WO2013184075A1 - Dispositifs microfluidiques et procédés pour fournir une émulsion d'une pluralité de fluides - Google Patents

Dispositifs microfluidiques et procédés pour fournir une émulsion d'une pluralité de fluides Download PDF

Info

Publication number
WO2013184075A1
WO2013184075A1 PCT/SG2013/000241 SG2013000241W WO2013184075A1 WO 2013184075 A1 WO2013184075 A1 WO 2013184075A1 SG 2013000241 W SG2013000241 W SG 2013000241W WO 2013184075 A1 WO2013184075 A1 WO 2013184075A1
Authority
WO
WIPO (PCT)
Prior art keywords
inlet
inlets
microfluidic
microfluidic channel
fluids
Prior art date
Application number
PCT/SG2013/000241
Other languages
English (en)
Inventor
Tandiono TANDIONO
Siew-Wan OHL
Siak-Wei Dave OW
Claus-Dieter Ohl
Original Assignee
Agency For Science, Technology And Research
Nanyang Technological University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency For Science, Technology And Research, Nanyang Technological University filed Critical Agency For Science, Technology And Research
Priority to SG11201408146SA priority Critical patent/SG11201408146SA/en
Publication of WO2013184075A1 publication Critical patent/WO2013184075A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/411—Emulsifying using electrical or magnetic fields, heat or vibrations
    • B01F23/4111—Emulsifying using electrical or magnetic fields, heat or vibrations using vibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/80—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
    • B01F31/84—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations for material continuously moving through a tube, e.g. by deforming the tube
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3012—Interdigital streams, e.g. lamellae

Definitions

  • Embodiments relate generally to microfluidic devices and methods for providing an emulsion of a plurality of fluids.
  • Emulsion is a mixture of two immiscible liquids, where one liquid (which may be referred to as the dispersed phase) is suspended in another liquid (which may be referred to as the continuous phase) in the form of small droplets or colloids.
  • Emulsions may be commonly used in food, cosmetics and pharmaceutical products, for example: for milk, butter, mayonnaise, vinaigrette, cream, and ointment. Thus, there may be a need to provide emulsions in an efficient manner. Summary
  • a microfluidic device may be provided.
  • the microfluidic device may include: a microfluidic channel with a plurality of inlets for fluids; and an ultrasound emitter configured to emit ultrasonic waves to the microfluidic channel.
  • a first inlet of the plurality of inlets may include or may be an inlet for a gas.
  • a second inlet of the plurality of inlets may include or may be an inlet for a liquid (for example for a first liquid, for example for water).
  • a third inlet of the plurality of inlets may include or may be an inlet for a liquid (for example for a second liquid, for example for a second liquid different from the first liquid, for example for oil).
  • an efficient and convenient method for providing an emulsion from a plurality of fluids may be provided.
  • the method may include: providing the plurality of fluids in a microfluidic channel via a plurality of inlets; and emitting ultrasonic waves to the microfluidic channel, for example to create parametric oscillations of interfaces and violent cavitation bubbles for intense mixing.
  • a first inlet of the plurality of inlets may include or may be an inlet for a gas.
  • a second inlet of the plurality of inlets may include or may be an inlet for a liquid.
  • a third inlet of the plurality of inlets may include or may be an inlet for a liquid.
  • FIG. 1A shows a microfluidic device in accordance with an embodiment
  • FIG. IB shows a microfluidic device in accordance with an embodiment
  • FIG. 1C shows a flow diagram illustrating a method for providing an emulsion of a plurality of fluids according to various embodiments
  • FIG. 2 shows a mixing system in a microfluidic channel according to various embodiments
  • FIG. 3A shows an example of a microfluidic system for creating emulsions according to various embodiments
  • FIG. 3B shows an illustration of the inlets and the microchannel in the microfluidic system according to various embodiments
  • FIG. 4 shows an illustration of a detailed process of emulsification created by acoustic cavitation bubbles in microfluidics according to various embodiments
  • FIG. 5 shows an example of water-in-oil emulsions produced using acoustic cavitation bubbles according to various embodiments
  • FIG. 6 shows an example of oil-in-water emulsions produced using acoustic cavitation bubbles according to various embodiments. Description
  • An emulsion is a mixture of two immiscible liquids, where one liquid (which may be referred to as the dispersed phase) is suspended in another liquid (which may be referred to as the continuous phase) in the form of small droplets or colloids.
  • Emulsions may be commonly used in food, cosmetics and pharmaceutical products, for example: for milk, butter, mayonnaise, vinaigrette, cream, and ointment.
  • emuls may be commonly used in food, cosmetics and pharmaceutical products, for example: for milk, butter, mayonnaise, vinaigrette, cream, and ointment.
  • the formation of emulsions (which may be referred to as emulsification) may be obtained through shear rupturing of two immiscible liquids, leading to the fragmentation of one liquid in the other.
  • emulsions may for example include: high-pressure homogenization, membrane emulsification, spontaneous emulsification, phase inversion, and mechanical stirring.
  • emulsions may be produced by forcing the dispersed phase into the continuous phase.
  • Colloidal droplets may be generated based on coaxial flow or flow focusing methods in a microchannel. Since no active force is applied to the fluids to create high shear flow, the droplet size and the production rate may depend on a geometry of the microchannel, pressures/flowrate and surface tension of the fluids. Despite its ability to produce monodisperse droplets, the production rate of this method may be low.
  • a rapid method may be provided for forming an emulsion on a nano/microfluidic scale involving the application of ultrasonic excitation to a micro-chamber containing two immiscible fluids and a gas.
  • a device may be provided for mixing and creating the emulsion mentioned.
  • a surfactant- free emulsification technique in microfluidics may be provided.
  • Various embodiments relate to microfluidics and nanofluidics, mixing, emulsification, acoustic bubbles, and fluid dynamics.
  • the ability to create intense cavitation in microfluidics may open-up many applications in a micro-scale system. Similar to mechanical stirring or homogenization, the rapidly collapsing cavitation bubbles may create shearing flows, leading to intense mixing and fragmentation of the liquids. According to various embodiments, devices and methods may be provided for developing a technique to create surfactant-free emulsions in microfluidics based on this principle.
  • the cavitation bubbles may be created by exciting gas-liquid interfaces by ultrasound vibrations.
  • Devices and methods according to various embodiments may create monodisperse emulsions from very small amount of liquids, i.e. as little as picoliters, without any surfactant. Nevertheless, surfactants may be added to produce more stable emulsions. The production rate may be faster than commonly used microchannel emulsification techniques because of the use of ultrasound vibration as a "stirring" force in the micro-scale. Furthermore, the devices and methods according to various embodiments may be used to create emulsions from very high viscosity liquids.
  • the devices and methods may be used to produce water-in-oil (W/O) and oil-in- water (O/W) emulsions from water and silicone oil with viscosity of up to 1000 cSt (centistokes), demonstrating the viability of the methods and devices according to various embodiments for mixing fluids with very high viscosity ratio.
  • Viscosity ratio may refer to the ratio of the viscosity of the fluid with higher viscosity (e.g. oil) to the viscosity of the fluid with lower viscosity (e.g. water) in the emulsion.
  • FIG. 1A shows a microfluidic device 100 in accordance with an embodiment.
  • the microfluidic device 100 may include a microfluidic channel 102 with a plurality of inlets for fluids and an ultrasound emitter 104 configured to emit ultrasonic waves to the microfluidic channel 102.
  • a first inlet of the plurality of inlets may include or may be an inlet for a gas.
  • a second inlet of the plurality of inlets may include or may be an inlet for a liquid (for example for a first liquid, for example for water).
  • a third inlet of the plurality of inlets may include or may be an inlet for a liquid (for example for a second liquid, for example for a second liquid different from the first liquid, for example for oil).
  • microfluidic channel is not to be considered to be restricted to a particular size of the microfluidic channel, so that also a micro chamber (or microfluidic chamber) may be understood as a microfluidic channel in the context of the microfluidic device 100.
  • a fluid may be a liquid or a gas.
  • the ultrasound emitter 104 may include or may be a piezoelectric transducer.
  • FIG. IB shows a microfluidic device 106 in accordance with an embodiment.
  • the microfluidic device 106 may, similar to the microfluidic device 100 of FIG. 1A, include a microfluidic channel 102 and an ultrasound emitter 104.
  • the microfluidic device 106 may further include an inlet 108 (or a plurality of inlets 108), like will be described below.
  • the microfluidic device 106 may further include an outlet 110, like will be described below.
  • the microfluidic device 106 may further include a power amplifier 112, like will be described below.
  • the ultrasound emitter 104 and the power amplifier 112 may be coupled with each other, for example via a connection 114, for example an electrical connection, such as for example a cable or a computer bus or via any other suitable electrical connection to exchange electrical signals.
  • the power amplifier 1 12 may be configured to drive the piezoelectric transducer at a resonance frequency of the microfluidic device 100.
  • the piezoelectric transducer may include or may be a ceramic made of Lead oxide, Zirconium oxide, Titanium oxide, and Lanthanum oxide.
  • the ultrasound emitter 104 may be configured to emit ultrasonic waves to the microfluidic channel 102 along a fluid movement direction in the microfluidic channel 102.
  • the ultrasound emitter 104 may be configured to emit ultrasonic waves to the microfluidic channel 102 through a common substrate of the ultrasound emitter 104 and the microfluidic channel 102. [0022] According to various embodiments, the ultrasound emitter 104 may be configured to emit the ultrasonic waves in bursts.
  • the ultrasound emitter 104 may be configured to generate collapsing cavitational bubbles in the fluids.
  • the ultrasound emitter 104 may be configured to generate oscillating interfaces and cavitation bubbles in the fluids.
  • the plurality of inlets may be combined to a (single) inlet 108 for a combination (or for a mixture) of a plurality of fluids.
  • the microfluidic device 106 may include a (single) inlet 108 through which all fluids of the plurality of liquids are provided to the microfluidic channel 102.
  • the inlet 108 may be an inlet for a combination of at least one liquid and at least one gas, for example a combination of a plurality of liquids and/ or gases.
  • the inlet 108 may be an inlet to the microfluidic channel 102.
  • the microfluidic device 106 may include an outlet for an emulsion based on a plurality of liquids input to the microfluidic channel.
  • the outlet 1 10 may be an outlet from the microfluidic channel 102.
  • a plurality of microfluidic channels running in parallel may be provided, for example to increase throughput.
  • the microfluidic device 106 may further include a plurality of microfluidic channels, each microfluidic channel with a plurality of inlets for fluids.
  • the ultrasound emitter 104 may be configured to emit ultrasonic waves to the plurality of microfluidic channels.
  • a first inlet of the plurality of inlets of each microfluidic channel may include or may be an inlet for a gas.
  • a second inlet of the plurality of inlets of each microfluidic channel may include or may be an inlet for a liquid.
  • a third inlet of the plurality of inlets of each microfluidic channel may include or may be an inlet for a liquid. It will be understood that, like described above for a microfluidic channel, the plurality of inlets for a microfluidic channel of the plurality of microfluidic channels may be combined (in other words: the microfluidic channel may include a (single) inlet).
  • the microfluidic device 106 may further include a plurality of ultrasound emitters configured to transmit ultrasonic waves to the one or more microfluidic channels.
  • FIG. 1C shows a flow diagram 116 illustrating a method for providing an emulsion of a plurality of fluids according to various embodiments.
  • the plurality of fluids may be provided in a microfluidic channel via (or using) a plurality of inlets.
  • ultrasonic waves may be emitted to the microfluidic channel.
  • a first inlet of the plurality of inlets may include or may be an inlet for a gas.
  • a second inlet of the plurality of inlets may include or may be an inlet for a liquid.
  • a third inlet of the plurality of inlets may include or may be an inlet for a liquid.
  • the ultrasonic waves may be emitted using a piezoelectric transducer.
  • the microfluidic channel may be provided in a microfluidic device.
  • the method may further include driving the piezoelectric transducer at a resonance frequency of the microfluidic device using a power amplifier.
  • the ultrasonic waves may be emitted using a piezoelectric transducer comprising a ceramic made of Lead oxide, Zirconium oxide, Titanium oxide, and Lanthanum oxide.
  • the method may further include emitting the ultrasonic waves to the microfluidic channel along a fluid movement direction in the microfluidic channel.
  • the method may further include emitting the ultrasonic waves to the microfluidic channel through a common substrate of the ultrasonic transducer and the microfluidic channel.
  • the method may further include emitting the ultrasonic waves in bursts.
  • the method may further include generating collapsing cavitational bubbles in the fluids.
  • the method may further include generating oscillating interfaces and cavitation bubbles in the fluids-
  • the plurality of fluids may be provided in the microfluidic channel using an inlet for a combination (or for a mixture) of the plurality of fluids.
  • the (single) inlet may be an inlet for a combination of at least one liquid and at least one gas, for example a combination of a plurality of liquids and/ or gases.
  • the method may further include outputting from the microfluidic channel an emulsion based on the plurality of liquids.
  • the method may further include: providing the plurality of fluids in a plurality of microfluidic channels via a plurality of inlets; and emitting ultrasonic waves to the plurality of microfluidic channels.
  • Each microfluidic channel of the plurality of microfluidic channels may include a plurality of inlets.
  • a first inlet of the plurality of inlets of each microfluidic channel may include or may be an inlet for a gas.
  • a second inlet of the plurality of inlets of each microfluidic channel may include or may be an inlet for a liquid.
  • a third inlet of the plurality of inlets of each microfluidic channel may include or may be an inlet for a liquid.
  • the method may further include transmitting ultrasonic waves to the one or more microfluidic channels using a plurality of ultrasound emitters.
  • FIG. 2 shows a mixing system in a microfluidic channel 200 according to various embodiments.
  • a first liquid 202 for example oil
  • a second liquid 204 for example water
  • gas 206 are supplied into a single (microfluidic) channel 200.
  • cavitation bubbles are generated in a portion 210 of the microfluidic channel 200, and they oscillate to create the emulsion 214 as shown.
  • FIG. 2 illustrates a further portion 212 of the microfluidic channel 200, and this may be not to scale.
  • the interfaces (for example between gas and water and/ or between water and oil) may become unstable. Small gas bubbles may be ejected from the gas-liquid interface and subsequently induce strong mixing in the micro-chamber to create emulsion.
  • the system may include a microfluidic device and piezoelectric transducer(s) attached on a solid surface (e.g. a glass slide).
  • the microfluidic device may be made of polydimethylsiloxane (PDMS) or other soft material.
  • the microchannel may be designed such that the gas pockets are present in the channel, for example, in the form of gas-liquid interfaces or crevices.
  • the channel height may be configured to be sufficient low for surface instability to take place, e.g. typically in the range of a few micrometers to a few ten micrometers.
  • the piezoelectric transducers may be attached near the microchannel.
  • An RF power amplifier may be used to drive the transducer at its resonance frequency.
  • FIG. 3A shows an example of a microfluidic system 300 for creating emulsions according to various embodiments.
  • the system has one or more (for example two) piezoelectric materials, for example one or more (for example two) piezoelectric transducers, for example a first piezoelectric transducer 312 and a second piezoelectric transducer 314, and a microfluidic device (including a microchannel 302) attached on a glass substrate 316, for example a microscope slide.
  • the first transducer 312 and/ or the second transducer 314 may include or may be a ceramic made of Lead oxide, Zirconium oxide, Titanium oxide, and Lanthanum oxide.
  • the transducers 312 and 314 may be glued onto the glass substrate 316, at the sides of the microchannel 302, for example using a very thin layer of epoxy glue.
  • the microfluidic device may be made of PDMS (Polydimethylsiloxane), for example using standard soft lithography techniques.
  • the microchannel 302 may have one outlet 310 and three inlets, for example an inlet 304 for oil, an inlet 306 for water, and an inlet 308 for gas.
  • the inlets 304, 306, 308 may be connected to the main channel 302 in such a way that gas-liquids interfaces are formed along the channel 302.
  • FIG. 3B shows an illustration 318 of the inlets 304, 306, 308 and the microchannel 302 in the micro fluidic system (which also may be referred to as a microfluidic device) according to various embodiments.
  • the inlet 306 for water may be provided so that it surrounds the oil in the microchannel.
  • the inlet 308 for gas may be provided so that it surrounds the water in the microchannel.
  • a gas-water interface 320 and 326 and a water-oil interface 322 and 324 is shown. It will be understood that FIG.
  • FIG. 3B shows a cross-section, so that in the illustration two inlets are shown for gas and two inlets are shown for water, and also two gas-water interfaces and two water-oil interfaces are shown.
  • FIG. 3B shows the schematic of exemplary gas-liquids interfaces, for example of exemplary gas-water-oil-water-gas interfaces created in the microchannel.
  • the thickness of liquid films may be varied by adjusting the flowrate and/ or the pressure of the liquids and gas supplies.
  • FIG. 4 shows an illustration 400 of a detailed process of emulsification created by cavitation bubbles in microfluidics according to various embodiments.
  • Cavitation bubbles may be initiated at gas-liquid interface. The bubbles may then be brought into the other liquid phase. Emulsion may be formed due to the high shear generated by the oscillating bubbles that fragments the liquid film attached on the bubbles surface and along the interfaces.
  • a first stage 402 gas-liquid interfaces between gas 404 and water 406 may be provided.
  • the interfaces for example as shown in FIG. 3B
  • ultrasound vibrations for example an acoustic wave like indicated by arrow 408
  • surface instability may occur at gas-water interfaces resulting in parametric oscillations of the interfaces.
  • the nonlinear surface oscillation may entrap gas bubbles 412 which may move towards liquid phases and later serve as cavitation nuclei. As the bubbles 412 oscillate and collapse violently, the intense mixing may take place in the whole microchannel.
  • a third stage 414 when the oscillating bubbles travel from water to oil phase 416, they may carry a thin layer of water on their surfaces. Those layers may subsequently be fragmented into small water droplets due to shearing flow generated by the cavitation bubbles, resulting in the formation of water-in-oil-emulsion 420 in a fourth stage 418.
  • the thin layer of water along the oscillating interfaces may also be the source of water droplets in the continuous phase (oil).
  • oil-in-water emulsions will be obtained.
  • the type of emulsion may be controlled by the thickness of liquid film injected into the microchannel 318.
  • the dispersed phase may typically the one with thin film (or less liquid).
  • the oil layer 304 may be made as thin as possible.
  • the water layer 306 may be made as thin as possible to produce water-in-oil emulsions.
  • the transducer (which may for example include Plumbum Zirconate Titanate material, and may be a disc transducer, with 25 mm diameter with 2.1 -mm thickness) may be driven by an amplifier, which may be connected to a function generator.
  • the driving voltage of the transducers may be set at 200 V at the resonance frequency of the micro fluidic device 100 of about 100 kHz.
  • the ultrasound may be exposed in a burst mode to prevent overheating of the transducer.
  • the total exposure duration may range from milliseconds to seconds.
  • Emulsions may be obtained from water and silicone oils with different viscosity ranging from 10 to 1000 cSt (it will be understood that viscosity of water is 1 cSt).
  • FIG. 5 and FIG. 6 Images of the emulsions produced according to various embodiments are shown in FIG. 5 and FIG. 6 for water-in-oil and oil-in-water emulsions, respectively.
  • the images were taken by a camera connected to an objective lens with a lOOx magnification. The zoom of a small region is given on the right of each image.
  • FIG. 5 shows an illustration 500 of water-in-oil emulsions produced using acoustic cavitation bubbles according to various embodiments.
  • a scale 504 of a photo 502 of the emulsion is given.
  • the driving voltage of the piezoelectric transducer is 200 V and the driving frequency is about 100 kHz.
  • the exposure duration is less than 1 second.
  • the emulsions were obtained from water and 100 cSt silicone oil.
  • a zoom picture 506 on the right of FIG. 5 shows the monodisperse emulsions in an enlarged scale 508.
  • FIG. 6 shows an illustration 600 of oil-in-water emulsions produced using acoustic cavitation bubbles according to various embodiments.
  • a scale 604 of a photo 602 of the emulsion is given.
  • the driving voltage of the piezoelectric transducer is 200 V and the driving frequency is about 100 kHz.
  • the exposure duration is less than 1 second.
  • the emulsions were obtained from water and 100 cSt silicone oil.
  • a zoom picture 606 on the right of FIG. 6 shows the oil-in-water emulsions in an enlarged scale 608.
  • the water-in-oil emulsions are monodisperse with a size of about 1.4 ⁇ .
  • the size of the oil droplets in oil-in-water emulsions may not be uniform, ranging from submicron to few microns size. This may be explained by the non- homogeneous shear stress generated by violent cavitation bubbles. The coalescence of two or more adjacent droplets may also deteriorate the uniformity of the emulsions. For example, monodisperse emulsions may be achieved by increasing the exposure duration and/or adding surfactant.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

L'invention concerne, conformément à divers modes de réalisation, un dispositif microfluidique. Le dispositif microfluidique peut comprendre : un canal microfluidique ayant une pluralité d'entrées pour des fluides ; et un émetteur d'ultrasons configuré pour émettre des ondes ultrasoniques vers le canal microfluidique. Conformément à divers modes de réalisation, une première entrée de la pluralité d'entrées peut comprendre ou peut être une entrée pour un gaz. Conformément à divers modes de réalisation, une deuxième entrée de la pluralité d'entrées peut comprendre ou peut être une entrée pour un liquide. Conformément à divers modes de réalisation, une troisième entrée de la pluralité d'entrées peut comprendre ou peut être une entrée pour un liquide.
PCT/SG2013/000241 2012-06-08 2013-06-10 Dispositifs microfluidiques et procédés pour fournir une émulsion d'une pluralité de fluides WO2013184075A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SG11201408146SA SG11201408146SA (en) 2012-06-08 2013-06-10 Microfluidic devices and methods for providing an emulsion of a plurality of fluids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SG201204244-6 2012-06-08
SG201204244 2012-06-08

Publications (1)

Publication Number Publication Date
WO2013184075A1 true WO2013184075A1 (fr) 2013-12-12

Family

ID=49712349

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SG2013/000241 WO2013184075A1 (fr) 2012-06-08 2013-06-10 Dispositifs microfluidiques et procédés pour fournir une émulsion d'une pluralité de fluides

Country Status (1)

Country Link
WO (1) WO2013184075A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104162395A (zh) * 2014-03-21 2014-11-26 中国科学院大连化学物理研究所 一种强化微反应器内气液过程的方法
CN104923137A (zh) * 2014-03-19 2015-09-23 中国科学院大连化学物理研究所 一种强化微反应器内流体混合的方法
CN112244087A (zh) * 2020-10-28 2021-01-22 江南大学 一种超声波杀菌协同微滤生产高活性延长货架期乳的方法
US11007495B2 (en) 2016-01-20 2021-05-18 Oxford University Innovation Limited Method and apparatus for generating bubbles

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040066703A1 (en) * 2002-10-03 2004-04-08 Protasis Corporation Fluid-handling apparatus and methods
US20050214933A1 (en) * 2003-12-19 2005-09-29 Korea Institute Of Machinery & Materials Ultrasonic micromixer with radiation perpendicular to mixing interface
US7942568B1 (en) * 2005-06-17 2011-05-17 Sandia Corporation Active micromixer using surface acoustic wave streaming

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040066703A1 (en) * 2002-10-03 2004-04-08 Protasis Corporation Fluid-handling apparatus and methods
US20050214933A1 (en) * 2003-12-19 2005-09-29 Korea Institute Of Machinery & Materials Ultrasonic micromixer with radiation perpendicular to mixing interface
US7942568B1 (en) * 2005-06-17 2011-05-17 Sandia Corporation Active micromixer using surface acoustic wave streaming

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104923137A (zh) * 2014-03-19 2015-09-23 中国科学院大连化学物理研究所 一种强化微反应器内流体混合的方法
CN104162395A (zh) * 2014-03-21 2014-11-26 中国科学院大连化学物理研究所 一种强化微反应器内气液过程的方法
US11007495B2 (en) 2016-01-20 2021-05-18 Oxford University Innovation Limited Method and apparatus for generating bubbles
CN112244087A (zh) * 2020-10-28 2021-01-22 江南大学 一种超声波杀菌协同微滤生产高活性延长货架期乳的方法

Similar Documents

Publication Publication Date Title
Dong et al. Continuous ultrasonic reactors: design, mechanism and application
Rasouli et al. An ultra-rapid acoustic micromixer for synthesis of organic nanoparticles
US10556428B2 (en) Acoustophoretic printing apparatus and method
Wiklund et al. Acoustofluidics 14: Applications of acoustic streaming in microfluidic devices
US8465706B2 (en) On-demand microfluidic droplet or bubble generation
Collins et al. Surface acoustic waves for on-demand production of picoliter droplets and particle encapsulation
Mittal et al. Dynamics of step-emulsification: From a single to a collection of emulsion droplet generators
Gao et al. Acoustic bubble-based bidirectional micropump
Mulvana et al. Ultrasound assisted particle and cell manipulation on-chip
US20110127164A1 (en) Non-invasive acoustic technique for mixing and segregation of fluid suspensions in microfluidic applications
Meng et al. Acoustic aligning and trapping of microbubbles in an enclosed PDMS microfluidic device
Feng et al. 2-D steering and propelling of acoustic bubble-powered microswimmers
US20130273591A1 (en) On-demand microfluidic droplet or bubble generation
WO2013184075A1 (fr) Dispositifs microfluidiques et procédés pour fournir une émulsion d'une pluralité de fluides
Orbay et al. Acoustic actuation of in situ fabricated artificial cilia
WO2011058881A1 (fr) Appareil de production de gouttelettes de liquide ultrafines
Yamamoto et al. High-speed imaging of ultrasonic emulsification using a water-gallium system
Ohl et al. Creation of cavitation activity in a microfluidic device through acoustically driven capillary waves
Cui et al. Determination of dynamic interfacial tension during the generation of tiny droplets in the liquid–liquid jetting flow regime
US11007495B2 (en) Method and apparatus for generating bubbles
Kishi et al. Microdroplet generation using an ultrasonic torsional transducer which has a micropore with a tapered nozzle
Iida et al. Bubble motions confined in a microspace observed with stroboscopic technique
Fang et al. LCAT pump optimization for an integrated microfluidic droplet generator
Goldowsky et al. Acousto-fluidic system assisting in-liquid self-assembly of microcomponents
Zhao et al. Ultrasound emulsification in microreactors: effects of channel material, surfactant nature, and ultrasound parameters

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 13800765

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 13800765

Country of ref document: EP

Kind code of ref document: A1