WO2014022807A3 - Compositions and methods of using the compositions for plaque softening - Google Patents
Compositions and methods of using the compositions for plaque softening Download PDFInfo
- Publication number
- WO2014022807A3 WO2014022807A3 PCT/US2013/053489 US2013053489W WO2014022807A3 WO 2014022807 A3 WO2014022807 A3 WO 2014022807A3 US 2013053489 W US2013053489 W US 2013053489W WO 2014022807 A3 WO2014022807 A3 WO 2014022807A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compositions
- methods
- disclosed
- plaque
- softening
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
Abstract
Disclosed herein is a compound for use in a composition applied to a blood vessel, wherein the compound softens and/or disrupts the crystalline matrix of calcified plaque. Methods of treatment comprising applying the disclosed composition are also disclosed. Plaque-softening compounds are also disclosed.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261679365P | 2012-08-03 | 2012-08-03 | |
US61/679,365 | 2012-08-03 | ||
US201361793170P | 2013-03-15 | 2013-03-15 | |
US61/793,170 | 2013-03-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2014022807A2 WO2014022807A2 (en) | 2014-02-06 |
WO2014022807A3 true WO2014022807A3 (en) | 2014-05-30 |
Family
ID=50028673
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2013/053489 WO2014022807A2 (en) | 2012-08-03 | 2013-08-02 | Compositions and methods of using the compositions for plaque softening |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2014022807A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105541855B (en) * | 2015-11-25 | 2018-08-07 | 内蒙古自治区科学技术研究院有限责任公司东部分院 | A kind of 1,8- naphthalimide compounds being bonded with spiro-pyrans and preparation method and application |
EP3662034B1 (en) * | 2017-08-03 | 2023-04-26 | ChampionX USA Inc. | Thiol adducts for corrosion inhibition |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6410505B1 (en) * | 1999-06-28 | 2002-06-25 | Microbiomed Corp. | Dimeric non-azo naphthalimides and uses for the same |
US20040180391A1 (en) * | 2002-10-11 | 2004-09-16 | Miklos Gratzl | Sliver type autonomous biosensors |
US20060069068A1 (en) * | 2004-07-15 | 2006-03-30 | Nanobac Pharmaceuticals, Inc. | Methods and compositions for the treatment of diseases characterized by pathological calcification |
US20060182751A1 (en) * | 2004-12-01 | 2006-08-17 | Genentech, Inc. | Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use |
US20090181927A1 (en) * | 2003-11-05 | 2009-07-16 | Photobiomed Corporation | Bonding tissues and cross-linking proteins with naphthalimide compounds |
US7666980B2 (en) * | 2006-07-20 | 2010-02-23 | Chisso Corporation | Calcium-binding photoprotein, gene encoding the same, and use thereof |
US20100144869A1 (en) * | 2006-07-17 | 2010-06-10 | Abraham Nudelman | Conjugates Comprising a gaba-or glycine compound, pharmaceutical compositions and combinations thereof as well as their use in treating cns disorders |
US20100168428A1 (en) * | 2007-02-26 | 2010-07-01 | Massachusetts Institute Of Technology | Environmentally sensitive fluorophores |
WO2011130537A2 (en) * | 2010-04-14 | 2011-10-20 | Northwestern University | Pharmaceutical compositions and methods for digesting atherosclerotic plaques |
US20120039980A1 (en) * | 2004-04-28 | 2012-02-16 | Angiodevice International Gmbh | Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use |
-
2013
- 2013-08-02 WO PCT/US2013/053489 patent/WO2014022807A2/en active Application Filing
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6410505B1 (en) * | 1999-06-28 | 2002-06-25 | Microbiomed Corp. | Dimeric non-azo naphthalimides and uses for the same |
US20040180391A1 (en) * | 2002-10-11 | 2004-09-16 | Miklos Gratzl | Sliver type autonomous biosensors |
US20090181927A1 (en) * | 2003-11-05 | 2009-07-16 | Photobiomed Corporation | Bonding tissues and cross-linking proteins with naphthalimide compounds |
US20120039980A1 (en) * | 2004-04-28 | 2012-02-16 | Angiodevice International Gmbh | Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use |
US20060069068A1 (en) * | 2004-07-15 | 2006-03-30 | Nanobac Pharmaceuticals, Inc. | Methods and compositions for the treatment of diseases characterized by pathological calcification |
US20060182751A1 (en) * | 2004-12-01 | 2006-08-17 | Genentech, Inc. | Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use |
US20100144869A1 (en) * | 2006-07-17 | 2010-06-10 | Abraham Nudelman | Conjugates Comprising a gaba-or glycine compound, pharmaceutical compositions and combinations thereof as well as their use in treating cns disorders |
US7666980B2 (en) * | 2006-07-20 | 2010-02-23 | Chisso Corporation | Calcium-binding photoprotein, gene encoding the same, and use thereof |
US20100168428A1 (en) * | 2007-02-26 | 2010-07-01 | Massachusetts Institute Of Technology | Environmentally sensitive fluorophores |
WO2011130537A2 (en) * | 2010-04-14 | 2011-10-20 | Northwestern University | Pharmaceutical compositions and methods for digesting atherosclerotic plaques |
Also Published As
Publication number | Publication date |
---|---|
WO2014022807A2 (en) | 2014-02-06 |
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