WO2013102118A3 - Imageable patient tumors in mice - Google Patents

Imageable patient tumors in mice Download PDF

Info

Publication number
WO2013102118A3
WO2013102118A3 PCT/US2012/072134 US2012072134W WO2013102118A3 WO 2013102118 A3 WO2013102118 A3 WO 2013102118A3 US 2012072134 W US2012072134 W US 2012072134W WO 2013102118 A3 WO2013102118 A3 WO 2013102118A3
Authority
WO
WIPO (PCT)
Prior art keywords
tumor
imageable
mice
animal
metastasis
Prior art date
Application number
PCT/US2012/072134
Other languages
French (fr)
Other versions
WO2013102118A2 (en
Inventor
Robert M. Hoffman
Original Assignee
Anticancer, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anticancer, Inc. filed Critical Anticancer, Inc.
Publication of WO2013102118A2 publication Critical patent/WO2013102118A2/en
Publication of WO2013102118A3 publication Critical patent/WO2013102118A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to a fluorescent animal model for monitoring tumor-stroma interactions during progression, angiogenesis and/or metastasis of tumor cells, methods of producing such animal models, and methods of using such animal models, for example, for assaying the effects of a drug on tumor-stroma interactions during progression, angiogenesis and/or metastasis of tumor cells. The animal model comprises an immunocompromised or syngeneic experimental animal implanted with tumor cells and stromal cells, wherein said stromal cells express one or more fluorescent proteins, such as green fluorescent protein (GFP).
PCT/US2012/072134 2011-12-30 2012-12-28 Imageable patient tumors in mice WO2013102118A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161581901P 2011-12-30 2011-12-30
US61/581,901 2011-12-30

Publications (2)

Publication Number Publication Date
WO2013102118A2 WO2013102118A2 (en) 2013-07-04
WO2013102118A3 true WO2013102118A3 (en) 2015-06-25

Family

ID=48698813

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/072134 WO2013102118A2 (en) 2011-12-30 2012-12-28 Imageable patient tumors in mice

Country Status (1)

Country Link
WO (1) WO2013102118A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3332814A4 (en) * 2015-08-03 2018-07-25 FUJIFILM Corporation Cell structure, non-human model animal, method for producing non-human model animal, and method for evaluating test substance
WO2018030193A1 (en) * 2016-08-08 2018-02-15 コニカミノルタ株式会社 Method relating to evaluation of tumor tissue of experimental animal

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070087435A1 (en) * 2003-05-05 2007-04-19 Rappaport Family Institute For Research In The Medical Sciences Multicellular compositions of pluripotent human embryonic stem cells and cancer cells
WO2011090778A1 (en) * 2010-01-25 2011-07-28 Albert Einstein College Of Medicine Of Yeshiva University Device for collecting and analyzing migratory tumor cells
US20110183866A1 (en) * 2005-06-13 2011-07-28 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US20110206614A1 (en) * 2007-11-23 2011-08-25 Whitehead Institute For Biomedical Research Systemic instigation systems to study tumor growth or metastasis

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070087435A1 (en) * 2003-05-05 2007-04-19 Rappaport Family Institute For Research In The Medical Sciences Multicellular compositions of pluripotent human embryonic stem cells and cancer cells
US20110183866A1 (en) * 2005-06-13 2011-07-28 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US20110206614A1 (en) * 2007-11-23 2011-08-25 Whitehead Institute For Biomedical Research Systemic instigation systems to study tumor growth or metastasis
WO2011090778A1 (en) * 2010-01-25 2011-07-28 Albert Einstein College Of Medicine Of Yeshiva University Device for collecting and analyzing migratory tumor cells

Also Published As

Publication number Publication date
WO2013102118A2 (en) 2013-07-04

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