WO2013173265A1 - Edible energy composition - Google Patents
Edible energy composition Download PDFInfo
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- WO2013173265A1 WO2013173265A1 PCT/US2013/040842 US2013040842W WO2013173265A1 WO 2013173265 A1 WO2013173265 A1 WO 2013173265A1 US 2013040842 W US2013040842 W US 2013040842W WO 2013173265 A1 WO2013173265 A1 WO 2013173265A1
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- WIPO (PCT)
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- amount
- composition
- energy composition
- present
- vitamin
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- 239000000203 mixture Substances 0.000 title claims abstract description 88
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 36
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 30
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 27
- 229940024606 amino acid Drugs 0.000 claims description 23
- 150000001413 amino acids Chemical class 0.000 claims description 23
- 235000019152 folic acid Nutrition 0.000 claims description 19
- 239000011724 folic acid Substances 0.000 claims description 19
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 claims description 18
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 18
- 235000019158 vitamin B6 Nutrition 0.000 claims description 18
- 239000011726 vitamin B6 Substances 0.000 claims description 18
- 229940011671 vitamin b6 Drugs 0.000 claims description 18
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims description 16
- 150000003248 quinolines Chemical class 0.000 claims description 15
- 229940088594 vitamin Drugs 0.000 claims description 15
- 229930003231 vitamin Natural products 0.000 claims description 15
- 235000013343 vitamin Nutrition 0.000 claims description 15
- 239000011782 vitamin Substances 0.000 claims description 15
- 229960003080 taurine Drugs 0.000 claims description 13
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 12
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 11
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 11
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- 239000000796 flavoring agent Substances 0.000 claims description 11
- 235000019634 flavors Nutrition 0.000 claims description 11
- 229960000304 folic acid Drugs 0.000 claims description 11
- 235000019163 vitamin B12 Nutrition 0.000 claims description 11
- 239000011715 vitamin B12 Substances 0.000 claims description 11
- 235000005152 nicotinamide Nutrition 0.000 claims description 10
- 239000011570 nicotinamide Substances 0.000 claims description 10
- 229960003966 nicotinamide Drugs 0.000 claims description 10
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- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 9
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- UYUXSRADSPPKRZ-SKNVOMKLSA-N D-glucurono-6,3-lactone Chemical compound O=C[C@H](O)[C@H]1OC(=O)[C@@H](O)[C@H]1O UYUXSRADSPPKRZ-SKNVOMKLSA-N 0.000 claims description 8
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims description 8
- 229960001948 caffeine Drugs 0.000 claims description 8
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims description 8
- 229950002441 glucurolactone Drugs 0.000 claims description 8
- 229960001682 n-acetyltyrosine Drugs 0.000 claims description 8
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- CAHKINHBCWCHCF-JTQLQIEISA-N N-acetyl-L-tyrosine Chemical compound CC(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 CAHKINHBCWCHCF-JTQLQIEISA-N 0.000 claims description 7
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- RZZPDXZPRHQOCG-OJAKKHQRSA-M CDP-choline(1-) Chemical compound O[C@@H]1[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OCC[N+](C)(C)C)O[C@H]1N1C(=O)N=C(N)C=C1 RZZPDXZPRHQOCG-OJAKKHQRSA-M 0.000 claims description 2
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- 150000003722 vitamin derivatives Chemical class 0.000 claims description 2
- 150000003862 amino acid derivatives Chemical class 0.000 claims 5
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims 3
- QDGAVODICPCDMU-UHFFFAOYSA-N 2-amino-3-[3-[bis(2-chloroethyl)amino]phenyl]propanoic acid Chemical compound OC(=O)C(N)CC1=CC=CC(N(CCCl)CCCl)=C1 QDGAVODICPCDMU-UHFFFAOYSA-N 0.000 claims 2
- 230000008901 benefit Effects 0.000 abstract description 12
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 8
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 8
- 229940014144 folate Drugs 0.000 description 8
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- 230000036626 alertness Effects 0.000 description 7
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- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 7
- 238000003786 synthesis reaction Methods 0.000 description 7
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 6
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- 229940088598 enzyme Drugs 0.000 description 6
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 6
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- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/322—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the nervous system or on mental function
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/33—High-energy foods and drinks, sports drinks
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/02—Acid
- A23V2250/06—Amino acid
- A23V2250/0644—Taurine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/02—Acid
- A23V2250/06—Amino acid
- A23V2250/0652—Tyrosine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
- A23V2250/21—Plant extracts
- A23V2250/2108—Caffeine, coffee extract
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/30—Other Organic compounds
- A23V2250/304—Choline
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/70—Vitamins
- A23V2250/704—Vitamin B
Definitions
- these products may include undesirable amounts of calories due to, for example, the inclusion of sugars, and/or may provide an unpleasant taste and/or may fail to provide sufficient physical and mental benefits for an adequate period of time.
- consumers continually desire palatable, unique and healthy formulations. Accordingly, there is a need for improved edible compositions that provide consumers with benefits such as increased energy and alertness.
- the present invention describes an edible energy composition that includes a methylated xanthine in an amount from about 0.05 % to about 0.5%, a choline derivative in an amount from about 0,005 % to about 0.09 % (w/w), and at least one flavorant.
- the present invention also describes an edible energy composition that includes methylated xanthine, a choline derivative, amino acids, vitamins, taurine, acidulants and at least one flavorants and where consumption of said composition provides a user with at least one benefit such as increased alertness, increased mental acuity, increased continuity of attention and increased self-related awareness.
- the present invention also relates to an edible energy composition that includes a methylated xanthine, a choline derivative, amino acids, vitamins, taurine, glucuronolactone, acidulants and at least one flavorant.
- the disclosure relates to a stable, edible energy composition.
- the composition may be in liquid or solid form or include both liquid and solid forms.
- the composition may be provided in any mass or volume.
- the composition may be provided as a solid food item in the form of bars, crackers, cookies or similar products, having the mass and shape of these types of products.
- the composition may also be provided as a liquid consumable such as a "shot", drink, beverage or gel, which may be served at a wide range of temperatures from freezing (0°C) to up to about 90°C.
- the composition is stable and edible for at least two years and may be stable and edible up to about five years.
- the composition may counter, reduce or prevent drowsiness.
- the composition may also provide a feeling of alertness and mental acuity.
- the composition may also provide a significant increase in the power of attention, continuity of attention, quality of working memory, quality of episodic memory, speed of memory and self-related alertness, the sum of the benefits providing a perceived feeling of energy.
- the cognitive and physiological effects of the composition are sustained for an extended period of time.
- the effect of the composition on alertness and energy is greater than would be observed than when ingesting an equivalent amount of any if the ingredients alone.
- the benefits are sustained longer than the time for the peak plasma concentration of caffeine to be achieved when caffeine is consumed alone.
- the composition may provide benefits for least five hours, longer than the effects of an equivalent amount of caffeine taken alone.
- the ingredients of the composition act synergistically to produce benefits to a consumer that exceed the benefits achieved when the ingredients are taken individually.
- the composition may be provided in an aqueous medium in a volume from about 10 mis to about 300 mis.
- the composition may be provided in a volume from about 0.3 ounces to about ten (10) ounces.
- the composition may be provided in about 0.5 fluid ounces, or about one (1) fluid ounce or about two (2) fluid ounces.
- the composition is provided as a "shot" where the consumer ingests the ingredients in a small volume, such as from about 55 to about 60 mis and where the ingredients are in a highly concentrated form.
- derivatives are defined to include, but are not limited to, precursors, metabolites, structurally-similar compounds and analogs of a particular substance.
- precursors of a given substance are defined to include, but are not limited to, molecules that may be transformed, directly or indirectly, into that substance in vivo or in vitro.
- metabolites of a substance are defined to include, but are not limited to, molecules that are produced in vivo by transformation of that substance.
- structurally similar-compounds are defined to include, but are not limited to, molecules that are structurally similar to the identified substance but possess at least one structural difference and are functionally similar.
- analogs are defined to include, but are not limited to molecules that are chemically distinct from an identified substance but which exert the same biological activity.
- the energy composition includes at least one methylated xanthine and at least one choline derivative including precursors, structurally-similar compounds, analogs and/or metabolites of these substances.
- the composition may also include vitamins, amino acids, taurine, glucuronolactone, glucono-delta-lactone, and glucuronic acid, fiavorants, sweeteners and preservatives, including precursors, structurally-similar compounds, analogs and/or metabolites of these substances.
- Methylated xanthines include but are not limited to caffeine, theobromine, aminophylline, theophylline and paraxanthine.
- methylated xanthines induce a feeling of alertness when ingested.
- methylated xanthines competitively block the binding of adenosine to its target sites in the human nervous system. Consequently, the mood-altering and sleep-inducing effects of adenosine are mitigated and xanthines thus prevent the body from being affected by the depressing effects of adenosine.
- Choline is used in the synthesis of phospholipids, phosphatidylcholine and sphingomyelin, structural components of all cell membranes. Choline is also involved in cell signaling.
- phosphatidylcholine and sphingomyelin are precursors for the intracellular messenger molecules, diacylglycerol and ceramide.
- Choline is required for the synthesis of platelet activating factor (PAF) and sphingophosphorylcholine, which are aiso cell- signaling molecules.
- PAF platelet activating factor
- Choline is also a precursor for acetylcholine, an important neurotransmitter involved in muscle control, memory and mood.
- Supplementation with choline is implicated in improved cognition, memory and learning and may provide neuroprotective benefits.
- Choline is oxidized in the body to form betaine which is a source of methyl (CH 3 ) groups required for methylation reactions.
- betaine is a source of methyl (CH 3 ) groups required for methylation reactions.
- methyl groups from betaine may be used to convert homocysteine to methionine, thereby reducing homocysteine levels. Elevated levels of homocysteine in the blood have been associated with increased risk of cardiovascular diseases.
- the composition may include at least one vitamin.
- the composition may include vitamin B6.
- Vitamin B6 in its various forms, is involved in more than 100 enzymatic reactions involved in amino acid metabolism and the metabolism of one-carbon units, carbohydrates, and lipids. Vitamin B6 is also required for the biosynthesis of neurotransmitters. In the brain, the synthesis of the neurotransmitter serotonin from the amino acid tryptophan is catalyzed by a vitamin B6-dependent enzyme. Other neurotransmitters, such as dopamine, norepinephrine and gamma-aminobutyric acid (GABA), are also synthesized using vitamin B6-dependent enzymes. Vitamin B6 functions as a coenzyme in the synthesis of heme, an iron-containing component of hemoglobin.
- GABA gamma-aminobutyric acid
- the amount of homocysteine in the blood is regulated by at least three vitamins: folic acid, vitamin B12, and vitamin B6.
- Vitamin B6 is also involved in gluconeogenesis, glycogenolysis and immune function. It serves as a coenzyme for a key enzyme involved in the mobilization of single-carbon functional groups (one-carbon metabolism) including reactions that are involved in the synthesis of nucleic acids.
- the effect of vitamin B6 deficiency on the function of the immune system may be partly related to its role in one-carbon metabolism.
- vitamin B6 The binding of vitamin B6 to steroid receptors for estrogen, progesterone, testosterone, and other steroid hormones suggests that the vitamin B6 status of an individual may have implications for diseases affected by steroid hormones, including breast cancer and prostate cancer.
- the composition may include folate.
- Folate is required for DNA and RNA synthesis. Folate is required to make normal red biood cells and to prevent anemia. Folate is also essential for the metabolism of homocysteine, helping to maintain normal levels of this amino acid.
- vitamin B12 or vitamin B6 may increase blood levels of homocysteine, and folate supplementation has been shown to decrease homocysteine levels and to improve endothelial cell function.
- At least one study has linked low dietary folate intake with an increased risk of coronary events. Some evidence associates low blood levels of folate with a greater risk of cancer, possibly through increased DNA damage that may lead to cancer.
- the composition includes vitamin B12.
- Vitamin B12 exists in several forms containing the mineral cobalt, e.g. methyicobalamin and 5-deoxyadenosylcobalamin. Vitamin B12 is required for proper red blood cell formation, neurological function, and DNA synthesis. Vitamin B12 functions as a cofactor for two enzymes that catalyze the conversion of homocysteine to methionine. Methionine, in turn, is required for the formation of S- adenosylmethionine, a universal methyi donor for almost 100 different substrates, including DNA, RNA, hormones, proteins, and lipids. Methylation of DNA may be important in cancer prevention, inadequate function of methionine synthase can lead to an accumulation of homocysteine, which has been associated with increased risk of cardiovascular diseases.
- the composition may include niacin, also known as nicotinic acid or vitamin B3 and derivatives of niacin, including precursors, structurally related compounds, analogs and metabolites.
- Nicotinamide used by the body to form the coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) which are used in numerous enzymatic reactions, mainly to accept or donate electrons for redox reactions.
- NAD functions most often in energy producing reactions involving the catabolism of carbohydrates, fats, proteins, and alcohol.
- NADP functions more often in biosynthetic (anabolic) reactions.
- Cellular NAD is consumed in the synthesis of ADP-ribose polymers, which play a role in DNA repair, and cyclic ADP-ribose may also mediate cell-signaling pathways important in cancer prevention.
- niacin supplementation decreased the risk of ultraviolet light-induced skin cancers in mice.
- the composition may include one or more amino acids, including, without limitation, precursors, structurally-similar compounds, analogs, metabolites, salts, esters or isomeric forms of amino acids.
- amino acids play numerous roles in physiological processes and supplementation with amino acids has been studied in numerous contexts.
- phenylalanine is an essential amino acid and plays a key role in the biosynthesis of other amino acids and some neurotransmitters.
- tyrosine is required for the synthesis of adrenal hormones epinephrine, norepinephrine, dopamine and the thyroid hormones, including thyroxine.
- Tyrosine through its effect on neurotransmitters, is used to treat conditions including mood enhancement, appetite suppression, and growth hormone (HGH) stimulation. Tyrosine is also involved in the production of melanin, the pigment responsible for hair and skin color.
- Embodiments of methylated xanthines include but are not limited to caffeine theobromine, aminophylline, theophylline and paraxanthine and includes precursors, structurally-similar compounds, analogs and metabolites of methylated xanthines.
- the methylated xanthine is present in an amount from about 0.05% to about 0.5 % by weight ⁇ i.e. w/w) (or for some liquid forms from about 0.0005 g/m! to about 0.005 g/ml).
- a % by weight ⁇ i.e. w/w
- the methylated xanthine is present in an amount from about 0.05% to about 0.5 % by weight ⁇ i.e. w/w) (or for some liquid forms from about 0.0005 g/m! to about 0.005 g/ml).
- the methylated xanthine is present in an amount from about 0.35% to about 0.45% w/w (or from about 0.0035 g/ml to about 0.0045 g/ml). In still other embodiments, the methylated xanthine is present in an amount from about 0.37 % to about 0.39% ( or from about 0.0037 g/ml to about 0.0039 g/ml) or the methylated xanthine is present in an amount from about 0.32 % to about 0.34 % by weight ( or from about 0.0032 g/ml to about 0.0034 g/ml).
- the choline derivatives including precursors, structurally-similar compounds, analogs and metabolites of choline may include but are not limited to choline, citicho!ine, phosphocholine, and betaine and phosphatidyl choline.
- the choline derivative is citicoline.
- the choline derivative is present in an amount from about 0.005% to about 0.09% by weight or from about 0.00005 g/ml to about 0.0009 g/mi. In another embodiment, the choline derivative is present in an amount from about 0.03 % to about 0.07% by weight or from about 0.0003 g/ml to about 0.0007 g/ml. In still another embodiment, the choline derivative is present in an amount from about 0.04% to about 0.06% by weight (or from about 0.0004 g/m! to about 0.0006 g/ml). In still another embodiment, the choline derivative is present in an amount from about 0.015% to about 0.019% ⁇ or from about 0.000 5 g/ml to about 0.00019 g/ml).
- the energy composition may further include one or more amino acids including, without limitation, precursors, structurally-similar compounds and analogs, metabolites, salts, esters or isomeric forms of amino acids.
- the amino acids include, but are not limited to, N-acetyl L-tyrosine, tyrosine and phenylalanine.
- amino acids are present in an amount from 0.5% to 5.0% by weight or from about 0.005 g /ml to about 0.05 g/ml.
- amino acids are present in an amount from about 1% to about 4% by weight (or from about 0.01 to about 0.04 g/ml).
- amino acids are present in an amount from about 1% to about 3% by weight (or from about 0.01 g/ml to about 0.03 g/ml).
- amino acids include theanine, glutamic acid, alanine and ⁇ -alanine.
- the edible composition includes N-acetyl L- tyrosine in an amount from about 0.1% to about 0.8% by weight (or about 0.001 to about 0,008 g/ml). In another embodiment, N-acetyl L-tyrosine is present in an amount from 0.2% to about 0.6% (or from about 0.002 g/ml to about 0.006 g/ml). In still another embodiment, N-acetyl L-tyrosine is present in an amount from about 0.3% to about 0.5% by weight (or from about 0.003 g/ml to about 0.005 g/ml).
- the composition may also include phenylalanine.
- L- phenylalanine is present in an amount from about 0.1 % to about 0.8% by weight (or from about 0.001 to about 0.008 g/ml). In one embodiment, L-phenylalanine is present in an amount from about 0.2% to about 0.6% by weight (or from about 0.002 to about 0.006 g/ml). in still another embodiment, L-phenylalanine is present in an amount from about 0.3% to about 0.5% (or about 0.003 to about 0.005 g/ml).
- the composition may also include taurine, including derivatives of taurine which may include precursors, structurally-similar compounds, analogs and/or metabolites.
- taurine is present in an amount from about 0,2% to about 1.6 % by weight (or from about 0.002g/ml to about 0.016 g/ml).
- taurine is present in an amount from about 0,4 % to about ,2 % by weight (or from about 0.004g/ml to about 0.0 2 g/ml).
- taurine is present in an amount from about 0,2% to about 1.6 % by weight (or from about 0.002g/ml to about 0.016 g/ml).
- taurine is present in an amount from about 0,4 % to about ,2 % by weight (or from about 0.004g/ml to about 0.0 2 g/ml).
- taurine is present in an amount from about 0.7 % to about 1.0 % (or from about 0.007 g/ml to about 0.010 g/ml)
- the energy composition includes additional components that may reduce fatigue and provide energy.
- additional components may include, for example, one or more of glucurono!actone, glucono delta-lactone, and glucuronic acid.
- glucuronolactone is present in an amount from about 0.1 % to about 1.2 % (or from about 0.001 g/ml to about 0.012 g/ml).
- glucuronolactone is present in an amount from about 0.003 to about 0.09 %. (or from about 0.00003 g/ml to about 0.0009 g/ml).
- glucuronolactone is present in an amount from about 0.5% to about 0.7 % ( or from about 0.005 g g/ml to about 0.007 g/ml).
- the composition may also include ma!ic and/or citric acid. Citric and malic acid are intermediates in the conversion of food to energy e.g. they are part of the citric acid cycle.
- the pH of the composition is from about 1.0 to about 9.0. In a preferred embodiment, the pH of the composition is acidic. For example, the pH may be from about 2.0 to about 3.0.
- the energy composition may further include one or more pH-modifying components. In one
- the pH-modifying components are acidulants.
- Suitable pH- modifying components include edible inorganic acids, such as phosphoric acid.
- the composition includes edible organic acids.
- Preferred embodiments of edible organic acids include malic acid and citric acid.
- the pH-modifying components are present in an amount from about 0.10% to about 1.2% or from about 0.001 g/ml to about 0.012 g/ml. In one embodiment, the pH-modifying components are present in an amount from about 0.3% to about 0.9 % (or from about 0.003 to about 0.009 g/ml). In stiil another embodiment, the pH-modifying components are present in an amount from about 0.5 to about 0.7 % (or from about 0.005 g/ml to about 0.007 g/ml).
- the energy composition further comprises one or more vitamins, including, without limitation, precursors, structurally-similar compounds, analogs, metabolites, isomers, salts of vitamins.
- vitamins include, but are not limited to B6, B12, niacinamide niacin and folic acid.
- vitamins are present in an amount from about 0.05 % to about 0.8% or from about 0.0005 g/mi to about 0.008 g/mi.
- vitamins are present in an amount from about 0.1 % to about 0.5 % or from about 0.001 g/ml to about 0.005 g/ml .
- vitamins are present in an amount from about 0.10 % to about 0.25 % ( or from about 0.001 g/ml to about 0.0025 g/ml).
- the energy composition may include vitamin B6.
- the B6 is present in an amount from about 0.01 % to about 0.3 % or from about 0.001 g/ml to about 0.003 g/ml).
- the vitamin B6 is present in an amount from about 0.03 % to about 0.2 % (or from about 0.0003 g/ml to about 0.002 g/ml).
- the vitamin B6 is present in an amount from about 0.06 % to about 0.09 % (or from about 0.0006 g/ml to about 0.0009 g/ml).
- the composition may provide from about 50% to about 3000% of the recommended daily allowance of vitamin B6.
- the energy composition may include vitamin B12.
- the B12 is present in an amount from about 0.0001 % to about 0.003 % (or from about 0.00001 g/ml to about 0.00003 g/ml).
- the B12 is present in an amount from about 0.0003 % to about 0.002 % ( or from about 0.00003 g/ml to about 0.00002 g/ml).
- the B12 is present in an amount from about 0.0006 % to about 0.001 % (or from about 0.000006 g/ml to about 0.00001 g/ml).
- the composition may provide from about 50% to about 10000% of the recommended daily allowance of vitamin B12.
- the energy composition may include niacin and/or niacinamide.
- niacinamide is present in an amount from about 0.00001 % to about 0.3 % (or from about 0.0000001 g/ml or from about 0.003 g/ml).
- the niacinamide or a derivative thereof is present in an amount from about 0.01 % to about 0.3 % (or about 0.0001 g/ml to about 0.003 g/ml).
- the niacinamide or a derivative thereof is present in an amount from about 0.03 % to about 0.2 % (or about 0.0003 g/ml to about 0.002 g/ml).
- the niacinamide or a derivative thereof is present in an amount from about 0.06 % to about 0.09 % (or about 0.0006 g/mi to about 0.0009 g/mi).
- the composition may provide from about 20% to about 300% of the recommended daily allowance of niacin.
- the energy composition may include folic acid.
- the folic acid is present in an amount from about 0.00001% to about 0.02 % ⁇ or about 0.0000001 g/ml to about 0.0002 g/ml).
- the folic acid is present in an amount from about 0.0005 % to about 0.02 % ⁇ or about 0.000005 g/ml to about 0.0002 g/ml).
- the folic acid is present in an amount from about 0.001 % to about 0.008 % (or about 0.00001 g/ml to about 0.00008 g/ml).
- the folic acid is present in an amount from about 0.002 % to about 0.004 % (or about 0.00002 g/ml to about 0.0004 g/ml).
- the composition may provide from about 10% to about 100% of the recommended daily allowance of folic acid.
- the energy composition of the present embodiment includes one or more fiavorants and/or sweeteners.
- the fiavorants are present in an amount from about 0.0001 % to about 0.8 % (or about 0.0000001 g/ml to about 0.008 g/ml). In another embodiment, the fiavorants are present in an amount from about 0.1 % to about 0.8 %.
- nutritive or non-nutritive sweeteners may be added.
- sweeteners include, but are not limited to xylitol, stevia, aspartame, sucralose and other non-nutritive sweeteners known to those of ordinary skill in the art.
- sucralose is may be used.
- sucralose is present in an amount from 0.001 % to about 0.4 % (or about 0.00001 g/ml to about 0.004 g/ml).
- sucralose is present in an amount from about 0.05% to about 0.4 % (or about 0. 0005 g/ml to about 0.004 g/ml).
- sucralose is present in an amount from about 0.08% to about 0.3 % (or about 0.0008 g/ml to about 0.003 g/ml). In still another embodiment, sucralose is present in an amount from about 0.1 % to about 0.2 % (or about 0.001 g/ml to about 0.002 g/ml).
- preservative agents may be added to the composition.
- Ethylene diamine tetraacetic acid (“EDTA”) may also be included to improve flavor and stability.
- EDTA is present in an amount from about 0.002 % to about 0.009 % (or about 0.00002 g/ml to about 0.00009 g/ml).
- the EDTA is present in an amount from about 0.003 % to about 0.007 % (or about 0.00003 g/mi to about 0.000007 g/ml).
- the EDTA is present in an amount from about 0.004 % to about 0.006 % (or about 0.00004 g/ml to about 0.00006 g/ml).
- the EDTA is present in an amount from about 0.002 % to about 0.003 % (or about 0.00002 g/ml to about 0.00003 g/ml).
- the energy composition also includes one or more fruit flavorants.
- fruit flavorants include, but are not limited to lemon lime flavors, orange flavors, berry flavors, high fructose corn syrup, raspberry juice concentrates, berry juice concentrates and the like.
- the energy composition further includes one or more enzymes. Embodiments of such enzymes include, but are not limited to, amylase, protease, lactase, lipase, cellulase, and combinations thereof.
- the energy composition may also include added fiber.
- Cellulose is an example of a fiber that may be used in the present variation.
- the energy composition may further include at least one preservative.
- the preservative is a natural preservative.
- useful preservatives include, but are not limited to, benzoic acid and benzoic acid derivatives such as sodium benzoate, calcium benzoate, potassium benzoate, magnesium benzoate, and combinations thereof.
- the preservative may include sorbic acid derivatives such as potassium sorbate, In one embodiment, the preservative is present in an amount from about 0.01 % to about 1.0 % (or from about 0.0001 g/ml to about 0.01 g/ml). in one embodiment, the preservative is present in an amount from about 0.1 % to about 0.8 %.
- the composition provides food energy, i.e. provides calories.
- the composition provides a relatively small amount of food energy.
- the composition may provide less than about 0.1 kcal/g (or kcal/ml), or less than about 0.2 kcal/g or (kcal/ml) or less than about 0.3 kcal/g (or kcal/ml) of food energy.
- the composition provides about four (4) kcal in about 55 to 60 mis.
- the composition does not contain sugars such as glucose, lactose, sucrose or fructose.
- Tables 1-5 provide a set of components that may be introduced into such a liquid. The amounts provided in tables 1-5 are particularly useful to form compositions having a total final volume of about 2 fluid ounces.
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- Proteomics, Peptides & Aminoacids (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
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Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
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AU2013263025A AU2013263025B2 (en) | 2008-08-26 | 2013-05-14 | Edible energy composition |
SG11201407298TA SG11201407298TA (en) | 2012-05-14 | 2013-05-14 | Edible energy composition |
MX2014013800A MX345908B (en) | 2012-05-14 | 2013-05-14 | Edible energy composition. |
CA2873403A CA2873403A1 (en) | 2012-05-14 | 2013-05-14 | Edible energy composition comprising methylated xanthine and choline derivative |
IL235535A IL235535A0 (en) | 2012-05-14 | 2014-11-06 | Edible energy composition |
ZA2014/09135A ZA201409135B (en) | 2012-05-14 | 2014-12-11 | Edible energy composition |
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US13/470,462 US9049879B2 (en) | 2008-06-13 | 2012-05-14 | Edible energy composition |
US13/470,462 | 2012-05-14 |
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WO2013173265A1 true WO2013173265A1 (en) | 2013-11-21 |
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AU (1) | AU2013263025B2 (en) |
CA (1) | CA2873403A1 (en) |
IL (1) | IL235535A0 (en) |
MX (1) | MX345908B (en) |
SG (1) | SG11201407298TA (en) |
WO (1) | WO2013173265A1 (en) |
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WO2023009655A1 (en) * | 2021-07-27 | 2023-02-02 | Ingenious Ingredients, LP | Bioactive compositions and methods of use thereof |
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Publication number | Priority date | Publication date | Assignee | Title |
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US20090074936A1 (en) * | 2007-09-17 | 2009-03-19 | Schmidt James C | Energy beverage |
US20090162488A1 (en) * | 2007-12-21 | 2009-06-25 | The Concentrate Manufacturing Company Of Ireland | Beverage products and flavor systems having a non-sweetening amount of monatin |
US20090162483A1 (en) * | 2007-12-20 | 2009-06-25 | Wendy Lynn Constantine | Sports beverage and method of making |
US20090311382A1 (en) * | 2008-06-13 | 2009-12-17 | Bio Clinical Development, Inc. | Edible energy composition |
US20100285179A1 (en) * | 2007-11-16 | 2010-11-11 | Bioclinical Development, Inc | Edible energy composition with low caffeine |
-
2013
- 2013-05-14 CA CA2873403A patent/CA2873403A1/en not_active Abandoned
- 2013-05-14 MX MX2014013800A patent/MX345908B/en active IP Right Grant
- 2013-05-14 WO PCT/US2013/040842 patent/WO2013173265A1/en active Application Filing
- 2013-05-14 AU AU2013263025A patent/AU2013263025B2/en active Active
- 2013-05-14 SG SG11201407298TA patent/SG11201407298TA/en unknown
-
2014
- 2014-11-06 IL IL235535A patent/IL235535A0/en active IP Right Grant
- 2014-12-11 ZA ZA2014/09135A patent/ZA201409135B/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090074936A1 (en) * | 2007-09-17 | 2009-03-19 | Schmidt James C | Energy beverage |
US20100285179A1 (en) * | 2007-11-16 | 2010-11-11 | Bioclinical Development, Inc | Edible energy composition with low caffeine |
US20090162483A1 (en) * | 2007-12-20 | 2009-06-25 | Wendy Lynn Constantine | Sports beverage and method of making |
US20090162488A1 (en) * | 2007-12-21 | 2009-06-25 | The Concentrate Manufacturing Company Of Ireland | Beverage products and flavor systems having a non-sweetening amount of monatin |
US20090311382A1 (en) * | 2008-06-13 | 2009-12-17 | Bio Clinical Development, Inc. | Edible energy composition |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023009655A1 (en) * | 2021-07-27 | 2023-02-02 | Ingenious Ingredients, LP | Bioactive compositions and methods of use thereof |
Also Published As
Publication number | Publication date |
---|---|
MX345908B (en) | 2017-02-22 |
AU2013263025B2 (en) | 2017-03-30 |
MX2014013800A (en) | 2015-01-26 |
ZA201409135B (en) | 2016-07-27 |
AU2013263025A1 (en) | 2015-01-15 |
SG11201407298TA (en) | 2015-01-29 |
CA2873403A1 (en) | 2013-11-21 |
IL235535A0 (en) | 2015-01-29 |
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