WO2013173819A1 - Acne treatment and prevention - Google Patents
Acne treatment and prevention Download PDFInfo
- Publication number
- WO2013173819A1 WO2013173819A1 PCT/US2013/041738 US2013041738W WO2013173819A1 WO 2013173819 A1 WO2013173819 A1 WO 2013173819A1 US 2013041738 W US2013041738 W US 2013041738W WO 2013173819 A1 WO2013173819 A1 WO 2013173819A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ecaw
- ppm
- concentration
- treatment
- individual
- Prior art date
Links
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 21
- 206010000496 acne Diseases 0.000 title claims abstract description 21
- 238000011282 treatment Methods 0.000 title claims abstract description 15
- 230000002265 prevention Effects 0.000 title abstract description 4
- 238000000034 method Methods 0.000 claims abstract description 22
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 230000000699 topical effect Effects 0.000 claims description 7
- 230000001580 bacterial effect Effects 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- 241000894007 species Species 0.000 claims description 5
- 241000186427 Cutibacterium acnes Species 0.000 claims description 3
- 241000191967 Staphylococcus aureus Species 0.000 claims description 3
- 241000191963 Staphylococcus epidermidis Species 0.000 claims description 3
- 229940055019 propionibacterium acne Drugs 0.000 claims description 3
- 239000000645 desinfectant Substances 0.000 claims 3
- 108700024827 HOC1 Proteins 0.000 claims 2
- 101100178273 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) HOC1 gene Proteins 0.000 claims 2
- 238000005660 chlorination reaction Methods 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 6
- 230000003115 biocidal effect Effects 0.000 description 4
- 230000000845 anti-microbial effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000005868 electrolysis reaction Methods 0.000 description 2
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 239000012266 salt solution Substances 0.000 description 2
- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 description 1
- FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 239000004342 Benzoyl peroxide Substances 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229960003022 amoxicillin Drugs 0.000 description 1
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
- 229960003722 doxycycline Drugs 0.000 description 1
- 229960003276 erythromycin Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229960004023 minocycline Drugs 0.000 description 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
- 229960001082 trimethoprim Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B11/00—Oxides or oxyacids of halogens; Salts thereof
- C01B11/04—Hypochlorous acid
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/46—Treatment of water, waste water, or sewage by electrochemical methods
- C02F1/461—Treatment of water, waste water, or sewage by electrochemical methods by electrolysis
- C02F1/467—Treatment of water, waste water, or sewage by electrochemical methods by electrolysis by electrochemical disinfection; by electrooxydation or by electroreduction
- C02F1/4672—Treatment of water, waste water, or sewage by electrochemical methods by electrolysis by electrochemical disinfection; by electrooxydation or by electroreduction by electrooxydation
- C02F1/4674—Treatment of water, waste water, or sewage by electrochemical methods by electrolysis by electrochemical disinfection; by electrooxydation or by electroreduction by electrooxydation with halogen or compound of halogens, e.g. chlorine, bromine
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2103/00—Nature of the water, waste water, sewage or sludge to be treated
- C02F2103/02—Non-contaminated water, e.g. for industrial water supply
- C02F2103/026—Treating water for medical or cosmetic purposes
Definitions
- Embodiments of the invention relate generally to the treatment of acne and, more particularly, to the treatment and prevention of acne vulgaris by chlorination.
- Acne vulgaris is a common skin condition affecting 60-70% of Americans at some point during their lives. Severe acne vulgaris is inflammatory and often caused by infection by one or more bacterial species, including Propionibacterium acnes,
- Staphylococcus aureus and Staphylococcus epidermidis .
- Acne starts when oil and dead skin cells clog the skin's pores. If germs get into the pores, the result can be swelling, redness, and the production of pus.
- acne vulgaris is treated with a topical active, such as benzoyl peroxide, either alone or in combination with an antibiotic, such as tetracycline, doxycycline, minocycline, erythromycin, trimethoprim, or amoxicillin.
- Topical actives are less effective in cases of severe acne vulgaris and antibiotic treatment of acne vulgaris, as with all antibiotic treatments, creates a risk of increasing the prevalence of antibiotic-resistant bacterial strains.
- the invention provides a method of treating acne vulgaris in an individual in need of such treatment, the method comprising: applying to a skin surface of the individual a quantity of electro-chemically activated water (ECAW) having a hypochlorous acid (H0C1) concentration between about 100 ppm and about 300 ppm.
- ECAW electro-chemically activated water
- H0C1 hypochlorous acid
- the invention provides a topical medicament for the treatment of acne vulgaris comprising ECAW gel having a concentration of H0C1 between about 100 ppm and about 300 ppm of the ECAW.
- the invention provides a method of preventing acne vulgaris in an individual in need of such treatment, the method comprising: applying to a skin surface of the individual a quantity of electro-chemically activated water (ECAW) or ECAW gel having a hypochlorous acid (H0C1) concentration between about 100 ppm and about 300 ppm two to four times a day.
- ECAW electro-chemically activated water
- H0C1 hypochlorous acid
- Electro-chemically activated water includes, as an active component, hypochlorous acid (H0C1) , a potent antimicrobial effective in rapidly destroying bacteria, viruses , and spores .
- the hypochlorite ion (CIO-), also known as chlorate(I), is typically also found in ECAW. It, too, is a potent antimicrobial, although its antimicrobial activity is typically less than that of HOCl.
- ECAW may be produced, for example, by electrolysis of a dilute salt solution. Such electrolysis may be accomplished by passing the dilute salt solution through an electrolytic cell.
- electrolytic cell which will not be described in further detail herein.
- One embodiment of the invention provides a method of treating or preventing acne vulgaris, including severe or inflammatory acne vulgaris.
- the method includes applying a surface of the skin of an individual with liquid ECAW containing HOCl at a concentration of between about 100 ppm and about 300 ppm. In some embodiments of the invention, the HOCl concentration is less than or equal to about 200 ppm.
- a gelled ECAW containing a similar concentration of HOCl, i.e. , between about 100 ppm and about 300 ppm. In some embodiments of the invention, the HOCl concentration is less than or equal to about 200 ppm. In any case, application may be made by spraying, washing, wiping, or any other method or technique.
- the ECAW whether liquid or gelled, has a pH between about 4.5 and about 6.2. In some embodiments, the ECAW has a pH of about 5.5. Maintaining a pH of about 5.5 at the skin surface promotes maintenance of the acid mantle, which defends against bacterial infection.
- Some embodiments of the invention include periodic application of a liquid or gelled ECAW, as described above, as a preventive measure.
Abstract
Embodiments of the invention relate generally to the treatment and prevention of acne and, more particularly, to the treatment of acne vulgaris by chlorination. In one embodiment, the invention provides a method of treating acne vulgaris in an individual in need of such treatment, the method comprising: applying to a skin surface of the individual a quantity of electro-chemically activated water (ECAW) having a hypochlorous acid (H0C1) concentration between about 100 ppm and about 300 ppm.
Description
ACNE TREATMENT AND PREVENTION
CROSS-REFERENCE TO RELATED APPLICATIONS This application claims the benefit of co-pending US Provisional Patent Application No. 61/649,225, filed 18 May 2012, which is hereby incorporated herein.
TECHNICAL FIELD
Embodiments of the invention relate generally to the treatment of acne and, more particularly, to the treatment and prevention of acne vulgaris by chlorination.
BACKGROUND
Acne vulgaris is a common skin condition affecting 60-70% of Americans at some point during their lives. Severe acne vulgaris is inflammatory and often caused by infection by one or more bacterial species, including Propionibacterium acnes,
Staphylococcus aureus, and Staphylococcus epidermidis . Acne starts when oil and dead skin cells clog the skin's pores. If germs get into the pores, the result can be swelling, redness, and the production of pus.
Typically, acne vulgaris is treated with a topical active, such as benzoyl peroxide, either alone or in combination with an antibiotic, such as tetracycline, doxycycline, minocycline, erythromycin, trimethoprim, or amoxicillin. Topical actives are less effective in cases of severe acne vulgaris and antibiotic
treatment of acne vulgaris, as with all antibiotic treatments, creates a risk of increasing the prevalence of antibiotic-resistant bacterial strains.
SUMMARY
In one embodiment, the invention provides a method of treating acne vulgaris in an individual in need of such treatment, the method comprising: applying to a skin surface of the individual a quantity of electro-chemically activated water (ECAW) having a hypochlorous acid (H0C1) concentration between about 100 ppm and about 300 ppm.
In another embodiment, the invention provides a topical medicament for the treatment of acne vulgaris comprising ECAW gel having a concentration of H0C1 between about 100 ppm and about 300 ppm of the ECAW.
In still another embodiment, the invention provides a method of preventing acne vulgaris in an individual in need of such treatment, the method comprising: applying to a skin surface of the individual a quantity of electro-chemically activated water (ECAW) or ECAW gel having a hypochlorous acid (H0C1) concentration between about 100 ppm and about 300 ppm two to four times a day.
DETAILED DESCRIPTION
Electro-chemically activated water (ECAW) includes, as an active component, hypochlorous acid (H0C1) , a potent antimicrobial effective in rapidly destroying bacteria, viruses , and spores . The hypochlorite ion (CIO-), also known as chlorate(I), is typically
also found in ECAW. It, too, is a potent antimicrobial, although its antimicrobial activity is typically less than that of HOCl. ECAW may be produced, for example, by electrolysis of a dilute salt solution. Such electrolysis may be accomplished by passing the dilute salt solution through an electrolytic cell. One of ordinary skill in the art will understand the use of an electrolytic cell, which will not be described in further detail herein.
One embodiment of the invention provides a method of treating or preventing acne vulgaris, including severe or inflammatory acne vulgaris. The method includes applying a surface of the skin of an individual with liquid ECAW containing HOCl at a concentration of between about 100 ppm and about 300 ppm. In some embodiments of the invention, the HOCl concentration is less than or equal to about 200 ppm.
Other embodiments of the invention include the application of a gelled ECAW containing a similar concentration of HOCl, i.e. , between about 100 ppm and about 300 ppm. In some embodiments of the invention, the HOCl concentration is less than or equal to about 200 ppm. In any case, application may be made by spraying, washing, wiping, or any other method or technique.
In some embodiments of the invention, the ECAW, whether liquid or gelled, has a pH between about 4.5 and about 6.2. In some embodiments, the ECAW has a pH of about 5.5. Maintaining a pH of about 5.5 at the skin surface promotes maintenance of the acid mantle, which defends against bacterial infection.
Some embodiments of the invention include periodic
application of a liquid or gelled ECAW, as described above, as a preventive measure.
This written description uses examples to disclose the invention, including the best mode, and also to enable any person skilled in the art to practice the invention, including making and using any devices or systems and performing any related or incorporated methods. The patentable scope of the invention is defined by the claims, and may include other examples that occur to those skilled in the art. Such other examples are intended to be within the scope of the claims if they have structural elements that do not differ from the literal language of the claims, or if they include equivalent structural elements with insubstantial differences from the literal language of the claims.
Claims
1. A method of treating acne vulgaris in an individual in need of such treatment, the method comprising:
applying to a skin surface of the individual a quantity of electro-chemically activated water (ECAW) having a hypochlorous acid (H0C1) concentration between about 100 ppm and about 300 ppm.
2. The method of claim 1, wherein the ECAW is in a gelled form.
3. The method of claim 1, wherein the ECAW has a pH between about 4.5 and about 6.2.
4. The method of claim 1, wherein the concentration of H0C1 is effective as a disinfectant against at least one bacterial species.
5. The method of claim 4, wherein the at least one bacterial species is selected from a group consisting of: Propionibacterium acnes r Staphylococcus aureus, and Staphylococcus epidermidis .
6. A topical medicament for the treatment of acne vulgaris comprising ECAW having a concentration of HOC1 between about 100 ppm and about 300 ppm of the ECAW.
The topical medicament of claim 6, wherein the medicament
in a gelled form.
8. The topical medicament of claim 6 having a pH between about 4.5 and about 6.2.
9. The topical medicament of claim 6, wherein the concentration of H0C1 is effective as a disinfectant against at least one bacterial species selected from a group consisting of: Propionibacterium acnes r Staphylococcus aureus, and Staphylococcus epidermidis .
10. A method of preventing acne vulgaris in an individual in need of such treatment, the method comprising:
applying to a skin surface of the individual a quantity of electro-chemically activated water (ECAW) having a hypochlorous acid (H0C1) concentration between about 100 ppm and about 300 ppm two to four times daily.
11. The method of claim 10, wherein the ECAW is in a gelled form.
12. The method of claim 10, wherein the ECAW has a pH between about 4.5 and about 6.2.
13. The method of claim 10, wherein the concentration of HOC1 is effective as a disinfectant against at least one bacterial species.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261649225P | 2012-05-18 | 2012-05-18 | |
| US61/649,225 | 2012-05-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2013173819A1 true WO2013173819A1 (en) | 2013-11-21 |
Family
ID=49584368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2013/041738 WO2013173819A1 (en) | 2012-05-18 | 2013-05-18 | Acne treatment and prevention |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2013173819A1 (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007122625A2 (en) * | 2006-04-26 | 2007-11-01 | Bromine Compounds Ltd. | Multifunctional solid formulations for water conditioning |
| WO2009098599A2 (en) * | 2008-02-07 | 2009-08-13 | Radical Waters Ip (Pty) Ltd. | Beverage manufacture, processing, packaging and dispensing using electrochemically activated water |
| WO2010080572A1 (en) * | 2008-12-18 | 2010-07-15 | Cunningham Emmett M | Treatment or prevention of viral infection by chlorination |
-
2013
- 2013-05-18 WO PCT/US2013/041738 patent/WO2013173819A1/en active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007122625A2 (en) * | 2006-04-26 | 2007-11-01 | Bromine Compounds Ltd. | Multifunctional solid formulations for water conditioning |
| WO2009098599A2 (en) * | 2008-02-07 | 2009-08-13 | Radical Waters Ip (Pty) Ltd. | Beverage manufacture, processing, packaging and dispensing using electrochemically activated water |
| WO2010080572A1 (en) * | 2008-12-18 | 2010-07-15 | Cunningham Emmett M | Treatment or prevention of viral infection by chlorination |
Non-Patent Citations (1)
| Title |
|---|
| "Kak borotsya s pryschami", PRICHINY VOZNIKNOVENIYA PRYSCHEI, 2011, Retrieved from the Internet <URL:http://russianusa.tarima.org/acne-reasons.html> [retrieved on 20130805] * |
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