WO2013106944A3 - Méthode de ciblage sélectif de cellules nanoencapsulées dans des organes ou des tissus blancs - Google Patents
Méthode de ciblage sélectif de cellules nanoencapsulées dans des organes ou des tissus blancs Download PDFInfo
- Publication number
- WO2013106944A3 WO2013106944A3 PCT/CL2013/000003 CL2013000003W WO2013106944A3 WO 2013106944 A3 WO2013106944 A3 WO 2013106944A3 CL 2013000003 W CL2013000003 W CL 2013000003W WO 2013106944 A3 WO2013106944 A3 WO 2013106944A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- organs
- nanoencapsulated
- cells
- target tissue
- selective targeting
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
- A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
- A61K47/6935—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
- A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
- A61K47/6939—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being a polysaccharide, e.g. starch, chitosan, chitin, cellulose or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nanotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Optics & Photonics (AREA)
- Cell Biology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
L'invention concerne une méthode et un système de ciblage cellulaire ("cell targeting") destinés à cibler des cellules nanoencapsulées dérivées de tissu humain ou animal dans des tissus ou des organes spécifiques, au moyen d'anticorps conjugués pour une thérapie cellulaire qui a pour but de trouver une solution aux déficiences physiologiques et physiopathologiques par l'administration et/ou l'implantation de cellules vivantes dans des organes ou des tissus blancs de l'organisme humain ou animal.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CL2012000145A CL2012000145A1 (es) | 2012-01-18 | 2012-01-18 | Metodo de direccionamiento celular de celulas a tejidos u organos especificos que comprende las etapas de nanoencapsulacion de celulas con una primera capa que comprende un polication y una capa final que comprende un polianion con grupos carboxilos activados a los cuales se une un anticuerpo especifico contra una celula blanco. |
CL145-2012 | 2012-01-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2013106944A2 WO2013106944A2 (fr) | 2013-07-25 |
WO2013106944A3 true WO2013106944A3 (fr) | 2013-09-12 |
Family
ID=48799764
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CL2013/000003 WO2013106944A2 (fr) | 2012-01-18 | 2013-01-17 | Méthode de ciblage sélectif de cellules nanoencapsulées dans des organes ou des tissus blancs |
Country Status (2)
Country | Link |
---|---|
CL (1) | CL2012000145A1 (fr) |
WO (1) | WO2013106944A2 (fr) |
-
2012
- 2012-01-18 CL CL2012000145A patent/CL2012000145A1/es unknown
-
2013
- 2013-01-17 WO PCT/CL2013/000003 patent/WO2013106944A2/fr active Application Filing
Non-Patent Citations (4)
Title |
---|
KROL S.: "Multilayer Nanoencapsulation. New Approach for Immune Protection of Human Pancreatic Islets.", NANO LETTERS, vol. 6, no. 9, 2006, pages 1933 - 1939 * |
MESSERSCHMIDT SKE.: "Targeted lipid-coated nanoparticles: Delivery of tumor necrosis factor-functionalized particles to tumor cells.", JOURNAL OF CONTROLLED RELEASE., vol. 137, 2009, pages 69 - 77 * |
NAIR HB.: "Delivery of antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer.", BIOCHEMICAL PHARMACOLOGY, vol. 80, 2010, pages 1833 - 1843 * |
VEERABADRAN NG.: "Nanoencapsulation of Stem Cells within Polyelectrolyte Multilayer Shells.", MACROMOLECULAR BIOSCIENCE. 2007., vol. 7, 2007, pages 877 - 882 * |
Also Published As
Publication number | Publication date |
---|---|
WO2013106944A2 (fr) | 2013-07-25 |
CL2012000145A1 (es) | 2014-02-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2012002760A3 (fr) | Méthode de diagnostic et de traitement du cancer par des microvésicules cellulaires | |
MX347893B (es) | Conjugados de farmaco y anticuerpo humano contra factor de tejido. | |
MX2013006591A (es) | Formas farmaceuticas orales de liberacion controlada de farmacos escasamente solubles y los usos de estas. | |
WO2014183066A3 (fr) | Modification protéique de cellules vivantes à l'aide de sortase | |
MX2013005046A (es) | Agentes citotoxicos que comprenden nuevos derivados de ansamitocina. | |
MY191040A (en) | Therapy involving antibodies against claudin 18.2 for treatment of cancer | |
WO2011106788A3 (fr) | Peptide car pour le homing, le diagnostic, & la thérapie ciblée pour les troubles pulmonaires et fibrotiques | |
WO2009100137A3 (fr) | Cellules magnétiques utilisées pour localiser une administration et réparer des tissus | |
BR112018072714A2 (pt) | composições de ligação a hcl para e método de tratamento de distúrbios de ácido-base | |
EP2949344A3 (fr) | Utilisation d'enzymes intracellulaires pour libérer des produits bioactifs liés par covalence | |
WO2016210376A3 (fr) | Peptides thérapeutiques et leurs procédés d'utilisation | |
WO2014006506A3 (fr) | Système et méthode de déploiement direct | |
WO2012048170A3 (fr) | Animaux humanisés par ingénierie tissulaire et leurs utilisations | |
WO2013184922A3 (fr) | Procédés d'amélioration du progrès génétique dans une lignée ou race de porcs au moyen de spermatozoïdes sélectionnés en fonction du sexe | |
SG11201804755VA (en) | Method for manufacturing tissue/organ by using blood cells | |
PH12016501185A1 (en) | Compounds to fibrolast growth factor receptor-3 (fgfr3) and therapeutic uses | |
WO2014028668A3 (fr) | Composés thérapeutiques activant les cellules souches | |
WO2013052158A3 (fr) | Nanovecteurs ciblés et leur utilisation pour le traitement de tumeurs cérébrales | |
EP4321218A3 (fr) | Vaccins contre le cancer ciblant des cellules souches cancéreuses | |
WO2011091154A3 (fr) | Utilisation d'érythrocytes humains dans la prévention et le traitement de la dissémination et de la croissance du cancer | |
WO2011163512A3 (fr) | Traitement anticancéreux | |
MX2015006096A (es) | Leucocitos como celulas de administracion para imagen y terapia de enfermedad. | |
WO2008011473A3 (fr) | Compositions et leurs utilisations liées à l'hbxip | |
WO2013106944A3 (fr) | Méthode de ciblage sélectif de cellules nanoencapsulées dans des organes ou des tissus blancs | |
WO2011133685A3 (fr) | Nanoparticule ciblant l'ischémie à des fins d'imagerie et de traitement |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
122 | Ep: pct application non-entry in european phase |
Ref document number: 13738040 Country of ref document: EP Kind code of ref document: A2 |