WO2013093298A1 - Pansement interface adherent - Google Patents
Pansement interface adherent Download PDFInfo
- Publication number
- WO2013093298A1 WO2013093298A1 PCT/FR2012/052897 FR2012052897W WO2013093298A1 WO 2013093298 A1 WO2013093298 A1 WO 2013093298A1 FR 2012052897 W FR2012052897 W FR 2012052897W WO 2013093298 A1 WO2013093298 A1 WO 2013093298A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- styrene
- ethylene
- knit
- dressing according
- weight
- Prior art date
Links
- 239000000853 adhesive Substances 0.000 title abstract description 6
- 230000001070 adhesive effect Effects 0.000 title abstract description 6
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000011159 matrix material Substances 0.000 claims abstract description 19
- 239000004744 fabric Substances 0.000 claims abstract description 17
- -1 styrene - (ethylene - butylene) - styrene Chemical class 0.000 claims abstract description 16
- 230000001464 adherent effect Effects 0.000 claims abstract description 14
- 229920001971 elastomer Polymers 0.000 claims abstract description 13
- 239000000806 elastomer Substances 0.000 claims abstract description 13
- 239000000416 hydrocolloid Substances 0.000 claims abstract description 13
- 229920000359 diblock copolymer Polymers 0.000 claims abstract description 9
- 230000002209 hydrophobic effect Effects 0.000 claims abstract description 9
- 239000002245 particle Substances 0.000 claims abstract description 7
- HQQADJVZYDDRJT-UHFFFAOYSA-N ethene;prop-1-ene Chemical group C=C.CC=C HQQADJVZYDDRJT-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000002480 mineral oil Substances 0.000 claims abstract description 5
- 235000010446 mineral oil Nutrition 0.000 claims abstract description 5
- 239000000499 gel Substances 0.000 claims description 23
- 239000000203 mixture Substances 0.000 claims description 19
- 150000001875 compounds Chemical class 0.000 claims description 9
- 239000005662 Paraffin oil Substances 0.000 claims description 6
- 239000003921 oil Substances 0.000 claims description 6
- 235000019271 petrolatum Nutrition 0.000 claims description 6
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 5
- 230000035876 healing Effects 0.000 claims description 5
- 229920000728 polyester Polymers 0.000 claims description 5
- 239000006185 dispersion Substances 0.000 claims description 4
- 239000013543 active substance Substances 0.000 claims description 3
- 239000004952 Polyamide Substances 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- 230000002421 anti-septic effect Effects 0.000 claims description 2
- 230000003115 biocidal effect Effects 0.000 claims description 2
- 229920002647 polyamide Polymers 0.000 claims description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229920002633 Kraton (polymer) Polymers 0.000 description 15
- 206010052428 Wound Diseases 0.000 description 10
- 208000027418 Wounds and injury Diseases 0.000 description 10
- 229920000428 triblock copolymer Polymers 0.000 description 8
- 239000011248 coating agent Substances 0.000 description 7
- 238000000576 coating method Methods 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 241000765083 Ondina Species 0.000 description 6
- 230000002745 absorbent Effects 0.000 description 6
- 239000002250 absorbent Substances 0.000 description 6
- 229920001935 styrene-ethylene-butadiene-styrene Polymers 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 5
- 235000019198 oils Nutrition 0.000 description 5
- 230000001681 protective effect Effects 0.000 description 4
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 3
- 239000004264 Petrolatum Substances 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 229920001400 block copolymer Polymers 0.000 description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 238000009998 heat setting Methods 0.000 description 3
- 229940066842 petrolatum Drugs 0.000 description 3
- 229920002742 polystyrene-block-poly(ethylene/propylene) -block-polystyrene Polymers 0.000 description 3
- BGYHLZZASRKEJE-UHFFFAOYSA-N [3-[3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoyloxy]-2,2-bis[3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoyloxymethyl]propyl] 3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoate Chemical compound CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(CCC(=O)OCC(COC(=O)CCC=2C=C(C(O)=C(C=2)C(C)(C)C)C(C)(C)C)(COC(=O)CCC=2C=C(C(O)=C(C=2)C(C)(C)C)C(C)(C)C)COC(=O)CCC=2C=C(C(O)=C(C=2)C(C)(C)C)C(C)(C)C)=C1 BGYHLZZASRKEJE-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 150000001336 alkenes Chemical class 0.000 description 2
- 239000002260 anti-inflammatory agent Substances 0.000 description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 210000000416 exudates and transudate Anatomy 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- QRLSTWVLSWCGBT-UHFFFAOYSA-N 4-((4,6-bis(octylthio)-1,3,5-triazin-2-yl)amino)-2,6-di-tert-butylphenol Chemical compound CCCCCCCCSC1=NC(SCCCCCCCC)=NC(NC=2C=C(C(O)=C(C=2)C(C)(C)C)C(C)(C)C)=N1 QRLSTWVLSWCGBT-UHFFFAOYSA-N 0.000 description 1
- 108010087765 Antipain Proteins 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- SDNYTAYICBFYFH-TUFLPTIASA-N antipain Chemical compound NC(N)=NCCC[C@@H](C=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 SDNYTAYICBFYFH-TUFLPTIASA-N 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000000022 bacteriostatic agent Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 238000009940 knitting Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- SSDSCDGVMJFTEQ-UHFFFAOYSA-N octadecyl 3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)CCC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 SSDSCDGVMJFTEQ-UHFFFAOYSA-N 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000002530 phenolic antioxidant Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/225—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A—HUMAN NECESSITIES
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01008—Non-adhesive bandages or dressings characterised by the material
- A61F13/01017—Non-adhesive bandages or dressings characterised by the material synthetic, e.g. polymer based
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01021—Non-adhesive bandages or dressings characterised by the structure of the dressing
- A61F13/01025—Non-adhesive bandages or dressings characterised by the structure of the dressing made of a single layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/34—Oils, fats, waxes or natural resins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04B—KNITTING
- D04B21/00—Warp knitting processes for the production of fabrics or articles not dependent on the use of particular machines; Fabrics or articles defined by such processes
- D04B21/10—Open-work fabrics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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- A61L2300/406—Antibiotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
-
- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2509/00—Medical; Hygiene
- D10B2509/02—Bandages, dressings or absorbent pads
- D10B2509/022—Wound dressings
Definitions
- the present invention relates to an adhesive interface dressing intended to be applied directly in contact with a wound.
- Wound treatment has long been known by dressings intended to be brought into contact with the wound by providing an interface between said wound and an absorbent pad which is deposited on the dressing in order to absorb the exudates of the wound.
- Such dressings are usually referred to as "interface dressings”.
- the dressing assembly interface plus absorbent compress is usually immobilized either with a band that is wrapped around the part to be treated, for example around the arm or leg, or with a tape.
- Interface dressings are for example marketed by Laboratoires URGO or Molnlycke Health Care respectively under the names URGOTUL® and Mepitel®.
- These products generally consist of an armature made of an open mesh fabric whose son are coated with a cohesive gel, so as to leave the meshes essentially unsealed.
- the URGOTUL® interface dressing has remarkable properties as regards the promotion of the healing process and in particular the proliferation of fibroblasts.
- This gel is formed of a specific composition consisting of a highly plasticized hydrophobic elastomeric matrix and containing in dispersion a small amount of hydrophilic particles of a hydrocolloid.
- the URGOTUL® product nevertheless has the disadvantage of not adhering to the skin.
- the dressing falls quickly before the caregiver has been able to apply the pad or permanently fix the interface plus compress with a band.
- WO 2005/056069 proposes to produce an interface dressing which comprises an absorbent matrix. But the product described in this document remains non-adherent to the skin, and therefore suffers from the same disadvantages as the product URGOTUL®.
- an additive promoting adhesion such as a tackifier product.
- tackifying compounds modifies the rheological properties of the gel, which gives rise to very important, even insurmountable, technical difficulties for obtaining a correct coating of the yarns of the fabric under economically acceptable industrial production conditions.
- the purpose of the present invention is to provide a more adherent dressing than the dressing described in WO 00/16725. modify the nature of the compounds used, or incorporate new compounds, into the formulation of the cohesive gel that it incorporates.
- the present invention therefore relates to an adhesive interface dressing comprising:
- a non - adherent, cohesive gel formed of a hydrophobic elastomeric matrix consisting of a triblock elastomer of the styrene - (ethylene - butylene) - styrene or styrene (ethylene - propylene) - styrene type optionally combined with a diblock copolymer of the styrene type - ( ethylene - butylene) or styrene - (ethylene - propylene), said elastomer being strongly plasticized by means of a mineral oil, and containing in dispersion a small amount of hydrophilic particles of a hydrocolloid; and
- an open-mesh flexible fabric said fabric comprising yarns which are coated with the non-adherent cohesive gel so as to leave the stitches substantially unobstructed,
- the fabric is a thermofixed knit with screened yarns, said yarns being non-elastic filament continuous yarns, which has in the transverse direction an extensibility measured according to EN 13726-4 between
- the hydrophobic elastomeric matrix comprises an elastomer chosen from triblock block polymers of the ABA type comprising two styrene terminal blocks and a central block B which is a saturated olefin such as, for example, ethylene-butylene or ethylene-propylene.
- triblock copolymers may be optionally combined with AB type diblock copolymers comprising a styrene block A and an ethylene-propylene or ethylene-butylene B block.
- KRATON POLYMERS under the name KRATON G®, and in particular under the name KRATON G1651®, KRATON G1654® or KRATON G1652® for block copolymers poly (styrene - (- ethylene-butylene -) - styrene) (in abbreviated SEBS);
- SEPS block copolymers poly (styrene - (- ethylene-propylene -) - styrene) (abbreviated to SEPS).
- a triblock SEBS such as in particular the product marketed by KRATON POLYMERS under the name KRATON G1651®;
- poly (styrene-olefin) diblock copolymer such as in particular poly (styrene-ethylene-propylene) marketed by Kraton
- SEBS or SEPS triblock copolymers having a styrene content of between 25 and 45% by weight relative to the weight of said SEBS or SEPS and having a medium or high molecular weight and a Brookfield viscosity at less than 300 cp (measured at 25 ° C for a 10% solution in toluene).
- triblock block copolymers alone, preferably triblock copolymers SEBS and in particular the products sold by the company KRATON POLYMERS under the names KRATON G1651® or KRATON G1654®.
- the hydrophobic elastomer is plasticized by addition of an oily element which makes it possible to obtain a highly cohesive, elastic gel with a greasy appearance.
- the oil element will preferably be chosen from a mineral oil having both good compatibility with the previously described elastomers and a recognized tolerance towards skin tissues.
- Paraffin oils of preferably low viscosities or mixtures of paraffin oil and petrolatum.
- plasticizing oils that are particularly suitable, mention may be made of the products marketed by SHELL under the names ONDINA® and RISELLA® which consist of a mixture based on naphthenic and paraffinic compounds.
- a plasticizing oil chosen from the products sold under the names ONDINA 963®, ONDINA 15®, ONDINA 919® and in particular an oil marketed under the names ONDINA 15® or ONDINA 919® in combination with a petrolatum according to US Pat. the French pharmacopoeia.
- the hydrophobic matrix comprises 1000 to 2000 parts by weight of paraffin oil, preferably of low viscosity and 0 to 400 parts by weight of petroleum jelly, per 100 parts by weight of elastomer.
- this matrix will comprise 100 parts by weight of high molecular weight SEBS elastomer, for example KRATON G 1651®, and 1600 parts by weight of an oily plasticizer composed of 95% by weight of paraffin oil of low viscosity and 5% by weight of petrolatum.
- SEBS elastomer for example KRATON G 1651®
- oily plasticizer composed of 95% by weight of paraffin oil of low viscosity and 5% by weight of petrolatum.
- the hydrophobic matrix further contains in dispersion a small amount of hydrophilic particles of a hydrocolloid.
- hydrocolloid or hydrocolloid particles is meant here any compound usually used by those skilled in the art for its ability to absorb aqueous liquids such as water, saline or wound exudates.
- Suitable hydrocolloids include, for example, pectin, alginates and carboxymethylcellulose and its alkali metal salts such as sodium and calcium.
- hydrocolloids preferred in the context of the present invention are the alkali metal salts of carboxymethylcellulose, and in particular sodium carboxymethylcellulose (CMC).
- the size of the hydrocolloid particles is advantageously between 50 and 100 microns, in particular of the order of 80 microns.
- the amount of hydrocolloids incorporated in the elastomer composition will advantageously be of the order of 2 to 20% by weight, preferably 5 to 18% by weight and more preferably 12 to 16% by weight, based on the total weight of the elastomeric matrix.
- the elastomeric matrix may further comprise one or more antioxidant agents.
- antioxidant agents examples include:
- phenolic antioxidants such as in particular the products marketed by CIBA SPECIALTY CHEMICALS under the names IRGANOX 1010®, IRGANOX 565® and IRGANOX 1076®.
- antioxidants may be used in an amount of about 0.05 to 1% by weight, preferably from 0.1 to 0.5% by weight, based on the total weight of the elastomeric matrix.
- the elastomeric matrix may also contain active ingredients having a favorable role in the treatment of the wound. These active ingredients can in particular induce or accelerate healing.
- These active agents may be used in an amount of about 0.01 to 20% by weight, preferably from 1 to 15% by weight and in particular from 2 to 10% by weight, based on the total weight of the elastomeric matrix. .
- active substances that may be used in the context of the invention, mention may be made, by way of example, of antiseptic, antibiotic, bactericidal or bacteriostatic agents, agents promoting healing, anti-pain agents or anti-inflammatory agents. anti-inflammatory agents.
- the reinforcement of the dressing is an open mesh fabric constituted by a specific knit.
- the adhesion to the skin depends not only on the nature of the gel but also on the nature of the tissue on which the gel is coated.
- thermofixed knit with screened yarns which has a particular level of extensibility in the transverse direction, when it is subjected to small deformations, makes it possible to obtain an adherent product without modifying the nature of the constituents of the cohesive gel.
- the essential characteristic of such a knit is to present in the transverse direction an extensibility, measured according to standard NF EN 13726-4, between 0.01 and 0.5 N / cm.
- this extensibility will be between 0.05 to 0.3 N / cm and more preferably between 0.08 to 0.15 N / cm.
- this knit will present in the longitudinal direction an extensibility measured according to the same standard of between 15 and 30 N / cm and preferably between 20 and 25 N / cm.
- Such extensibility in the longitudinal direction allows indeed an easier and more regular coating of the knit by cohesive gel from the industrial point of view.
- this knit is made with screened yarns, and will be manufactured in particular according to the technology called "knit stitches”.
- this knit is heat-set.
- thermofixation makes it possible to stabilize the structure of the knitted fabric after knitting by thermal effect.
- This thermofixation operation is commonly used by those skilled in the art during the manufacture of a knit which is wanted to freeze the three-dimensional structure. It can be implemented using different technologies either by passing the knit in a series of thermoregulated furnaces, or by passing the knit in an autoclave, or by passing the knit between one or more heated cylinders. In the context of the present invention, it will be preferred to carry out this heat-setting operation by passing the knit between two heated rolls.
- this knit is made using continuous filaments with non-elastic filaments.
- continuous filament yarn is meant a yarn formed of one or more long, stranded filaments.
- This yarn will preferably be chosen from 33 to 115 dtex yarns comprising 12 to 36 filaments.
- the constituent material of the yarns is preferably of a synthetic and hydrophobic nature. This material is advantageously chosen from polyesters and polyamides.
- This knit may have a grammage of between 20 to 40 g / m 2 and preferably between 24 to 32 g / m 2 .
- This knit may have rectangular, square or polygonal meshes.
- These meshes advantageously have openings whose unit area before coating is of the order of 0.5 to 3 mm 2 and preferably between 0.85 and 1.25 mm 2 .
- a knit that has trapezoidal meshes.
- a knit with such a mesh is schematically illustrated in FIG. 1.
- the angle a is defined as the average connection angle of the rows (1) and columns (2) of the knit.
- this knit has an average mesh surface of the order of 0.95 mm 2 and an angle a as described in FIG. 1 between 75 and 85 degrees.
- the coating of the cohesive gel on the knit is carried out in such a way as to leave the stitches essentially unsealed, according to the techniques known to those skilled in the art and so as to obtain a coating which varies from 110 to 160 g / m 2 and preferably from 125 to 135 g / m 2 .
- Figure 1 attached schematically shows a mesh of the fabric of a dressing according to a preferred embodiment of the invention.
- the fabric was a heat-bonded marquisette, made of polyester yarn, manufactured by the company MDB TEXINOV under the reference 555. Its basis weight was 45 g / m 2 .
- This marquisette had an extensibility, measured according to EN 13726-4, of 2.7 N / cm in the transverse direction and 24 N / cm in the longitudinal direction.
- Example according to the invention :
- a dressing according to the invention was produced according to the same manufacturing method and with the same gel composition as in example 1 of the patent application WO 00/16275 but replacing the marquisette with a knitted yarn with heat-set rovings, made of polyester yarn, manufactured by the company MDB TEXINOV under the reference 601. Its basis weight was 28 g / m 2 .
- This knit had an extensibility, measured according to EN 13726-4, of 0.09 N / cm in the transverse direction and 24 N / cm in the longitudinal direction.
- the elbow was cleaned with soapy water, dried with a tissue and repeated with another sample.
- This protocol was repeated 10 times by cutting the samples once in the longitudinal direction and once in the transverse direction, ie in total 40 samples tested.
- a second series of tests was carried out with a second tester, ie again 40 samples tested.
- Table 1 illustrate the advantages of the product according to the invention compared to the URGOTUL® product.
- the product according to the invention almost never falls regardless of the tester, the tested elbow, the cutting direction of the dressing sample and this result is reproducible with several dressings. It fell only 4 times out of 40 tests.
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Abstract
Description
Claims
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2858939A CA2858939C (fr) | 2011-12-19 | 2012-12-12 | Pansement interface adherent |
JP2014548141A JP6200900B2 (ja) | 2011-12-19 | 2012-12-12 | 粘着性インターフェース創傷被覆材 |
DK12816721.0T DK2793773T3 (en) | 2011-12-19 | 2012-12-12 | Adhesive interface dressing |
PL12816721T PL2793773T3 (pl) | 2011-12-19 | 2012-12-12 | Przylegający opatrunek kontaktowy |
KR1020147016506A KR20140107269A (ko) | 2011-12-19 | 2012-12-12 | 점착성 계면 밴드 |
US14/366,190 US11285238B2 (en) | 2011-12-19 | 2012-12-12 | Adhesive interface bandage |
BR112014014684-5A BR112014014684B1 (pt) | 2011-12-19 | 2012-12-12 | curativo com interface aderente |
SG11201403284UA SG11201403284UA (en) | 2011-12-19 | 2012-12-12 | Adhesive interface bandage |
CN201280063086.1A CN104010603B (zh) | 2011-12-19 | 2012-12-12 | 粘附性交界面敷料 |
EP12816721.0A EP2793773B1 (fr) | 2011-12-19 | 2012-12-12 | Pansement interface adherent |
MX2014007395A MX337475B (es) | 2011-12-19 | 2012-12-12 | Vendaje de zona interfacial adhesivo. |
ES12816721.0T ES2558170T3 (es) | 2011-12-19 | 2012-12-12 | Apósito con superficie de contacto adherente |
AU2012356546A AU2012356546B2 (en) | 2011-12-19 | 2012-12-12 | Adhesive interface bandage |
PH12014501391A PH12014501391A1 (en) | 2011-12-19 | 2014-06-18 | Adhesive interface bandage |
ZA2014/05081A ZA201405081B (en) | 2011-12-19 | 2014-07-11 | Adhesive interface bandage |
HK14112765.2A HK1199196A1 (zh) | 2011-12-19 | 2014-12-22 | 粘附性交界面敷料 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/FR2011/053043 WO2013093213A1 (fr) | 2011-12-19 | 2011-12-19 | Pansement interface adherent |
FRPCT/FR2011/053043 | 2011-12-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2013093298A1 true WO2013093298A1 (fr) | 2013-06-27 |
Family
ID=47599067
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2011/053043 WO2013093213A1 (fr) | 2011-12-19 | 2011-12-19 | Pansement interface adherent |
PCT/FR2012/052897 WO2013093298A1 (fr) | 2011-12-19 | 2012-12-12 | Pansement interface adherent |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2011/053043 WO2013093213A1 (fr) | 2011-12-19 | 2011-12-19 | Pansement interface adherent |
Country Status (22)
Country | Link |
---|---|
US (1) | US11285238B2 (fr) |
EP (2) | EP2959873B1 (fr) |
JP (1) | JP6200900B2 (fr) |
KR (1) | KR20140107269A (fr) |
CN (1) | CN104010603B (fr) |
AU (1) | AU2012356546B2 (fr) |
BR (1) | BR112014014684B1 (fr) |
CA (1) | CA2858939C (fr) |
CL (1) | CL2014001604A1 (fr) |
CO (1) | CO7071116A2 (fr) |
DK (1) | DK2793773T3 (fr) |
ES (2) | ES2558170T3 (fr) |
HK (1) | HK1199196A1 (fr) |
HU (1) | HUE027062T2 (fr) |
MX (1) | MX337475B (fr) |
MY (1) | MY175014A (fr) |
PH (1) | PH12014501391A1 (fr) |
PL (1) | PL2793773T3 (fr) |
PT (1) | PT2793773E (fr) |
SG (1) | SG11201403284UA (fr) |
WO (2) | WO2013093213A1 (fr) |
ZA (1) | ZA201405081B (fr) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2837370A4 (fr) * | 2012-03-01 | 2016-02-17 | Alcare Co Ltd | Pansement |
JP2017502745A (ja) * | 2013-12-20 | 2017-01-26 | エイチシーピー ヘルスケア アジア ピーティーイー.リミテッド | 空洞創傷を充填するための複合材料 |
WO2018210969A1 (fr) | 2017-05-17 | 2018-11-22 | Urgo Recherche Innovation Et Developpement | Utilisation de composes oligosaccharidiques pour traiter les plaies des patients diabetiques arteriopatiques |
WO2022043636A1 (fr) | 2020-08-26 | 2022-03-03 | Urgo Recherche Innovation Et Developpement | Utilisation de composes oligosaccharidiques pour augmenter l'oxygenation de la peau lors du traitement de l'ischemie ou des plaies ischemiques |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2993182B1 (fr) | 2012-07-13 | 2014-10-17 | Urgo Lab | Pansement a liberation prolongee d'actifs |
KR101645277B1 (ko) * | 2014-12-05 | 2016-08-04 | 주식회사 불스원 | 젤쿠션의 제조방법 |
FR3030225B1 (fr) * | 2014-12-19 | 2017-01-13 | Urgo Lab | Pansement comprenant un support et une matrice elastomerique hydrophobe |
FR3050937B1 (fr) * | 2016-05-04 | 2018-05-25 | Urgo Recherche Innovation Et Developpement | Composition optimisee pour pansement interface |
FR3053892A1 (fr) | 2016-07-12 | 2018-01-19 | Urgo Recherche Innovation Et Developpement | Pansement permettant la liberation controlee et prolongee de la metformine |
FR3082123B1 (fr) | 2018-06-07 | 2020-10-16 | Urgo Rech Innovation Et Developpement | Pansement cellularise et son procede de fabrication |
CN112168494B (zh) * | 2020-09-27 | 2022-04-29 | 西安工程大学 | 一种3d间隔织物-气凝胶复合医用敷料及其制备方法 |
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WO2000016275A1 (fr) | 1998-09-16 | 2000-03-23 | S.D.S. Smart Data & Security Systems Ltd. | Systeme de verrouillage electronique |
WO2000016725A2 (fr) | 1998-09-18 | 2000-03-30 | Laboratoires D'hygiene Et De Dietetique | Compresse non adherente sterile |
WO2005056069A1 (fr) | 2003-12-05 | 2005-06-23 | 3M Innovative Properties Company | Pansements et procedes correspondants |
FR2936159A1 (fr) * | 2008-09-24 | 2010-03-26 | Plasto | Interface chirurgicale pour plaie, avec support |
EP2168607A1 (fr) | 2008-09-24 | 2010-03-31 | Plasto | Interface chirurgicale pour plaie, sans support |
Family Cites Families (6)
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US5512354A (en) * | 1993-01-25 | 1996-04-30 | Minnesota Mining And Manufacturing Company | Fabric backing for orthopedic support materials |
AT408347B (de) * | 1997-09-30 | 2001-10-25 | Gerhard Melcher | Überwiegend anorganische masse, daraus hergestelltes schaumprodukt und verfahren seiner herstellung |
KR100596118B1 (ko) * | 2001-10-31 | 2006-07-06 | 아사히 가세이 셍이 가부시키가이샤 | 다층 구조를 갖는 탄성 편물, 성형 의류, 탄성 환편물의 제조방법, 탄성 편물의 제조방법 및 실 공급장치 |
FR2838748B1 (fr) * | 2002-04-17 | 2004-07-09 | Urgo Laboratoires | Nouvelles compositions adhesives thermofusibles hydrophiles |
US7960603B2 (en) * | 2008-01-25 | 2011-06-14 | Bsn Medical, Inc. | Medical bandage cover, medical bandage, and medical bandaging product |
FR2993464B1 (fr) * | 2012-07-17 | 2014-08-22 | Urgo Lab | Pansement interface autoporte |
-
2011
- 2011-12-19 WO PCT/FR2011/053043 patent/WO2013093213A1/fr active Application Filing
-
2012
- 2012-12-12 HU HUE12816721A patent/HUE027062T2/en unknown
- 2012-12-12 PT PT128167210T patent/PT2793773E/pt unknown
- 2012-12-12 CA CA2858939A patent/CA2858939C/fr active Active
- 2012-12-12 JP JP2014548141A patent/JP6200900B2/ja active Active
- 2012-12-12 MY MYPI2014701617A patent/MY175014A/en unknown
- 2012-12-12 WO PCT/FR2012/052897 patent/WO2013093298A1/fr active Application Filing
- 2012-12-12 ES ES12816721.0T patent/ES2558170T3/es active Active
- 2012-12-12 US US14/366,190 patent/US11285238B2/en active Active
- 2012-12-12 PL PL12816721T patent/PL2793773T3/pl unknown
- 2012-12-12 AU AU2012356546A patent/AU2012356546B2/en active Active
- 2012-12-12 EP EP15181660.0A patent/EP2959873B1/fr active Active
- 2012-12-12 KR KR1020147016506A patent/KR20140107269A/ko active Search and Examination
- 2012-12-12 SG SG11201403284UA patent/SG11201403284UA/en unknown
- 2012-12-12 DK DK12816721.0T patent/DK2793773T3/en active
- 2012-12-12 BR BR112014014684-5A patent/BR112014014684B1/pt active IP Right Grant
- 2012-12-12 MX MX2014007395A patent/MX337475B/es active IP Right Grant
- 2012-12-12 EP EP12816721.0A patent/EP2793773B1/fr active Active
- 2012-12-12 CN CN201280063086.1A patent/CN104010603B/zh active Active
- 2012-12-12 ES ES15181660.0T patent/ES2669693T3/es active Active
-
2014
- 2014-06-18 PH PH12014501391A patent/PH12014501391A1/en unknown
- 2014-06-18 CO CO14132717A patent/CO7071116A2/es unknown
- 2014-06-18 CL CL2014001604A patent/CL2014001604A1/es unknown
- 2014-07-11 ZA ZA2014/05081A patent/ZA201405081B/en unknown
- 2014-12-22 HK HK14112765.2A patent/HK1199196A1/zh not_active IP Right Cessation
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WO2000016275A1 (fr) | 1998-09-16 | 2000-03-23 | S.D.S. Smart Data & Security Systems Ltd. | Systeme de verrouillage electronique |
WO2000016725A2 (fr) | 1998-09-18 | 2000-03-30 | Laboratoires D'hygiene Et De Dietetique | Compresse non adherente sterile |
WO2005056069A1 (fr) | 2003-12-05 | 2005-06-23 | 3M Innovative Properties Company | Pansements et procedes correspondants |
FR2936159A1 (fr) * | 2008-09-24 | 2010-03-26 | Plasto | Interface chirurgicale pour plaie, avec support |
EP2168607A1 (fr) | 2008-09-24 | 2010-03-31 | Plasto | Interface chirurgicale pour plaie, sans support |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
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EP2837370A4 (fr) * | 2012-03-01 | 2016-02-17 | Alcare Co Ltd | Pansement |
US10849794B2 (en) | 2012-03-01 | 2020-12-01 | Alcare Co., Ltd. | Wound dressing |
JP2017502745A (ja) * | 2013-12-20 | 2017-01-26 | エイチシーピー ヘルスケア アジア ピーティーイー.リミテッド | 空洞創傷を充填するための複合材料 |
WO2018210969A1 (fr) | 2017-05-17 | 2018-11-22 | Urgo Recherche Innovation Et Developpement | Utilisation de composes oligosaccharidiques pour traiter les plaies des patients diabetiques arteriopatiques |
WO2022043636A1 (fr) | 2020-08-26 | 2022-03-03 | Urgo Recherche Innovation Et Developpement | Utilisation de composes oligosaccharidiques pour augmenter l'oxygenation de la peau lors du traitement de l'ischemie ou des plaies ischemiques |
FR3113583A1 (fr) | 2020-08-26 | 2022-03-04 | Urgo Recherche Innovation Et Developpement | Utilisation de composes oligosaccharidiques pour augmenter l’oxygenation de la peau lors du traitement des plaies ischemiques |
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