WO2013146012A1

WO2013146012A1 - Liquid administration device

Info

Publication number: WO2013146012A1
Application number: PCT/JP2013/054910
Authority: WO
Inventors: 滋晃冨家; 正臣今井; 学有延
Original assignee: テルモ株式会社
Priority date: 2012-03-30
Filing date: 2013-02-26
Publication date: 2013-10-03

Abstract

This liquid administration device (1) is provided with: a syringe assembly (2) having an inner tube (3), a needle tube (11), a gasket, a plunger (13), and an outer tube (5); a guide member (6); an energizing means; an intermediate tube (4) having an intermediate tube main body (41) and a pinion gear (45); and a pair of shutters (8a, 8b) that are provided in a manner so as to be able to move to the tip side of the intermediate tube (4) and that have a rack gear (82) that meshes with the pinion gear (45). In the initial state, the syringe assembly (2) is positioned at a first position, the shutters (8a, 8b) are open, and the needle tube (11) is protruding, when administration of a liquid by means of an operation of moving the plunger (13) is complete, the syringe assembly (2) moves to a second position by means of the energizing force of the energizing means, and at such a time, the shutters (8a, 8b) close in a manner so as to cover the needle tip (111) at the tip side of the needle tube (11).

Description

Liquid dosing device

The present invention relates to a liquid administration device.

Conventionally, a prefilled syringe is known in which a liquid preparation is filled aseptically and the liquid preparation can be administered (see, for example, Patent Document 1).

The prefilled syringe includes a syringe outer cylinder having a mouth part for discharging the liquid preparation, a needle tube provided at the mouth part of the syringe outer cylinder and having a sharp needle tip at a tip, and a gasket that can slide in the syringe outer cylinder, A liquid preparation filled in a space surrounded by the syringe outer cylinder and the gasket, a plunger connected to the proximal end side of the gasket, and pressing the gasket toward the distal direction to discharge the liquid preparation from the mouth; It has. When a liquid preparation is administered using a prefilled syringe, the needle tube is punctured into the living body, and the plunger is pressed in this punctured state. Thereby, a liquid formulation will be discharged from a mouth part with a gasket, Therefore The said liquid formulation can be administered to a biological body via a needle tube.

The prefilled syringe has a cylindrical member as a protector for preventing erroneous puncture after administration of the liquid preparation. That is, in the prefilled syringe, when administration of the liquid preparation is completed, the cylindrical member moves in the distal direction until the distal end of the cylindrical member is positioned on the distal end side of the needle tip of the needle tube, and the outer peripheral side of the needle tube is cylindrical. It is comprised so that it may be covered with a member.

However, in such a conventional prefilled syringe, the outer peripheral side of the needle tube is only covered with the cylindrical member after administration of the liquid preparation. For example, when a finger is inserted into the cylindrical member from the distal end side, the finger is inserted into the needle tube. There is a problem that the needle is punctured.

Japanese Patent No. 4314117

An object of the present invention is to provide a liquid administration device that can easily and reliably cover the needle tip of a needle tube and prevent erroneous punctures after the administration of the liquid is completed.

Such an object is achieved by the present invention described below.
The present invention is a liquid administration device for administering a liquid to a living body,
An inner cylinder having a bottom portion on the distal end side and an opening portion on the proximal end side and capable of storing a liquid therein, a sharp needle tip attached to the bottom portion and projecting from the bottom portion on the distal end, A needle tube whose end communicates with the inside of the inner cylinder, a gasket capable of moving from the proximal position to the distal position along the axial direction of the inner cylinder, and pressing the gasket toward the distal direction A syringe assembly comprising a plunger for
A guide member installed on the outer peripheral side of the inner cylinder and supporting the syringe assembly movably along the axial direction of the inner cylinder;
An intermediate cylinder main body that is rotatably installed with respect to the guide member between the guide member and the inner cylinder, and is fixed to the distal end side of the intermediate cylinder main body, and is radial with respect to the axis of the intermediate cylinder main body An intermediate cylinder provided with a pinion gear having teeth protruding to
A rack gear meshing with the pinion gear; a shutter having an insertion portion through which the needle tube can be inserted; and a covering portion capable of covering the needle tip from the distal end side; and fixed to the distal end side of the guide member; A shutter assembly including a shutter support portion that is movably supported in a direction orthogonal to the axial direction of the inner cylinder,
In the syringe assembly, the needle tip is retracted from the covering portion to the proximal end side from a first position where the needle tube is inserted through the insertion portion, and the needle tip protrudes toward the distal end side from the shutter assembly. Move to a second position,
The liquid administration device includes a first engagement means capable of holding the syringe assembly 2 in the first position, and a second engagement means capable of holding the syringe assembly 2 in the second position. And further comprising
One of the syringe assembly and the intermediate cylinder includes a spiral rail protrusion or rail groove whose axis is the axis of the intermediate cylinder main body, and the other is a protrusion that engages with the rail protrusion or the rail groove. With
When the gasket is located at the proximal end position, the syringe assembly is held at the first position by the engagement of the first engagement means,
When the plunger is operated to move the gasket from the proximal end position to the distal end position, the plunger disengages the first engaging means, and the syringe assembly is moved from the first position. Move to the second position,
When the syringe assembly is moved from the first position to the second position, the syringe assembly is held at the second position by the engagement of the second engaging means, When the protrusion moves along the rail protrusion or the rail groove, the intermediate cylinder body rotates together with the pinion gear with respect to the guide member, the rotational force of the pinion gear is transmitted to the rack gear, and the shutter moves. The covering portion covers the needle tip from the tip side.

In the liquid administration device of the present invention, the first engagement means is provided in the guide member and the syringe assembly,
The guide member includes an elastic piece capable of releasing the engagement of the first engagement means by elastic deformation,
The plunger includes an engagement release portion that elastically deforms the elastic piece to release the engagement of the first engagement means when the plunger is operated from the initial state and the gasket is fully pressed. It is preferable to provide.

In the liquid administration device of the present invention, the liquid administration device further includes an urging means for urging the syringe assembly in the proximal direction with respect to the guide member,
The syringe assembly is provided non-rotatably with respect to the guide member, and includes an outer cylinder that houses and fixes at least a part of the inner cylinder on the inside thereof.
The guide member is preferably installed between the outer cylinder and the intermediate cylinder.

In the liquid administration device of the present invention, the elastic piece has a convex portion formed to project toward the inner periphery of the outer cylinder,
The outer cylinder is provided with a first hole with which the convex portion engages and a second hole with which the protrusion engages on the tip side of the first hole,
It is preferable that the first engaging means includes the convex portion and the first hole, and the second engaging means includes the convex portion and the second hole.

In the liquid administration device of the present invention, one of the outer cylinder and the guide member is provided with a guide groove formed along the axial direction of the inner cylinder, and the other is provided with a guide portion to be inserted into the guide groove. It is preferable that

In the liquid administration device of the present invention, the guide groove is provided on the inner periphery of the outer cylinder so as to face each other with the inner cylinder interposed therebetween,
The guide portion has a plate shape extending along the axial direction of the inner cylinder, and is provided on the guide member as a pair of guide pieces facing each other across the inner cylinder,
Preferably, the guide member includes a support portion that is provided at a distal end portion of the pair of guide pieces and supports the pair of guide pieces.

In the liquid administration device of the present invention, the guide member includes an elastic piece capable of releasing the engagement of the first engagement means by elastic deformation,
The elastic piece is provided at a proximal end portion of the guide piece,
It is preferable that the first hole and the second hole are provided in the guide groove.

In the liquid administration device of the present invention, the shutter has a plate-like portion having a thickness in the axial direction of the inner cylinder, and a protruding portion protruding from the plate-like portion toward the proximal end side,
The insertion part consists of a through-hole or notch that penetrates the plate-like part in its thickness direction,
The covering portion is provided as a part of the plate-like portion,
The rack gear is preferably provided on a side surface of the protruding portion.

In the liquid administration device of the present invention, the shutter assembly includes a pair of the shutters,
When the syringe assembly is located at the first position, the pair of shutters protrude from the shutter support portions in directions opposite to each other in a direction orthogonal to the axial direction of the inner cylinder. preferable.

In the liquid administration device of the present invention, the shutter support portion can store the pair of shutters,
When the syringe assembly is moved from the first position to the second position, the pair of shutters are moved in a direction opposite to the direction in which they protrude, and are accommodated in the shutter support portion. preferable.

In the liquid administration device of the present invention, the inner cylinder is preferably filled with a liquid in advance.
In the liquid administration device of the present invention, the liquid is preferably a chemical solution.

According to the present invention, when the administration of the liquid is completed and the syringe assembly is moved to the second position, the needle tip of the needle tube is covered by the shutter, so that erroneous puncture after the liquid administration can be prevented.

In addition, when the liquid administration device includes an urging means for urging the syringe assembly in the proximal direction with respect to the guide member, the needle of the needle tube is automatically made by the shutter when the administration of the liquid is completed. Since the tip is covered, it is easier to operate than when manually performing the operation of covering the needle tip of the needle tube, and the needle tip of the needle tube can be reliably covered.

FIG. 1 is a perspective view showing an embodiment of a liquid administration device of the present invention. 2 is a cross-sectional perspective view of the liquid administration device shown in FIG. 3 is a cross-sectional view of the liquid administration device shown in FIG. 1 immediately before completion of liquid administration. FIG. 4 is a perspective view showing a state in which the pair of shutters are closed after the liquid administration of the liquid administration device shown in FIG. 1 is completed, and is a view in which most of the first member of the outer cylinder is removed. . FIG. 5 is a perspective view showing an inner cylinder and a needle tube of the liquid administration device shown in FIG. 6 is an exploded perspective view showing a middle tube of the liquid administration device shown in FIG. FIG. 7 is an exploded perspective view showing an outer cylinder of the liquid administration device shown in FIG. FIG. 8 is a perspective view showing a guide member of the liquid administration device shown in FIG. 9 is a perspective view showing a shutter support portion of the liquid administration device shown in FIG. FIG. 10 is a perspective view showing a pair of shutters of the shutter of the liquid administration device shown in FIG.

Hereinafter, the liquid administration device of the present invention will be described in detail based on preferred embodiments shown in the accompanying drawings.

<Embodiment>
FIG. 1 is a perspective view showing an embodiment of a liquid administration device of the present invention. 2 is a cross-sectional perspective view of the liquid administration device shown in FIG. 3 is a cross-sectional view of the liquid administration device shown in FIG. 1 immediately before completion of liquid administration. 4 is a perspective view showing a state in which the pair of shutters are closed after the liquid administration of the liquid administration device shown in FIG. 1 is completed, and is a view in which most of the first member of the outer cylinder is removed. . FIG. 5 is a perspective view showing an inner cylinder and a needle tube of the liquid administration device shown in FIG. 6 is an exploded perspective view showing a middle tube of the liquid administration device shown in FIG. FIG. 7 is an exploded perspective view showing an outer cylinder of the liquid administration device shown in FIG. FIG. 8 is a perspective view showing a guide member of the liquid administration device shown in FIG. 9 is a perspective view showing a shutter support portion of the liquid administration device shown in FIG. FIG. 10 is a perspective view showing a pair of shutters of the shutter of the liquid administration device shown in FIG.

In the following description, the lower side in FIGS. 1 to 10 is referred to as the “front end” and the upper side as the “base end (rear end)”.

A liquid administration device 1 shown in FIGS. 1 to 4 is a medical instrument used when a liquid is administered (injected) into a living body. The liquid is appropriately selected according to the purpose of use. For example, hematopoietic agents, vaccines, hormone preparations, anti-rheumatic agents, anti-cancer agents, anesthetics, anticoagulants, etc. are mainly injected subcutaneously. Chemicals.

The liquid administration device 1 includes a syringe assembly 2 and a pair of guide pieces 62 having a plate shape extending along the axial direction of the inner cylinder 3 to be described later, and the shaft of the inner cylinder 3 to be described later. A guide member 6 that is movably supported along the direction, a coil spring 14 that is an urging means for urging the syringe assembly 2 in the proximal direction with respect to the guide member 6, and a cylindrical shape. On the other hand, an intermediate cylinder 4 installed between an outer cylinder 5 and an inner cylinder 3 (to be described later) of the syringe assembly 2 and a shutter assembly 8 provided at the distal end portion are provided.

The syringe assembly 2 has a cylindrical shape, an inner cylinder 3 that can store liquid therein, a sharp needle tip 111 at the tip, a needle tube 11 that is attached to the inner cylinder 3 and communicates with the inner cylinder 3; The gasket 12 that can move from the proximal end position to the distal end position along the axial direction of the inner cylinder 3 in the inner cylinder 3, and the operation of moving the gasket 12 along the axial direction of the inner cylinder 3, that is, toward the distal direction. And a plunger 13 that presses and an outer cylinder 5 that has a cylindrical shape and that houses and fixes at least a part of the inner cylinder 3 therein. The gasket 12 is connected to the tip of the plunger 13.

The syringe assembly 2 is installed so as to be movable with respect to the guide member 6. That is, in the syringe assembly 2, the needle tube 11 is inserted into an opening 83 to be described later of the shutter assembly 8, and the needle tip 111 protrudes to the distal end side from the shutter assembly 8 so that liquid can be administered from the needle tube 11. From this position, the needle tip 111 is movable to a second position retracted to the base end side from a plate-like portion 812 (to be described later) of the shutter assembly 8.

When the syringe assembly 2 is located at the first position, the needle tip 111 of the needle tube 11 is located on the distal end side with respect to the distal end of the bottom wall 72 of the shutter support portion 7 described later of the shutter assembly 8. (See FIG. 3). When the syringe assembly 2 is located at the second position, the needle tip 111 of the needle tube 11 is located on the proximal end side of the shutter assembly 8, that is, in the intermediate cylinder body 41 described later of the intermediate cylinder 4. (Refer to FIG. 4).

The liquid administration device 1 further includes first engaging means that can hold the syringe assembly 2 in the first position, and second engaging means that can be held in the second position. . The first engaging means is configured by projections 632 of the guide member 6 and first holes 53 of the outer cylinder 5 which will be described later. Further, the second engaging means is constituted by projections 632 of the guide member 6 to be described later and second holes 54 of the outer cylinder 5.

The constituent materials of the inner cylinder 3, the intermediate cylinder 4, the outer cylinder 5, the guide member 6, the shutter support portion 7, the plunger 13, and the

shutters

8a and 8b described later are not particularly limited. For example, polyvinyl chloride, Polyethylene, polypropylene, cyclic polyolefin, polystyrene, poly- (4-methylpentene-1), polycarbonate, acrylic resin, acrylonitrile-butadiene-styrene copolymer, polyester such as polyethylene terephthalate, polyethylene naphthalate, butadiene-styrene copolymer Various resins such as coalescence, polyamide (for example, nylon 6,

nylon

6,6, nylon 6,10, nylon 12) can be mentioned. Among them, polypropylene, cyclic polyolefin, polyester are preferable because they are easy to mold. , Poly- (4- Resins such as Chirupenten -1) is preferred.

As shown in FIGS. 1 to 5, the inner cylinder 3 is composed of a bottomed cylindrical member having a bottom portion on the distal end side and an opening on the proximal end side, and a central portion of the bottom portion on the distal end side. The needle tube 11 is attached. In this embodiment, the side wall of the inner cylinder 3 has a cylindrical shape. A flange 31 is integrally formed on the outer periphery of the base end portion of the inner cylinder 3.

In such an inner cylinder 3, a gasket 12 made of an elastic material is accommodated (inserted) so as to be slidable along the axial direction of the inner cylinder 3. A plurality (two in the present embodiment) of ring-shaped protrusions 121 are formed on the entire outer periphery of the gasket 12, and these protrusions 121 are in close contact with the inner peripheral surface of the inner cylinder 3. By sliding, liquid-tightness can be more reliably maintained and slidability can be improved.

Note that the space surrounded by the gasket 12 and the inner cylinder 3 is filled with liquid in advance. The liquid in the inner cylinder 3 can be pushed out from the needle tube 11 by moving the gasket 12 toward the distal end, that is, from the base end position in the inner cylinder 3 to the distal end position. Here, the base end position of the gasket 12 is the position of the gasket 12 in the axial direction of the inner cylinder 3 in a state where the space surrounded by the gasket 12 and the inner cylinder 3 is filled with the liquid. The tip position is the position of the gasket 12 in the axial direction of the inner cylinder 3 in a state where all the above-mentioned filled liquid is discharged.

The constituent material of the gasket 12 is not particularly limited. For example, various rubber materials such as natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, silicone rubber, polyurethane, polyester, polyamide, Examples thereof include elastic materials such as various thermoplastic elastomers such as olefins and styrenes, or mixtures thereof.

The plunger 13 has a rod-shaped main body 131 whose cross section is cross-shaped. A disc-shaped flange 133 is formed on the base end side of the main body 131. An inclined surface 134 is formed on the outer peripheral portion of the flange 133 on the proximal end side over the entire circumference. The inclined surface 134 constitutes an engagement release portion that releases the engagement of the first engagement means constituted by a projection 632 (described later) of the guide member 6 and a first hole 53 (described later) of the outer cylinder 5. Is done. In addition, the gasket 12 is fixed to the tip of the main body 131.

The needle tube 11 has a sharp needle tip 111 protruding from the bottom of the inner cylinder 3 toward the tip side at the tip. A living body can be punctured with the needle tip 111. Further, the proximal end of the needle tube 11 communicates with the inside of the inner cylinder 3. That is, the lumen (hollow part) of the needle tube 11 communicates with the inner cylinder 3 and functions as a flow path 112 through which the liquid from the inner cylinder 3 passes. Then, with the living body punctured with the needle tip 111, the liquid is injected into the living body via the flow path 112.

The constituent material of the needle tube 11 is not particularly limited. For example, the needle tube 11 is made of a metal material such as stainless steel, aluminum, an aluminum alloy, titanium, or a titanium alloy.

Note that a cap (not shown) is attached to the needle tube 11, and the needle tip 111 is sealed by the cap.

As shown in FIG. 7, the outer cylinder 5 is comprised by 2 members, ie, the 1st member 5a and the 2nd member 5b, in this embodiment. The first member 5a and the second member 5b are the same except that only the first member 5a has the protrusion 521.

As shown in FIGS. 2, 3, and 7, the outer cylinder 5 is disposed concentrically on the outer peripheral side of the inner cylinder 3 so as to be movable in the axial direction of the inner cylinder 3 with respect to the guide member 6. That is, the outer cylinder 5 houses the inner cylinder 3. In the present embodiment, the outer cylinder 5 has a quadrangular cylindrical shape.

A pair of fixed portions 51 having a recess 511 into which the flange 31 of the inner cylinder 3 is inserted are formed on the inner peripheral surface of the base end portion of the outer cylinder 5. Each fixing portion 51 is disposed so as to face each other with the inner cylinder 3 interposed therebetween. By inserting the flange 31 of the inner cylinder 3 into the concave portion 511 of each fixing part 51, the inner cylinder 3 is fixed to the outer cylinder 5, so that the outer cylinder 5 and the inner cylinder 3 are integrally integrated with the guide member 6. Can move in the axial direction of the inner cylinder 3.

Further, on the inner peripheral surface of the outer cylinder 5, a protruding portion 52 having an inner peripheral surface having a shape corresponding to the outer peripheral surface of the intermediate cylinder 4 is formed. A protrusion 521 that protrudes toward the center is formed on the inner peripheral surface of the protrusion 52. This protrusion 521 is inserted into a rail groove 42 of the intermediate cylinder 4 described later, that is, engages with a rail groove 42 of the intermediate cylinder 4 described later.

Further, a pair of guide grooves 55 are formed on the inner peripheral surface of the outer cylinder 5 along the axial direction of the inner cylinder 3 from the proximal end to the distal end. The guide grooves 55 are arranged so as to face each other with the inner cylinder 3 interposed therebetween. Each guide groove 55 extends along the axial direction of the inner cylinder 3. Each guide groove (guide portion) 62 described later of the guide member 6 is inserted into each guide groove 55. Thereby, the outer cylinder 5 can move along each guide piece 62 of the guide member 6, and cannot rotate with respect to the guide member 6. The guide groove may be formed in the guide member 6 and the guide portion may be formed in the outer cylinder 5.

Also, a pair of first holes 53 penetrating the wall portion is formed in the wall portion of the base end portion of the outer cylinder 5. Each first hole 53 is formed in a portion of the guide groove 55 of the outer cylinder 5 and is disposed so as to face each other with the inner cylinder 3 interposed therebetween. The first hole 53 and a projection 632 (described later) of the guide member 6 constitute a first engaging means. In addition, a pair of second holes 54 penetrating the wall portion are formed in the central wall portion of the outer cylinder 5, that is, in the wall portion on the distal end side of the first hole 53 of the outer cylinder 5. Has been. Each second hole 54 is formed in a portion of the guide groove 55 of the outer cylinder 5 and is disposed so as to face each other with the inner cylinder 3 interposed therebetween. The second engagement means is configured by the second hole 54 and a projection 632 described later of the guide member 6. The first hole 53 and the second hole 54 are arranged along the axial direction of the inner cylinder 3. The first hole 53 and the second hole 54 may each be a recess that does not penetrate the wall portion of the outer cylinder 5, that is, a recess.

As shown in FIGS. 2, 3, and 8, the intermediate cylinder 4 is installed concentrically with the outer cylinder 5 and the inner cylinder 3 between the guide member 6 and the inner cylinder 3. Further, the intermediate cylinder 4 is installed to be rotatable with respect to the guide member 6, the outer cylinder 5 and the inner cylinder 3.

As shown in FIG. 6, the intermediate cylinder 4 has an intermediate cylinder main body 41 and a gear member 43 installed at the tip of the intermediate cylinder main body 41.

The gear member 43 has a fixed portion 44 and a pinion gear 45 formed at the tip of the fixed portion 44. The fixed portion 44 of the gear member 43 is inserted into the distal end portion of the intermediate cylinder main body 41. That is, the fixed portion 44 and the tip portion of the intermediate cylinder main body 41 are fitted.

The fixing portion 44 is formed with a plurality of (four in this embodiment) slits 441 extending in the axial direction of the inner cylinder 3. A plurality of (four in the present embodiment) ribs 412 formed on the inner peripheral surface of the distal end portion of the intermediate cylinder main body 41 are inserted into the slit 441, whereby the gear member 43 rotates with respect to the intermediate cylinder main body 41. Be blocked.

The intermediate cylinder body 41 has a cylindrical shape in this embodiment. A rail groove 42 into which the protrusion 521 of the outer cylinder 5 is inserted is formed on the outer peripheral surface of the intermediate cylinder main body 41.

The rail groove 42 includes a linear groove 421 formed linearly in the axial direction of the inner cylinder 3 on the outer peripheral surface of the intermediate cylinder body 41 and a spiral spiral groove 422 having the central axis of the intermediate cylinder body 41 as a rotation axis. And a linear groove 423 formed linearly in the axial direction of the inner cylinder 3. Note that. In the present embodiment, the spiral groove 422 is formed shorter than one round. These linear grooves 421, spiral grooves 422, and linear grooves 423 are continuously formed in this order from the distal end side toward the proximal end side. When the outer cylinder 5 moves in the axial direction of the inner cylinder 3 by the rail groove 42 and the protrusion 521 of the outer cylinder 5, the intermediate cylinder 4 rotates by a predetermined angle with respect to the guide member 6 in a predetermined direction.

Also, an annular rib 411 is formed on the outer peripheral surface of the tip of the intermediate cylinder main body 41. The rib 411 is located on the distal end side of the support portion 61 of the guide member 6 and engages with an edge facing the opening of the support portion 61, thereby moving the intermediate cylinder 4 relative to the guide member 6 in the proximal direction. Is blocked.

As shown in FIGS. 2, 3 and 8, the guide member 6 is installed on the outer peripheral side of the inner cylinder 3, that is, between the intermediate cylinder 4 and the outer cylinder 5. The guide member 6 includes a support portion 61 and a pair of guide pieces 62 that are formed in a plate shape extending along the axial direction of the inner cylinder 3 and are arranged to face each other with the inner cylinder 3 interposed therebetween. Yes. The support portion 61 is provided at the distal end portion of the guide piece 62 and supports each guide piece 62. In the present embodiment, the support portion 61 has a plate shape, and each guide piece 62 is erected from the base end side surface of the support portion 61 toward the axial base end side of the inner cylinder 3.

In the present embodiment, the support portion 61 has a rectangular shape (including a square) in plan view. And a pair of guide piece 62 is arrange | positioned so that it may oppose along a pair of edge | side where the rectangle opposes. In addition, the shape of the support part 61 is not restricted to this, For example, other quadrilaterals, such as a trapezoid, other polygons, such as a pentagon, circle, ellipse, etc. are mentioned by planar view.

Further, an opening 611 through which the intermediate cylinder 4 is inserted is formed in the central portion of the support portion 61, that is, between the pair of guide pieces 62.

Further, four protrusions 612 are formed on the edge portion on the base end side of the support portion 61. Two protrusions 612 are formed on each of a pair of opposing sides different from the pair of sides on the side where the guide piece 62 of the support portion 61 is disposed.

Since each guide piece 62 is the same, one guide piece 62 will be typically described below.

The guide piece 62 has a guide piece main body 64 and an elastic piece 63 formed at the base end of the guide piece main body 64 so as to protrude in the base end direction. The width of the elastic piece 63 is set smaller than the width of the guide piece main body 64. Thereby, the guide piece 62 can be easily elastically deformed.

Further, an inclined surface 631 is formed on the base end portion of the elastic piece 63 and on the side opposite to the other elastic piece 63. The inclined surface 631 is formed so that the thickness of the elastic piece 63 gradually decreases in the proximal direction.

Further, the elastic piece 63 is projected in the axial direction of the inner cylinder 3 on the opposite side of the other elastic piece 63 to the outside, that is, toward the inner periphery of the outer cylinder 5, Projections (convex portions) 632 that can be engaged with the inner surface of the first hole 53 and the inner surface of the second hole 54 are formed.

The elastic piece 63 is configured to be able to release the engagement between the protrusion 632 and the first hole 53 of the outer cylinder 5 by elastic deformation thereof.

The shutter assembly 8 is provided on the front end side of the intermediate cylinder 4. The shutter assembly 8 includes a pair of

shutters

8a and 8b shown in FIG. 10 and a shutter support portion 7 shown in FIG. 9 that can accommodate the

shutters

8a and 8b. The shutter support portion 7 includes each shutter 8a. , 8b are movably supported in a direction perpendicular to the axial direction of the inner cylinder 3.

As shown in FIGS. 2, 3 and 9, the shutter support portion 7 is installed on the distal end side of the guide member 6, that is, on the support portion 61. The shutter support portion 7 includes a bottom wall 71 and a pair of side walls 72 formed so as to protrude from the bottom wall 71 toward the proximal direction.

In the present embodiment, the bottom wall 71 is rectangular (including a square) in plan view. Note that the shape of the bottom wall 71 is not limited to this, and may include other quadrangles such as trapezoids, other polygons such as pentagons, circles, ellipses, and the like in plan view.

Further, an opening 711 is formed at the center of the bottom wall 71. In the present embodiment, the shape of the opening 711 is circular. In addition, the shape of the opening 711 is not limited to this, For example, an ellipse, polygons, such as a rectangle, etc. are mentioned.

Each side wall 72 is formed so as to protrude in the proximal direction from a pair of opposite sides of the bottom wall 71. Since each side wall 72 is the same, one side wall 72 is typically described below.

Claws 721 that engage with the support portions 61 of the guide member 6 are formed at both ends of the side wall 72, respectively. In this embodiment, the claw 721 has an L shape, protrudes from the side wall 72 in the proximal direction, and protrudes in a direction perpendicular to the side wall 72.

The support portions 61 are held by the shutter support portion 7 by the claws 721 of the side walls 72 being engaged with the support portions 61.

Further, a slit 722 extending in the axial direction of the inner cylinder 3 is formed at the boundary between the portion of the side wall 72 where the claw 721 is formed and the portion closer to the center. Thereby, the site | part in which the nail | claw 721 of the side wall 72 is formed can be easily elastically deformed, and the nail | claw 721 can be easily engaged with the support part 61 at the time of the assembly of the liquid administration tool 1, The support portion 61 can be easily attached to the shutter support portion 7.

Further, in a state where the support portion 61 is mounted on the shutter support portion 7, each claw 721 is engaged with the support portion 61, and further, a corresponding protrusion 612 of the support portion 61 is engaged with each claw 721 from the center side. Thus, it is possible to prevent the support portion 61 from being displaced or detached from the shutter support portion 7.

In the unused state, that is, in the initial state, only a part of each

shutter

8a, 8b is accommodated in the shutter support portion 7 (see FIG. 2). Since the shutter 8a and the shutter 8b are the same, the shutter 8a will be described below as a representative.

As shown in FIGS. 2 and 10, the shutter 8 a includes a shutter main body 81 having a plate-like portion 812 having a thickness in the axial direction of the inner cylinder 3 and a protruding portion 813 protruding from the plate-like portion 812 to the proximal end side. And a rack gear 82 formed on the side surface of the protruding portion 813.

In this embodiment, the plate-like portion 812 has an L shape in plan view. In addition, a notch 811 that is cut out in a semicircular shape is formed at the end of the plate-like portion 812. Note that a predetermined portion other than the notch portion 811 of the plate-like portion 812 constitutes a covering portion that can cover the needle tip 111 of the needle tube 11 from the distal end side.

In the initial state, the

shutters

8 a and 8 b are arranged so that the notch portions 811 coincide with each other, and an opening (through hole) 83 that penetrates the plate-like portion 812 in the thickness direction is formed by each notch portion 811. Is done. In this initial state, the needle tube 11 is inserted through the opening 83 and protrudes in the distal direction. A state in which the needle tube 11 is inserted through the opening 83 is a state in which the

shutters

8a and 8b are opened (hereinafter also simply referred to as “open state”). The opening 83 constitutes an insertion portion through which the needle tube 11 can be inserted. The insertion portion is not limited to the opening 83, and may be a notch, for example.

Further, the L-shaped part on one end side and the part on the other end side of the plate-like portion 812 are shifted in the axial direction of the inner cylinder 3 by the thickness thereof, whereby the

shutters

8a and 8b are closed. The

shutters

8a and 8b can be closed by overlapping the one end portion and the other end portion of the

shutters

8a and 8b. The state in which the needle tip 111 of the needle tube 11 is covered with the plate-like portion 812 is a state in which the

shutters

8a and 8b are closed (hereinafter also simply referred to as “closed state”). When the

shutters

8a and 8b are closed, the notch 811 of the shutter 8a and the shutter body 81 of the shutter 8b overlap, and the notch 811 of the shutter 8b and the shutter body 81 of the shutter 8a overlap.

Further, the rack gears 82 of the

shutters

8a and 8b mesh with the pinion gear 45 of the intermediate cylinder 4, respectively. Further, the rack gear 82 of the shutter 8a and the rack gear 82 of the shutter 8b are arranged to face each other with the pinion gear 45 interposed therebetween, that is, to be parallel to each other. Thereby, when the pinion gear 45 rotates, the

shutters

8a and 8b move in directions opposite to each other.

In addition, the pair of

shutters

8a and 8b have a function as a pair of finger rests in the open state. That is, in the open state, the

shutters

8a and 8b protrude outward from the outer peripheral portion of the outer cylinder 5 in opposite directions. Thereby, when operating the plunger 11, the liquid administration tool 1 can be pressed toward the living body by touching the

shutters

8a and 8b with the fingers while touching the

shutter

8a and 8b. Thereby, the attitude | position of the liquid administration tool 1 can be maintained reliably at the time of operation of the plunger 13, Therefore Liquid administration can be performed easily.

In the initial state, that is, when the syringe assembly 2 is located at the first position, the

shutters

8a and 8b are in directions opposite to each other in a direction perpendicular to the axial direction of the inner cylinder 3 from the shutter support portion 7. Protrusively.

When the syringe assembly 2 is moved from the first position to the second position, the

shutters

8a and 8b are moved and closed in directions opposite to the protruding directions, and are stored in the shutter support portion 7. .

The coil spring 14 is installed in a contracted state between the projecting portion 52 of the outer cylinder 5 and the support portion 61 of the guide member 6. By this coil spring 14, the outer cylinder 5, that is, the syringe assembly 2 is urged in the proximal direction with respect to the guide member 6.

Next, a method of using the liquid administration device 1 and an operating state at the time of use will be described with reference to FIGS.

[1] As shown in FIGS. 1 and 2, a liquid administration device 1 in an unused state (initial state) is prepared. In the unused liquid administration device 1, the syringe assembly 2 is located at the first position shown in FIGS. That is, the protrusion 632 of each elastic piece 63 of the guide member 6 as the first engagement means engages with the first hole 53 of the outer cylinder 5, and thereby the proximal direction of the syringe assembly 2 is increased. The movement is prevented and the syringe assembly 2 is held in the first position. Further, the gasket 12 is located at the base end position of the inner cylinder 3.

Further, the pair of

shutters

8a and 8b are open. That is, the

shutters

8 a and 8 b protrude from the shutter support portion 7 in directions opposite to each other in a direction perpendicular to the axial direction of the inner cylinder 3. Then, the needle tube 11 protrudes between the shutter 8a and the shutter 8b, that is, from the opening 83 to the distal end side (see FIG. 3).

[2] Next, the cap (not shown) is removed from the needle tube 11, the needle tube 11 is punctured into the living body, and the

shutters

8a and 8b are brought into contact with the living body, and the fingers are respectively applied to the

shutters

8a and 8b, so The administration tool 1 is pressed toward the living body. Then, the plunger 13 is moved and operated in the distal direction. Thereby, the gasket 12 is moved together with the plunger 11 in the distal direction, that is, from the proximal end position of the inner cylinder 3 to the distal end position, and the liquid is discharged from the needle tube 11 and administered to the living body.

[3] As shown in FIG. 3, immediately before the plunger 11 moves to the end in the distal direction, that is, immediately before the administration of the liquid is completed, the inclined surface 134 of the plunger 11 is inclined to each guide piece 62 of the guide member 6. When the pressing is started toward the center of the surface 631 and the administration of the liquid is completed, the engagement of the protrusions 632 of each guide piece 62 is released. That is, the protrusion 632 of each guide piece 62 is detached from the first hole 53 of the outer cylinder 5, and the engagement between the protrusion 632 and the inner surface of the first hole 53 of the outer cylinder 5 is released. Thereby, the syringe assembly 2 can be moved from the first position to the second position.

Then, as shown in FIG. 4, the syringe assembly 2 moves in the proximal direction by the biasing force of the coil spring 14. That is, the syringe assembly 2 moves to the second position shown in FIG. 4, and the needle tube 11 moves into an intermediate cylinder body 41 (described later) of the intermediate cylinder 4. At this time, the protrusion 521 of the outer cylinder 5 moves in the proximal direction along the rail groove 42 of the intermediate cylinder 4, so that the intermediate cylinder 4, that is, the pinion gear 45, has a predetermined angle with respect to the guide member 6 in a predetermined direction. Rotate. This rotational movement of the pinion gear 45 is converted into a linear movement of the rack gear 82 of the

shutters

8a and 8b. That is, the rotational force of the pinion gear 45 is transmitted to the rack gear 82 of the

shutters

8a and 8b, the

shutters

8a and 8b move in opposite directions, and are stored in the shutter support portion 7, and the

shutters

8a and 8b are Close by side. Thereby, the needle tip 111 of the needle tube 11 is covered by the

shutters

8a and 8b.

In addition, the protrusion 632 of each guide piece 62 of the guide member 6 engages with the inner surface of the second hole 54 of the outer cylinder 5, thereby preventing the syringe assembly 2 from moving in the proximal direction, and the syringe assembly The solid 2 is held at the second position. Thereby, it is possible to prevent the syringe assembly 2 from being detached from the guide member 6.

As described above, according to the liquid administration device 1, when the administration of the liquid is completed and the syringe assembly 2 is moved to the second position, the needle tip 111 of the needle tube 11 is covered by the

shutters

8a and 8b. In addition, erroneous puncture after liquid administration can be prevented.

In the present embodiment, the liquid administration device 1 includes the coil spring 14 that urges the syringe assembly 2 in the proximal direction with respect to the guide member 6. The

shutters

8a and 8b move, and the needle tip 111 of the needle tube 11 is covered by the

shutters

8a and 8b. Thereby, compared with the case where the operation of manually covering the needle tip of the needle tube is performed, the operation is easy, and the needle tip 111 of the needle tube 11 can be reliably covered.

The liquid administration device of the present invention has been described based on the illustrated embodiment, but the present invention is not limited to this, and the configuration of each part is replaced with an arbitrary configuration having the same function. can do. In addition, any other component may be added to the present invention.

In the above-described embodiment, the inner cylinder is preliminarily filled with the liquid. However, the present invention is not limited to this, and the inner cylinder is not filled with the liquid. May be filled with a liquid.

In the above-described embodiment, the intermediate cylinder has a spiral rail groove, and the outer cylinder of the syringe assembly has a protrusion that engages with the rail groove. However, the present invention is not limited to this. The outer cylinder of the syringe assembly may have a spiral rail groove, and the intermediate cylinder may have a protrusion that engages with the rail groove. Further, instead of the rail groove, a spiral rail protrusion may be provided. Further, the spiral rail groove and the protrusion that engages with the rail groove may be provided on the outer peripheral surface of the inner cylinder and the inner peripheral surface of the intermediate cylinder. In this case, the inner cylinder is fixed so as not to rotate with respect to the outer cylinder.

In the above-described embodiment, the shutter assembly includes a pair of shutters. However, the present invention is not limited to this, and the shutter assembly may include only one shutter. You may have three or more.

In the above-described embodiment, the guide member has the guide piece. However, the guide member is not limited to this and may have a cylindrical guide body instead of the guide piece. In this case, the guide part is comprised from the protrusion provided in the outer peripheral part of the guide main body along the axial direction of the inner cylinder. Further, in this case, the guide portion is constituted by a protrusion provided on the inner peripheral portion of the outer cylinder along the axial direction of the inner cylinder, and the guide groove is formed on the outer peripheral portion of the guide body along the axial direction of the inner cylinder. You may be comprised from the provided groove | channel.

In the above-described embodiment, the liquid administration device includes the biasing member, but the biasing member may be omitted. In this case, when the administration of the liquid is completed, the guide member is grasped with one hand, and the syringe assembly is grasped with the other hand. In this state, when the syringe assembly is moved from the first position to the second position, the intermediate cylinder body rotates together with the pinion gear relative to the guide member, the rotational force of the pinion gear is transmitted to the rack gear, and the shutter moves. Then, the needle tip of the needle tube is covered by the shutter. In this case, the outer cylinder may be further omitted. When the outer cylinder is omitted, the spiral rail groove is provided on the inner peripheral surface of the intermediate cylinder, and the protrusion that engages with the rail groove is provided on the outer peripheral surface of the inner cylinder. The flange of the inner cylinder is provided with an opening, and the elastic piece of the guide member is formed with a convex portion that can be engaged with the edge of the opening. That is, the first engaging means is constituted by the edge portion and the convex portion of the opening. Then, the engagement between the edge portion of the opening and the convex portion can be released by the engagement release portion of the plunger. The intermediate cylinder has an extension groove that communicates with the proximal end side of the spiral rail groove and ends at the distal end side from the proximal end of the intermediate cylinder. Between the rail groove and the extension groove, the bottom of the groove is provided. A protrusion projecting from is provided. When the syringe assembly moves from the first position to the second position, the protrusion of the inner cylinder gets over the protrusion formed between the rail groove and the extension groove and reaches the extension groove. The protrusion of the inner cylinder is engaged from the proximal end side with the protrusion between the rail groove and the extension groove, and is engaged from the proximal end side and the distal end side facing the extension groove. Thereby, the syringe assembly is held in the second position. That is, the second engaging portion is constituted by the protrusion between the rail groove and the extension groove and the protrusion of the inner cylinder. When the outer cylinder is omitted, the guide member preferably has a cylindrical guide body instead of the guide piece. As a result, when the syringe assembly is moved from the first position to the second position, the guide main body can be gripped by hand, and the syringe assembly can be easily moved.

The liquid throwing device of the present invention is a liquid administration device for administering a liquid to a living body,
An inner cylinder having a bottom portion on the distal end side and an opening portion on the proximal end side and capable of storing a liquid therein, a sharp needle tip attached to the bottom portion and projecting from the bottom portion on the distal end, A needle tube whose end communicates with the inside of the inner cylinder, a gasket capable of moving from the proximal position to the distal position along the axial direction of the inner cylinder, and pressing the gasket toward the distal direction A syringe assembly comprising a plunger for
A guide member installed on the outer peripheral side of the inner cylinder and supporting the syringe assembly movably along the axial direction of the inner cylinder;
An intermediate cylinder main body that is rotatably installed with respect to the guide member between the guide member and the inner cylinder, and is fixed to the distal end side of the intermediate cylinder main body, and is radial with respect to the axis of the intermediate cylinder main body An intermediate cylinder provided with a pinion gear having teeth protruding to
A rack gear meshing with the pinion gear; a shutter having an insertion portion through which the needle tube can be inserted; and a covering portion capable of covering the needle tip from the distal end side; and fixed to the distal end side of the guide member; A shutter assembly including a shutter support portion that is movably supported in a direction orthogonal to the axial direction of the inner cylinder,
In the syringe assembly, the needle tip is retracted from the covering portion to the proximal end side from a first position where the needle tube is inserted through the insertion portion, and the needle tip protrudes toward the distal end side from the shutter assembly. Move to a second position,
The liquid administration device includes a first engagement means capable of holding the syringe assembly 2 in the first position, and a second engagement means capable of holding the syringe assembly 2 in the second position. And further comprising
One of the syringe assembly and the intermediate cylinder includes a spiral rail protrusion or rail groove whose axis is the axis of the intermediate cylinder main body, and the other is a protrusion that engages with the rail protrusion or the rail groove. With
When the gasket is located at the proximal end position, the syringe assembly is held at the first position by the engagement of the first engagement means,
When the plunger is operated to move the gasket from the proximal end position to the distal end position, the plunger disengages the first engaging means, and the syringe assembly is moved from the first position. Move to the second position,
When the syringe assembly is moved from the first position to the second position, the syringe assembly is held at the second position by the engagement of the second engaging means, When the protrusion moves along the rail protrusion or the rail groove, the intermediate cylinder body rotates together with the pinion gear with respect to the guide member, the rotational force of the pinion gear is transmitted to the rack gear, and the shutter moves. The covering portion covers the needle tip from the tip side.
According to the present invention, when the administration of the liquid is completed and the syringe assembly is moved to the second position, the needle tip of the needle tube is covered by the shutter, so that erroneous puncture after the liquid administration can be prevented.
In addition, when the liquid administration device includes an urging means for urging the syringe assembly in the proximal direction with respect to the guide member, the needle of the needle tube is automatically made by the shutter when the administration of the liquid is completed. Since the tip is covered, it is easier to operate than when manually performing the operation of covering the needle tip of the needle tube, and the needle tip of the needle tube can be reliably covered.
Therefore, it has industrial applicability.

DESCRIPTION OF SYMBOLS 1 Liquid administration tool 2 Syringe assembly 3 Inner cylinder 31 Flange 4 Intermediate cylinder 41 Intermediate cylinder

main body

411, 412 Rib 42

Rail groove

421, 423 Linear groove 422 Spiral groove 43 Gear member 44 Fixed part 441 Slit 45 Pinion gear 5 Outer cylinder 5a First 1 member 5b second member 51 fixed portion 511 recessed portion 52 protruding portion 521 protrusion 53 first hole 54 second hole 55 guide groove 6 guide member 61 support portion 611 opening 612 protrusion 62 guide piece 63 elastic piece 631 inclined surface 632 Projection 64 Guide piece main body 7 Shutter support portion 71 Bottom wall 711 Opening 72 Side wall 721 Claw 722 Slit 8

Shutter assembly

8a, 8b Shutter 81 Shutter body 811 Notch portion 812 Plate-like portion 813 Projection portion 82 Rack gear 83 Opening 11 Needle tube 111 Needle tip 112 Flow path 12 Gasket 121 Protrusion portion 13 Plunger 131 Body portion 133 Flange 134 Inclined surface 14 Coil spring

Claims

A liquid administration device for administering a liquid to a living body,
An inner cylinder having a bottom portion on the distal end side and an opening portion on the proximal end side and capable of storing a liquid therein, a sharp needle tip attached to the bottom portion and projecting from the bottom portion on the distal end, A needle tube whose end communicates with the inside of the inner cylinder, a gasket capable of moving from the proximal position to the distal position along the axial direction of the inner cylinder, and pressing the gasket toward the distal direction A syringe assembly comprising a plunger for
A guide member installed on the outer peripheral side of the inner cylinder and supporting the syringe assembly movably along the axial direction of the inner cylinder;
An intermediate cylinder main body that is rotatably installed with respect to the guide member between the guide member and the inner cylinder, and is fixed to the distal end side of the intermediate cylinder main body, and is radial with respect to the axis of the intermediate cylinder main body An intermediate cylinder provided with a pinion gear having teeth protruding to
A rack gear meshing with the pinion gear; a shutter having an insertion portion through which the needle tube can be inserted; and a covering portion capable of covering the needle tip from the distal end side; and fixed to the distal end side of the guide member; A shutter assembly including a shutter support portion that is movably supported in a direction orthogonal to the axial direction of the inner cylinder,
In the syringe assembly, the needle tip is retracted from the covering portion to the proximal end side from a first position where the needle tube is inserted through the insertion portion, and the needle tip protrudes toward the distal end side from the shutter assembly. Move to a second position,
The liquid administration device includes a first engagement means capable of holding the syringe assembly 2 in the first position, and a second engagement means capable of holding the syringe assembly 2 in the second position. And further comprising
One of the syringe assembly and the intermediate cylinder includes a spiral rail protrusion or rail groove whose axis is the axis of the intermediate cylinder main body, and the other is a protrusion that engages with the rail protrusion or the rail groove. With
When the gasket is located at the proximal end position, the syringe assembly is held at the first position by the engagement of the first engagement means,
When the plunger is operated to move the gasket from the proximal end position to the distal end position, the plunger disengages the first engaging means, and the syringe assembly is moved from the first position. Move to the second position,
When the syringe assembly is moved from the first position to the second position, the syringe assembly is held at the second position by the engagement of the second engaging means, When the protrusion moves along the rail protrusion or the rail groove, the intermediate cylinder body rotates together with the pinion gear with respect to the guide member, the rotational force of the pinion gear is transmitted to the rack gear, and the shutter moves. And the said coating | coated part covers the said needle tip from the front end side, The liquid administration tool characterized by the above-mentioned.
The first engagement means is provided on the guide member and the syringe assembly,
The guide member includes an elastic piece capable of releasing the engagement of the first engagement means by elastic deformation,
The plunger includes an engagement release portion that elastically deforms the elastic piece to release the engagement of the first engagement means when the plunger is operated from the initial state and the gasket is fully pressed. The liquid administration device according to claim 1 provided.
The liquid administration device further includes a biasing unit that biases the syringe assembly in the proximal direction with respect to the guide member,
The syringe assembly is provided non-rotatably with respect to the guide member, and includes an outer cylinder that houses and fixes at least a part of the inner cylinder on the inside thereof.
The liquid administration device according to claim 1 or 2, wherein the guide member is installed between the outer cylinder and the intermediate cylinder.
The elastic piece has a convex portion formed to protrude toward the inner periphery of the outer cylinder,
The outer cylinder is provided with a first hole with which the convex portion engages and a second hole with which the protrusion engages on the tip side of the first hole,
The liquid administration according to claim 3, wherein the first engagement means includes the convex portion and the first hole, and the second engagement means includes the convex portion and the second hole. Ingredients.
The guide groove formed along the axial direction of the said inner cylinder is provided in one of the said outer cylinder and the said guide member, and the guide part inserted in the said guide groove is provided in the other. A liquid administration device according to 1.
The guide groove is provided on the inner periphery of the outer cylinder so as to face each other across the inner cylinder,
The guide portion has a plate shape extending along the axial direction of the inner cylinder, and is provided on the guide member as a pair of guide pieces facing each other across the inner cylinder,
The liquid administration device according to claim 5, wherein the guide member includes a support portion that is provided at a distal end portion of the pair of guide pieces and supports the pair of guide pieces.
The guide member includes an elastic piece capable of releasing the engagement of the first engagement means by elastic deformation,
The elastic piece is provided at a proximal end portion of the guide piece,
The liquid administration device according to claim 6, wherein the first hole and the second hole are provided in the guide groove.
The shutter has a plate-like portion having a thickness in the axial direction of the inner cylinder, and a protruding portion that protrudes from the plate-like portion to the proximal end side,
The insertion part consists of a through-hole or notch that penetrates the plate-like part in its thickness direction,
The covering portion is provided as a part of the plate-like portion,
The liquid administration device according to any one of claims 1 to 7, wherein the rack gear is provided on a side surface of the protrusion.
The shutter assembly includes a pair of the shutters,
When the syringe assembly is located at the first position, the pair of shutters protrude from the shutter support portions in directions opposite to each other in a direction orthogonal to the axial direction of the inner cylinder. 9. A liquid administration device according to 8.
The shutter support portion can store the pair of shutters,
When the syringe assembly is moved from the first position to the second position, the pair of shutters are moved in a direction opposite to a protruding direction and are accommodated in the shutter support portion. 9. A liquid administration device according to 9.
The liquid administration device according to any one of claims 1 to 10, wherein the inner cylinder is prefilled with a liquid.
The liquid administration device according to any one of claims 1 to 11, wherein the liquid is a chemical solution.