WO2013106851A3 - Syncollin, pancreatic triacylglycerol lipase, and other biomarkers for diabetes - Google Patents

Syncollin, pancreatic triacylglycerol lipase, and other biomarkers for diabetes Download PDF

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Publication number
WO2013106851A3
WO2013106851A3 PCT/US2013/021476 US2013021476W WO2013106851A3 WO 2013106851 A3 WO2013106851 A3 WO 2013106851A3 US 2013021476 W US2013021476 W US 2013021476W WO 2013106851 A3 WO2013106851 A3 WO 2013106851A3
Authority
WO
WIPO (PCT)
Prior art keywords
diabetes
biomarkers
syncollin
type
triacylglycerol lipase
Prior art date
Application number
PCT/US2013/021476
Other languages
French (fr)
Other versions
WO2013106851A2 (en
Inventor
Jerry L. Nadler
Shamina M. GREEN-MITCHELL
Julius O. NYALWIDHE
Original Assignee
Eastern Virginia Medical School
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eastern Virginia Medical School filed Critical Eastern Virginia Medical School
Publication of WO2013106851A2 publication Critical patent/WO2013106851A2/en
Publication of WO2013106851A3 publication Critical patent/WO2013106851A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Abstract

The present invention provides biomarkers that are useful in determining whether a subject has type 1 diabetes or is at risk for developing type I diabetes. Specifically, syncollin, pancreatic triacylglycerol lipase, as well as fragments and variants of these proteins can be used to diagnose an individual with type I diabetes or one at risk for developing type I diabetes. Additional type I diabetes biomarkers are also provided.
PCT/US2013/021476 2012-01-13 2013-01-14 Syncollin, pancreatic triacylglycerol lipase, and other biomarkers for diabetes WO2013106851A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261586363P 2012-01-13 2012-01-13
US61/586,363 2012-01-13

Publications (2)

Publication Number Publication Date
WO2013106851A2 WO2013106851A2 (en) 2013-07-18
WO2013106851A3 true WO2013106851A3 (en) 2013-09-12

Family

ID=48782103

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/021476 WO2013106851A2 (en) 2012-01-13 2013-01-14 Syncollin, pancreatic triacylglycerol lipase, and other biomarkers for diabetes

Country Status (1)

Country Link
WO (1) WO2013106851A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104677884A (en) * 2015-03-17 2015-06-03 北京理工大学 High-spatial-resolution laser spectral-pupil differential confocal mass spectrum microscopic imaging method and device

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3158337B1 (en) 2014-06-18 2019-03-06 Turun yliopisto Methods for determining risk of type-1 diabetes by serum protein biomarkers
CN105911287A (en) * 2016-04-06 2016-08-31 深圳市老年医学研究所 Method for establishing molecular diagnosis model for sialoprotein fingerprint of type 2 diabetes spleen-deficiency syndrome

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030152939A1 (en) * 2001-04-09 2003-08-14 Glennda Smithson Novel secreted proteins and polynucleotides encoding them
US20070036874A1 (en) * 2005-08-05 2007-02-15 Litao Zhong Compositions and methods for controlling glucose and lipid uptake from foods
US20070224638A1 (en) * 2006-03-27 2007-09-27 Institut Pasteur Secreted proteins as early markers and drug targets for autoimmunity, tumorigenesis and infections

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030152939A1 (en) * 2001-04-09 2003-08-14 Glennda Smithson Novel secreted proteins and polynucleotides encoding them
US20070036874A1 (en) * 2005-08-05 2007-02-15 Litao Zhong Compositions and methods for controlling glucose and lipid uptake from foods
US20070224638A1 (en) * 2006-03-27 2007-09-27 Institut Pasteur Secreted proteins as early markers and drug targets for autoimmunity, tumorigenesis and infections

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE UNIPROT 30 November 2010 (2010-11-30), "The MGC Project Team.", retrieved from http://www.uniprot.org/uniprot/Q0VAF6.txt?version=36 accession no. OVAF6 *
DATABASE UNIPROT 30 November 2010 (2010-11-30), LOWE ET AL., retrieved from http://www.uniprot.org/uniprot/P16233.txt?version=121 accession no. 16233 *
DUAN ET AL.: "Increase in Pancreatic Lipase and Trypsin Activity and their mRNA Levels in Streptozotocin-Induced Diabetic Rats.", DIGESTIVE DISEASES AND SCIENCES., vol. 34, no. 8, August 1989 (1989-08-01), pages 1243 - 1248 *
SEMAKULA ET AL.: "Abnormal Circulating Pancreatic Enzyme Activities in More than Twenty-Five Percent of Recent-Onset Insulin-Dependent Diabetic Patients: Association of Hyperlipasemia with High-Titer Islet Cell Antibodies.", PANCREAS., vol. 12, no. 4, May 1996 (1996-05-01), pages 321 - 333 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104677884A (en) * 2015-03-17 2015-06-03 北京理工大学 High-spatial-resolution laser spectral-pupil differential confocal mass spectrum microscopic imaging method and device
CN104677884B (en) * 2015-03-17 2017-07-11 北京理工大学 High-space resolution laser light splitting pupil differential confocal mass spectrum micro imaging method and device

Also Published As

Publication number Publication date
WO2013106851A2 (en) 2013-07-18

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