the triggering unit (33) ends the animation or animation is terminated with a button on the touch screen (21) or the animation spontaneously ends at the end of a predetermined time interval (H I),
  • the patient is taught the animations and the tasks that he has to make on practice trials using the touch screen (21) (101). After the practice trials, the patient is taken to the MRI scanner room (102) and placed in the MRI scanner (3).
  • the animations and sounds with which visual acuity of the patient, the ability to distinguish colors, and to hear sounds in different frequencies are chosen (103).
  • the sound level is adjusted to a level that the patient can easily hear 104).
  • the animation to be shown to the patient is chosen over the touch screen (21) in the control room (105).
  • the triggering unit (33) sends a command to the control unit (2) to start the animation.
  • functional MRI and animations start simultaneously (106).
  • animation is started manually upon the advent of MR imaging by using the button on the touch screen (21) (106).
  • the animation is sent by the projector (41) to the mirror (32) over the rear projection stimulus screen (31) (107).
  • the animation is sent to the patient directly over the monitor (42) (107).
  • the patient watches the animations over the mirror (32) or over the monitor (42), he/she responds as taught using the buttons on the response pad (52) or responds covertly without using the response pad.
  • Activations are produced in the brain as the patient performs the tasks that he/she has been taught (108).
  • MRI scanner (3) performs imaging throughout the duration of the animations. Accordingly, imaging of behavioral responding and imaging of the activated brain is provided (109).
  • Brain activity signals that are obtained through MR imaging and behavioral responses that are obtained from the response pads are stored (1 10) in databases (23-24).
  • the triggering unit (33) sends a command to the control unit (2) and the unit terminates the production of the animations.
  • the animation is manually terminated by means of a button on the touch screen (21) when functional MRI ends.
  • the animation is spontaneously terminated at the end of a predetermined time period (111).
  • MR imaging is performed simultaneously with stimulation animations.
  • data stored in the databases (23) (24) are analyzed in order to make neuro-cognitive assessments (1 12).
  • the stimulation tasks in the Brain Mapping Battery's section on basic cognitive functions trigger visual perception, auditory perception, body perception and motor responding.
  • the Battery's section on basic cognitive functions thus shows the functionality of the visual, auditory and sensory-motor areas of the brain.
  • the stimulation tasks in the Battery's section on advanced cognitive functions trigger the functions of language, working memory, learning and conflict resolution.
  • the Battery's section on the advanced cognitive functions thus shows the functionality of Broca's area, Wernicke's area, prefrontal cortex, anterior cingulate and orbitofrontal cortex.
  • the animation consists of a 6-second preparation section followed by 8 blocks, 4 of which are task and 4 of which are rest blocks. Each block resides in the stimulation screen (31) for 18 seconds.
  • the animation starts with the task instruction "LOOK AT THE PICTURE".
  • the 1 -second black screen is followed by the task block.
  • two kinds of whole-screen (31) achromatic checkerboards are shown in alternation. Animation starts with the checkerboard with the black center; this is followed by the checkerboard with the white center. Each checkerboard resides on the screen for 66.9 milliseconds. Total number of checkerboards is 270.
  • the task is to look at the checkerboards as the black parts turn into white and vice versa (101).
  • the task blocks are followed by rest blocks. Rest blocks consist of a white plus (+) sign on a black screen.
  • the task block-rest block pairs are shown 4 times and visual animation ends with a screen showing the script "END".
  • ADHD Attention Deficit Hyperactivity Disorder
  • the stimulation tasks in the ADHD Battery trigger focused attention, selective attention and sustained attention.
  • the battery's section on attention enables the scanning of the state of the prefrontal lobe and parietal lobe of the brain.
  • Stimulation tasks in the battery's section on inhibition-control triggers the abilities of inhibition of a potential response, inhibition of an ongoing response and inhibiting of an automatic behavior.
  • the battery's section on inhibition enables the scanning of the state of the prefrontal lobes and the anterior cingulate cortex.
  • the brain stimulation method (100) applied for mapping brain activations during attention and inhibition-control a 3-second black screen and ae 2-second screen with the script "STARTING" on it is followed by a 3-second black screen.
  • the stimuli are green and red flying saucers.
  • the tasks are arranged in 4 blocks. In each block, there are 20 stimuli, 16 of which are green and 4 of which are red flying saucers. Accordingly, the total of 4 task blocks are composed of 80 stimuli, 64 of which are green and 16 of which are red flying saucers.
  • the patient is asked to press the button of the response pad (52) at the 9:00 o'clock position with the thumb when the image is a green flying saucer and not to press any button (52) when the image is a red flying saucer.
  • the task ends with "END” and "WELL- DONE, SUCCESSFUL" script.
  • PTSD post- traumatic stress disorder
  • the stimulation tasks in the battery require covertly uttering the color of the objects, uttering the color of words by suppressing the automatic response of reading, and uttering the color of the words on the incident causing stress.
  • the animation is composed of a preparation screen of 3 seconds white screen followed by a 2.65-second "SAY THE COLORS COVERTLY" instruction screen. This is followed by a 19-seconds white screen with a black plus (+) sign on it.
  • the task block that follows is made up of an image that stays on the screen for 35 seconds. The images are discs of four different colors. Task blocks are followed by 25-second rest blocks. Rest blocks are composed of a white plus (+) sign on a black screen. Unlike the preceding ones, the last (4 th ) rest block is 40 seconds long. The task is to specify the color of the discs (101).
  • inventive brain stimulation method (100) for functional magnetic resonance imaging (1) a system and a method that can be used under routine clinic conditions and applied by the MR technician is provided.
  • the system and method is not only for laboratory research and does not include complex controls.
  • inventive brain stimulation method (100) for functional magnetic resonance imaging (1) it is possible to develop a wide variety of embodiments of the inventive brain stimulation method (100) for functional magnetic resonance imaging (1).
  • the invention cannot be limited to the examples described herein; it is essentially as defined in the claims.

Abstract

La présente invention concerne des dispositifs médicaux et des procédés de stimulation qui sont utilisés dans la production d'activations cérébrales sur la base desquelles des évaluations cognitives sont réalisées par imagerie par résonance magnétique fonctionnelle. On décrit un procédé et un système de stimulation cérébrale destinés à être utilisés dans la réalisation d'évaluations neurocognitives en IRM fonctionnelle, en vue de produire des activations à l'aide de tâches standard dans des conditions cliniques de routine et en vue d'enregistrer les réponses comportementales et les activations cérébrales.
PCT/IB2013/056757 2012-09-03 2013-08-20 Stimulation et suivi de la réponse en imagerie par résonance magnétique fonctionnelle WO2014033588A1 (fr)

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TR2012/10030 2012-09-03
TR201210030 2012-09-03

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WO2014033588A1 true WO2014033588A1 (fr) 2014-03-06

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016134446A1 (fr) * 2015-02-26 2016-09-01 Sunnybrook Research Institute Système et procédé pour caractérisation peropératoire de fonction cérébrale à l'aide d'entrée sur un dispositif de panneau tactile
CN109917905A (zh) * 2017-12-12 2019-06-21 艾博纽诺股份公司 一种具有实时解剖显示和控制功能的用于交互式脑和身体导航的控制装置和机器

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020103428A1 (en) 2001-01-30 2002-08-01 Decharms R. Christopher Methods for physiological monitoring, training, exercise and regulation
US20030098844A1 (en) * 2001-11-29 2003-05-29 Ivan Melnyk Magnetic resonance imaging compatible response device
US20050273001A1 (en) * 2004-06-04 2005-12-08 The Mcw Research Foundation MRI display interface for medical diagnostics and planning
US20070167724A1 (en) * 2005-12-09 2007-07-19 Gadagkar Hrishikesh P fMRI data acquisition system
US20070299359A1 (en) 2004-12-08 2007-12-27 Schizodetect Ab System And Method For Diagnosis Of Brainstem Disorders
WO2008024722A2 (fr) * 2006-08-21 2008-02-28 Omnicell, Inc. Postes de travail mobiles à pile solaire
US20100194389A1 (en) 2009-02-04 2010-08-05 Sutton Bradley P Method for dynamic motion guided functional magnetic resonance imaging
US20100234722A1 (en) * 2009-03-13 2010-09-16 Milan Trcka Interactive mri system

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020103428A1 (en) 2001-01-30 2002-08-01 Decharms R. Christopher Methods for physiological monitoring, training, exercise and regulation
US20030098844A1 (en) * 2001-11-29 2003-05-29 Ivan Melnyk Magnetic resonance imaging compatible response device
US20050273001A1 (en) * 2004-06-04 2005-12-08 The Mcw Research Foundation MRI display interface for medical diagnostics and planning
US20070299359A1 (en) 2004-12-08 2007-12-27 Schizodetect Ab System And Method For Diagnosis Of Brainstem Disorders
US20070167724A1 (en) * 2005-12-09 2007-07-19 Gadagkar Hrishikesh P fMRI data acquisition system
WO2008024722A2 (fr) * 2006-08-21 2008-02-28 Omnicell, Inc. Postes de travail mobiles à pile solaire
US20100194389A1 (en) 2009-02-04 2010-08-05 Sutton Bradley P Method for dynamic motion guided functional magnetic resonance imaging
US20100234722A1 (en) * 2009-03-13 2010-09-16 Milan Trcka Interactive mri system

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MULLER T J ET AL: "The neurophysiological time pattern of illusionary visual perceptual transitions: a simultaneous EEG and fMRI study", INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 55, no. 3, 1 March 2005 (2005-03-01), pages 299 - 312, XP027661262, ISSN: 0167-8760, [retrieved on 20050301] *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016134446A1 (fr) * 2015-02-26 2016-09-01 Sunnybrook Research Institute Système et procédé pour caractérisation peropératoire de fonction cérébrale à l'aide d'entrée sur un dispositif de panneau tactile
US10506962B2 (en) 2015-02-26 2019-12-17 St. Michael's Hospital System and method for intraoperative characterization of brain function using input from a touch panel device
CN109917905A (zh) * 2017-12-12 2019-06-21 艾博纽诺股份公司 一种具有实时解剖显示和控制功能的用于交互式脑和身体导航的控制装置和机器

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