WO2013166264A3 - Methods for altering virus replication - Google Patents
Methods for altering virus replication Download PDFInfo
- Publication number
- WO2013166264A3 WO2013166264A3 PCT/US2013/039234 US2013039234W WO2013166264A3 WO 2013166264 A3 WO2013166264 A3 WO 2013166264A3 US 2013039234 W US2013039234 W US 2013039234W WO 2013166264 A3 WO2013166264 A3 WO 2013166264A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- viral replication
- virus
- altering
- virus replication
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
- C12N2310/141—MicroRNAs, miRNAs
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/10—Applications; Uses in screening processes
- C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/10—Applications; Uses in screening processes
- C12N2320/12—Applications; Uses in screening processes in functional genomics, i.e. for the determination of gene function
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Abstract
Provided herein are methods for altering viral replication in a cell. The virus may be a member of the family Orthomyxoviridae, such as an influenza virus, or a member of the family Paramyxoviridae, such as human respiratory syncytial virus. Altering viral replication is accomplished through the use of polynucleotides. In one embodiment, a polynucleotide decreases expression of a polypeptide, such as a protease or a kinase. In one embodiment, a polynucleotide is an miRNA or an miRNA inhibitor. In some embodiments viral replication is decreased, and in other embodiments viral replication is increased. Also included are methods for treating a subject, and genetically modified cells having the characteristic of altered virus replication compared to a control cell.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261641664P | 2012-05-02 | 2012-05-02 | |
US61/641,664 | 2012-05-02 |
Publications (2)
Publication Number | Publication Date |
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WO2013166264A2 WO2013166264A2 (en) | 2013-11-07 |
WO2013166264A3 true WO2013166264A3 (en) | 2014-01-16 |
Family
ID=49515035
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2013/039234 WO2013166264A2 (en) | 2012-05-02 | 2013-05-02 | Methods for altering virus replication |
Country Status (1)
Country | Link |
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WO (1) | WO2013166264A2 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017007784A1 (en) * | 2015-07-06 | 2017-01-12 | University Of Georgia Research Foundation | Methods and compositions related to increased influenza virus production |
CN108884461A (en) | 2015-11-24 | 2018-11-23 | 联邦科学技术研究组织 | Virus is generated in birds, beasts and eggs |
US11174466B2 (en) | 2015-11-24 | 2021-11-16 | Commonwealth Scientific And Industrial Research Organisation | Production of viruses in cell culture |
MA45496A (en) | 2016-06-17 | 2019-04-24 | Hoffmann La Roche | NUCLEIC ACID MOLECULES FOR PADD5 OR PAD7 MRNA REDUCTION FOR TREATMENT OF HEPATITIS B INFECTION |
KR102619197B1 (en) | 2017-01-23 | 2024-01-03 | 리제너론 파마슈티칼스 인코포레이티드 | HSD17B13 variant and its uses |
JP2020516283A (en) | 2017-04-11 | 2020-06-11 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | Assay for screening the activity of modulators of hydroxysteroid (17-beta) dehydrogenase (HSD17B) family members |
WO2019075181A1 (en) | 2017-10-11 | 2019-04-18 | Regeneron Pharmaceuticals, Inc. | Inhibition of hsd17b13 in the treatment of liver disease in patients expressing the pnpla3 i148m variation |
SG11202003461TA (en) | 2017-10-16 | 2020-05-28 | Hoffmann La Roche | NUCLEIC ACID MOLECULE FOR REDUCTION OF PAPD5 AND PAPD7 mRNA FOR TREATING HEPATITIS B INFECTION |
CA3103054A1 (en) | 2018-07-03 | 2020-01-09 | F. Hoffmann-La Roche Ag | Oligonucleotides for modulating tau expression |
CA3123890A1 (en) * | 2019-01-04 | 2020-07-09 | Cargill Incorporated | Engineered nucleases to generate mutations in plants |
CN110261611B (en) * | 2019-06-14 | 2021-06-22 | 上海四核生物科技有限公司 | Application of ZNF709 protein as gastric cancer serum biomarker and kit thereof |
WO2022119560A1 (en) * | 2020-12-01 | 2022-06-09 | National Health Research Institutes | Cell strain having increased virus production ability and production method thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002057461A2 (en) * | 2001-01-18 | 2002-07-25 | Bayer Aktiengesellschaft | Regulation of human adam-ts-like zinc metalloprotease |
US20090170720A1 (en) * | 2004-10-15 | 2009-07-02 | Galapagos Nv | Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases |
WO2011017535A2 (en) * | 2009-08-05 | 2011-02-10 | University Of South Florida | Method of rapidly visualizing essential neural pathways |
WO2012045067A2 (en) * | 2010-10-01 | 2012-04-05 | Zirus, Inc. | Mammalian genes involved in infection |
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2013
- 2013-05-02 WO PCT/US2013/039234 patent/WO2013166264A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002057461A2 (en) * | 2001-01-18 | 2002-07-25 | Bayer Aktiengesellschaft | Regulation of human adam-ts-like zinc metalloprotease |
US20090170720A1 (en) * | 2004-10-15 | 2009-07-02 | Galapagos Nv | Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases |
WO2011017535A2 (en) * | 2009-08-05 | 2011-02-10 | University Of South Florida | Method of rapidly visualizing essential neural pathways |
WO2012045067A2 (en) * | 2010-10-01 | 2012-04-05 | Zirus, Inc. | Mammalian genes involved in infection |
Non-Patent Citations (1)
Title |
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MELIOPOULOS.: "UNDERSTANDING HOST PROTEASE GENE INVOLVEMENT DURING INFLUENZA VIRUS REPLICATION AS A POTENTIAL DISEASE INTERVENTION STRATEGY", DOCTORAL DISSERTATION, December 2011 (2011-12-01), pages 1 - 222 * |
Also Published As
Publication number | Publication date |
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WO2013166264A2 (en) | 2013-11-07 |
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