WO2013184986A3 - Methods and compositions for inhibiting angiogenesis - Google Patents

Methods and compositions for inhibiting angiogenesis Download PDF

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Publication number
WO2013184986A3
WO2013184986A3 PCT/US2013/044637 US2013044637W WO2013184986A3 WO 2013184986 A3 WO2013184986 A3 WO 2013184986A3 US 2013044637 W US2013044637 W US 2013044637W WO 2013184986 A3 WO2013184986 A3 WO 2013184986A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptide
compositions
seq
amino acid
present
Prior art date
Application number
PCT/US2013/044637
Other languages
French (fr)
Other versions
WO2013184986A2 (en
Inventor
Olga Volpert
Yelena Mirochnik
Original Assignee
Northwestern University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/492,357 external-priority patent/US9096689B2/en
Application filed by Northwestern University filed Critical Northwestern University
Publication of WO2013184986A2 publication Critical patent/WO2013184986A2/en
Publication of WO2013184986A3 publication Critical patent/WO2013184986A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to methods and compositions for modulating angiogenesis. In particular, the present invention relates to Pigment Epithelial-derived Factor (PEDF) fragments for use in modulating angiogenesis and treating angiogenesis mediated disease. In some embodiments, the present invention provides compositions comprising an isolated peptide, wherein the peptide consists of an amino acid sequence selected from: SEQ ID NOs:2, 12, 13, 22, 23, 33, 34, 41, 42, 43-49, 52, 53, 62, 63, 73, 74, 84, 85, and 92-118. In other embodiments, the peptide comprises, or consists of, SEQ ID NOs: 1-49 and 52-118. In certain embodiments, the peptide comprises, or consists of, or consists essentially of SEQ ID NO:102 (NFGYDLYRVRS). In certain embodiments, one or more of the amino acid in any of these sequences are substituted with modified versions of the appropriate amino acid or amino acids that do not detrimentally affect the anti-angiogenic activity of the peptide.
PCT/US2013/044637 2012-06-08 2013-06-07 Methods and compositions for inhibiting angiogenesis WO2013184986A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/492,357 US9096689B2 (en) 2007-11-07 2012-06-08 Methods and compositions for inhibiting angiogenesis
US13/492,357 2012-06-08

Publications (2)

Publication Number Publication Date
WO2013184986A2 WO2013184986A2 (en) 2013-12-12
WO2013184986A3 true WO2013184986A3 (en) 2014-01-30

Family

ID=49712860

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/044637 WO2013184986A2 (en) 2012-06-08 2013-06-07 Methods and compositions for inhibiting angiogenesis

Country Status (1)

Country Link
WO (1) WO2013184986A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017189715A1 (en) 2016-04-26 2017-11-02 Northwestern University Modified pigment epithelium-derived factor (pedf) peptides and uses thereof for treating neovascular diseases, inflammatory diseases, cancer, and for cytoprotection
KR101998155B1 (en) 2017-09-22 2019-07-10 (주)케어젠 Peptides for inhibiting angiogenesis and the use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060189519A1 (en) * 2002-09-26 2006-08-24 Karl Volz Anti-angiogenic fragments fo pigment epithelium-derived factor (pedf)
US20080274967A1 (en) * 2005-11-14 2008-11-06 Galia Maik-Rachline Variants of Pigment Epithelium Derived Factor and Uses Thereof
US20100331263A1 (en) * 2007-11-07 2010-12-30 Northwestern University Methods and compositions for inhibiting angiogenesis
US20120316115A1 (en) * 2007-11-07 2012-12-13 Northwestern University Methods and compositions for inhibiting angiogenesis

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060189519A1 (en) * 2002-09-26 2006-08-24 Karl Volz Anti-angiogenic fragments fo pigment epithelium-derived factor (pedf)
US20080274967A1 (en) * 2005-11-14 2008-11-06 Galia Maik-Rachline Variants of Pigment Epithelium Derived Factor and Uses Thereof
US20100331263A1 (en) * 2007-11-07 2010-12-30 Northwestern University Methods and compositions for inhibiting angiogenesis
US20120316115A1 (en) * 2007-11-07 2012-12-13 Northwestern University Methods and compositions for inhibiting angiogenesis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DAWSON ET AL.: "Pigment Epithelium Derived Factor: A Potent Inhibitor of Angiogenesis", SCIENCE, vol. 285, no. 5425, 9 July 1999 (1999-07-09), pages 245 - 248 *
MIROCHNIK ET AL.: "Short Pigment Epithelial-Derived Factor-Derived Peptide Inhibits Angiogenesis and Tumor Growth", CLINICAL CANCER RESEARCH, vol. 15, no. 5, 17 February 2009 (2009-02-17), pages 1655 - 1663 *

Also Published As

Publication number Publication date
WO2013184986A2 (en) 2013-12-12

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