WO2013179140A3 - Optical rotation measuring device, optically rotational ingredient analyzing device, and optically rotational ingredient analyzing method - Google Patents

Optical rotation measuring device, optically rotational ingredient analyzing device, and optically rotational ingredient analyzing method Download PDF

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Publication number
WO2013179140A3
WO2013179140A3 PCT/IB2013/001512 IB2013001512W WO2013179140A3 WO 2013179140 A3 WO2013179140 A3 WO 2013179140A3 IB 2013001512 W IB2013001512 W IB 2013001512W WO 2013179140 A3 WO2013179140 A3 WO 2013179140A3
Authority
WO
WIPO (PCT)
Prior art keywords
optical
optical rotation
specimen
rotational
ingredient
Prior art date
Application number
PCT/IB2013/001512
Other languages
French (fr)
Other versions
WO2013179140A2 (en
Inventor
Hiroshi Kajioka
Original Assignee
Global Fiberoptics, Ltd.
Shionogi & Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Global Fiberoptics, Ltd., Shionogi & Co., Ltd. filed Critical Global Fiberoptics, Ltd.
Publication of WO2013179140A2 publication Critical patent/WO2013179140A2/en
Publication of WO2013179140A3 publication Critical patent/WO2013179140A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14558—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters by polarisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/21—Polarisation-affecting properties
    • G01N21/23—Bi-refringence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Medical Informatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

To provide an optical rotation measuring device and an optical rotational ingredient analyzing device for invasively or non-invasively measuring with high precision the optical rotation of a substance contained in a specimen, such as glucide, a living tissue, blood, and a molecule, and analyzing ingredients of a substance having optical rotation, such as solution or a living body, a set of opposing polarized-light converting optical systems (7-1,7-2) are installed along an optical loop path of a ring interferometer. The polarized- light converting optical systems (7-1,7-2) are divided into an optical rotation linearly polarizing module (15-1,15-2) and a circularly polarizing module (16-1,16-2), and a TEC-processed tip end of a single mode optical fiber (4-1,4-2), which sandwiches the specimen (11) in the circularly polarizing module. The TEC-processing enhances measurement precision of the specific optical rotation. In addition, a method for changing temperature of the specimen (11) or wavelength of the light source (1) at N points (N is an integer) and calculating concentration of ingredients of N types substances having optical rotatory is provided.
PCT/IB2013/001512 2012-05-29 2013-05-29 Optical rotation measuring device, optically rotational ingredient analyzing device, and optically rotational ingredient analyzing method WO2013179140A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261652535P 2012-05-29 2012-05-29
US61/652,535 2012-05-29

Publications (2)

Publication Number Publication Date
WO2013179140A2 WO2013179140A2 (en) 2013-12-05
WO2013179140A3 true WO2013179140A3 (en) 2014-04-17

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2013/001512 WO2013179140A2 (en) 2012-05-29 2013-05-29 Optical rotation measuring device, optically rotational ingredient analyzing device, and optically rotational ingredient analyzing method

Country Status (1)

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WO (1) WO2013179140A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107233097A (en) * 2017-07-20 2017-10-10 苏州安莱光电科技有限公司 A kind of novel optical fiber Gan Wataru types life physical sign monitoring devices and method

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5235404A (en) * 1991-06-27 1993-08-10 Board Of Trustees, Leland Stanford Junior University, Stanford University Interferometric technique for measurement of nonreciprocal optical effects in a sample
JP2005274380A (en) * 2004-03-25 2005-10-06 Optoquest Co Ltd Double refraction measuring instrument
WO2011145652A1 (en) * 2010-05-19 2011-11-24 塩野義製薬株式会社 Defocused optical rotation measurement apparatus, optical rotation measurement method and defocused optical fiber system
EP2405253A1 (en) * 2009-03-04 2012-01-11 Global Fiberoptics, Ltd. Optical rotation measuring device and optical rotation measuring method

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4052461B2 (en) 2003-04-17 2008-02-27 長崎県 Non-invasive measuring device for blood glucose level
JP4480653B2 (en) 2005-09-27 2010-06-16 株式会社アタゴ Polarization state measuring device, circular dichroism measuring device and method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5235404A (en) * 1991-06-27 1993-08-10 Board Of Trustees, Leland Stanford Junior University, Stanford University Interferometric technique for measurement of nonreciprocal optical effects in a sample
JP2005274380A (en) * 2004-03-25 2005-10-06 Optoquest Co Ltd Double refraction measuring instrument
EP2405253A1 (en) * 2009-03-04 2012-01-11 Global Fiberoptics, Ltd. Optical rotation measuring device and optical rotation measuring method
WO2011145652A1 (en) * 2010-05-19 2011-11-24 塩野義製薬株式会社 Defocused optical rotation measurement apparatus, optical rotation measurement method and defocused optical fiber system
EP2573544A1 (en) * 2010-05-19 2013-03-27 Shionogi & Co., Ltd. Defocused optical rotation measurement apparatus, optical rotation measurement method and defocused optical fiber system

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AMY M WINKLER ET AL: "Optical polarimetry for noninvasive glucose sensing enabled by Sagnac interferometry", APPLIED OPTICS, OPTICAL SOCIETY OF AMERICA, WASHINGTON, DC; US, vol. 50, no. 17, 10 June 2011 (2011-06-10), pages 2719 - 2731, XP001563575, ISSN: 0003-6935, [retrieved on 20110609], DOI: 10.1364/AO.50.002719 *
MCNICHOLS R J ET AL: "OPTICAL GLUCOSE SENSING IN BIOLOGICAL FLUIDS: AN OVERVIEW", JOURNAL OF BIOMEDICAL OPTICS, S P I E - INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING, US, vol. 5, no. 1, 1 January 2000 (2000-01-01), pages 5 - 16, XP001034908, ISSN: 1083-3668, DOI: 10.1117/1.429962 *
SHIRAISHI K ET AL: "LIGHT-PROPAGATION CHARACTERISTICS IN THERMALLY DIFFUSED EXPANDED CORE FIBERS", JOURNAL OF LIGHTWAVE TECHNOLOGY, IEEE SERVICE CENTER, NEW YORK, NY, US, vol. 11, no. 10, 1 October 1993 (1993-10-01), pages 1584 - 1591, XP000418376, ISSN: 0733-8724, DOI: 10.1109/50.249900 *

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Publication number Publication date
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