WO2013128444A1 - Two way fluid control device - Google Patents

Two way fluid control device Download PDF

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Publication number
WO2013128444A1
WO2013128444A1 PCT/IL2013/050167 IL2013050167W WO2013128444A1 WO 2013128444 A1 WO2013128444 A1 WO 2013128444A1 IL 2013050167 W IL2013050167 W IL 2013050167W WO 2013128444 A1 WO2013128444 A1 WO 2013128444A1
Authority
WO
WIPO (PCT)
Prior art keywords
vial
liquid
drug
drug vial
adapter
Prior art date
Application number
PCT/IL2013/050167
Other languages
French (fr)
Inventor
Igor Denenburg
Original Assignee
Medeq Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201261605770P priority Critical
Priority to US61/605,770 priority
Application filed by Medeq Llc filed Critical Medeq Llc
Publication of WO2013128444A1 publication Critical patent/WO2013128444A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/162Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089Containers or vials which are to be joined to each other in order to mix their contents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096Combination of a vial and a syringe for transferring or mixing their contents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22Valves or arrangement of valves
    • A61M39/223Multiway valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006Piercing means
    • A61J1/201Piercing means having one piercing end
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006Piercing means
    • A61J1/2013Piercing means having two piercing ends
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048Connecting means
    • A61J1/2058Connecting means having multiple connecting ports
    • A61J1/2062Connecting means having multiple connecting ports with directional valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10Tube connectors; Tube couplings
    • A61M2039/1077Adapters, e.g. couplings adapting a connector to one or several other connectors

Abstract

Two way fluid control device including a rigid L-shaped housing having a liquid vial adapter for telescopic mounting on the liquid vial and a syringe port for receiving the needleless syringe, a drug vial adapter for telescopic mounting on the drug vial and a flow control member rotatable in the L-shaped housing for enabling flow communication between the drug vial adapter and either the liquid vial adapter or the syringe port. The two way fluid control device undergoes manipulation from an initial T-shaped configuration with the drug vial adapter inline with the liquid vial adapter to a final T-shaped configuration with the drug vial adapter inline with the syringe port for enabling inline aspiration of a liquid drug from a drug vial to the needleless syringe for administration purposes.

Description

TWO WAY FLUID CONTROL DEVICE

Field of the Invention

The invention pertains to two way fluid control devices. Background of the Invention

Commonly owned US Patent No. 6,379,340 entitled Fluid Control Device to Zinger et al. discloses two way fluid control devices for use with a pair of medicinal vials and a needleless syringe for preparation of a liquid drug for aspiration to the needleless syringe for administration purposes (see Figures 23 to 28). The two way fluid control devices have a rigid T-shaped housing including an inline configuration of two opposite vial adapters for telescopic mounting on a pair of medicinal vials and a syringe port perpendicular thereto for receiving a needleless syringe. The vial adapters are formed with puncturing cannulas for puncturing a vial stopper on telescopic mounting on a medicinal vial. The syringe port is integrally formed with a flow control member manually rotatable between two operative positions for controlling flow communication between the two opposite vial adapters and the syringe port.

US Patent No. 6,379,340 Figures 23 to 25 disclose a two way fluid control device particularly suitable for use with medicinal vials containing a powdered drug under negative pressure. The two way fluid control device includes a flow control member having a semi-circular peripheral groove for enabling direct flow communication between its two opposite vial adapters for enabling negative pressure drawing of liquid contents from a medicinal vial containing liquid contents to a medicinal vial containing powdered drug contents under negative pressure for forming a liquid drug in the latter medicinal vial. The flow control member also includes an L-shaped lumen for enabling operation of the needleless syringe to aspirate the liquid drug to the needleless syringe. US Patent No. 6,379,340 Figures 26 and 27 disclose a two way fluid control device similar to the former two way fluid control device except without the semi-circular peripheral groove. The latter two way fluid control device requires additional steps of aspirating the liquid contents from the medicinal vial containing liquid contents to the needleless syringe and injecting the liquid contents to the medicinal vial containing powdered drug contents for forming a liquid drug ready for aspiration to the needleless syringe. The latter two way fluid control device is typically employed for medicinal vials containing liquid drug contents or powdered drug contents not under negative pressure.

Both two way fluid control devices require a user to hold a fluid control device in one hand and a needleless syringe in his other hand and operate the needleless syringe in a transverse direction to the fluid control device. Some professional users and particularly non-professional users may find such handling inconvenient and unintuitive.

There is a need for a two way fluid control device for use with a pair of medicinal vials and a needleless syringe for preparation of a liquid drug for aspiration to the needleless syringe for administration purposes which is more convenient and intuitive to use than the hitherto described fluid control devices. Summary of the Invention

The present invention is directed toward a two way fluid control device for use with a liquid vial, a drug vial under negative pressure, and a needleless syringe for preparation of a liquid drug in the drug vial for inline aspiration to the needleless syringe for administration purposes. The two way fluid control device includes a rigid L- shaped housing having a liquid vial adapter for telescopic mounting on the liquid vial and a syringe port for receiving the needleless syringe, a drug vial adapter for telescopic mounting on the drug vial and a flow control member rotatable in the L- shaped housing for enabling flow communication between the drug vial adapter and either the liquid vial adapter or the syringe port. The two way fluid control device undergoes manipulation from an initial T-shaped configuration with the drug vial adapter inline with the liquid vial adapter to a final T-shaped configuration with the drug vial adapter inline with the syringe port for affording convenient and intuitive operation of the needleless syringe for inline aspiration of the liquid drug from the drug vial to the needleless syringe for administration purposes.

Brief Description of the Drawings

In order to understand the invention and to see how it can be carried out in practice, a preferred embodiment will now be described, by way of a non- limiting example only, with reference to the accompanying drawings, in which similar parts are likewise numbered, and in which:

Fig. 1 is a pictorial representation of a two way fluid control device having a liquid vial adapter, a drug vial adapter and a syringe port, a drug vial, a liquid vial, and a needleless syringe;

Fig. 2 is an exploded view of the two way fluid control device;

Fig. 3 is a front perspective view of the two way fluid control device in an initial T-shaped configuration for inline flow communication between the drug vial adapter and the liquid vial adapter;

Fig. 4 is a longitudinal cross section of the two way fluid control device along line A- A in Figure 3;

Fig. 5 is a front perspective view of the two way fluid control device in a final T-shaped configuration for inline flow communication between the drug vial adapter and the syringe port;

Fig. 6 is a longitudinal cross section of the two way fluid control device along line B-B in Figure 5; and

Figs. 7A to 7E show the use of the two way fluid control device for preparing the needleless syringe with a liquid drug for administration purposes. Detailed Description of the Drawings

Figure 1 shows a two way fluid control device 100 for use with a drug vial 10, a liquid vial 20, and a needleless syringe 30. The drug vial 10 has a longitudinal drug vial axis 10A and includes a drug vial bottle 11 having a drug vial opening 12 sealed by a drug vial stopper 13. The drug vial 10 contains a drug component 14 under negative pressure. The liquid vial 20 has a longitudinal drug vial axis 20A and includes a liquid vial bottle 21 having a liquid vial opening 22 sealed by a liquid vial stopper 23. The liquid vial 20 is filled with a liquid component 24. The liquid component 24 can be diluent only. Alternatively, the liquid component 24 can include an active component. The syringe 30 includes a barrel 31 with a plunger 32 and a male connector 33. The male connector 33 is preferably a male Luer lock connector.

Figures 1 to 6 show the fluid control device 100 includes a rigid L-shaped housing 101 defining an imaginary plane. The L-shaped housing 101 includes a tubular manifold 102 with a longitudinal manifold axis 102 A perpendicular to the imaginary plane. The manifold 102 includes a peripheral manifold wall 103 and opposite manifold end faces 104 A and 104B. The manifold 102 is integrally formed with a liquid vial adapter 106 for telescopic mounting on the liquid vial 20 and a syringe port 107 for receiving the needleless syringe 30. The liquid vial adapter 106 is formed with a puncturing cannula 108 for puncturing the liquid vial stopper 23. The syringe port 107 is formed as a female connector 109 for sealingly receiving the male connector 33. The female connector 109 is preferably formed as a female Luer connector.

The manifold wall 103 is formed with a generally quarter turn throughgoing slot 111 at the opposite side to liquid vial adapter 106 and the syringe port 107. The throughgoing slot 111 has a first slot end 111 A opposite the liquid vial adapter 106 and a second slot end 11 IB opposite the syringe port 107. The manifold wall 103 is formed with a first throughgoing bore 112 opposite the first slot end 111 A and in flow communication with the puncturing cannula 108. The manifold wall 103 is formed with a second throughgoing bore

113 opposite the second slot end 11 IB and in flow communication with the syringe port 107. The manifold end faces 104 A and 104B are each formed with an indent 114 aligned with the first throughgoing bore 112 and an indent 116 aligned with the second throughgoing bore 113.

The fluid control device 100 includes a solid flow control member 117 rotatable in the L-shaped housing 101 about a rotation axis 118 co-axial with longitudinal manifold axis 102 A. The flow control member 117 includes a diametrical lumen 119 having a stepped diameter including a major wide diameter section 119A and a minor small diameter section 119B.

The fluid control device 100 includes a drug vial adapter 121 for telescopic mounting on the drug vial 10 and formed with a puncturing cannula 122 for puncturing the drug vial stopper 13. The drug vial adapter 121 includes a tubular extension 123 extending from the puncturing cannula 122 through the throughgoing slot 111 into the major wide diameter section 119A. The drug vial adapter 121 is formed with a pair of downward depending supports 124 generally co-extensive with the extension 123. The supports 124 are each formed with an inward directed projection 126 for click fit insertion into either the indent pair

114 or the indent pair 116. Figure 2 shows the drug vial adapter 121 partly broken away to better show the far projection 126 and the opposite projection

126 in dotted lines.

The drug vial adapter 121 engages the flow control member 117 and is rotatable about the rotation axis 118 in the L-shaped housing 101 's imaginary plane for urging the flow control member 117 from a first operative position for inline flow communication between the drug vial adapter 121 and the liquid vial adapter 106 to a second operative position for inline flow communication between the drug vial adapter 121 and the syringe port 107.

The two way fluid control device 100 has an initial T-shaped configuration in the first operative position wherein the projection pair 126 are disposed at the indent pair 114, the extension 123 is disposed at the first slot end 111 A and the diametrical lumen 119 is in inline flow communication with the first throughgoing bore 112 (see Figures 3 and 4).

Pursuant to counter-clockwise rotation of the drug vial adapter 121 relative to the L- shaped housing 101 as denoted by arrow A in Figure 3, the two way fluid control device 100 has a final T-shaped configuration in the second operative position wherein the projection pair 126 is disposed at the indent pair 116, the extension 123 is disposed at the second slot end 111B and the diametrical lumen 119 is in flow communication with the second throughgoing bore 113 (see Figures 5 and 6).

The drug vial 10 and the drug vial adapter 121 are preferably colored in one color and the liquid vial 20 and the liquid vial adapter 106 are preferably colored in a different color to assist a user to telescopically mount the fluid control device 100 on the drug vial 10 and the liquid vial 20 in the correct order as now described hereinbelow with reference to Figures 7 A to 7E.

Figure 7 A shows the two way fluid control device 100 in its initial T- shaped configuration and disposed above a liquid vial 20 prior to its liquid vial adapter 106 being telescopically mounted on the liquid vial 20 as denoted by arrow B.

Figure 7B shows the liquid vial adapter 106 telescopically mounted on the liquid vial 20.

Figure 7C shows the two way fluid control device 100 inverted with respect to Figure 7B and disposed above a drug vial 10 prior to its drug vial adapter 121 being telescopically mounted on the drug vial 10 as denoted by arrow C.

Figure 7D shows the liquid contents of the liquid vial 20 drawn into the drug vial 10 for mixing with the drug component to form a liquid drug LD in the drug vial 10. The drug vial 10 is rotated in a clockwise direction as denoted by arrow D to dispose the two way fluid control device 100 in its final T-shaped configuration with the drug vial 10 inline with the syringe port 107 as shown in Figure 7E.

Figure 7E shows the fluid control device 100 is turned through a quarter turn clockwise with respect to Figure 7D ready for inline aspiration of the liquid drug LD to the needleless syringe 30 as denoted by arrow E.

While the invention has been described with respect to a limited number of embodiments, it will be appreciated that many variations, modifications, and other applications of the invention can be made within the scope of the appended claims.

Claims

Claims:
1. A two way fluid control device for use with a drug vial, a liquid vial, and a needleless syringe, the drug vial including a drug vial bottle containing a drug component under negative pressure and having a drug vial opening stopped by a drug vial stopper, the liquid vial including a liquid vial bottle containing liquid contents for mixing with the drug component to form a liquid drug and having a liquid vial opening stopped by a liquid vial stopper, the fluid control device comprising:
(a) a rigid L- shaped housing defining an imaginary plane and integrally formed with a liquid vial adapter for telescopic mounting on the liquid vial and having a puncturing cannula for flow communication with liquid vial bottle on puncturing the liquid vial stopper, and a syringe port for receiving the needleless syringe;
(b) a drug vial adapter for telescopic mounting on the drug vial and including a puncturing cannula for flow communication with the drug vial bottle on puncturing the drug vial stopper; and
(c) a flow control member rotatable in said L- shaped housing about a rotation axis perpendicular to said imaginary plane from a first operative position for flow communication between said drug vial adapter and said liquid vial adapter to a second operative position for flow communication between said drug vial adapter and said syringe port,
said drug vial adapter being manually rotatable about said rotation axis for urging said flow control member from said first operative position to said second operative position,
the two way fluid control device having an initial T-shaped configuration in said first operative position with said drug vial adapter inline with said liquid vial adapter for enabling negative pressure drawing of the liquid contents from the liquid vial to the drug vial to form a liquid drug in the drug vial on initial telescopic mounting the liquid vial adapter on the liquid vial and subsequent telescopic mounting the drug vial adapter on the drug vial, and
the two way fluid control device having a final T-shaped configuration in said second operative position with said drug vial adapter inline with said syringe port for enabling operation of the needleless syringe for inline aspiration of the liquid drug from the drug vial to the needleless syringe for administration purposes.
PCT/IL2013/050167 2012-03-02 2013-02-27 Two way fluid control device WO2013128444A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US201261605770P true 2012-03-02 2012-03-02
US61/605,770 2012-03-02

Publications (1)

Publication Number Publication Date
WO2013128444A1 true WO2013128444A1 (en) 2013-09-06

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Application Number Title Priority Date Filing Date
PCT/IL2013/050167 WO2013128444A1 (en) 2012-03-02 2013-02-27 Two way fluid control device
PCT/IL2013/050180 WO2013128455A1 (en) 2012-03-02 2013-02-28 Universal three way fluid control device

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/IL2013/050180 WO2013128455A1 (en) 2012-03-02 2013-02-28 Universal three way fluid control device

Country Status (1)

Country Link
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016203464A1 (en) * 2015-06-14 2016-12-22 Dali Medical Devices Ltd. Systems for interfacing between a syringe, a drug vial, and a needle

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4735608A (en) * 1986-05-14 1988-04-05 Del F. Kahan Apparatus for storing and reconstituting antibiotics with intravenous fluids
US6379340B1 (en) * 1995-03-20 2002-04-30 Medimop Medical Projects Lts. Fluid control device
WO2009146088A1 (en) * 2008-04-01 2009-12-03 Yukon Medical, Llc Dual container fluid transfer device
WO2011077434A1 (en) * 2009-12-23 2011-06-30 Medimop Medical Projects Ltd Medical apparatus and single use kit including flow control device for use therewith for reconstitution and administration of liquid drug dosage

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4735608A (en) * 1986-05-14 1988-04-05 Del F. Kahan Apparatus for storing and reconstituting antibiotics with intravenous fluids
US6379340B1 (en) * 1995-03-20 2002-04-30 Medimop Medical Projects Lts. Fluid control device
WO2009146088A1 (en) * 2008-04-01 2009-12-03 Yukon Medical, Llc Dual container fluid transfer device
WO2011077434A1 (en) * 2009-12-23 2011-06-30 Medimop Medical Projects Ltd Medical apparatus and single use kit including flow control device for use therewith for reconstitution and administration of liquid drug dosage

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016203464A1 (en) * 2015-06-14 2016-12-22 Dali Medical Devices Ltd. Systems for interfacing between a syringe, a drug vial, and a needle

Also Published As

Publication number Publication date
WO2013128455A1 (en) 2013-09-06

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