WO2013154768A1 - Apodisation de pupille optique afin de réduire le flou optique induit par conception de verre ophtalmique multifocal - Google Patents

Apodisation de pupille optique afin de réduire le flou optique induit par conception de verre ophtalmique multifocal Download PDF

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Publication number
WO2013154768A1
WO2013154768A1 PCT/US2013/032319 US2013032319W WO2013154768A1 WO 2013154768 A1 WO2013154768 A1 WO 2013154768A1 US 2013032319 W US2013032319 W US 2013032319W WO 2013154768 A1 WO2013154768 A1 WO 2013154768A1
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WO
WIPO (PCT)
Prior art keywords
apodization
lens
eye
pupil
optical
Prior art date
Application number
PCT/US2013/032319
Other languages
English (en)
Inventor
Geunyoung Yoon
Original Assignee
University Of Rochester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Rochester filed Critical University Of Rochester
Publication of WO2013154768A1 publication Critical patent/WO2013154768A1/fr

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Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes
    • G02C7/041—Contact lenses for the eyes bifocal; multifocal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/142—Cornea, e.g. artificial corneae, keratoprostheses or corneal implants for repair of defective corneal tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/06—Lenses; Lens systems ; Methods of designing lenses bifocal; multifocal ; progressive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1616—Pseudo-accommodative, e.g. multifocal or enabling monovision
    • A61F2/1618—Multifocal lenses
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C2202/00—Generic optical aspects applicable to one or more of the subgroups of G02C7/00
    • G02C2202/20—Diffractive and Fresnel lenses or lens portions

Definitions

  • the present invention is directed to pupil apodization and more particularly to pupil apodization for use with presbyopia.
  • the two factors affecting retinal image quality are the phase W(x,y) and the amplitude (transmission) A(x,y).
  • the pupil function P(x,y) is given by
  • the amplitude A(x,y) is the transmission function and is affected by such things as pupil size and apodization.
  • the phase W(x,y) is affected by wavefront aberrations, including refraction (sphere and cylinder) and higher-order aberrations (those of higher order than sphere and cylinder).
  • OSF optical transfer function
  • MTF modulation transfer function
  • Presbyopia The age-related lack of accommodation in the eye is called "presbyopia.” Since that happens to everybody at some point in life, there is a huge demand for therapeutic tools.
  • Such tools include spectacles (bifocal or progressive addition lens), multifocal contact lenses 102 or intraocular lenses 104 (IOL's) applied to the eye E ( Figures 1A and IB), refractive surgery performed on the cornea C of the eye E ( Figure 1C), and injection of elastic polymer gel.
  • Multifocal contact lenses or IOL's which increase depth of focus are one of the popular options used to overcome presbyopia.
  • those lenses cause halo (optical blur) around the image of objects, induced by the contribution of out-of-focus rays. That optical blur becomes significant for near vision, causing unsatisfactory performance for some patients.
  • Figure 2 shows the effect of optical pupil apodization, that is, variable-intensity attenuation in the pupil, in terms of normalized amplitude as a function of distance from the pupil center.
  • the examples are shown for radially symmetric Gaussian apodization for a 4 mm pupil diameter and include a flat top (uniform 100% transmission) and Gaussian curves with different widths (variable transmission).
  • Figure 3 shows the effects on a spot of no apodization (flat top) and Gaussian apodization. As seen, the apodization produces a smoother edge of the pupil at the expense of brightness at the edges.
  • Figure 4 shows the effect of pupil apodization in image quality in terms of reduction of optical blur (halo).
  • the example shows a reduction of the effects of defocus and spherical aberrations by converting the image produced by a flat top (no apodization) to the image produced by a Gaussian apodization such as one of the apodizations of Figure 2.
  • Figures 5 and 6 show that presbyopia-correcting intraocular lenses, especially multifocals, increase depth of focus effectively, but that they cause substantial halo, thus degrading image quality.
  • the present invention uses optical pupil apodization that reduces optical blur in images through focus (object distances from far to near), resulting in improved through-focus performance of a multifocal ophthalmic lens design. That is, the present invention combines multifocal design with optical pupil apodization to produce through-focus image quality with less halo.
  • the pupil amplitude apodization can mitigate the shortcomings of multifocal designs.
  • the present invention can be implemented with any suitable lens (spectacle, contact, IOL, etc.) and any suitable technique for pupil apodization.
  • Amplitude apodization reduces the impact of light rays from the pupil's periphery. It thus improves intermediate image quality for diffractive multifocals, improves near image quality with negative SA, and degrades near image quality with positive SA. Apodization is a promising approach for improving through-focus image quality in the presbyopic eye.
  • Figures 1A-1C are diagrams showing various known techniques for correcting vision
  • Figure 2 is a graph showing various forms of optical pupil apodization in terms of normalized amplitude
  • Figure 3 is a set of graphs and images showing the effect of apodization on a pupil
  • Figure 4 is a set of images showing the effect of optical pupil apodization in terms of reduction of optical blur
  • Figures 5 and 6 are sets of images showing halo caused by presbyopia-correcting intraocular lenses
  • Figure 7 is a set of curves for various degrees of apodization
  • Figure 8 is a set of images showing the results of multifocal design using spherical aberration with Gaussian pupil apodization
  • Figure 9 is a set of graphs showing three metrics for different values of defocus and different apodizations
  • Figures 10A and 10B are graphs showing the optical impact of amplitude optimization
  • Figure 11 is a set of images showing the results for a monofocal, aberration-free situation
  • Figure 12 is a set of images showing the results for a diffractive multifocal situation
  • Figure 13 is a set of images and graphs showing the results for a refractive bifocal situation
  • Figure 14 is a set of graphs and images showing the results for positive spherical aberration
  • Figure 15 is a set of graphs showing the results for negative spherical aberration
  • Figure 16 is a graph showing the visual benefits of apodization
  • Figure 17 is a diagram of a vision simulator
  • Figure 18 is a graph showing the results for no spherical aberration
  • Figures 19A and 19B are graphs showing the results with spherical aberration
  • Figures 20A and 20B are graphs showing the visual benefit and improvement in visual acuity.
  • Figure 21 is a block diagram of a system for implementing the preferred embodiment.
  • Figure 7 shows curves for no apodization (flat top) as well as Gaussian apodization functions with different widths.
  • Figure 8 shows the results of a multifocal design using spherical aberrations (primary and secondary) with Gaussian pupil apodization functions of different widths.
  • no apodization (the flat top) produces the best result for far defocus (0 D) and the worst result for near defocus (3.0 D), while for the narrowest apodization (width of 1.6 mm), the reverse is true.
  • the narrowest apodization provides the best result.
  • Figure 9 shows three metrics (areaMTF, VSOTF, and CCC) for different values of defocus and the different apodizations. It is seen again that while the narrowest apodization provides a poor result for 0 D defocus, it provides the best result overall.
  • Figures 10A and 10B show the optical impact of amplitude optimization.
  • Figure 10A shows the point spread function with and without apodization
  • Figure 10B shows the modulation transfer function with and without apodization.
  • the point spread function without apodization shows no side lobes and a larger full width at half maximum.
  • the modulation transfer function with apodization shows the same cutoff frequency and less contribution from higher spatial frequencies.
  • FIG. 11 shows the results for a monofocal, aberration-free situation for far, intermediate, and near focus with and without apodization and also shows the power map.
  • Figure 12 shows the same for a diffractive multifocal (+3D) situation and also includes a graph of image quality as a function of defocus. Image quality either improves or stays the same. The full aperture contributes to both far and near, and there is improvement in intermediate focus.
  • Figure 13 shows the same for a refractive bifocal (+1D) situation. A binary power distribution and a shift in best focus can be seen.
  • Figure 14 shows the same for positive spherical aberration. There is a continuous power distribution, with near focus in the periphery.
  • Figure 15 shows the same for negative spherical aberration. There is a continuous power distribution, with far focus in the periphery.
  • Figure 16 shows the visual benefit of apodization for the above situations. Visual benefit is calculated as follows: image quality with apodization
  • a visual benefit greater than 1 indicates an improvement.
  • Figure 17 shows a vision simulator 1.
  • a visual stimulus from a projector 3 passes through a collimating lens 5, a phase plate 7, an artificial pupil 9, a linear polarizer 11, an interference filter 13, and a lens 15 and is made incident via mirrors 17 and 19 and a lens 21 onto an amplitude apodization device 23, such as a liquid crystal spatial light modulator.
  • the light then passes through a lens 25, a Badal optometer 27, a lens 29, and a linear polarizer 31 and into the eye E.
  • Figure 18 shows the results for no spherical aberration with and without apodization.
  • Figures 19A and 19B show results with spherical aberration. For positive spherical aberration, there is a worsening at near; for negative spherical aberration, there is an improvement at near.
  • Figures 20A and 20B show the visual benefit and the improvement in visual acuity for native higher order aberrations, positive spherical aberration, and negative spherical aberration.
  • Figure 21 shows a system for applying the preferred or any other embodiment to the patient's eye E.
  • An apodization component 51 applies the apodization described above.
  • Another component 53 which can include a multifocal lens or a device configured to perform surgery on the eye E, applies multifocal correction.
  • the components 51 and 53 are individually known, but the combination thereof in the context of the present invention is considered to be novel.

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  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Transplantation (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • General Physics & Mathematics (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Eyeglasses (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne l'apodisation de pupille optique, utilisée avec des verres multifocaux, afin de réduire le flou optique dans des images par focalisation (distances d'objets éloignés à proches), ce qui améliore les performances de focalisation d'une conception de verre ophtalmique multifocal.
PCT/US2013/032319 2012-04-12 2013-03-15 Apodisation de pupille optique afin de réduire le flou optique induit par conception de verre ophtalmique multifocal WO2013154768A1 (fr)

Applications Claiming Priority (2)

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US201261623173P 2012-04-12 2012-04-12
US61/623,173 2012-04-12

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WO2013154768A1 true WO2013154768A1 (fr) 2013-10-17

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9195074B2 (en) 2012-04-05 2015-11-24 Brien Holden Vision Institute Lenses, devices and methods for ocular refractive error
US9201250B2 (en) 2012-10-17 2015-12-01 Brien Holden Vision Institute Lenses, devices, methods and systems for refractive error
US9541773B2 (en) 2012-10-17 2017-01-10 Brien Holden Vision Institute Lenses, devices, methods and systems for refractive error
EP3285110A1 (fr) * 2016-08-18 2018-02-21 Johnson & Johnson Vision Care Inc. Lentille de contact présentant une meilleure performance visuelle et un halo minimisé faisant appel à l'apodisation de la pupille

Citations (5)

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US6338559B1 (en) * 2000-04-28 2002-01-15 University Of Rochester Apparatus and method for improving vision and retinal imaging
US7648238B2 (en) * 2002-12-06 2010-01-19 AMO Manufacturing Presbyopia correction using patient data
US7670371B2 (en) * 2002-11-29 2010-03-02 Amo Groningen Bv Multifocal ophthalmic lens
US20100087921A1 (en) * 2004-12-01 2010-04-08 Simpson Michael J Apodized aspheric diffractive lenses
US20100161048A1 (en) * 2008-12-19 2010-06-24 Schaper Jr Dale T Radially segmented apodized diffractive multifocal design for ocular implant

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6338559B1 (en) * 2000-04-28 2002-01-15 University Of Rochester Apparatus and method for improving vision and retinal imaging
US7670371B2 (en) * 2002-11-29 2010-03-02 Amo Groningen Bv Multifocal ophthalmic lens
US7648238B2 (en) * 2002-12-06 2010-01-19 AMO Manufacturing Presbyopia correction using patient data
US20100087921A1 (en) * 2004-12-01 2010-04-08 Simpson Michael J Apodized aspheric diffractive lenses
US20100161048A1 (en) * 2008-12-19 2010-06-24 Schaper Jr Dale T Radially segmented apodized diffractive multifocal design for ocular implant

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10948743B2 (en) 2012-04-05 2021-03-16 Brien Holden Vision Institute Limited Lenses, devices, methods and systems for refractive error
US10209535B2 (en) 2012-04-05 2019-02-19 Brien Holden Vision Institute Lenses, devices and methods for ocular refractive error
US10466507B2 (en) 2012-04-05 2019-11-05 Brien Holden Vision Institute Limited Lenses, devices and methods for ocular refractive error
US10838235B2 (en) 2012-04-05 2020-11-17 Brien Holden Vision Institute Limited Lenses, devices, and methods for ocular refractive error
US9575334B2 (en) 2012-04-05 2017-02-21 Brien Holden Vision Institute Lenses, devices and methods of ocular refractive error
US9195074B2 (en) 2012-04-05 2015-11-24 Brien Holden Vision Institute Lenses, devices and methods for ocular refractive error
US11809024B2 (en) 2012-04-05 2023-11-07 Brien Holden Vision Institute Limited Lenses, devices, methods and systems for refractive error
US11644688B2 (en) 2012-04-05 2023-05-09 Brien Holden Vision Institute Limited Lenses, devices and methods for ocular refractive error
US9535263B2 (en) 2012-04-05 2017-01-03 Brien Holden Vision Institute Lenses, devices, methods and systems for refractive error
US10203522B2 (en) 2012-04-05 2019-02-12 Brien Holden Vision Institute Lenses, devices, methods and systems for refractive error
US11320672B2 (en) 2012-10-07 2022-05-03 Brien Holden Vision Institute Limited Lenses, devices, systems and methods for refractive error
US9759930B2 (en) 2012-10-17 2017-09-12 Brien Holden Vision Institute Lenses, devices, systems and methods for refractive error
US11333903B2 (en) 2012-10-17 2022-05-17 Brien Holden Vision Institute Limited Lenses, devices, methods and systems for refractive error
US9201250B2 (en) 2012-10-17 2015-12-01 Brien Holden Vision Institute Lenses, devices, methods and systems for refractive error
US10520754B2 (en) 2012-10-17 2019-12-31 Brien Holden Vision Institute Limited Lenses, devices, systems and methods for refractive error
US9541773B2 (en) 2012-10-17 2017-01-10 Brien Holden Vision Institute Lenses, devices, methods and systems for refractive error
US10534198B2 (en) 2012-10-17 2020-01-14 Brien Holden Vision Institute Limited Lenses, devices, methods and systems for refractive error
KR20180020909A (ko) * 2016-08-18 2018-02-28 존슨 앤드 존슨 비젼 케어, 인코포레이티드 동공 아포다이제이션을 이용한 개선된 시각적 성능 및 최소화된 헤일로를 갖는 콘택트 렌즈
CN107765449B (zh) * 2016-08-18 2021-02-26 庄臣及庄臣视力保护公司 利用瞳孔切趾的具有改善的视觉性能和最小化的光晕的接触镜片
CN113189789A (zh) * 2016-08-18 2021-07-30 庄臣及庄臣视力保护公司 利用瞳孔切趾的具有改善的视觉性能和最小化的光晕的接触镜片
AU2017206170B2 (en) * 2016-08-18 2021-12-02 Johnson & Johnson Vision Care, Inc. Contact lens with improved visual performance and minimized halo utilizing pupil apodization
US10838234B2 (en) 2016-08-18 2020-11-17 Johnson & Johnson Vision Care, Inc. Contact lens with improved visual performance and minimized halo utilizing pupil apodization
RU2676945C1 (ru) * 2016-08-18 2019-01-11 Джонсон Энд Джонсон Вижн Кэа, Инк. Контактная линза с улучшенными зрительными характеристиками и сведенным к минимуму гало при использовании аподизации зрачка
CN107765449A (zh) * 2016-08-18 2018-03-06 庄臣及庄臣视力保护公司 利用瞳孔切趾的具有改善的视觉性能和最小化的光晕的接触镜片
KR102529342B1 (ko) 2016-08-18 2023-05-09 존슨 앤드 존슨 비젼 케어, 인코포레이티드 동공 아포다이제이션을 이용한 개선된 시각적 성능 및 최소화된 헤일로를 갖는 콘택트 렌즈
US11686954B2 (en) 2016-08-18 2023-06-27 Johnson & Johnson Vision Care, Inc. Contact lens with improved visual performance and minimized halo utilizing pupil apodization
EP3285110A1 (fr) * 2016-08-18 2018-02-21 Johnson & Johnson Vision Care Inc. Lentille de contact présentant une meilleure performance visuelle et un halo minimisé faisant appel à l'apodisation de la pupille

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