WO2014020574A3 - Improved process for the preparation of calcimimetics - Google Patents

Improved process for the preparation of calcimimetics Download PDF

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Publication number
WO2014020574A3
WO2014020574A3 PCT/IB2013/056342 IB2013056342W WO2014020574A3 WO 2014020574 A3 WO2014020574 A3 WO 2014020574A3 IB 2013056342 W IB2013056342 W IB 2013056342W WO 2014020574 A3 WO2014020574 A3 WO 2014020574A3
Authority
WO
WIPO (PCT)
Prior art keywords
cinacalcet
free base
unsaturated free
phosphate salt
cooling
Prior art date
Application number
PCT/IB2013/056342
Other languages
French (fr)
Other versions
WO2014020574A2 (en
Inventor
Vijayabaskar Veerappan
Srimurugan SANKARESWARAN
Sathish Kumar Raman VISWANATHAN
Sambandamurthy SAKTHIVELMURUGAN
Original Assignee
Shasun Pharmaceuticals Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shasun Pharmaceuticals Limited filed Critical Shasun Pharmaceuticals Limited
Publication of WO2014020574A2 publication Critical patent/WO2014020574A2/en
Publication of WO2014020574A3 publication Critical patent/WO2014020574A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Disclosed are synthetic processes to produce phosphate salt of Cinacalcet unsaturated free base with a high degree of purity, and thereby producing Cinacalcet hydrochloride of very high purity by employing the above said intermediate along with an improved solvent system. A preferred process for preparing phosphate salt of cinacalcet unsaturated free base, comprising: dissolving cinacalcet unsaturated free base in organic solvent; cooling the reaction mixture; providing a source of phosphate; maintaining reaction mass obtained for sufficient time; cooling the reaction mixture; and isolating phosphate salt of cinacalcet unsaturated free base.
PCT/IB2013/056342 2012-08-02 2013-08-02 Improved process for the preparation of calcimimetics WO2014020574A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3167CH2012 2012-08-02
IN3167/CHE/2012 2012-08-02

Publications (2)

Publication Number Publication Date
WO2014020574A2 WO2014020574A2 (en) 2014-02-06
WO2014020574A3 true WO2014020574A3 (en) 2014-03-27

Family

ID=50028602

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2013/056342 WO2014020574A2 (en) 2012-08-02 2013-08-02 Improved process for the preparation of calcimimetics

Country Status (1)

Country Link
WO (1) WO2014020574A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107966511A (en) * 2017-11-23 2018-04-27 中山奕安泰医药科技有限公司 The method for detecting (R) -1- (1- naphthyls) ethamine chiral isomer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090197970A1 (en) * 2006-06-27 2009-08-06 Sandoz Ag Crystalline form of cinacalcet
US20110306794A1 (en) * 2009-02-19 2011-12-15 Zach System S.P.A. Process for preparing cinacalcet hydrochloride
US20110318417A1 (en) * 2008-12-08 2011-12-29 Actavis Group Ptc Ehf Highly pure cinacalcet or a pharmaceutically acceptable salt thereof
WO2012007954A1 (en) * 2010-07-16 2012-01-19 Hetero Research Foundation Process for cinacalcet hydrochloride

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090197970A1 (en) * 2006-06-27 2009-08-06 Sandoz Ag Crystalline form of cinacalcet
US20110318417A1 (en) * 2008-12-08 2011-12-29 Actavis Group Ptc Ehf Highly pure cinacalcet or a pharmaceutically acceptable salt thereof
US20110306794A1 (en) * 2009-02-19 2011-12-15 Zach System S.P.A. Process for preparing cinacalcet hydrochloride
WO2012007954A1 (en) * 2010-07-16 2012-01-19 Hetero Research Foundation Process for cinacalcet hydrochloride

Also Published As

Publication number Publication date
WO2014020574A2 (en) 2014-02-06

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