WO2013162933A2 - Active halogen antimicrobial composition and method of use - Google Patents
Active halogen antimicrobial composition and method of use Download PDFInfo
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- WO2013162933A2 WO2013162933A2 PCT/US2013/036614 US2013036614W WO2013162933A2 WO 2013162933 A2 WO2013162933 A2 WO 2013162933A2 US 2013036614 W US2013036614 W US 2013036614W WO 2013162933 A2 WO2013162933 A2 WO 2013162933A2
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
Definitions
- the present invention relates to an antimicrobial composition which is effective in decontaminating surfaces, delivery methods for applying the antimicrobial composition to the surface, and the method of decontaminating those surfaces.
- Antimicrobial compositions for decontamination, disinfection and/or sanitization must have an effective microbial kill rate to be suitable for use as decontamination, disinfection and/or sanitization compositions.
- These antimicrobial compositions are generally desirable to be low in corrosion to the surfaces being treated and to be low in odor.
- these compositions generally will only contain enough of the microbial control agent to be effective for a given application. Having too much of the microbial control agent does not provide any advantages to the resulting composition, essentially wasting any excess microbial control agent in the composition. Having too little microbial control agent will make the composition less than effective than needed for its intended use.
- Stabilized active halogen solutions have been used for the treatment of recirculated industrial cooling waters and are known in the art. Such products are typically used as-provided and applied at relatively low concentrations to achieve biocidal control of vegetative microbiological species in the recirculated water.
- stabilized active halogen solutions examples include Stabrex ® from Nalco Inc., which is generally described in US Patents 5,942,126; 6,007,726; 5,683,654;
- solutions typically contain a bromine stabilizer, such as sulfamic acid, and a source of active bromine and are generally provided to the user at elevated pH.
- the solutions are applied at a relatively low concentration, generally less than about 100 ppm of product, which generally translates to less than 10 ppm active halogen as CI2.
- These low application rates are insufficient to significantly alter the system pH, and the thus observed efficacy is that associated with the low level active halogen applications at an elevated pH.
- Such utility is insufficient to achieve hard surface disinfection, sanitation or sporicidal performance targets.
- Clostridium difficile commonly called C. diff.
- HAIs Hospital Acquired Infections
- the difficulty in controlling C. diff. results from the durability of the spore form. Since C. diff. spores are difficult to deactivate and kill, relatively high concentrations of aggressive disinfectants are required to control outbreaks when they occur.
- Chlorine bleach sodium
- hypochlorite and peracetic acid compositions at relatively high concentrations are examples of disinfectants used that are effective against C. diff. spores.
- both chlorine bleach and peracetic acid compositions present significant
- active halogen-containing compositions may be modified to form compositions which achieve sufficient efficacy for sanitizing, disinfecting and sporicidal applications and may additionally provide more favorable handling characteristics, such as reduced odor.
- an antimicrobial composition contains an active halogen-containing component and an acidic component.
- the active halogen-containing component will have an elevated pH (typically above a pH of 9).
- the acidic component is added to the active halogen-containing component in an amount sufficient to reduce the pH of the antimicrobial composition to a value lower than about 8.
- the pH of the active halogen-containing component containing composition is reduced, the resulting antimicrobial composition has been discovered to be effective as a disinfectant and, particularly, as a sporicide.
- the active halogen in the active halogen-containing component may be any halogen, but is typically active chlorine, active bromine or active iodine. Of these active halogens, active bromine is of the most interest.
- the active halogen-containing component contains an active halogen source derived a compound selected from the group consisting of bromine, bromine chloride, halogenated cyanurate, alkaline earth metal hypohalites, alkali metal hypohalites, chlorine gas, a halogenated hydantoin and mixtures thereof.
- an active halogen source derived a compound selected from the group consisting of bromine, bromine chloride, halogenated cyanurate, alkaline earth metal hypohalites, alkali metal hypohalites, chlorine gas, a halogenated hydantoin and mixtures thereof.
- the acidic component may be a strong acid selected from the group consisting of hydrochloric acid, nitric acid, phosphoric acid, sulfuric acid, and sulfamic acid; a partial salt of a strong acid selected from the group consisting of bisulfates, and dihydrogen phosphates; a weak acid selected from the group consisting of lactic acid, tartaric acid, citric acid, oxalic acid, glucolic acid, acetic acid, ascorbic acid, carbonic acid, salicylic acid, benzoic acid, maleic acid, succinic acid, gluconic acid, adipic acid and boric acid; a partial salt of a weak acids selected from the group consisting of bicarbonates, citrates, tartates, oxalates, glucolates, acetates, ascorbates, salicylates, benzoates, maleates, succinates, gluconates, adipates, and borates; a strong acid selected from the group consisting of hydro
- the acidic component is added to the composition in an amount to reduce the pH of the antimicrobial composition to a pH of 7.0 or below, typically to a pH of 6.0 or below, more typically a pH of 4.0 or below and most typically to a pH of 3.0 or below.
- the acidic component may have a pH of below 3.
- the antimicrobial composition may further contain a stabilizer.
- Suitable stabilizers include compounds that have N-H groups.
- One exemplary stabilizer is sulfamic acid.
- the stabilizer may be added to the active halogen-containing component or to the acid component.
- the antimicrobial composition will have concentration of the total active halogen in the resulting antimicrobial composition should generally be in the range between about 25 ppm and about 60,000 ppm, based on the total weight of the antimicrobial composition, on a CI2 equivalent basis. More typically, the total active halogen in the resulting antimicrobial composition will be in the range between about 50 ppm and 12,000 ppm, on a CI2 equivalent basis.
- the total active halogen in the resulting composition will be in the range of about 500 ppm and 10,000 ppm, on a CI2 equivalent basis.
- the total active halogen in the composition may be in the range of about 1000 ppm to about 9000 ppm and more typically between about 4,000 ppm and 8,000 ppm, on a Cl 2 equivalent basis.
- Other suitable ranges may also be used, for example in the range of about 5000 ppm to about 7000 ppm.
- the antimicrobial compositions contains the active halogen-containing component which is an active halogen source selected from the group consisting of bromine, bromine chloride, chlorinated cyanurate, calcium hypochlorite, chlorine gas, sodium hypochlorite, sodium hypobromite, lithium hypochlorite, lithium hypobromite, a halogenated hydantoin and mixtures thereof; and an acidic component is a strong acid selected from the group consisting of hydrochloric acid, phosphoric acid, sulfuric acid, and sulfamic acid; a partial salt of a strong acid selected from the group consisting of bisulfates, and dihydrogen phosphates; a weak acid selected from the group consisting of lactic acid, tartaric acid, citric acid, oxalic acid, glucolic acid, acetic acid, ascorbic acid, carbonic acid, salicylic acid, benzoic acid, maleic acid, succinic acid, gluconic acid
- the composition further contains an N-H containing compound as a stabilizer.
- the total active halogen concentration in the composition is between about 500 and 10,000 ppm on a CI2 equivalent basis and in particular the total active halogen concentration in the composition is between about 4000 and 8,000 ppm on a Cl 2 equivalent basis.
- a stable two-part antimicrobial composition having a first part which contains an active halogen-containing component having a source of an active halogen and having an elevated pH.
- the second part contains an acidic component.
- the first and second parts of the composition are kept separate from each other during storage and prior to use. The first part and the second part are mixed together just prior to use to obtain an antimicrobial composition.
- the active halogen remains stable and active during storage of the composition prior to use.
- the resulting antimicrobial composition can be stored for a defined period of time after mixing, while remaining effective.
- the first part is mixed with the second part, the resulting antimicrobial composition has been discovered to be effective as a disinfectant and, particularly, as a sporicide.
- the active halogen in the active halogen-containing component of the two-part composition may be any halogen, but is typically active chlorine, active bromine or active iodine. Of these active halogens, active bromine is of the most interest.
- the active halogen-containing component of the two- part composition contains an active halogen source derived a compound selected from the group consisting of bromine, bromine chloride, chlorinated cyanurate, calcium hypochlorite, chlorine gas, sodium hypochlorite, sodium hypobromite, lithium hypochlorite, lithium hypobromite, a halogenated hydantoin and mixtures thereof.
- an active halogen source derived a compound selected from the group consisting of bromine, bromine chloride, chlorinated cyanurate, calcium hypochlorite, chlorine gas, sodium hypochlorite, sodium hypobromite, lithium hypochlorite, lithium hypobromite, a halogenated hydantoin and mixtures thereof.
- the acidic component of the two-part composition may be a strong acid selected from the group consisting of hydrochloric acid, nitric acid, phosphoric acid, sulfuric acid, and sulfamic acid; a partial salt of a strong acid selected from the group consisting of bisulfates, and dihydrogen phosphates; a weak acid selected from the group consisting of lactic acid, tartaric acid, citric acid, oxalic acid, glucolic acid, acetic acid, ascorbic acid, carbonic acid, salicylic acid, benzoic acid, maleic acid, succinic acid, gluconic acid, adipic acid and boric acid; a partial salt of a weak acids selected from the group consisting of bicarbonates, citrates, tartates, oxalates, glucolates, acetates, ascorbates, salicylates, benzoates, maleates, succinates, gluconates, adipates, and
- the acidic component of the two-part composition is added to the first part in an amount to reduce the pH of the resulting antimicrobial composition to a pH of 7.0 or below, typically to a pH of 6.0 or below, more typically a pH of 4.0 or below and most typically to a pH of 3.0 or below.
- the acidic component may have a pH of below 3.
- the acidic component may contain a bromine containing compound as the source of bromine in the two-part antimicrobial composition.
- the two-part antimicrobial composition may further contain a stabilizer.
- the stabilizer may be present in the first part, or the second part, or both the first and second parts.
- Suitable stabilizers include compounds that have N-H groups.
- One exemplary stabilizer is sulfamic acid.
- the stabilizer may be added to the active halogen-containing component or to the acid component.
- two-part composition may be provided the end user in various ways.
- the first part is provided in a first container and the second part is provided in second container and the amount of the first part in the first container and the amount of the second part in the second container are proportional such that the entire contents of both containers are mixed together to form an antimicrobial composition.
- the first part and the second part are in a single container, wherein the first part is separated from the second part in the container by a separator.
- the separator may be removable from the container or movable in the container to allow the first part and the second part can mix together in the container.
- the container further have a spray head and the first part and the second part are mixed in the spray head as the composition is applied to the surface to be treated.
- the first part and the second part are provided in containers where a portion of the first part and a portion of the second part from each container are mixed together.
- a diluent may be added any of the above-described or herein-described antimicrobial compositions to reduce the concentration of the active halogen into a desired concentration range.
- the antimicrobial composition may also be saturated into a wipe and the wipe may be used to apply any of the above-described or herein-described antimicrobial composition to a surface to be treated.
- the antimicrobial composition may be in the form of a liquid that is sprayed, poured or otherwise applied onto a surface to be treated with the antimicrobial composition.
- a method of disinfecting a surface which includes applying any of the above-described or herein-described antimicrobial composition to the surface.
- a method of controlling spores on a surface in this method, any of the above-described or herein-described antimicrobial
- compositions is applied to the surface.
- the present invention relates to an antimicrobial composition containing active halogen-containing component and an acidic component. It has been discovered that the acidic component enhances the activity of the active halogen containing component in the antimicrobial composition when the antimicrobial composition has a pH of 8 or less.
- the resulting acidified active halogen-containing antimicrobial composition has an improved antimicrobial efficacy, and, particularly results in a composition having sporicidal efficacy.
- the antimicrobial composition described herein is especially effective as a disinfectant composition used to kill C. diff. spores.
- the acidified active halogen-containing antimicrobial composition can also have additional advantages of having reduced odor, as compared to currently available sporicidal compositions.
- the active halogen-containing component usable in the present invention may be derived from halogen sources including active chlorine, bromine, or iodine. Generally, the active halogen will contain at least active bromine as the active halogen; however the other halogens may be used.
- the active halogen- containing component is prepared from a source of an active halogen, such as bromine; bromine chloride; halogenated cyanurates; such as chlorinated cyanurates (mono chlor, dichlor and trichlor); halogenated cyanuric acid; alkaline earth metal hypohalites such as, calcium hypochlorite; chlorine gas; alkali metal hypohalites such as, sodium hypochlorite, sodium hypobromite, lithium hypochlorite, lithium hypobromite; halogenated hydantoins, and the like. It is also possible to use more than one of these active halogen-containing components as a source of the halogen.
- an active halogen such as bromine; bromine chloride; halogenated cyanurates; such as chlorinated cyanurates (mono chlor, dichlor and trichlor); halogenated cyanuric acid; alkaline earth metal hypohalites such as, calcium hypochlorite; chlorine gas; al
- bromine in the composition may be derived from a bromine-containing compound which is added to the composition containing an active chlorine- containing compound.
- the bromine source may be derived from a bromine compound such as sodium bromide, potassium bromide and other similar bromine containing compounds.
- the bromide is activated to form active bromine by another source of active halogen in the composition, for example, active chlorine.
- bromine has advantages over chlorine in that bromine typically has a less offensive odor as compared to chlorine. Also it has been discovered that bromine has superior efficacy in the presence of a nitrogenous substances, as described herein.
- the active halogen-containing component is generally in a solution with the active halogen-containing component dissolved in the solution.
- the active halogen solution will have an elevated pH.
- elevated pH it is intended that the solution has a pH in the basic range, typically above a pH of about 9.0.
- Active halogen solutions need to have an elevated pH to provide acceptable stability of the solution during production and storage. Not wishing to be bound by theory, but it is believed that the elevated pH minimizes the formation of the acid forms of the contained hypohalites, thus slowing the disproportionation reaction of the acid forms, which is generally the primary route of decomposition.
- active halogen- containing solutions thus are prepared at elevated pH, typically a pH greater than about 10.0 or more, so that the active halogen compound does not dissipate.
- an elevated pH solution is formed.
- This elevated pH solution is generally prepared by adding a basic component, such as sodium hydroxide to an aqueous solution.
- a basic component such as sodium hydroxide
- Other basic materials may be used to prepare the elevated pH solution without departing from the scope of the present invention.
- the active halogen source is added to the elevated pH solution which results in the active halogen-containing solution having an elevated pH.
- Other methods known in the art to form halogen-containing solutions may also be used.
- the active halogen-containing solution will generally be a concentrated halogen-containing solution, having a halogen content well above the typical concentration needed for disinfecting.
- the pH of the active halogen- containing solution is above about 9.0, more typically above 9.5, and most typically about 10.0 or above.
- the active halogen-containing component is stabilized in the solution by the addition of a stabilizer, which is described in more detail below.
- an acidic component is added to the active halogen-containing component.
- the acid serves to reduce the pH of the active halogen-containing component so that the active halogen-containing component in solution can be made useful as a
- Suitable acidic components include both strong acids, partial salts of strong acids, weak acids, partial salts of weak acids and mixtures thereof.
- Suitable strong acids include, but are not limited to, hydrochloric acid, nitric acid, phosphoric acid, sulfuric acid, and sulfamic acid.
- Suitable partial salts of strong acids include bisulfates, and dihydrogen phosphates partial salts, including, but are not limited to, sodium bisulfate, sodium dihydrogen phosphate and potassium dihydrogen phosphate.
- Suitable weak acids include, but are not limited to, lactic acid, tartaric acid, citric acid, oxalic acid, glucolic acid, acetic acid, ascorbic acid, carbonic acid, salicylic acid, benzoic acid, maleic acid, succinic acid, gluconic acid, adipic acid and boric acid.
- Suitable partial salts of weak acids include, but not limited to,
- the salts may be sodium salts, potassium salts, calcium salts, magnesium salts and the like.
- An exemplary partial salt of a weak acid includes, but not limited to, sodium bicarbonate. In addition mixtures of these acids may be used as the acidic component of the antimicrobial composition.
- the acidic component is added to the active halogen-containing solution to form the antimicrobial composition.
- the acid component is added in an amount to form an antimicrobial solution having a pH which is about 8 or lower.
- the acidic component is added to the active halogen-containing solution to form an antimicrobial composition which has a pH of about 7 or below, and more particularly a pH of about 6 or below.
- the pH of the solution can be even lower, for example, a pH of about 4 or below.
- the pH of the solution can be still even lower, for example, a pH of about 3 or below Again, the pH is adjusted by adding the acidic component.
- the concentration of the total active halogen in the resulting antimicrobial composition should generally be in the range between about 25 ppm and about 60,000 ppm, based on the total weight of the antimicrobial composition, on a CI2 equivalent basis. Concentrations above about 60,000 ppm, may be used in the present invention. More typically, the total active halogen in the resulting antimicrobial composition will be in the range between about 50 ppm and 12,000 ppm, on a CI2 equivalent basis.
- the total active halogen in the resulting composition will be in the range of about 500 ppm and 10,000 ppm, on a Cl 2 equivalent basis.
- the total active halogen in the composition may be in the range of about 1000 ppm to about 9000 ppm and more typically between about 4,000 ppm and 8,000 ppm, on a CI2 equivalent basis.
- Other suitable ranges may also be used, for example in the ranges of about 5000 ppm to about 7000 ppm.
- Active halogen as C ⁇ can be measured using methods know to those skilled in the art, for example by thiosulfate titration and colorimetric N,N- diethyl-p-phenylenediamine (DPD).
- Suitable stabilizer compounds which are classified as N-hydrogen compounds, include essentially any compound that stabilizes or complexes the active halogen in solution.
- N-hydrogen compounds are compounds which have an N-H group which is free to react and complex with active halogens.
- Exemplary classes of compounds include, for example, ammonium compound, sulfonamides, hydantoins, urea compounds, cyanuric compounds, oxizolidinone compounds and other similar compounds.
- ammonium compounds including but not limited to ammonium sulfate, ammonium chloride, ammonium carbonate, ammonium bromide; methanesulfonamide, glycoluril, dimethyl hydantoin, methyl ethyl hydantoin, urea, cyanuric acid and other similar compounds.
- suitable stabilizers include the stabilizers or mixtures, such as the mixtures described in US Patent Application Publication US 2012/01 14632 entitled “Stabilized Active Halogen Solutions" to Janek et al., which is hereby incorporated by reference.
- One particularly useful compound is sulfamic acid.
- Sulfamic acid may function as both the acid component and the stabilizer since sulfamic acid has the stabilizer moiety N-H in the structure. Without the stabilizer or stabilizer moiety, the addition of the acid to the active halogen- containing solution could result in the generation of halogen gas.
- the stabilizer is added to the active halogen-containing solution to further provide stability to the active halogen-containing solution. It is believed that stabilizer should be added in an amount of about 0.2 moles to about 2.0 moles of the N-hydrogen compound per mole of active halogen in the active halogen-containing solution and is typically added in an amount of about 0.4 moles to about 1 .25 moles of the N-hydrogen compound per mole of active halogen in the active halogen-containing solution. More typically, there is about 0.5 moles to about 1 .0 moles of the N-hydrogen compound per mole of the active halogen.
- the molar ratio is closer to 0.5, and when the active N-hydrogen compound has only one N-H group, then the stabilizer present at a molar ratio closer to 1 .0. It is noted that more or less of the stabilizer may be used, without departing from the scope of the invention, provided that stabilizing effect is achieved.
- the active halogen-containing component When sulfamic acid is added to the active halogen-containing component as the stabilizer, it is added in an amount that will not reduce the pH of the active-containing component below a pH of 9.0. Therefore, it is possible that the active halogen-containing component may contain an acidic compound. However, this acidic compound is distinct from the acidic component which is added to reduce the pH of the active halogen-containing component, even though the acid compound in the active halogen-containing component is the same as the acid in the acidic component.
- the addition of the stabilizer also serves to improve the shelf life of the antimicrobial composition once prepared.
- the stabilizer serves to reduce the rate in which the activity of the active halogen, in the active halogen-containing compound alone or in solution, is diminished over time. Further, it is also believed that the stabilizer contributes to the low overall odor of the resulting compositions, versus the active halogen-containing compound in a solution at an elevated pH.
- the stabilizer is combined with the active halogen-containing component, prior to the addition of the acidic component.
- the active halogen-containing component is part of a “stabilized active halogen-containing component", or a “stabilized active halogen containing solution”, in the case of the active halogen containing component is part of a solution, each having an elevated pH.
- elevated pH it is intended that the solution has a pH in the basic range, generally above a pH of about 9.0.
- stabilized active halogen solutions need to have an elevated pH to provide acceptable stability of the solution during production and storage.
- stabilized active halogen solutions thus are prepared at elevated pH, typically a pH greater than about 10.0 or more.
- the stabilized active halogen-containing solution also typically contains a stabilizer component which functions as a complexing agent.
- the stabilizer components described above may be used.
- One particularly effective stabilizer component for the active halogen-containing solutions is sulfamic acid, which has the ability to complex with the halogen to stabilize the halogen in solution. Sulfamic acid serves as stabilizer for the halogens in the solution. It is noted that the amount of the sulfamic acid added to the active halogen-containing solution for the purposes of stabilization does not reduce the pH out of the elevated range.
- the first step is to disperse the stabilizer component into an aqueous solution. As such, water is also a component of the stabilized active halogen-containing solution.
- an elevated pH solution is formed.
- the aqueous solution with an elevated pH contains of a stabilizer, for example sulfamic acid and, an alkali or alkaline metal containing basic compound.
- suitable alkali or alkaline metal salts include, but not limited to, for example alkali and alkaline carbonates, bicarbonates, oxides and hydroxide. Particularly useful are sodium hydroxide and potassium hydroxide, which will form a sulfamate salt of the sulfamic acid.
- the basic compound is added in excess, which causes the pH of the resulting solution to be elevated.
- the halogen source is added to the solution which results in the stabilized halogen-containing solution having an elevated pH.
- the stabilized active halogen-containing solutions will generally be a concentrated active halogen-containing solution, having a halogen content well above the typical concentration needed for disinfecting.
- the pH of the stabilized halogen-containing solution is about 9.0 or above, more typically 9.5 or above and most typically about 10.0 or above.
- the antimicrobial composition will be provided as a two-part system. This is because the activity of the antimicrobial composition diminishes with time once the acidic component is added to the active halogen-containing compound.
- the antimicrobial composition will have efficacy for about 7-30 days.
- the two parts of the two-part system will include Part A, which contains the active halogen-containing component, and Part B, which contains the acidic component.
- the stabilizer when used, may be present in either Part A or Part B.
- the resulting composition will have a resulting pH 8.0 or lower.
- This two part system can be delivered for mixing at the point of use by either the provision of two distinct products, or using specialized packaging that separates the two parts until the contents are applied, or provision of two separate products for use in an automated diluting device that meters in the proper amount of each part into a receiving container.
- the two part system can also be used to adjust the active halogen concentration to the desired level.
- Suitable two-part systems may include ready to use (RTU) solutions, where the two parts are mixed together and the resulting composition has the desired concentration of the active halogen and pH; or dilutable solutions where the two parts are mixed together to form a concentrated solution that needs to be diluted with water prior to use.
- RTU solutions may be prepared by mixing two liquids together, or adding a solid to a liquid.
- the RTU solutions may be provided in two separate containers or may be provided in a single container with a removable or breakable separator means that allows the two parts of the composition to be mixed together.
- an RTU solution may formed by drawing portions of Part A from one part of a container and a complementary portion from another part of the same container as the composition is released from the container.
- the RTU solution is prepared by having Part A and Part B drawn from a bulk container via an automated dilution device that meters out appropriate amounts of each part to obtain a ready to use solution.
- An exemplary means would be a spray means that mixes the parts in appropriate ratios prior to release from the container.
- Part A and Part B may be mixed in the spray head prior to release form the container.
- Another two-part system may form a solution which is concentrated and needs to be diluted prior to use. These are referred to as dilutable solutions.
- Dilutable solutions are solutions where the two parts are mixed together to form a concentrated solution and additional ingredients, such as water need to be mixed with the solution prior to use to ensure that the composition has the appropriate concentration prior to use.
- Dilutable solutions can be in the form of two separate containers of Part A and Part B that are added to a third container containing water.
- Alternative dilutable solutions can be formed where one of the Parts is first diluted with water prior to mixing with the other part. For example, if Part B is a concentrated solution, the concentrated solution is first diluted with an appropriate amount of water prior to addition to Part A.
- Part A and/or Part B is a solid, such as a powder or tablet
- the powder or tablet is generally first dissolved in water prior to addition of the complementary part.
- the solid may be placed in a water soluble pouch, a foil pouch, a sachet or a plastic container.
- Dilutable solutions may be made by using an automated dilution device which meters out appropriate amounts of each Part A and Part B from bulk containers into a delivery container, which is mixed with water that is present in the delivery or final use container, or with water that is added to the delivery or final use container as Part A and Part B are being added to the container or with water that is added after Part A and Part B are added to the delivery or final use container.
- the particular method the antimicrobial composition is prepared from Part A and Part B in not critical to the present invention, so long as the resulting composition has sufficient concentration of the active halogen and the pH is 8.0 or below.
- additives such as buffers, corrosion inhibitors, surfactants, chelators, builders, dyes and/or fragrances and the like, may be added.
- the antimicrobial composition can be delivered to a surface to be cleaned, sanitized or disinfected by conventional means such as pouring the composition on a surface, a spray, which is applied to a surface via a spray means, including but not limited to, pump spray applicators, pressurized spray applicators and the like; a saturated wipe; a rag and a bucket; a mop and bucket; a sponge and a bucket; or via automated cleaning equipment and other similar and conventional ways to apply an antimicrobial composition to a surface for the purposes of sanitizing or disinfecting the surface.
- a spray means including but not limited to, pump spray applicators, pressurized spray applicators and the like
- a saturated wipe including but not limited to, pump spray applicators, pressurized spray applicators and the like
- a saturated wipe including but not limited to, pump spray applicators, pressurized spray applicators and the like
- a saturated wipe including but not limited to, pump spray applicators, pressurized spray applicators
- Another possible means of application is preparation of ready to use solutions at the point of manufacture of the stabilized active halogen solution in combination with the acid at the desired active halogen concentration.
- Such solutions can be provided as the solution by itself or in combination with a wipe substrate.
- saturated wipes can be prepared by saturating wipes in a container with a antimicrobial solution made just prior to saturation in the wipe substrate.
- Suitable wipe substrates include woven and nonwoven materials.
- Nonwoven materials can be meltblown, coform, spunbond, airlaid, hydroentangled nonwovens, spunlace, bonded carded webs, and laminates thereof.
- the fibers used to prepare the wipe substrate may be cellulosic fiber, thermoplastic fibers and mixtures thereof.
- the fibers may also be continuous fibers, discontinuous fibers, staple fibers and mixtures thereof.
- a surface is treated with the substrate by spraying, pouring, wiping or otherwise applying the antimicrobial composition to the surface. Once applied to the surface, the
- antimicrobial composition is allowed to remain on the surface for a period of time.
- the antimicrobial composition may be applied to the surface and allowed to dry or may alternatively be dried by wiping the surface with a dry wipe or wiping device.
- Active halogen-containing compounds and active halogen-containing compound solutions having an elevated pH have been found to be insufficient to achieve hygienic disinfection targets, when used as provided at the elevated pH. Further, it has been discovered that dilution of stabilized active halogen products into water is also ineffective in achieving sporicidal efficacy. At typical levels of active ingredient concentrations that are generally found in disinfectants, diluted active halogen products have been found not to be effective as sporicidal composition alone.
- the efficacy of active halogen-containing compounds and solutions containing the active-halogen containing compound can be sufficiently enhanced for utility in hygienic disinfection applications by reducing the pH through acidification. It has been discovered that lowering the pH of the halogen-containing solutions, in particular stabilized active halogen-containing solutions, (a solution containing a stabilizer as described above) by the addition of an acidic component to adjust the pH level to about 8.0 or less of the resulting composition, results in a composition having disinfecting efficacy, and, particularly a composition having sporicidal efficacy. As such, the antimicrobial composition described herein is especially effective as a disinfectant solution used to kill C. diff. spores.
- the acidified solution of stabilized active halogen achieve enhanced efficacy desired for sporicidal applications
- the acidified application also has additional advantages of having a reduced odor, as compared to currently available sporicidal compositions. It has also been discovered that the compositions of the present invention also have an enhanced ability to pass the use dilution test.
- the antimicrobial composition of the present invention has utility as a disinfecting composition.
- the antimicrobial composition has a special utility when used in locations where C. diff. may be present including in health care facilities, such as doctor's offices, operating rooms, hospital rooms, emergency rooms, urgent care facilities and the like.
- the composition may also be used in veterinary facilities, daycare facilities, nursing homes and other similar locations where disinfecting or surfaces is necessary.
- compositions are generally compatible with floor finishes and will not remove such finishes.
- the composition generally leaves a low residue on the surface treated and generally does not streak on hard surfaces.
- Stabrex ® 20 is a stabilized bromine containing solution having a pH of about 13 and containing about 14% active bromine and is available from Nalco, having an office at 1601 W. Diehl Road, Naperville, IL 60563-1 198.
- BromMax ® 7.1 is a stabilized bromine containing solution containing sulfamic acid and sodium hydroxide having pH of about 13 and containing between about 16% active bromine and is made in accordance with US Patents 7,045,153 and 7,455,859, which are hereby incorporated by reference it their entirety. BromMax ® 7.1 is available from Enviro Tech Chemicals, having an office at 500 Winmoore Way, Modesto, CA 95358.
- stabilized bromine provided a lower and less noxious odor than other materials utilized as sporicides.
- Part A A 10g portion of Part A, commercial "6%" sodium hypochlorite solution (Clorox) was added to 90 grams of Part B, an aqueous solution containing 1 .9 grams of aqueous 46% NaBr and 0.82g sulfamic acid (SA).
- the initial pH of Part A solution was > 12.0, and the initial pH of solution Part B was 1 .1 .
- Active halogen a 10g portion of Part A, commercial "6%" sodium hypochlorite solution (Clorox) was added to 90 grams of Part B, an aqueous solution containing 1 .9 grams of aqueous 46% NaBr and 0.82g sulfamic acid (SA).
- SA sulfamic acid
- An acidified solution of stabilized active halogen-containing active bromine was produced by combining: Part A, commercial grade sodium hypochlorite and Part B, a mixture of sulfamic acid and sodium bromide. Generation of an acidified stabilized active halogen solution was demonstrated by the observation of a reduced pH (relative to commercial NaOCI) and a stable target active halogen concentration.
- Part A commercial "6%" sodium hypochlorite solution (Clorox) was added to 90 grams of Part B, an aqueous solution containing 1 .9 grams of aqueous 46% NaBr and 1 .64g sulfamic acid (SA).
- SA sulfamic acid
- hypochlorite and Part B aqueous sulfamic acid.
- Generation of an acidified stabilized active halogen solution was demonstrated by the observation of a reduced pH (relative to commercial NaOCI) and a stable target active halogen concentration.
- Part A commercial "6%" sodium hypochlorite solution (Clorox) was added to 90 grams of Part B, an aqueous solution containing 1 .64g sulfamic acid (SA).
- SA sulfamic acid
- the initial pH of Part A solution was > 12.0, and the initial pH of solution Part B was ⁇ 1 .0.
- Active halogen concentrations were measure using standard DPD methodology.
- An antimicrobial composition was prepared by combining sulfamic acid with a stabilized active halogen containing solution (BromMax ® 7.1 ) to obtain a pH of ⁇ 4.0.
- An antimicrobial composition was prepared by combining sulfamic acid (Part B) with a stabilized active halogen containing solution (Part A) (BromMax ® 7.1 ) to obtain a pH of ⁇ 4.0.
- the acidified stabilized active halogen containing antimicrobial composition was prepared by combining sulfamic acid (Part B) with a stabilized active halogen containing solution (Part A) (BromMax ® 7.1 ) to obtain a pH of ⁇ 4.0.
- a 12" X 1 1 " vinyl tile is placed in the bottom of the box. 10 grams of diluted finished product is absorbed onto a laboratory paper towel. The tile in the bottom of the box is wiped down with the paper towel. The paper towel is left inside the box and the top of the box is sealed with tape. [00103] Panelists were then asked to rank the odor in the based on both strength of odor from 0 to 10 with 0 being no odor and 10 being a very strong odor, as well as for pleasantness of odor, where 0 is very pleasant and 10 being very unpleasant / objectionable.
Abstract
Description
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CN201380031611.6A CN104394690A (en) | 2012-04-23 | 2013-04-15 | Active halogen antimicrobial composition and method of use |
BR112014026483-0A BR112014026483B1 (en) | 2012-04-23 | 2013-04-15 | ANTIMICROBIAL COMPOSITION |
EP13718749.8A EP2840893B1 (en) | 2012-04-23 | 2013-04-15 | Active halogen antimicrobial composition and method of use |
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CN105613489B (en) * | 2014-10-28 | 2020-01-07 | 艺康美国股份有限公司 | Microbial control system and use method thereof |
JP6020697B1 (en) * | 2015-11-09 | 2016-11-02 | 栗田工業株式会社 | Method for inhibiting concentration reduction of isothiazoline compounds |
US10897905B2 (en) | 2016-01-26 | 2021-01-26 | Metrex Research, LLC | Hypochlorite based hard surface disinfectants |
US10986841B2 (en) | 2018-11-06 | 2021-04-27 | The Clorox Company | Bleach compositions |
US11845916B2 (en) * | 2020-06-24 | 2023-12-19 | The Clorox Company | Burstable sporicidal cleaning wipe system containing stabilized hypochlorite |
WO2023063003A1 (en) * | 2021-10-13 | 2023-04-20 | オルガノ株式会社 | Disinfection composition and disinfection method |
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BR112014026483A2 (en) | 2017-06-27 |
EP2840893A2 (en) | 2015-03-04 |
US9220272B2 (en) | 2015-12-29 |
WO2013162933A3 (en) | 2013-11-21 |
BR112014026483B1 (en) | 2020-03-17 |
US20130280349A1 (en) | 2013-10-24 |
CN104394690A (en) | 2015-03-04 |
EP2840893B1 (en) | 2018-12-19 |
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