WO2013148359A1 - Éponge cellulosique à porosité élevée - Google Patents
Éponge cellulosique à porosité élevée Download PDFInfo
- Publication number
- WO2013148359A1 WO2013148359A1 PCT/US2013/032513 US2013032513W WO2013148359A1 WO 2013148359 A1 WO2013148359 A1 WO 2013148359A1 US 2013032513 W US2013032513 W US 2013032513W WO 2013148359 A1 WO2013148359 A1 WO 2013148359A1
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- WIPO (PCT)
- Prior art keywords
- gum
- sponge
- matrix material
- devices
- absorption
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/729—Agar; Agarose; Agaropectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Definitions
- the present invention relates to devices, compositions, and methods for, among other uses, reducing the amount, of nutrients or other compounds absorbed in the GI tract from ingested food.
- overweight refers to body weight above a normal range. Overweight and obesity are determined by calculating the body mass index (BMI), the weight in kilograms divided by height in meters squared. Overweight is generally defined as a BMI of 25 to 29.9 kg/m 2 , obesity is generally defined as a BMI of >30 kg/m 2 , and severe obesity is generally defined as a BMI >40 kg/m 2 (or BMI >35 kg/m 2 in the presence of other medical comorbidities). A BMI less than about 22.0 kg/m 2 is ideal, though this may be a difficult and perhaps unrealistic goal for many individuals.
- BMI body mass index
- Overweight and obesity are worldwide health epidemics, with increasing prevalence. In the United States, more than two-thirds of Americans are overweight and 26-55% are obese based on data collected in 2007 by the Centers for Disease Control and National Institutes of Health. Globally, overweight and obesity affects both established and developing countries. For example, about 23% of the population in the United Kingdom is obese, compared to about 11-23% in Mexico, approximately 30-40% in South Africa, and about 10% in Pakistan. Overweight and obesity are associated with many health risks including type 2 diabetes mellitus, hypertension, dyslipidemia, coronary heart disease, cancer and stroke among others, as well as premature death. Compared to normal weight individual's, a BMI of 26.5 to 29.9 kg/m 2 is associated with a 1.5 times increased risk of death.
- sympathomimetic drugs e.g., phendimetrazine, diethylpropion, phentermine
- Sympathomimetic drugs stimulate the release of norepinephrine and/or inhibit its reuptake into nerve terminals. In lay terms, this effect is analogous though much stronger than that produced by caffeine.
- Sympathomimetics cause appetite suppression but also may cause hypertension and potentially myocardial infarction, and as a result, are limited to ⁇ 12 weeks of use by the FDA.
- Ephedrine is a member of this class that was recently removed from the market because of these adverse side effects.
- Malabsorptive drugs are the other medication class that is FDA approved for use in obesity. Orlistat is the only representative of this group. Orlistat alters fat digestion by inhibiting pancreatic lipase, resulting in the malabsorption of 30% of ingested fat. Instead of being taken up by the body, this fat is excreted in stool. Orlistat is the only FDA approved medication for obesity that is acceptable for long term use (up to 4 years).
- weight loss For patients with severe obesity, the only proven mechanism of long-term weight Loss is bariatric surgery. Bariatric surgery effects weight loss through either malabsorption and/or restriction. Malabsorption (as with Orlistat above) means the incomplete absorption of ingested food. The body does not absorb the full amount of calories present in a meal or in a given food item. Restriction means a reduction in the size of the stomach, with resultant early satiety and reduced food consumption.
- compositions, devices, and methods for affecting (among other things) weight loss and/or weight control, by sequestering nutrients or other compounds (e.g., alcohol or toxins) from absorption in the digestive tract are suitable for routine use.
- the present invention provides a device or composition
- a device or composition comprising one or more members of a compressible absorbent matrix material designed to absorb and substantially retain nutrient material in the digestive tract, such as nutrient material present in the stomach after a meal.
- the device or composition may further employ one or more hydrogel(s), soluble or insoluble fibers, waxes and/or gums to provide the desired mechanical properties and/or absorptive or shielding properties, as described in detail herein.
- the device is in the form of a capsule comprising the matrix material members, which may be in the form of tubes.
- the device or composition may be a food additive.
- the present invention provides a method for absorbing and retaining (e.g., shielding) nutrients or other compounds from the absorptive action of the digestive tract.
- the method comprises providing the device or capsule for ingestion before, during, or after eating.
- the subject may be an overweight or obese subject, and the composition or device may be used routinely to affect weight loss.
- the subject may be of normal weight, but in need of weight control, for example, due to a pattern, or history of being overweight.
- the orally ingested device or composition in various embodiments contains one or a plurality of "sponges” or “sponge tubes” in a compressed or dense state, and which expand once in the GI tract.
- the sponge matrix or scaffolding greatly amplifies the volume displaced in the expansion of the sponges.
- the sponge material may itself absorb ten times or more its weight in fluid, which helps to shape the material as in a scaffolding. When the sponge expands it doesn't just absorb ten times its volume, but soaks in all the fluids contained in the void spaces of the scaffolding. That is, the "chambers" or “holes” of the sponge dramatically magnify the volume of fluids absorbed. These fluids will be then trapped inside the scaffolding of the sponge by hydrogels in the sponge cell walls that seal each chamber.
- the sponge absorbs portions of chyme suspension in the stomach, reducing the amount of food available for absorption in the small intestine. In this manner, calories are "sequestered” from the body, promoting weight loss.
- the device or composition design maximizes the capacity and/or efficiency for nutrient absorption (and concomitant sequestration of the nutrients) and avoids the side effects associated with drug-based treatments for obesity.
- the material and/or geometry of the matrix material, together with one or more hydrogel(s), soluble and/or insoluble fiber(s), wax(es) and gum(s) provides the desired mechanical properties, including efficient packing and desired elasticity and/or expansion of the matrix material, as well as the desired properties for absorption of nutrients and subsequent sequestering and shielding from digestive action.
- the present invention helps to reverse a trend in the food industry, which has progressively reduced fiber from foodstuffs and has replaced it with sugars.
- the present invention thus also supplies fiber to the diet while eliminating absorption of sugars.
- the present invention absorbs fluids rich in sugars and/or alcohol, which are typically soluble, and consequently, more absorbable by the GI than other less soluble nutrients. Further, sugars and/or alcohol may not be beneficial for health. Such fluids may then be sequestered by the compositions and devices in their native state and/or in a gelled or a mucilaginous state. For example, the fluids may be sequestered by absorption., reaction, or association with other compounds like soluble fibers. Accordingly, the body will "see” (e.g., will be able to absorb during digestion) fewer nutrients (e.g., sugars, carbohydrates, fats, alcohol and spirits, etc,), and on the contrary, will "see” more beneficial fibers.
- nutrients e.g., sugars, carbohydrates, fats, alcohol and spirits, etc,
- the present invention provides sequestration in the stomach or in the gastrointestinal tract of compounds, liquids (e.g., alcohol), drugs, or other dangerous or toxic substances that were willingly or unwillingly ingested.
- the composition or device has the potential to absorb and soak, ingested material, and gel it and safely and naturally remove it from the body.
- the present invention provides the sequestration of nutrients without changing an individual's usual diet, the usual taste, and the usual quantities of food ingested by the average consumer in a significant fashion.
- the device and compositions of the invention may be used routinely or chronically by the overweight and obese for sustained weight loss, or by the normal weight individual for weight control.
- the device may be used from once to twenty times weekly, for one or several years (e.g., 1, 2, 3, or more years).
- the device may be used from one to three times daily (e.g., with each meal) for one, two, or three years, or more.
- it may be used In the short term by normal weight individuals who have eaten excessively, and may wish to decrease the caloric "damage" of their indulgence.
- the present device and methods may provide a inexpensive, safe solution to obesity and overweight for hundreds, of millions people worldwide, with the corresponding benefits in the associated medical comorbidities, life span, health care expenditures and global economic burden.
- the device and compositions may be used to absorb and prevent digestion or biological effects of toxins or alcohol that is willingly or unwillingly ingested.
- the device or composition need not be used routinely, but may be taken with food that is at risk of containing toxin, or upon knowledge of toxin ingestion, or may be used to avoid or counter the effects of alcohol overconsumption.
- FIGS. 1 to 16 show exemplary designs for the absorbent materials.
- FIGS. 17 to 20 show exemplary absorbent materials.
- FIGS. 21 to 26 show other exemplary designs for devices of the present invention.
- the present invention provides compositions, devices, and methods for affecting, among other things, weight loss and/or weight control, by sequestering nutrients or other compounds such as toxins from absorption in the digestive tract.
- the compositions, devices, and methods employ one or more members made of a compressible, absorbent matrix material.
- the matrix material is suitable for routine use.
- the compressible absorbent matrix material has a size, shape and/or geometry configured for efficient packing into a small space, and/or configured to absorb and substantially retain digested material in the stomach.
- the devices and compositions may further comprise one or more hydrogel(s), soluble or insoluble fibers, waxes and/or gums to provide the desired mechanical properties and/or absorptive or shielding properties.
- compositions and devices reduce the calorie absorption by the body of ingested nutrients.
- the method of operation of the present devices may be referred to as "malabsorption” whereby nutrients are absorbed by the matrix material (e.g., sponge material) and sequestered in the GI tract. Accordingly, the sequestered nutrients are not metabolized or absorbed by the intestine, and are excreted with the matrix material.
- the devices are inert and operate in a passive fashion and do not substantially interfere with body metabolism, in essence, the device "shields” ingested nutrients from the absorption action, of the intestinal villi and other digestive activity.
- the compressible absorbent matrix material may, in some embodiments, be a sponge material, and may be in the form of "sponge tubes" and/or “sponge drops.” While tubes may be the most intuitive and simple shape for the matrix material, the matrix material may or may not be tubular in shape, as other geometries will be suitable and/or advantageous in certain embodiments. For example, irregularly shaped pieces of sponge, without any definite shape and that are each unique from one another, could be produced by mechanically grinding the sponge into bits, which could be suitable and/or advantageous in certain embodiments. That a volume is contained in a sponge is more important than its superficial shape.
- the sponge material may be a naturally occurring material or may be an artificially foamed type sponge comprising a multitude of open, spaces, e.g., open or closed "cells" which may be irregular or regular in shape, and defined by the sponge matrix "cell walls".
- the sponge material may also be a material having an alternation of empty and closed spaces, regular or irregular, having a defined geometry or amorphous, or a mixture of defined and irregular or amorphous spaces.
- the sponge material has geometrically engineered structures able to collapse under mechanical, chemical or thermal action, or a combination thereof, and can subsequently assume an expanded shape, expanded shape may be the original shape (before compression), or another intended shape.
- the expanded shape generally occurs in response to removal of the mechanical, chemical or thermal action upon interaction with stomach contents or/and chemical interactions with suitable additives present in the device.
- the matrix material when subject to mechanical compression, thermal and/or chemical treatment (e.g., by chemically modifying the material, crosslinking, compounding or covalent bonding compounding, etc.), can be reduced in size and/or volume to a size .and/or volume that is much smaller than the. original, uncompressed size and/or expanded volume.
- the compressible property allows for efficient packing of a plurality of matrix material members into a small space, such as a capsule or other vehicle for delivery.
- the compressed size or volume may be less than about 50% of the expanded size or in other embodiments, less than about 40%, less than about 30%, less than about 25%, less than about 20%, less than about 15%, less than about 10%, less than about 5%, less than about 1%, less than about 0.5%, or less than about 0.1% of the expanded size or volume.
- the material after release of an applied mechanical compression or chemical constraint (e.g., by chemical reaction, breaking, of crosslinking, etc.) or both, the material can assume its original, larger shape.
- the mechanism of expansion, of the matrix material may also be elastic return, where the material, although not elastomeric per se, may still be stiff enough (e.g., the molecular creep time is sufficiently long) that the material may still at least partially assume its original shape after a period of compression and/or stress.
- the matrix material can be mechanically flattened and stacked, or simply compressed, then encapsulated, e.g.. in a conventional pharmaceutical capsule for ingestion.
- the matrix material is generally made of an elastic and/or resilient material which can be compressed and is capable of absorbing liquid and/or material in the digestive tract.
- the matrix material generally has an internal porosity like a natural sponge.
- the cells of the sponge or sponge-like material may be random and/or amorphous (e.g., as in typical commercially available artificial or natural sponges). Alternatively, in some embodiments, the cells of the sponge material may be more regular and/or geometrically ordered, like a honeycomb or other geometric and/or volumetric arrangement.
- the geometric structure of the matrix material may also provide a magnifying and/or multiplicative effect on the expansion of the present, devices and their .digestive, fluid absorption and/or retention capacity, relative to amorphous and/or non-geometric devices comprising natural fibers.
- This magnifying and/or multiplicative effect can be at least 2 times, at least 5 times, at least 10 times, at least 50 times, or at least 100 times, relative to an amorphous device (e.g., a device having an irregular shape). Accordingly, a much smaller quantity, mass, volume, dosage or amount of the present device(s) or compositions is required in these embodiments.
- a user need only ingest a small pill or capsule (e.g., conventionally sized pill or capsule).
- a small pill or capsule e.g., conventionally sized pill or capsule.
- such a small pill or capsule may effectively provide a large capacity for absorption of digestive fluids and, consequently, sequestration or shielding thereof from absorption by the body.
- the sponge material may be a conventional or natural sponge produced by conventional methods.
- the sponge-type material may be produced from, e.g., foaming agents, reactive agents, percolating agents, and may be formed by extrusion, blow-molding, injection molding, thermoforming, mechanical or chemical carving and shaping, etc.
- the sponge material may be made by assembling of smaller segments and/or geometrical and/or random shaped units into larger units, allowing for careful selection of the sponge morphology.
- the sponge material may be made by extrusions processes, blow-molding processes, injection or thermoforming molding processes, or may be mechanically and/or chemically printed or mechanically carved or formed.
- the sponge material may be partially or totally elastic, elastomeric, resilient or not, recoiling, or partially rigid or semi-rigid, and/or plastic.
- FIGS. 17-20 illustrate certain exemplary sponge materials which may be suitable for use in the present invention.
- the sponge material is typically selected such that the cell walls will have "shape memory," namely, the cells generally at least partially return or expand to their original size and/or shape once an applied mechanical and/or chemically compression force is released.
- the sponge material may expand and contract solely due to water absorption that inflates the matrix material, similar to the swelling caused by air being compressed into an inflatable plastic matrix (e.g., an inflatable bounce house).
- the mechanism of expansion of the released sponge material may be, e.g., through the return of a shape memory material such that at. physiological conditions in the stomach (e.g., at 37°C) the material assumes at least partially its original shape.
- Elastomeric or resilient material may be employed for the sponge material, e.g., elastomeric materials like latex, guayule, polyurethane rubber, silicon rubber, cellulose, nanocellulose, nitrile rubber, or biological materials such as elastin, collagen and/or other natural proteins, or any other suitable materials that can retain and conserve their original shape after extended periods of time under compression, or which return to the memory shape or assume a different, shape.
- the mechanism of expansion may be largely due to fluid absorption of the sponge, for example, when including such materials as hemicellulose, which has a high absorption strength, and is able to create a hydraulic force to inflate the sponge scaffolding.
- the sponge matrix can be made of material safe for human ingestion. Examples of suitable materials include: polymer or copolymer of polyurethane, nylon, polyethylene, polypropylene, polyacrylate, EVA, natural rubber, silicon, silicon rubber, latex, epdm rubber, butile rubber, nitrile rubber, PVA, PLA.
- Suitable elastomeric biomaterials include silicones, thermoplastic elastomers, polyolefin and polydiene elastomers, poly(vinyl chloride), natural rubber, guayule rubber, heparinized polymers, hydrogels, polypeptides, and elastomers., which may be compounded with other polymer or natural or artificial elastomers and or fillers like, clay, starch, elastic fibers, elastic microfibers, elastic nanofibers, which may be further compounded with inert and/or natural compounds, such as cellulose and its derivates, elastic and non-elastic fillers and powders.
- suitable materials for the matrix include natural polymers such as cellulose, nanocellulose, bacterial cellulose, cellulose fibers, 'microfibers and nanofibers, methylcellulose, ethylcellulose, ethylmethylcellulose, other cellulose derivatives, cellulose compounded with natural or synthetic or artificial elastomers and/or fillers and natural hydrogels like chitosan, opuntia, arid other disaccharides. and natural clays (e.g., montmorillonite).
- natural polymers such as cellulose, nanocellulose, bacterial cellulose, cellulose fibers, 'microfibers and nanofibers, methylcellulose, ethylcellulose, ethylmethylcellulose, other cellulose derivatives, cellulose compounded with natural or synthetic or artificial elastomers and/or fillers and natural hydrogels like chitosan, opuntia, arid other disaccharides. and natural clays (e.g., montmorillonite).
- a sponge material may be employed which provides substantially all of the desired properties, e.g., swelling, absorbing, soaking, shielding, retaining, disintegrating, and may further be biocompatible, biodegradable and may comprise only natural materials.
- a suitable sponge may be produced by carboxylating a specially small-sized porosity cellulosic sponge and adding to the surface highly hydrophilic functional groups such as COONa and COOK, with a degree of substitution between 0,2 and 0,3.
- biodegradable fillers, compounds or fibers can be employed.
- the partial or total disintegration of these compounds, fillers or fibers in the digestive tract may induce the partial or total collapse of the sponge material. Accordingly, an average disintegration time of the material may be effected by adjusting the proportion of such additives.
- Exemplary fillers may include starches and/or other polysaccharides.
- the size of the sponge matrix may range from, for example, a diameter of about 1 nm to about 25 mm, or about 1 ⁇ to about 100 ⁇ .
- the length of the present sponge tubes may range from, for example, about 1 ⁇ to about 3". Accordingly, the geometry of the present "tubes" may vary according to the selected width and length.
- different sizes and shapes of sponges may be employed to selectively capture different particulate sizes and/or suspensions and/or colloids. Accordingly, a capsule may contain an assortment of sponges having various external geometries, sponge materials, sponge morphologies, etc.
- the sponge geometry may be selected to maximize packing or stacking efficiency, or maximize the number of sponges which may be compressed in a capsule, thereby maximizing the nutrient sequestrating capacity of each capsule.
- compositions and devices may further comprise other natural or synthetic materials to provide the desired mechanical properties, or desired absorptive and/or shielding properties.
- the fluids should be kept inside or sequestered in the matrix material once absorbed. Additionally, absorbed fluids or materials should be shielded from exposure to digestive enzymes. Accordingly, absorbed fluids may be gelled or made more viscous. Nutrients thus captured may be sealed or sequestered inside the tubes by one or more hydrogel(s), fiber(s) and/or gum(s ⁇ . Such hydrogel(s), fiber(s:) and/or gum(s) may be directly incorporated into the sponge material, compounded m the sponge walls matrix, contained and/or dispersed inside the sponge cells, or located at particular areas of the tubes, for example, the entrances or openings of the tubes as described herein.
- the present devices may act in part in a manner analogous to the behavior of dietary fiber (e.g., soluble and/or insoluble fiber) in the digestive system. That is, the compositions and devices may decrease and/or slow the absorption of nutrients, and/or may accelerate the passage of nutrients in the gastrointestinal tract.
- the compositions and devices may contain as much natural fiber as possible, either soluble, insoluble, or a combination of both.
- a combination of soluble and insoluble fibers arc employed.
- Insoluble fibers may be included to provide, inter alia, desired mechanical properties as described herein including expanding and shielding.
- Insoluble fibers may also be included for their mucillagenic properties of gelling of fluids and/or increasing the viscosity of entrapped, bound, encapsulated or entrained fluids.
- Non-limiting examples of suitable hydrogels include: polyvinyl alcohol, poly(ethylozazoline), polyvinylacetate-polyvinylalcohol copolymers, poly(2- hydroxyethylacrylate, poly(2-hydroxyethylmethacrylate), carboxymethylcellulose, polyacrylic acid, and copolymers thereof, disaccharides, polysaccharides, chitosans, alginates, water soluble proteins, and polynucleic acids, natural clays (e.g., montmorillonite), sodium bentonite, absorbent fibers, super absorbent fibers, micro and nanofibers, micro and nanopowders, and combinations thereof.
- natural clays e.g., montmorillonite
- sodium bentonite absorbent fibers
- super absorbent fibers e.g., micro and nanofibers, micro and nanopowders, and combinations thereof.
- hydrogels and/or mucilage and/or gum forming compounds in the sponge material may result in the cells, pores or walls of the sponges becoming less permeable, and accordingly may inhibit entrance or exit of fluids after initial absorption or sequestration of digestive fluids.
- exemplary natural compounds may include, soluble fibers, gums, etc. as described hereinabove.
- Individual hydrogels, gums or fiber material., or mixtures thereof may be selected to provide a desired absorption profile and/or other desired properties (e.g., expansion properties, absorption capacity, mechanical properties, etc.).
- the hydrogel(s), fiber(s) and/or gum(s) dispersed in the sponge matrix or added thereto and contained mechanically in the tubes or tube cells may seal the cells, creating a multitude of sealed or partially sealed compartments where the movements of fiidds may be partially or completely restricted in order to prevent leakage of absorbed nutrients or penetration by digestive enzymes as the sponge travels the ⁇ 31 tract prior to excretion.
- the hydrogel(s), fiber(s) and/or gum(s ⁇ in the sponge ceil walls will swell up with fluids until the expansion of the sponge cells will seal totally or partially the axial holes.
- Another effect of the hydrogel(s), fiber(s) and/or gum(s) may be to make the sponge tube more mechanically stable or robust, in order to better resist the final passage in the colon in the event the tubes are to be naturally expelled by the body.
- nutrients are trapped in the sponge by the hydrogel(s), fiber(s) and/or gum(s) and the sponges then disintegrate after passage through the upper GI tract.
- these components may disintegrate after the portions of the GI tract where most nutrient absorption occurs, such that mechanical stability may not be necessary.
- the sponge material can be selected such that the material at least partially or totally disintegrates in the lower GI tract, to assure safety in the ease of excessive consumption of the tubes or in a clinically slow discharging intestine (e.g., to avoid intestinal blockages).
- the compositions and devices comprise insoluble and soluble dietary fibers, such as resistant starches, non-resistant starches, and non-starch polysaccharides.
- examples include arabinoxylans, cellulose, dextrins, insulin, lignin, waxes, chitins, pectins, beta-glucans, and oligosaccharides, including galactosaccharides and fructooligosaccharides.
- Other exemplary polysaccharides include etheropolysaccharides like pectines.
- the compositions and devices may employ a mixture of different insoluble fibers, mixtures of different .soluble fibers, and/or mixtures of one or more of each of insoluble and soluble fiber(s). In certain embodiments, a mixture of the two types of fibers (e.g., insoluble and soluble) may be employed. Insoluble fiber(s) may provide a "sponge" skeleton and/or may provide a shielding functionality.
- the composition or device comprises one or more soluble fiber(s) selected from an exopolysaccharide mucilage.
- the exopolysaccharide mucilage may be from Aloe vera, Baseila alba (Malabar spinach), Cactus, Chondrus crispus (Irish moss), Dioscorea opposita (Nagaimo, Japanese mountain yam), Drosera (sundews), fenugreek, flax seeds, kelp, liquorice root, marshmallow, mullein, okra, Parthenium, Pingiucula (butterwort), psyllium seed husks, Salvia hispanica (chia) seed, Ulmus rubra bark (slippery elm, or any other suitable plant.
- compositions and devices may comprise cellulose or derivatives of cellulose like methyl cellulose, ethyl cellulose, and/or methyl- ethyl cellulose.
- compositions and devices may comprise natural gums, such as those that may be obtained from seaweeds and other sources.
- natural gums include polyelectrolytes:agar (E406), alginic acid (E400) and sodium alginate (E401); and Carrageenan (E407).
- Natural gums obtained from non-marine botanical resources include polyelectrolytes: gum arabic (E414) from the sap of Acacia trees, gum ghatti from the sap of Anogeissus trees, gum tragacanth (E4I3) from the sap of Astragalus shrubs, and karaya gum (E416) from the sap of Sterculia trees.
- guar gum E412 from guar beans, locust bean gum (E410) from the seeds of the carob tree, beta-glucan, from oat or barley bran, chicle gum obtained from the chicle tree, dammar gum from the sap of Dipteroearpaceae trees, glucomannan (E425) from the konjac plant, mastic gum, a chewing gum obtained from the mastic tree.
- the mucilage material includes Psyllium seed husks from the Plantago plant, spruce gum from spruce trees, tara gum (E417) from the seeds of the tara tree, and/or natural gums produced by bacterial fermentation, e.g., polyelectrolytes: gellan gum (E418) and xanthan gum (E415).
- Fibers of animal origin such as keratins (e.g., silk, etc.), elastin and/or collagen may also be employed. These natural gums or fibers may be obtained from commercial sources.
- the hydrogel(s), fiber(s), waxes, and/or gum(s) may provide an additional mechanism (or force) for expansion of the matrix material, by providing a chemical expansion, e.g., via absorption of water and other fluids.
- the matrix material may expand, or hydrogel(s), fiber(s) and/or gum(s) which may be present in the sponge cell walls may absorb water and fluids and stiffen the cell walls to return the sponge tube at least in part to its original size and/or shape prior to compression and/or stacking.
- the device or composition comprises hemicellulose or xylan, alone or compounded chemically and mechanically.
- This short chain polysaccharide hemicellulose
- the device or composition may comprise hemicellulose-citrate-chitosan, an aerogel foam, which is both elastic and extremely absorbent.
- the device or composition comprises, or further comprises one or more fillers such as crystalline cellulose and/or amorphous cellulose, lignin or other stiffening compounds.
- an expansion mechanism of the matrix is in part a result of absorption of fluids, which may stiffen the scaffolding material of the sponge, and may magnify the total expansion.
- the composition or device comprises an ester of hemicellulose with organic acid (e.g., having carboxylic groups).
- organic acid e.g., having carboxylic groups
- examples include hemicellulose citrate, hemicellulose acetate, and other organic acids, which make a foam having desirable flexibility and elastic recoil.
- the composition or device comprises hemicellulose alone or with chitosan.
- embodiments of the device or composition may employ starch-citrate-chitosan, starch-chitosan, or starch- hemicellulose-chitosan.
- additional compounds may be included, in the presence or absence of hemicellulose-citrate-chitosan.
- Such compounds include various types of cellulose or other artificial and synthetic compounds, such as one or more of: bovine serum albuminate pectinate, pectine-ethyl cellulose, calcium pectinate and chitosan, naproxen pectin, de-esterified pectin, zinc-pectinate gels, amylose, chondroitin-sulfate (crosslinked or uncrosslinked), cyclodextrins, dextran, calcium alginates and alginates, locust bean gum, guar gum, glutaraldehydes, and epiclorihydrine.
- guar gum is employed, which may be compounded or just dispersed in the hemicellulose matrix foam sponge.
- Another mechanism for expansion of the matrix material may include incorporation of a combination of compounds and/or protein-like substances or structures, arranged in a fashion analogous to muscle structure, wherein the shrinking, expanding and/or twisting of one component with respect to another may cause a rolling and/or twisting or expanding action, resulting in the expansion of the material.
- Still another mechanism for releasing the compressed matrix material may include foaming and/or gas releasing agents activated by the heat and/or acid environment of the stomach, which may produce gases and/or foaming to expand the material (e.g., NaHCC , etc.).
- foaming and/or gas releasing agents activated by the heat and/or acid environment of the stomach, which may produce gases and/or foaming to expand the material (e.g., NaHCC , etc.).
- all or part of the material of the sponge may react with the stomach acid, increasing at least partially in volume, and returning the sponge to its original shape.
- the matrix material which is typically released into the stomach after dissolution of a capsule (e g., a gelatin capsule or the like) containing the compressed material, typically expands inside the stomach and absorbs the fluids therein.
- Yet another mechanism of expansion may include electrostatic and/or magnetic repulsion and/or attraction of some parts of the sponge with other parts of the sponge, or the electrostatic interactions of a tube with another tube or similar entity included in the pill or introduced into the stomach independently.
- the matrix material might be introduced as twisted shapes with an elastic expansion mechanism as described above, which can then untwist and expand.
- the capture of nutrients may also be caused by the twisting (e.g. like the wrapping of a Caramel) or rolling of the matrix material, in such cases, the matrix material may have a flat geometric configuration, although such a mechanism may be possible with other shapes and may also comprise an absorbing mechanism associated with the sponge material.
- twisting and/or rolling may be caused or induced, by one or a combination of the above mentioned mechanisms.
- the matrix material may be cylindrical, and may have an elliptical, oval, square, rectangular, triangular or polygonal or trapezoidal cross-section or shape. Further, various regular or irregular shapes or cross sections may be used in forming the compositions and devices, and a given "tube" may comprise one of more discrete domains of a particular shape or cross-section.
- the geometries and cross sections may support efficient packing, e.g., into capsules, such that a sufficient amount of "tubes" may be delivered in a small space.
- the geometries, cross sections, and opening configurations may further allow efficient absorption of stomach digestion products. Mixed geometries or shapes are also possible.
- FIGS. 1-16 illustrate a number of exemplary shapes and cross-sectional geometries. Further, as illustrated, the matrix material will typically have one or more axial openings or holes along its longest axis, although more than one hole may exist along essentially any axis. FIGS. 1-16 illustrate a number of possible hole configurations.
- the hole(s) may be centered along, the main axis (e.g., along the longest side) of the tube, or may be off center.
- the hole(s) can have a circular, star, cross or other segmented geometry (see FIGS. 1-16).
- the purpose of this hole is to facilitate rapid absorption of nutrients in the stomach.
- the sponge architecture with holes is designed to facilitate the entrance and capture inside the sponge of larger sized particulates that otherwise might be absorbed in the interior of the sponge.
- the hole(s) generally decrease the volume of the compressed tube inside the capsule, so more tubes can be accommodate in a single capsule and a larger volume of nutrients can be sequestrated or with a single pill.
- the device or composition may comprise one or more releasing agents in the cavity or in the cavities, or in cells of the sponge, in order to avoid sticking between the walls of the cell.
- releasing agents could be natural or artificial waxes, wax compounds with a gum for elasticity, or just a small layer of a polymer such as polyethylene compounds or polyethylene glycols or just polyethylene.
- the releasing agent dissolves in the stomach or is a natural foaming agent (e.g., baking soda).
- the external skin of the matrix material can be essentially intact, smooth and free of perforations or holes,, or may have some holes, which may be small in some embodiments. Such totally or partially intact, skin may avoid loss of absorbed nutrients from the matrix material due to mechanical and enzymatic action of the digestion.
- the exterior of the matrix material is essentially the same, as the interior, and may be perforated or the like.
- Nutrients to be absorbed generally enter the matrix material via the openings, which may be present at the ends where no skin is present, or at the open ends of holes through the tubes.
- the sponge geometry and the number and placement of lubes in the sponge can be selected to accommodate the greatest possible number of tubes inside a fixed capsule volume, to assure the best possible shape memory return once the tubes are released from the capsule, to maximize absorption of each tube, or a combination of these or other factors.
- the matrix material may be manufactured by normal extrusion, or by foaming of a block of material, after the mechanical cutting of the desired shape. Alternatively, the matrix material could be punched from a fast advancing strip.
- the matrix material may be encapsulated by nip rolling a sheet of the .sponge material.
- the roils may be running films of a packing or protecting compounds, as used often in the pharmaceutical industry.
- the material may be PLA or other natural or artificial material.
- the nip rolls compress and cut the matrix material at the same time, and in ether rolls print and seal the films around the sponge. A plurality of these printed sponges contained by the double films are deposited in a normal gel cap capsule or other similar container.
- the "sponge" matrix, scaffolding could alternatively be manufactured by mechanically punching holes in the main scaffolding material (e.g., foam), and after folding the holed, cored, celled material on itself rolling or folding, and gluing or mechanically fastening the holed strip in order to retain a three dimensional structure, and then compressing and encapsulating it.
- the rolls could further be designed, not just to flatten the sponges, but to give a lateral compression as well.
- the invention may employ encapsulation, microencapsulation, or nanoencapsulation of the matrix material.
- the devices and compositions are encapsulated with casein.
- Techniques for micro or nanoencapsulation include: pan coating, air suspension coating, spray-drying, ionotropic gelation, coacervation, in situ polymerization.
- the sponges are encapsulated by freezing in a compressed state. With a small amount of water, once compressed and frozen, the sponge matrix will stay compressed allowing easy encapsulation.
- the sponge When a treated sponge is in expanded form, the sponge can be mixed with, for example, flavored fat to recompress the sponge and shape it into coated granules, ready for human ingestion.
- the composition or device as described is ingested before, during, or after meals, or any other food ingestion, e.g. breakfast, a snack, etc.
- the capsules can be specially tailored for large or small size human bodies and/or for light or heavy meals by adjusting the capsule size, and accordingly, the number of tubes and the total absorptive capacity of the capsule.
- the capsule dissolves, releasing the tubes either all at once, or in groups (e.g., in delayed release).
- the released tubes no longer mechanically or chemically constrained by the capsule, will then expand, absorbing, capturing, enclosing, soaking some fraction of the contents of the stomach or intestine present at the moment of the tubes are released.
- the composition or device may be used directly in food products (e.g., mixed therewith) to reduce the calorie content of the food containing the devices.
- the present devices may be dispersed, added, and/or mixed in a food product, or included as a separate component in a. packaged food product for addition to the food product (e.g., in prepackaged food products, with food served at a restaurant, or with food at home, in beverages, etc.).
- the present device(s) e.g., capsules, .etc.
- small sponge "drops” having, e.g., spheroidal or ellipsoid geometry, with dimensions of for example, less, than about 500 ⁇ , less than about 250 ⁇ , less than about 100 ⁇ . less than about 50 ⁇ , less than about 40 ⁇ , less than about 30 ⁇ , less than about 20 ⁇ , jess than about 10 ⁇ , less than about 5 ⁇ , or less than about 1 ⁇ (or any other value or range or values therein or therebelow) could be on or in, e.g.
- chocolate spreads, jams, peanut butter, butter, cereals, flours, sweets, candies, cakes, dough, pastas, sugars like sucrose or fructose or high fructose corn syrup, even soft or alcoholic drinks, juices and/or any other food generally for sale or served in restaurants.
- these capsules may allow them to avoid being destroyed during mastication, and may render them undetectable by the taste buds.
- the compositions may be tasteless, and/or (nay be scaled such that they provide a smooth "mouthfeel".
- the devices or 'drops" would be released from any encapsulating material and could then expand, absorb fluids, and, in embodiments wherein the devices are designed to do so (e.g., as described herein), gel the absorbed or encapsulated fluids.
- an encapsulation material may be selected to resist exposure to heat and/or exposure to cooking fluids. Such encapsulation may be effected by materials that may resist such thermal and/or fluid exposure, but may otherwise degrade or dissolve in the GI tract.
- an encapsulation material may be selected that is heat resistant and/or heat stable, and fluid resistant at normal pH but dissolves in an acidic environment (e.g., such as that in the stomach).
- Exemplary materials include polylactic acid (PLA), which may be resistant to temperatures as high as 190 degrees centigrade.
- the device and compositions may be used to absorb and prevent digestion or biological effects of toxins or alcohol that is willingly or unwillingly ingested, in these embodiments, the device or composition need not be used routinely, but may be taken with food that is at risk of containing toxin, or upon knowledge of toxin ingestion, or may be used to avoid or counter the effects of alcohol overconsumption.
- a commercially available pure cellulose sponge was obtained.
- the sponge was cut into small tube-like shapes having a diameter of approximately 3-4 mm and a length of approximately one inch.
- the strips were then coated in carboxymethylcellulose (CMC) powder (a hydrogel).
- CMC carboxymethylcellulose
- the cut, hydrogenl coated strips were then inserted into polyethylene terephthalate (PET) tubes having approximately 6 ⁇ thick walls (e.g., the thickness of a hair) and an internal diameter of about 4-5 mm.
- PET polyethylene terephthalate
- Bundles of 20 of these sponge-filled PET tubes were then aligned longitudinally, compressed, and inserted in gelatin, capsules approximately 25 mm long, and approximately 9 mm in diameter to form "pills.” Each pill weighed approximately 500 mg.
- the soup-saturated sponges were then removed from the mixture with a strainer and weighed. 'This experiment was repeated another 4 times, for a total of five experiments. The total weight of the sponges ranged from about 13 grams to about 19 grams.
- the sponge tubes were more rigid after absorbing the soup mixture.
- the fluid mixture had entered the sponge cells, wherein those fluids were gelled by CMC.
- the sponges had absorbed approximately 18.5 grams of the soup mixture.
- an exemplary pill could absorb approximately 72 kcal of nutrients, which .would be sequestered from absorption and metabolism in the GI tract,
- 5 pills as described would be able to sequester nutrients equivalent to a small hamburger from the daily diet of a user. Accordingly, a person consuming approximately 5 of the exemplary pills with food could lose approximately 15 pounds of body weight per year.
- a sponge pill having an approximate volume of 2.5 cm 3 containing sponges prepared from a sponge material that expands and absorbs approximately 100 times its original volume, could capture up to approximately 250 cm 3 of fluid. That volume (i.e., 250 cm 3 ) equates to at least 250 grams of nutrients, and therefore may achieve a caloric sequestration of approximately 1.000 kcal per pill.
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Child & Adolescent Psychology (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Nanotechnology (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Surgical Instruments (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2014143014A RU2662566C1 (ru) | 2012-03-27 | 2013-03-15 | Целлюлозная губка высокой пористости |
CA2868808A CA2868808A1 (fr) | 2012-03-27 | 2013-03-15 | Eponge cellulosique a porosite elevee |
JP2015503342A JP6230592B2 (ja) | 2012-03-27 | 2013-03-15 | 高多孔性セルローススポンジ |
CN201380028037.9A CN104640604A (zh) | 2012-03-27 | 2013-03-15 | 高孔隙度纤维素海绵 |
EP13769182.0A EP2916913A4 (fr) | 2012-03-27 | 2013-03-15 | Éponge cellulosique à porosité élevée |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261616037P | 2012-03-27 | 2012-03-27 | |
US61/616,037 | 2012-03-27 | ||
US13/841,138 US20140276330A1 (en) | 2013-03-15 | 2013-03-15 | High porosity cellulosic sponge |
US13/841,138 | 2013-03-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2013148359A1 true WO2013148359A1 (fr) | 2013-10-03 |
Family
ID=49261095
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2013/032513 WO2013148359A1 (fr) | 2012-03-27 | 2013-03-15 | Éponge cellulosique à porosité élevée |
Country Status (5)
Country | Link |
---|---|
JP (1) | JP6230592B2 (fr) |
CN (1) | CN104640604A (fr) |
CA (1) | CA2868808A1 (fr) |
RU (1) | RU2662566C1 (fr) |
WO (1) | WO2013148359A1 (fr) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9220688B2 (en) | 2004-02-10 | 2015-12-29 | Slendine Sa | Device and method for reducing calorie intake |
US9320715B2 (en) | 2011-03-29 | 2016-04-26 | Slendine Sa | Devices and methods for weight control and weight loss |
US10813375B2 (en) | 2016-05-19 | 2020-10-27 | Decafino, Inc. | Caffeine-adsorbing material, caffeine-adsorbing system, decaffeination system, and related methods of removing caffeine from solutions |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107033392A (zh) * | 2017-03-28 | 2017-08-11 | 常州大学 | 一种高纳污清洁海绵的制备方法 |
CN110333588B (zh) * | 2019-08-12 | 2020-09-29 | 深圳市承和润文化传播股份有限公司 | 一种基于物联网安全密钥通信联网设备 |
CN110743513B (zh) * | 2019-11-01 | 2022-06-14 | 浙江科技学院 | 一种用于铜离子吸附的纤维素海绵制备方法 |
Citations (6)
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WO2002074343A2 (fr) | 2001-03-19 | 2002-09-26 | The Procter & Gamble Company | Utilisation de mousses polymeres non digestibles pour sequestrer des matieres ingerees dans le but d'inhiber leur absorption par le corps |
US20090028996A1 (en) * | 2006-01-23 | 2009-01-29 | Hill's Pet Nutrition, Inc. | Methods for reducing food intake and controlling the weight of animals |
WO2010063466A1 (fr) * | 2008-12-03 | 2010-06-10 | Aesculap Ag | Corps médical absorbant, en particulier pour extraire les fluides de blessure des cavités corporelles humaines et/ou animales |
WO2010110882A1 (fr) | 2009-03-23 | 2010-09-30 | Paolo Costa | Barrière d'absorption et son procédé d'utilisation |
WO2011038949A1 (fr) * | 2009-09-30 | 2011-04-07 | Gunnar Loske | Drainage par éponge sous vide |
US20110295299A1 (en) * | 2010-03-03 | 2011-12-01 | Gavin Braithwaite | Gastric volume filling construct |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1718279A2 (fr) * | 2004-02-10 | 2006-11-08 | Itzhak Katz | Dispositif et methode de reduction de l'apport calorique |
EP2231212A2 (fr) * | 2007-12-20 | 2010-09-29 | 7L, Llc | Dispositif autodilatable à avaler occupant l'espace gastrique |
US20090259246A1 (en) * | 2008-04-14 | 2009-10-15 | Sherif Eskaros | Intragastric Volume-Occupying Device |
-
2013
- 2013-03-15 CN CN201380028037.9A patent/CN104640604A/zh active Pending
- 2013-03-15 RU RU2014143014A patent/RU2662566C1/ru not_active IP Right Cessation
- 2013-03-15 WO PCT/US2013/032513 patent/WO2013148359A1/fr active Application Filing
- 2013-03-15 JP JP2015503342A patent/JP6230592B2/ja not_active Expired - Fee Related
- 2013-03-15 CA CA2868808A patent/CA2868808A1/fr not_active Abandoned
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002074343A2 (fr) | 2001-03-19 | 2002-09-26 | The Procter & Gamble Company | Utilisation de mousses polymeres non digestibles pour sequestrer des matieres ingerees dans le but d'inhiber leur absorption par le corps |
US20030072804A1 (en) * | 2001-03-19 | 2003-04-17 | The Procter & Gamble Company | Use of non-digestible polymeric foams to sequester ingested materials thereby inhibiting their absorption by the body |
US20090028996A1 (en) * | 2006-01-23 | 2009-01-29 | Hill's Pet Nutrition, Inc. | Methods for reducing food intake and controlling the weight of animals |
WO2010063466A1 (fr) * | 2008-12-03 | 2010-06-10 | Aesculap Ag | Corps médical absorbant, en particulier pour extraire les fluides de blessure des cavités corporelles humaines et/ou animales |
WO2010110882A1 (fr) | 2009-03-23 | 2010-09-30 | Paolo Costa | Barrière d'absorption et son procédé d'utilisation |
WO2011038949A1 (fr) * | 2009-09-30 | 2011-04-07 | Gunnar Loske | Drainage par éponge sous vide |
US20110295299A1 (en) * | 2010-03-03 | 2011-12-01 | Gavin Braithwaite | Gastric volume filling construct |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9220688B2 (en) | 2004-02-10 | 2015-12-29 | Slendine Sa | Device and method for reducing calorie intake |
US9724306B2 (en) | 2004-02-10 | 2017-08-08 | Slendine Ag | Device and method for reducing calorie intake |
US11786474B2 (en) | 2004-02-10 | 2023-10-17 | Biolumen Inc. | Device and method for reducing calorie intake |
US9320715B2 (en) | 2011-03-29 | 2016-04-26 | Slendine Sa | Devices and methods for weight control and weight loss |
US10813375B2 (en) | 2016-05-19 | 2020-10-27 | Decafino, Inc. | Caffeine-adsorbing material, caffeine-adsorbing system, decaffeination system, and related methods of removing caffeine from solutions |
Also Published As
Publication number | Publication date |
---|---|
RU2662566C1 (ru) | 2018-07-26 |
JP2015515308A (ja) | 2015-05-28 |
CN104640604A (zh) | 2015-05-20 |
JP6230592B2 (ja) | 2017-11-15 |
CA2868808A1 (fr) | 2013-10-03 |
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