WO2013122375A3 - 바이러스 치료용 약학 조성물 및 항바이러스제 스크리닝 방법 - Google Patents
바이러스 치료용 약학 조성물 및 항바이러스제 스크리닝 방법 Download PDFInfo
- Publication number
- WO2013122375A3 WO2013122375A3 PCT/KR2013/001111 KR2013001111W WO2013122375A3 WO 2013122375 A3 WO2013122375 A3 WO 2013122375A3 KR 2013001111 W KR2013001111 W KR 2013001111W WO 2013122375 A3 WO2013122375 A3 WO 2013122375A3
- Authority
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- WIPO (PCT)
- Prior art keywords
- pharmaceutical composition
- antiviral agent
- viral treatment
- screening antiviral
- screening
- Prior art date
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- 239000003443 antiviral agent Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000012216 screening Methods 0.000 title abstract 2
- 230000003612 virological effect Effects 0.000 title 1
- 102100035473 2'-5'-oligoadenylate synthase-like protein Human genes 0.000 abstract 2
- 101000597360 Homo sapiens 2'-5'-oligoadenylate synthase-like protein Proteins 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- A—HUMAN NECESSITIES
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- C12N15/09—Recombinant DNA-technology
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N9/10—Transferases (2.)
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- C12N9/1241—Nucleotidyltransferases (2.7.7)
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- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
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- G01N2333/91245—Nucleotidyltransferases (2.7.7)
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Abstract
본 발명은 OASL1 단백질의 발현 양을 특이적으로 감소시킴으로써 바이러스에 대한 면역력을 증진시킬 수 있는 약학 조성물 및 OASL1 단백질의 발현 양을 비교함으로써 항 바이러스제로 이용될 수 있는 물질을 스크리닝하는 방법에 관한 것이다.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/376,987 US20150082467A1 (en) | 2012-02-13 | 2013-02-13 | Pharmaceutical composition for viral treatment, and method for screening antiviral agent |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2012-0014516 | 2012-02-13 | ||
KR1020120014516A KR101390417B1 (ko) | 2012-02-13 | 2012-02-13 | 바이러스 치료용 약학 조성물 및 항바이러스제 스크리닝 방법 |
Publications (3)
Publication Number | Publication Date |
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WO2013122375A2 WO2013122375A2 (ko) | 2013-08-22 |
WO2013122375A3 true WO2013122375A3 (ko) | 2013-10-10 |
WO2013122375A9 WO2013122375A9 (ko) | 2013-11-28 |
Family
ID=48984867
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/KR2013/001111 WO2013122375A2 (ko) | 2012-02-13 | 2013-02-13 | 바이러스 치료용 약학 조성물 및 항바이러스제 스크리닝 방법 |
Country Status (3)
Country | Link |
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US (1) | US20150082467A1 (ko) |
KR (1) | KR101390417B1 (ko) |
WO (1) | WO2013122375A2 (ko) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0208928D0 (en) * | 2002-04-19 | 2002-05-29 | Imp College Innovations Ltd | Methods |
US20070161003A1 (en) * | 2003-09-29 | 2007-07-12 | Morris David W | Novel therapeutic targets in cancer |
US20100267575A1 (en) * | 2006-10-17 | 2010-10-21 | Childrens Hospital Medical Center | Gene array technique for predicting response in inflammatory bowel diseases |
US20110104138A1 (en) * | 2009-11-03 | 2011-05-05 | Institut Pasteur | Use of the innate immunity gene oasl for preventing or treating infection with negative strand rna viruses |
-
2012
- 2012-02-13 KR KR1020120014516A patent/KR101390417B1/ko active IP Right Grant
-
2013
- 2013-02-13 US US14/376,987 patent/US20150082467A1/en not_active Abandoned
- 2013-02-13 WO PCT/KR2013/001111 patent/WO2013122375A2/ko active Application Filing
Non-Patent Citations (3)
Title |
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KRISTIANSEN, H. ET AL.: "The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities", JOURNAL OF INTERFERON & CYTOKINE RESEARCH, vol. 31, 2011, pages 41 - 47 * |
MARQUES, J. ET AL.: "The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domain", JOURNAL OF GENERAL VIROLOGY, vol. 89, 2008, pages 2767 - 2772, XP002623390, DOI: doi:10.1099/vir.0.2008/003558-0 * |
MELCHJORSEN, J. ET AL.: "Differential regulation of the OASL and OAS1 genes in response to viral infections", JOURNAL OF INTERFERON & CYTOKINE RESEARCH, vol. 29, 2009, pages 199 - 207, XP002623389, DOI: doi:10.1089/JIR.2008.0050 * |
Also Published As
Publication number | Publication date |
---|---|
KR20130094371A (ko) | 2013-08-26 |
WO2013122375A9 (ko) | 2013-11-28 |
KR101390417B1 (ko) | 2014-05-07 |
US20150082467A1 (en) | 2015-03-19 |
WO2013122375A2 (ko) | 2013-08-22 |
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