WO2013110010A1

WO2013110010A1 - Compositions and methods for incorporation of encapsulated materials in anhydrous materials

Info

Publication number: WO2013110010A1
Application number: PCT/US2013/022330
Authority: WO
Inventors: Paul Alan WOELBING; Benjamin Eduardo Baker LINS; Claudio Lucio Kolling LINS
Original assignee: Carma Laboratories, Inc.
Priority date: 2012-01-19
Filing date: 2013-01-19
Publication date: 2013-07-25

Abstract

Compositions for the skin and lips comprising an encapsulated phase, a dispersant phase, and an anhydrous phase. The composition may comprise an encapsulated phase comprising at least one hydrophobic agent providing a benefit to the skin or lips. The encapsulated phase may be dispersed in a dispersant phase comprising at least one of an oil, a sweetener, a thickener, an emollient, and a combination thereof. The composition may include an anhydrous phase comprising a polymer and an emollient.

Description

COMPOSITIONS AND METHODS FOR INCORPORATION OF ENCAPSULATED

MATERIALS IN ANHYDROUS MATERIALS

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims priority to U.S. Provisional Patent Application No. 61/588,522, filed January 19, 2012, which is incorporated herein by reference in its entirety.

INTRODUCTION

[0002] Various components are desired in compositions designed for topical administration to the skin, but due to their chemical nature and tendency to separate from one another, the compositions may be difficult to mix and often form heterogenous mixtures. Conventional skin and lip balm compositions may circumvent these issues to form a homogenous composition by excluding these problematic components or using harsh mechanical mixing methods. A homogenous composition including components such as hydrophobic agents having benefits for the skin that do not separate and is easily formed with simple mixing methods would be desired.

SUMMARY

[0003] In one aspect, provided is a cosmetic composition for topical application to the skin or lips. The composition may comprise an encapsulated phase comprising at least one hydrophobic agent providing a benefit to the skin or lips. The encapsulated phase may be dispersed in a dispersant phase comprising at least one of an oil, a sweetener, a thickener, an emollient, and a combination thereof. The composition may include an anhydrous phase comprising a polymer and an emollient.

[0004] In a further aspect, provided is a composition comprising at least one hydrophobic agent; an aqueous vehicle; a dispersant component; and an anhydrous component, wherein the composition is homogenous.

[0005] In a further aspect, provided is a homogenous topical composition for skin or lips, the composition comprising (a) about 0.1 % to about 5.0% by weight of at least one hydrophobic agent comprising at least one of menthol, camphor, and phenol, or a combination thereof; (b) about 0.1 % to about 5.0% by weight of water; (c) about 0.1 % to about 25.0% by weight of a dispersant comprising at least one of an oil, a sweetener, a thickener, an emollient, or a combination thereof; and (d) about 1 % to about 70% by weight of an emollient, a polymer, or a combination thereof, wherein the composition is homogenous and topically applied to the skin or lips.

[0006] In yet another aspect, provided is a method of making a composition for topical application to the skin or lips, the method comprising:

(a) dispersing an encapsulated phase in a dispersant phase comprising at least one of an oil, a sweetener, a thickener, and an emollient, or a combination thereof, the encapsulated phase comprising a wall phase encapsulating a hydrophobic agent in an aqueous vehicle; and

(b) mixing the composition resulting from step (b) with an anhydrous phase comprising at least one of a polymer, an emollient and a combination thereof to form a composition for topical administration to the skin or lips.

[0007] In a further aspect, provided is a method of treating or preventing a skin condition comprising administering to the skin of a subject in need thereof a composition comprising an encapsulated phase, a dispersant phase, and an anhydrous phase. The encapsulated phase may comprise an agent, and the anhydrous phase may comprise a polymer and an emollient.

[0008] In another aspect, provided is a method of treating dry lips comprising administering to the lips of a subject in need thereof a composition comprising an encapsulated phase, a dispersant phase, and an anhydrous phase. The encapsulated phase may comprise an agent, and the anhydrous phase may comprise a polymer and an emollient.

[0009] The disclosure provides for other aspects and embodiments that will be apparent in light of the following detailed description and accompanying Figures.

BRIEF DESCRIPTION OF THE DRAWINGS

[0010] Figure 1 shows an encapsulated phase comprising agent in an aqueous vehicle.

[0011] Figure 2 shows an encapsulated phase comprising agent in a non-aqueous vehicle of mineral oil.

DETAILED DESCRIPTION

[0012] In a broad sense, the disclosure relates to formulations including aqueous and anhydrous components. The inventors have discovered homogenous compositions comprising agents in an aqueous vehicle and incorporated with anhydrous materials, as well as methods for making such homogenous compositions using convenient and simple mixing methods.

[0013] Compositions

[0014] In certain aspects, provided are homogenous compositions comprising an encapsulated phase that is dispersed in a dispersant phase and mixed with an anhydrous phase. An encapsulated phase may be dispersed in a dispersant phase, and then mixed with an anhydrous phase to form compositions that are useful when applied to the skin.

[0015] Encapsulated Phase

[0016] The encapsulated phase comprises at least one agent encapsulated in an aqueous vehicle. In one embodiment, a wall phase encapsulates the aqueous vehicle and agent. Examples are available from International Specialty Product, Inc. (Wayne, NJ) as ISP Captivates™. Some may be in the form of small pellets.

[0017] The wall phase may comprise at least one of guar, gum arabic or a combination thereof may. For example, a 50-50 mixture of guar and gum arabic may be used.

[0018] The agent may be hydrophobic. The agent may include, but is not limited to, at least one conditioning agent, anti-aging agent, anti-acne agent, vitamin, flavor, sunscreening or sunblocking agent, fragrance, or a combination thereof. More than one agent may be used in, in which case one agent may be hydrophobic and the other agent or agents may or may not be hydrophobic.

[0019] Examples of conditioning agents include, but are not limited to, an emollient, humectant, occlusive agent, or other moisturizer to provide moisturizing, skin softening, skin barrier maintenance, anti-irritation, or other skin health benefits.

[0020] Suitable emollients include, but are not limited to, polar esters, stearyl alcohol, glyceryl monoricinoleate, glyceryl monostearate, propane-1 ,2-diol, butane-1 ,3-diol, mink oil, cetyl alcohol, iso-propyl isostearate, stearic acid, iso-butyl palmitate, isocetyl stearate, oleyl alcohol, isopropyl laurate, hexyl laurate, decyl oleate, octadecan-2-ol, isocetyl alcohol, cetyl palmitate, cetyl myristate, stearoxytrimethylsilane, polydimethylsiloxane, di-n-butyl sebacate, iso-propyl myristate, iso-propyl palmitate, iso-propyl stearate, butyl stearate, polyethylene glycol, triethylene glycol, lanolin, sesame oil, coconut oil, arachis oil, castor oil, acetylated lanolin alcohols, petroleum, mineral oil, butyl myristate, isostearic acid, palmitic acid, isopropyl linoleate, lauryl lactate, myristyl lactate, decyl oleate, myristyl myristate, alkyl benzoate, silicone oils, dimethicone, glyceryl dioleate, methyl laurate, PPG-9 laurate, octyl palmitate, propylene glycol, glycerol, fatty acids, natural oils such as sunflower, almond, mineral, canola, sesame, soybean, wheat germ, corn, peanut and olive, myristyl alcohol, aloe vera, hydrolyzed silk protein, Vitamin E, stearyl alcohol, isopropyl palmitate, sorbitol, and amino acid complexes, and combinations thereof. Emollients may further include triethylhexanoin (commercially available as PELEMOL® GTO from Phoenix Chemical Company, Somerville, NJ), isopropyl myristate, and 2-octyldodecanol. Particularly suitable polar esters include Spider Esters™ (SurfaTech Corporation, Georgia, USA). In some embodiments, the emollient comprises sorbeth-2 hexaoleate, which is commercially available as Spider Ester™ ESO from SurfaTech Corporation (Georgia, USA).

[0021] Some non-limiting examples of humectants include hydroxyethyl urea, agarose, arginine PCA, ethylhexylglycerin, fructose, glucose, glutamic acid, glycerol, honey, lactose, maltose, propylene glycol (e.g., 1 ,2-propylene glycol), butylene glycol (e.g., 1 ,3-butylene glycol), polyethylene glycols and ethers thereof, polypropylene glycols and ethers thereof (e.g., polypropylene glycol ethers such as polypropylene glycol-14 butyl ether), sorbitol and mixtures thereof.

[0022] Some non-limiting examples of occlusive agents include petrolatum, shea butter, alkyl dimethicones, avocado oil, balm mint oil, canola oil, cod liver oil, corn oil, methicone, mineral oil, olive oil, phenyl trimethicone, trimyristin, soybean oil, glycol distearate, stearyl stearate, synthetic wax, or mixtures thereof.

[0023] Some non-limiting examples of other moisturizers include aloe vera, cholesterol, cystine, hyaluronic acid, keratin, lecithin, egg yolk, glycine, PPG-12, panthenol, retinol, vegetable oil, and mixtures thereof. Some non-limiting examples of anti-irritants include bisabolol and panthenol.

[0024] Some non-limiting examples of anti-aging agents include anti-oxidant/radical scavengers; retinoids; tocopherol; alpha-hydroxy acids such as lactic acid, malic acid, glycolic, or citric acid; salicyclic acid; ubiquinones; cinnamic acid; mucopolysaccharides particularly hyaluronic acid; and botulinum. Free radical scavengers or antioxidants include, but are not limited to vitamin E, ubiquinones, superoxide dismutase, alpha-lipoic acid, Licorice extract, Rosemary extract, and derivatives thereof. Purified isoflavonoids may also be used as anti- aging agents and may include genistein, daidzein, biochanin A, formononetin, O- desmethylangolensin, glycitin, and equol.

[0025] Some non-limiting examples of anti-acne agents include topical steroids, azelaic acid, benzoyl peroxide, retinoids or retinoic acid and derivatives thereof, salicylic acid, mandelic acid, alpha hydroxy acids, and zinc salts such as zinc cysteate, zinc oxide, and antibiotic or antibacterial agents. Antibiotic or antibacterial agents may include, for example, tetracycline, erythromycin, and clindamycin.

[0026] Examples of vitamins include, but are not limited to, Vitamin E, Vitamin A, Vitamin D, Vitamin K, Vitamin B12, and other vitamins.

[0027] Examples of flavors include, but are not limited to, menthol, vanillin, clover, and essential oils. Essential oils, synthetic flavors, or mixtures thereof may be used, including, but not limited to, oils derived from plants and fruits, such as citrus oils, fruit essences, peppermint oil, spearmint oil, other mint oils, clove oil, oil of wintergreen, anise and the like, phenol, camphor, thymol, geraniol, carvacrol, citral, hinokitiol, eucalyptol, catechol (particularly 4-allyl catechol), and mixtures thereof.

[0028] Suncreening and sunblocking agents regulate skin darkening resulting from exposure to ultraviolet light. Examples of useful sunblocks include, but are not limited to, zinc oxide, titanium dioxide, and combinations thereof. Sagarin et al. at Chapter VIII, pages 189 et seq., of Cosmetics Science and Technology (1972), disclose numerous suitable sunscreens. Specific suitable sunscreening agents include, for example: p-aminobenzoic acid and its salts and derivatives (ethyl, isobutyl, glyceryl esters; p-dimethylaminobenzoic acid); anthranilates (i.e., o-aminobenzoates; methyl, menthyl, phenyl, benzyl, phenylethyl, linalyl, terpinyl, and cyclohexenyl esters); salicylates (amyl, phenyl, benzyl, menthyl, glyceryl, and dipropyleneglycol esters); cinnamic acid derivatives (menthyl and benzyl esters, ophenyl cinnamonitrile; butyl cinnamoyl pyruvate); dihydroxycinnamic acid derivatives (umbelliferone, methylumbelliferone, methylaceto-umbelliferone); trihydroxycinnamic acid derivatives (esculetin, methylesculetin, daphnetin, and the glucosides, esculin and daphnin); hydrocarbons (diphenylbutadiene, stilbene); dibenzalacetone and benzalacetophenone; naphtholsulfonates (sodium salts of 2- naphthol-3,6-disulfonic and of 2-naphthol-6,8-disulfonic acids); dihydroxy-naphthoic acid and its salts; o- and p-hydroxybiphenyldisulfonates; coumarin derivatives (7-hydroxy, 7-methyl, 3- phenyl); diazoles (2-acetyl-3-bromoindazole, phenyl benzoxazole, methyl naphthoxazole, various aryl benzothiazoles); quinine salts (bisulfate, sulfate, chloride, oleate, and tannate); quinoline derivatives (8-hydroxyquinoline salts, 2-phenylquinoline); hydroxy- or methoxy- substituted benzophenones; uric and vilouric acids; tannic acid and its derivatives (e.g., hexaethylether); (butyl carbotol) (6-propyl piperonyl) ether; benzophenones (oxybenzene, sulisobenzone, dioxybenzone, benzoresorcinol, 2,2',4,4'-tetrahydroxybenzophenone, 2,2'- dihydroxy-4,4'-dimethoxybenzophenone, octabenzone; 4-isopropyldibenzoylmethane; 4,4'-t- butylmethoxydibenzoylmethane; and etocrylene. Suitable sunscreens include 2-ethylhexyl-p- methoxycinnamate, 4,4'-t-butylmethoxydibenzoylmethane, 4,4'-t- butylmethoxydibenzoylmethane, 2-hydroxy-4-methoxybenzophenone, octyldimethyl-p- aminobenzoic acid, digalloyltrioleate, 2,2-dihydroxy-4-methoxybenzophenone, ethyl-4- (bis(hydroxypropyl)) aminobenzoate, 2-ethylhexyl-2-cyano-3,3-diphenylacrylate, 2- ethylhexylsalicylate, glyceryl-p-aminobenzoate, 3,3,5-trimethylcyclohexylsalicylate, methylanthranilate, p-dimethyl-aminobenzoic acid or aminobenzoate, 2-ethylhexyl-p-dimethyl- amino-benzoate, 2-phenylbenzimidazole-5-sulfonic acid, 2-(p-dimethylaminophenyl)-5- sulfonicbenzoxazoic acid and mixtures thereof. Also useful in the compositions are sunscreens such as those disclosed in U.S. Pat. No. 4,937,370 and U.S. Pat. No. 4,999, 186. The sunscreening agents disclosed therein have, in a single molecule, two distinct chromophore moieties which exhibit different ultra-violet radiation absorption spectra. One of the chromophore moieties absorbs predominantly in the UVB radiation range and the other absorbs strongly in the UVA radiation range. Suitable members of this class of sunscreening agents include 4-N,N-(2-ethylhexyl)methylaminobenzoic acid ester of 2,4-dihydroxybenzophenone; N,N-di-(2-ethylhexyl)-4-aminobenzoic acid ester with 4-hydroxydibenzoylmethane; 4-N,N-(2- ethylhexyl) methylaminobenzoic acid ester with 4-hydroxydibenzoylmethane; 4-N,N-(2- ethylhexyl)methylaminobenzoic acid ester of 2-hydroxy-4-(2-hydroxyethoxy)benzophenone; 4- N,N-(2-ethylhexyl)-methylaminobenzoic acid ester of 4-(2-hydroxyethoxy)dibenzoylmethane; N,N-di-(2-ethylhexyl)-4-aminobenzoic acid ester of 2-hydroxy-4-(2- hydroxyethoxy)benzophenone; and N,N-di-(2-ethylhexyl)-4-aminobenzoic acid ester of 4-(2- hydroxyethoxy)dibenzoylmethane and mixtures thereof.

[0029] The agent may be mixed with additional hydrophobic components including, but not limited to, gelatin, guar hydroxypropyltrimonium, gum arabic, alginate, carrageen, and chitosan. In certain embodiments, the agents include menthol, camphor, phenol, salicylic acid, vitamin, shea butter, and flavor. [0030] The aqueous vehicle may be hydrophilic and polar. The aqueous vehicle may include, but is not limited to, water, glycerol, alcohols such as ethanol and isopropanol, and other polyglycols such as propylene glycol and polyglycol-modified silicones, oils such as mineral oils, as well as a combination thereof. The aqueous vehicle may further comprise colorants or dyes.

[0031] In some embodiments, the agent may comprise at least one of menthol, camphor, phenol, salicylic acid, vitamin, shea butter, and flavor, and the aqueous vehicle may comprise at least one of alcohol and water. In other embodiments, the agent may comprise at least one of menthol, camphor, phenol, salicylic acid, vitamin E, shea butter and flavor, and the aqueous vehicle may comprise water.

[0032] The agent may be encapsulated in the aqueous vehicle. The agent may form a hydrophobic particle in the aqueous vehicle with the aqueous vehicle as the continuous phase. The encapsulated phase may be described as an oil-in-water composition. The particles may comprise different shells and charges with multiple layers. Particularly suitable are ISP Captivates HC0009 and HC0012 available from International Specialty Product, Inc. (Wayne, NJ).

[0033] The encapsulated phase may comprise agent in an amount of at least about 0.1 %, at least about 37%, or at least about 40% by weight of the encapsulated phase. The encapsulated phase may comprise agent in an amount less than about 70%, less than about 57%, or less than about 50% by weight of the encapsulated phase. The encapsulated phase may comprise agent in the amount of about 0.1 % to about 70%, about 37% to about 57%, or about 40% to about 50% of the encapsulated phase.

[0034] The final composition (i.e., the dispersant and encapsulated and anhydrous phases combined) may comprise agent in an amount of at least about 0.1 %, at least about 0.2%, at least about 0.3%, at least about 0.4%, at least about 0.5%, at least about 0.6%, at least about 0.7%, at least about 0.8%, at least about 0.9%, or at least about 1 % by weight of the final composition. The final composition may comprise agent in amount of less than about 5%, less than about 4%, or less than about 3% by weight of the final composition. The final composition may comprise agent in an amount of about 0.1 % to about 5%, about 0.2% to about 4%, or about 0.3% to about 3% of the final composition. [0035] The agent may be encapsulated in and form particles of different sizes in the aqueous vehicle. A particle may be at least about 0.5 μηη, at least about 1 .0 μηη, at least about 1.5 μηη, at least about 2.0 μηη, at least about 2.5 μηη, at least about 3.0 μηη, at least about 3.5 μηη, at least about 4.0 μηη, at least about 4.5 μηη, or at least about 5.0 μηη in diameter. A particle may be less than about 5.0 mm, less than about 4.5 mm, less than about 4.0 mm, less than about 3.5 mm, or less than about 3.0 mm in diameter. This may include a range of particle sizes of about 0.5 μηη to about 5.0 mm, about 1 .0 μηη to about 4.0 mm, about 2.0 μηη to about 3.0 mm, or about 3.0 μηη to about 2.0 mm in diameter.

[0036] Each particle may be separate from other particles in the aqueous vehicle, that is, the particles may not clump or stick together in the aqueous vehicle. In certain embodiments, at least about 80%, at least about 85%, at least about 90%, at least about 95%, at least about 98%, or at least about 99% of the particles may be separate from other particles in the aqueous vehicle. For example, Figure 1 shows an encapsulated phase as described herein comprising hydrophobic agent in an aqueous vehicle, wherein the majority of particles are separate from other particles. In contrast, Figure 2 shows a conventional encapsulated phase comprising hydrophobic agent in a non-aqueous vehicle of mineral oil, wherein the majority of particles are clumped together with other particles. The components of the conventional composition in Figure 2 separate, while the composition according to the invention and shown in Figure 1 is homogenous and uniform without separation of components.

[0037] The final composition may comprise the encapsulated phase in an amount of at least about 0.1 %, at least about 0.2%, or at least about 0.3% by weight of the final composition. The final composition may comprise the encapsulated phase in an amount of less than about 5.0%, less than about 3.0%, or less than about 1 .0% by weight of the final composition. The final composition may comprise the encapsulated phase in an amount of about 0.1 % to about 5.0%, about 0.2% to about 3.0%, or about 0.3% to about 1.0% by weight of the final composition.

[0038] Dispersant Phase

[0039] The dispersant phase may comprise at least one of an oil, a sweetener, a thickener, and an emollient, or a combination thereof.

[0040] Examples of oils include, but are not limited to, castor oil, olive oil, corn oil, canola oil, peanut oil, safflower oil, flax oil, sunflower oil, mineral oil, ginger oil, sunflower oil, grape seed oil, sweet almond oil, and camellia (tea seed oil). In some embodiments, the oil comprises castor oil.

[0041] Suitable sweeteners include, but are not limited to, sucrose, dextrose, maltose, dextrin, dried invert sugar, fructose, glucose, galactose, corn syrup solids, stevioside, Lo-Han Guo, agave, and the like, alone or in combination. Sugarless sweeteners include, but are not limited to, sugar alcohols such as sorbitol, mannitol, xylitol, polyols, stevia, hydrogenated starch hydrolysates, maltitose, and the like, alone or in combination. High intensity artificial sweeteners can also be used alone or in combination with other sweeteners. These sweeteners include, but are not limited to, sucralose, aspartame, MAPM derivatives such as neotame, salts of acesulfame, altitame, saccharin and its salts, cyclamic acid and its salts, glycyrrhizinate, dihydrochalcones, thaumatin, monellin, and the like, alone or in combination.

[0042] Thickeners in the dispersant phase may enhance or increase the viscosity of the composition. Examples of thickeners may include, but are not limited to, menthyl lactate. Menthyl lactate is commercially available as FRESCOLAT® from Symrise (Holzminden, Germany). The compositions may comprise a cooling agent. Suitable cooling agents include, but are not limited to, isopulegol and menthol derivatives, for example menthyl lactate, menthyl pyrrolidone carboxylic acid, menthyl methyl ether, menthoxypropanediol, menthone glycerol acetal (9-methyl-6-(1 -methylethyl)-1 ,4-dioxaspiro(4.5)decane-2-methanol), monomenthyl succinate, and 2-hydroxymethyl-3,5,5-trimethylcyclohexanol. The thickener may also act as a cooling agent. In some embodiments, the dispersant phase comprises menthyl lactate, which may act as a thickener as well as a cooling agent.

[0043] Suitable emollients are detailed above. In some embodiments, the dispersant phase comprises at least one of castor oil and menthyl lactate. In other embodiments, the dispersant phase comprises at least one of castor oil, sweetener, and menthyl lactate. In highly preferred embodiments, the dispersant phase comprises castor oil, sweetener, menthyl lactate, and sorbeth-2 hexaoleate.

[0044] The dispersant phase may be comprised entirely of or substantially entirely of at least one of an oil, a sweetener, a thickener, and an emollient, or a combination thereof. The dispersant phase may comprise 100% by weight of an oil, a sweetener, a thickener, an emollient, or a combination thereof. [0045] The encapsulated phase may be dispersed within the dispersant phase and form a homogenous mixture.

[0046] The encapsulated phase may be dispersed in the dispersant phase, the product of which may comprise at least about 0.1 %, at least about 0.5%, or at least about 1 .0% by weight the encapsulated phase, or less than about 5.0%, less than about 3.0%, or less than about 2.5% by weight of the encapsulated phase. The encapsulated phase may be dispersed in the dispersant phase in an amount of about 0.1 % to about 5.0%, about 0.5% to about 3.0%, or about 1 .0% to about 2.5% by weight.

[0047] The final composition may comprise the dispersant phase in an amount of at least about 5.0%, at least about 10.0%, or at least about 15% by weight of the final composition. The final composition may comprise the dispersant phase in an amount of less than about 40%, less than about 30%, or less than about 25% by weight of the final composition. The final composition may comprise the dispersant phase in an amount of about 5% to about 40%, about 10% to about 30%, or about 15% to about 25% by weight of the final composition.

[0048] Anhydrous Phase

[0049] The anhydrous phase may be anhydrous or hydrophobic. The anhydrous phase comprises at least one polymer, emollient, or a combination thereof. Polymers may be non- polar. Polymers may include, but are not limited to, polyamides such as ethylene diamine hydrogenated dimer diliniolate copolymer bis-di-Ci₄-i₈ alkyl (commercially available as SYLVACLEAR™ A200 from Arizona Chemical Company, Jacksonville, FL), and bis-stearyl ethylenediamine/neopentyl glycol/stearyl hydrogenated dimmer dilinoleate copolymer (commercially available as SYLVACLEAR™ C75V from Arizona Chemical Company, Jacksonville, FL). Emollients are detailed above. In some embodiments the anhydrous phase comprises an emollient including, but not limited to, triethylhexanoin (commercially available as PELEMOL® GTO from Phoenix Chemical Company, Somerville, NJ), isopropyl myristate, and 2-octyldodecanol (commercially available as EUTANOL® G from Cognis Corporation, Monheim, Germany).

[0050] The anhydrous phase may comprise polymer in an amount of at least about 1 .0%, at least about 20%, at least about 30% by weight of the anhydrous phase. The anhydrous phase may comprise polymer in an amount of less than about 70%, less than about 60%, or less than about 40% by weight of the anhydrous phase. The anhydrous phase may comprise polymer in an amount of about 1.0% to about 70%, about 20% to about 60%, or about 30% to about 40% by weight.

[0051] The anhydrous phase may comprise emollient in an amount of at least about 1.0%, at least about 20%, at least about 50% by weight of the anhydrous phase. The anhydrous phase may comprise emollient in an amount of less than about 95%, less than about 85%, or less than about 81 % by weight of the anhydrous phase. The anhydrous phase may comprise emollient in an amount of about 1 .0% to about 95%, about 20% to about 85%, about 50% to about 81 % by weight.

[0052] The anhydrous phase may further include at least one conditioning agent, anti-aging agent, anti-acne agent, vitamin, flavor, sunscreening or sunblocking agent, fragrance, or a combination thereof, which are described above. The anhydrous phase may comprise such agent in an amount of at least about 0.1 %, at least about 0.2%, at least about 0.3%, or at least about 0.4% by weight of the final composition. The anhydrous phase may comprise agent in an amount of less than about 5%, less than about 4%, or less than about 3% by weight of the final composition. The anhydrous phase may comprise such an agent in a range of about 0.1 % to about 5%, about 0.2% to about 4%, or about 0.3% to about 3% by weight of the final composition.

[0053] The anhydrous phase may comprise such an agent in an amount of at least about 0.1 %, at least about 0.2%, or at least about 0.5% by weight of the anhydrous phase. The anhydrous phase may comprise such agent in an amount of less than about 10%, less than about 8%, less than about 5% by weight of the anhydrous phase. The anhydrous phase may comprise such agent in an amount of about 0.1 % to about 10%, about 0.2% to about 8%, or about 0.5% to about 5% by weight.

[0054] The final composition may comprise the anhydrous phase in an amount of at least about 1 %, at least about 20%, or at least about 50% by weight of the final composition. The final composition may comprise the anhydrous phase in an amount of less than about 95%, less than about 85%, or less than about 81 % by weight of the final composition. The final composition may comprise the anhydrous phase in an amount of about 1 % to about 95%, about 20% to about 85%, or about 50% to about 81 % by weight.

[0055] The encapsulated phase dispersed within the dispersant phase may be mixed with the anhydrous phase. The encapsulated phase dispersed within the dispersant phase may be mixed with the anhydrous phase in an amount such as to result in a percent weight of individual components in the final composition as detailed above. For example, the encapsulated phase dispersed within the dispersant phase may be mixed with the anhydrous phase in an amount of at least about 5%, at least about 20%, or at least about 25% by weight. The encapsulated phase dispersed within the dispersant phase may be mixed with the anhydrous phase in an amount of less than about 50%, less than about 45%, less than about 40%, less than about 35%, or less than about 30% by weight. The encapsulated phase dispersed within the dispersant phase may be mixed with the anhydrous phase in a range of about 5% to about 50%, about 20% to about 45%, or about 10% to about 50% by weight.

[0056] Methods for Making Compositions

[0057] The encapsulated phase may be dispersed within the dispersant phase by conventional means known in the art. The encapsulated phase and dispersant phase may be simply mixed together until homogenous. Suitably, high mechanical force, shearing, or pressure is not necessary to mix the phases together. In other words, the encapsulated phase may be dispersed within the dispersant phase without at least one of high mechanical force, shearing or increased pressure. The encapsulated phase and dispersant phase may be mixed with heat, for example, at temperatures of about 90°F to about 170°F.

[0058] The encapsulated phase dispersed within the dispersant phase may be mixed with the anhydrous phase by conventional means known in the art. The phases may be simply mixed together until homogenous. Suitably, high mechanical force or pressure is not necessary to mix the phases together. In other words, the encapsulated phase may be dispersed within the dispersant phase without at least one of high mechanical force, shearing or increased pressure. The encapsulated phase dispersed within the dispersant phase may be mixed with the anhydrous phase with heat, for example, at temperatures of about 90°F to about 170°F.

[0059] After the phases are combined, a final composition is formed. The final composition may be homogenous. The final composition may comprise: a) at least one agent;

b) water;

c) at least one of an oil, a sweetener, a thickener, an emollient, or a combination thereof; and

d) at least one of an emollient, a polymer, or a combination thereof. [0060] In one embodiment, the final composition may comprise: a) about 0.1 % to about 5.0% by weight of at least one hydrophobic agent; b) about 0.1 % to about 5.0% by weight of water; c) about 0.1 % to about 25.0% by weight of a dispersant comprising at least one of an oil, a sweetener, a thickener, and an emollient, or a combination thereof; and d) about 1 % to about 70% by weight of an emollient, a polymer, or a combination thereof.

[0061] The hydrophobic agent may suitably comprise at least one of menthol, camphor, and phenol, or a combination thereof.

[0062] The final composition may comprise component a) in an amount of at least about 0.1 %, at least about 0.5%, or at least about 1.0% by weight of the final composition. The final composition may comprise component a) in an amount of less than about 5.0%, less than about 4.0%, or less than about 3.0% by weight of the final composition. The final composition may comprise component a) in an amount of about 0.1 % to about 5.0%, about 0.5% to about 4.0%, about 1 % to about 3.0% by weight.

[0063] The final composition may comprise component b) in an amount of at least about 0.1 %, at least about 0.5%, or at least about 1.0% by weight of the final composition. The final composition may comprise component b) in an amount of less than about 5.0%, less than about 4.0%, or less than about 3.0% by weight of the final composition. The final composition may comprise component b) in an amount of about 0.1 % to about 5.0%, about 0.5% to about 4.0%, about 1 % to about 3.0% by weight.

[0064] The final composition may comprise component c) in an amount of at least about 0.1 %, at least about 2.5%, or at least about 5.0% by weight of the final composition. The final composition may comprise component c) in an amount of less than about 25.0%, less than about 20.0%, or less than about 15.0% by weight of the final composition. The final composition may comprise component c) in an amount of about 0.1 % to about 25.0%, about 2.5% to about 20%, or about 5% to about 15% by weight. [0065] The final composition may comprise component d) in an amount of at least about 0.1 %, at least about 5.0% or at least about 10.0% by weight of the final composition. The final composition may comprise component d) in an amount of less than about 70%, less than about 65%, or less than about 50% by weight of the final composition. The final composition may comprise component d) in an amount of about 1.0% to about 70%, 5.0% to about 65%, or about 10% to about 50%.

[0066] Uses

[0067] Compositions described herein may be useful as cosmetic compositions. The resulting compositions may be used in a variety of topical applications designed for the skin or lips, and may be applied locally to the skin or lips. In some embodiments, the compositions may be formulated as a solution, oil, cream, ointment, gel, lotion, conditioner, cleanser, moisturizer, foam, mousse, spray, or lip product. Lip products may include, for example, lip stick, lip cream, lip balm, lip gloss, medicated lip treatment, lip moisturizer, lip cosmetic, lip sunscreen, and lip flavorant, and the like, as described, for example, in U.S. Patent Nos. 8,302,774 and 7,695,727, which are incorporated herein by reference. In one embodiment, the lip product is a creamy, flowable lip product. In certain embodiments, products according to the invention may have the consistency of a semi-viscous liquid or paste. For example, the compositions described herein may be poured into or molded in a container and cooled to form a shape, for example, a stick for lip balm.

[0068] The compositions may also be used to treat a skin condition. The skin condition may include, for example, dryness, sunburn, acne, and aging or wrinkles. The compositions may be used as a moisturizer, a sunscreen, an anti-acne composition, or an anti-aging composition. For example, compositions described herein may be formulated and used as lip balm to moisturize and heal dry, chapped lips. In certain aspects, provided are methods of treating dry lips comprising administering to the lips of a subject in need thereof a homogenous composition comprising an encapsulated phase, a dispersant phase, and an anhydrous phase as described herein.

[0069] The use of the terms "a" and "an" and "the" and similar referents in the context of describing the invention are to be construed to cover both the singular and the plural, unless otherwise indicated herein or clearly contradicted by context. The terms "comprising," "having," "including," and "containing" are to be construed as open-ended terms (i.e., meaning "including but not limited to") unless otherwise noted. All methods described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context. The use of any and all examples, or exemplary language (e.g., "such as") provided herein, is intended merely to illustrate aspects and embodiments of the disclosure and does not limit the scope of the claims.

[0070] Recitation of ranges of values herein are merely intended to serve as a shorthand method of referring individually to each separate value falling within the range, unless otherwise indicated herein, and each separate value is incorporated into the specification as if it were individually recited herein. For example, if a concentration range is stated as 1 % to 50%, it is intended that values such as 2% to 40%, 10% to 30%, or 1 % to 3%, etc., are expressly enumerated in this specification. These are only examples of what is specifically intended, and all possible combinations of numerical values between and including the lowest value and the highest value enumerated are to be considered to be expressly stated in this disclosure. Use of the word "about" to describe a particular recited amount or range of amounts is meant to indicate that values very near to the recited amount are included in that amount, such as values that could or naturally would be accounted for due to manufacturing tolerances, instrument and human error in forming measurements, and the like.

EXAMPLES

Example 1

[0071] An encapsulated phase was made by encapsulating 0.7% by weight menthol, 1.7% by weight camphor, and 0.4% by weight phenol in an aqueous vehicle of water. Next, the encapsulated phase (0.3% by weight) was mixed with a dispersant phase of 10% castor oil, 5% sweetener, and 10% FRESCOLAT® at 140°F with agitation.

[0072] An anhydrous phase of 25% by weight SYLVACLEAR™ A200, 10% by weight SYLVACLEAR™ C75V, 32.6% by weight PELEMOL® GTO, 14.4% by weight isopropyl myristate, and 14.6% by weight EUTANOL® G was mixed at 203°F until melted.

[0073] The encapsulated phase in the dispersant phase was then mixed with the anhydrous phase at 160°F. The phases were mixed together for 10 min, poured into stick containers, and allowed to cool to form a lip balm. The amounts are indicated in % by weight in the final composition. Example 2

[0074] An encapsulated phase of 38-56% by weight peppermint in water, an encapsulated phase of 38-56% by weight vitamin E in water, and an encapsulated phase of 38-56% by weight shea butter in water were purchased from International Specialty Product, Inc. (Wayne, NJ) as ISP Captivates™ HC004 (peppermint), ISP Captivates™ HC009 (vitamin E), ISP Captivates™ HC001 (shea butter), and ISP Captivates™ HC007 (vitamin E). The encapsulated phase (0.3%) was mixed with a dispersant phase of 5% castor oil, 5% sweetener, 5% FRESCOLAT® and 5% Sorbeth-2 hexaoleate at 140°F with agitation, wherein the amounts are indicated in percent by weight of the final composition.

[0075] An anhydrous phase of 17.15% SYLVACLEAR™ A200, 7% SYLVACLEAR™ C75V, 23.15% PELEMOL® GTO, 14.4% isopropyl myristate, and 14.6% EUTANOL® G was mixed at 194°F until melted and all components were dissolved. A mixture of 0.7% menthol, 1 .7% camphor, and 0.4% phenol, 0.3% vanillin, and 0.3% clover bouquet was added to form a final anhydrous phase. The amounts are indicated in percent by weight of the final composition.

[0076] The encapsulated phase in the dispersant phase was then mixed with the anhydrous phase at 165°F with good agitation. The phases were mixed together for 5 min, poured into stick containers, and allowed to cool to form a lip balm.

Claims

CLAIMS We claim:

1. A cosmetic composition for topical application to the skin or lips, the composition comprising:

an encapsulated phase comprising at least one hydrophobic agent providing a benefit to the skin or lips, the encapsulated phase being dispersed in a dispersant phase comprising at least one of an oil, a sweetener, a thickener, an emollient, and a combination thereof; and

an anhydrous phase comprising a polymer and an emollient.

2. The composition of claim 1 , wherein the composition comprises hydrophobic agent in an amount of about 0.1 % to about 5.0% by weight; an oil, a sweetener, a thickener, or an emollient in an amount of about 0.1 % to about 25.0% by weight; and a polymer or emollient in an amount of about 1 % to about 70% by weight.

3. The composition of claim 1 or 2, wherein the agent comprises at least one of menthol, camphor, and phenol.

4. The composition of any one of the above claims, wherein the encapsulated phase is oil- in-water emulsion.

5. The composition of any one of the above claims, wherein the encapsulated phase comprises the agent encapsulated in an aqueous vehicle.

6. The composition of claim 5, wherein the agent is encapsulated in the aqueous vehicle in an amount of about 0.1 % to about 5.0% by weight.

7. The composition of claim 6, wherein the agent forms a particle of less than about 5 mm in diameter in the aqueous vehicle.

8. The composition of any one of the above claims, wherein the dispersant phase comprises oil, and the oil comprises castor oil.

9. The composition of any one of the above claims, wherein the dispersant phase comprises thickener, and the thickener comprises menthyl lactate.

10. The composition of any one of the above claims, wherein the dispersant phase comprises emollient, and the emollient comprises sorbeth-2 hexaoleate.

1 1 . The composition of any one of the above claims, wherein the encapsulated phase is dispersed within the dispersant phase in an amount of about 0.1 % to about 5.0%.

12. The composition of any one of the above claims, wherein the anhydrous phase comprises emollient in an amount of about 1 % to about 70% by weight.

13. The composition of any one of the above claims, wherein the anhydrous phase comprises polymer in an amount of about 1 % to about 95% by weight.

14. The composition of any one of the above claims, wherein the anhydrous phase comprises at least one of diamine hydrogenated dimer diliniolate copolymer bis-di-Ci₄-i₈ alkyl, bis-stearyl ethylenediamine/neopentyl glycol/stearyl hydrogenated dimmer dilinoleate copolymer, triethylhexanoin, isopropyl myristate, and 2-octyldodecanol.

15. A homogenous topical composition for skin or lips, the composition comprising:

a) about 0.1 % to about 5.0% by weight of at least one hydrophobic agent providing a benefit to the skin;

b) about 0.1 % to about 5.0% by weight of water;

c) about 0.1 % to about 25.0% by weight of a dispersant comprising at least one of an oil, a sweetener, a thickener, an emollient, or a combination thereof; and

d) about 1 % to about 70% by weight of an emollient, a polymer, or a combination thereof,

wherein the composition is homogenous and topically applied to the skin or lips.

16. The composition of claim 15, wherein the agent comprises at least one of menthol, camphor, and phenol, or a combination thereof.

17. The composition of claim 15, wherein the dispersant comprises oil, and the oil comprises castor oil.

18. The composition of claim 15, wherein the dispersant comprises thickener, and the thickener comprises menthyl lactate.

19. The composition of claim 15, wherein the dispersant comprises emollient, and the emollient comprises sorbeth-2 hexaoleate.

20. The composition of any one of claims 15-19, wherein the composition comprises at least one of diamine hydrogenated dimer diliniolate copolymer bis-di-C_14-18 alkyl, bis- stearylethylenediamine/neopentyl glycol/stearyl hydrogenated dimmer dilinoleate copolymer, triethylhexanoin, isopropyl myristate, and 2-octyldodecanol.

21 . The composition of any one of the above claims, wherein the composition comprises essentially no silicone.

22. The composition of any one of the above claims, wherein the composition is formulated as a lipstick, lip gloss, lip balm, cream, or ointment.

23. A method of making a composition for topical application to the skin or lips, the method comprising:

(b) mixing the composition resulting from step (b) with an anhydrous phase comprising at least one of a polymer, an emollient or a combination thereof to form a composition for topical administration to the skin or lips.

24. The method of claim 23, wherein the method is performed with no high mechanical force, shearing, or increased pressure.

25. The method of claim 23 or 24, wherein the encapsulated phase comprises at least one of menthol, camphor, and phenol.

26. The method of any one of claims 23-25, wherein the encapsulated phase is oil-in-water emulsion.

27. The method of any one of claims 23-26, wherein the agent is encapsulated in the aqueous vehicle in an amount of about 0.1 % to about 5.0% by weight.

28. The method of claim 27, wherein the agent forms a particle of less than about 5 mm in diameter in the aqueous vehicle.

29. The method of claim 27 or 28, wherein at least about 80% of the particles are separate from other particles in the aqueous vehicle.

30. The method of any one of claims 23-29, wherein the dispersant phase comprises oil, and the oil comprises castor oil.

31 . The method of any one of claims 23-29, wherein the dispersant phase comprises thickener, and the thickener comprises menthyl lactate.

32. The method of any one of claims 23-29, wherein the dispersant phase comprises emollient, and the emollient comprises sorbeth-2 hexaoleate.

33. The method of any one of claims 23-29, wherein the dispersant phase comprises at least one of castor oil, sweetener, menthyl lactate, and sorbeth-2 hexaoleate, or a combination thereof.

34. The method of any one of claims 23-33, wherein the encapsulated phase is dispersed within the dispersant phase in an amount of about 0.1 % to about 5.0%.

35. The method of any one of claims 23-34, wherein the anhydrous phase comprises emollient in an amount of about 1 % to about 70% by weight.

36. The method of any one of claims 23-34, wherein the anhydrous phase comprises polymer in an amount of about 1 % to about 95% by weight.

37. The method of any one of claims 23-34, wherein the anhydrous phase comprises at least one of ethylene diamine hydrogenated dimer diliniolate copolymer bis-di-Ci₄-i₈ alkyl, bis- stearylethylenediamine/neopentyl glycol/stearyl hydrogenated dimer dilinoleate copolymer, triethylhexanoin, isopropyl myristate, and 2-octyldodecanol.

38. The method of any one of claims 23-37, wherein the composition comprises essentially no silicone.

39. The method of any one of claims 23-38, wherein the composition is formulated as a lipstick, lip gloss, lip balm, cream, or ointment.

40. A method of treating or preventing a skin condition comprising administering to the skin of a subject in need thereof the composition of any one of claims 1 -22.

41 . The method of claim 40, wherein the skin condition is selected from dryness, sunburn, acne, and wrinkles.

42. The method of claim 40 or 41 , wherein the skin is of the lips, face, or feet.

43. A method of treating dry lips comprising administering to the lips of a subject in need thereof the composition of any one of claims 1 -22.

44. The method of claims 23-43, wherein the wall phase comprises at least one of guar, gum arabic or a combination thereof.