WO2014028780A3 - Antifungal compounds and methods of use - Google Patents

Antifungal compounds and methods of use Download PDF

Info

Publication number
WO2014028780A3
WO2014028780A3 PCT/US2013/055211 US2013055211W WO2014028780A3 WO 2014028780 A3 WO2014028780 A3 WO 2014028780A3 US 2013055211 W US2013055211 W US 2013055211W WO 2014028780 A3 WO2014028780 A3 WO 2014028780A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
antifungal compounds
antifungal
compounds
tolnaftate
Prior art date
Application number
PCT/US2013/055211
Other languages
French (fr)
Other versions
WO2014028780A2 (en
Inventor
Bassam Damaj
Richard Martin
Original Assignee
Nexmed Holdings, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nexmed Holdings, Inc. filed Critical Nexmed Holdings, Inc.
Publication of WO2014028780A2 publication Critical patent/WO2014028780A2/en
Publication of WO2014028780A3 publication Critical patent/WO2014028780A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Disclosed herein are compositions and methods for treating fungus infections of skin using tolnaftate and other antifungal agents.
PCT/US2013/055211 2012-08-15 2013-08-15 Antifungal compounds and methods of use WO2014028780A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261683710P 2012-08-15 2012-08-15
US61/683,710 2012-08-15

Publications (2)

Publication Number Publication Date
WO2014028780A2 WO2014028780A2 (en) 2014-02-20
WO2014028780A3 true WO2014028780A3 (en) 2014-05-01

Family

ID=50101613

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/055211 WO2014028780A2 (en) 2012-08-15 2013-08-15 Antifungal compounds and methods of use

Country Status (1)

Country Link
WO (1) WO2014028780A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090258098A1 (en) * 2008-04-15 2009-10-15 Lane Rolling Penetrating carrier, antifungal composition using the same and method for treatment of dermatophyte infections
WO2011075654A1 (en) * 2009-12-18 2011-06-23 Exodos Life Sciences Limited Partnership Methods and compositions for treating inflammation of skin
US20110237558A1 (en) * 2008-10-03 2011-09-29 William Shifeng Stabilized composition for treating psoriasis
WO2012075107A2 (en) * 2010-12-02 2012-06-07 Nexmed Holdings, Inc. Active enantiomer of dodecyl 2-(n,n-dimethylamino)-propionate

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090258098A1 (en) * 2008-04-15 2009-10-15 Lane Rolling Penetrating carrier, antifungal composition using the same and method for treatment of dermatophyte infections
US20110237558A1 (en) * 2008-10-03 2011-09-29 William Shifeng Stabilized composition for treating psoriasis
WO2011075654A1 (en) * 2009-12-18 2011-06-23 Exodos Life Sciences Limited Partnership Methods and compositions for treating inflammation of skin
WO2012075107A2 (en) * 2010-12-02 2012-06-07 Nexmed Holdings, Inc. Active enantiomer of dodecyl 2-(n,n-dimethylamino)-propionate

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MEIER-DAVIS, SR ET AL.: "Enhancing the Skin Flux of Tolnaftate Utilizing the Novel Excipient, Dodecyl-2-N,N-Dimethylaminopropionate (DDAIP).", JOURNAL OF PHARMACEUTICS & DRUG DELIVERY RESEARCH, vol. 1, no. 1, 13 August 2012 (2012-08-13), pages 1 - 3, Retrieved from the Internet <URL:http://www.scitechnol.com/2325-960412325-9604-1-102.pdf> [retrieved on 20131220] *

Also Published As

Publication number Publication date
WO2014028780A2 (en) 2014-02-20

Similar Documents

Publication Publication Date Title
HK1220624A1 (en) Composition and formulation of antimicrobial agents, processes thereof and methods for treating microbial infections
WO2014052836A3 (en) Methods and compositions for treating infection
WO2012173689A3 (en) Antimicrobial compounds and methods of making and using the same
TR201813877T4 (en) COMPOUNDS FOR TREATMENT OF SPINAL MUSCULAR ATROPHY.
EP2531025A4 (en) Method for treating fungal infections, fungicidal compositions and their use
EP2714081A4 (en) Methods, compositions, and kits for the treatment of cancer
EP3082819A4 (en) Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith
WO2013056148A3 (en) Scd1 antagonists for treating cancer
NZ628294A (en) Compositions and methods of use of phorbol esters for the treatment of stroke
MX2014012477A (en) Pyrrolopyrazone inhibitors of tankyrase.
EP2967049A4 (en) Methods, compounds, and compositions for the treatment of angiotensin-related diseases
MX367393B (en) ANTIFUNGAL COMPOSITIONS FOR THE TREATMENT OF SKIN and NAILS.
WO2010032011A3 (en) Anti-fungal therapy
WO2012103810A1 (en) Certain chemical entities, compositions, and methods
EP3111918A4 (en) Skin cosmetic composition, antibacterial agent for skin cosmetic, and method for enhancing antibacterial effect of diol compound
WO2013120022A3 (en) Treatment of hypoglycemia
GB2511470B (en) Treatment of fungal infections using alternative oxidase inhibitors
EP2707007A4 (en) Antifungal compositions for the treatment of skin and nails
PL2841549T3 (en) Formulations, use of same as or for manufacture of dish-washing agents and their manufacture
PL2841548T3 (en) Formulations, use of same as or for manufacture of dish-washing agents and their manufacture
EP3180993A4 (en) Composition for improving skin, containing pomegranate concentrate as active ingredient
WO2012017321A3 (en) Treatment for dyslipidemia
WO2014097318A3 (en) Agents for eliminating tumour-initiating cells
WO2013166282A3 (en) Methods and compositions for treating bacterial infection
WO2013155338A3 (en) Substituted benzamides and their uses

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 13829185

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 13829185

Country of ref document: EP

Kind code of ref document: A2