WO2014005076A3 - Methods and biomarkers for detection of kidney disorders - Google Patents

Methods and biomarkers for detection of kidney disorders Download PDF

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Publication number
WO2014005076A3
WO2014005076A3 PCT/US2013/048688 US2013048688W WO2014005076A3 WO 2014005076 A3 WO2014005076 A3 WO 2014005076A3 US 2013048688 W US2013048688 W US 2013048688W WO 2014005076 A3 WO2014005076 A3 WO 2014005076A3
Authority
WO
WIPO (PCT)
Prior art keywords
samples
biomarkers
detection
methods
kidney disorders
Prior art date
Application number
PCT/US2013/048688
Other languages
French (fr)
Other versions
WO2014005076A9 (en
WO2014005076A2 (en
Inventor
Friedhelm Hildebrandt
Original Assignee
The Regents Of The University Of Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of Michigan filed Critical The Regents Of The University Of Michigan
Publication of WO2014005076A2 publication Critical patent/WO2014005076A2/en
Publication of WO2014005076A3 publication Critical patent/WO2014005076A3/en
Publication of WO2014005076A9 publication Critical patent/WO2014005076A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy

Abstract

Provided herein are compositions, kits, methods and biomarkers for detection and characterization and diagnosis of kidney disorders (e.g., one or more of nephronophthisis-related ciliopathies (NPHP-RC), congenital abnormalities of the kidney and urinary tract (CAKUT)), and karyomegalic interstitial nephritis (KIN)) in biological samples (e.g., tissue samples, blood samples, plasma samples, cell samples, serum samples).
PCT/US2013/048688 2012-06-29 2013-06-28 Methods and biomarkers for detection of kidney disorders WO2014005076A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261666423P 2012-06-29 2012-06-29
US61/666,423 2012-06-29
US201261672916P 2012-07-18 2012-07-18
US61/672,916 2012-07-18

Publications (3)

Publication Number Publication Date
WO2014005076A2 WO2014005076A2 (en) 2014-01-03
WO2014005076A3 true WO2014005076A3 (en) 2014-02-20
WO2014005076A9 WO2014005076A9 (en) 2014-04-03

Family

ID=48790654

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/048688 WO2014005076A2 (en) 2012-06-29 2013-06-28 Methods and biomarkers for detection of kidney disorders

Country Status (1)

Country Link
WO (1) WO2014005076A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105256378B (en) * 2015-04-13 2018-01-05 卢彦平 A kind of genetic chip for primary cilium relevant disease Disease-causing gene examination
KR102345006B1 (en) * 2020-03-19 2021-12-29 지니너스 주식회사 Use of ICK and KLC3 for the diagnosis of ciliary injury disease

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Publication number Publication date
WO2014005076A9 (en) 2014-04-03
WO2014005076A2 (en) 2014-01-03

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