WO2013090567A3 - Immunohistochemical assay validation devices and methods - Google Patents

Immunohistochemical assay validation devices and methods Download PDF

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Publication number
WO2013090567A3
WO2013090567A3 PCT/US2012/069499 US2012069499W WO2013090567A3 WO 2013090567 A3 WO2013090567 A3 WO 2013090567A3 US 2012069499 W US2012069499 W US 2012069499W WO 2013090567 A3 WO2013090567 A3 WO 2013090567A3
Authority
WO
WIPO (PCT)
Prior art keywords
slide
methods
control group
parameter
immunohistochemical assay
Prior art date
Application number
PCT/US2012/069499
Other languages
French (fr)
Other versions
WO2013090567A2 (en
Inventor
Jeffrey David BASSLER
Barry Michael Sandbank
Erico VON BUEREN
Original Assignee
Lab Vision Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lab Vision Corporation filed Critical Lab Vision Corporation
Publication of WO2013090567A2 publication Critical patent/WO2013090567A2/en
Publication of WO2013090567A3 publication Critical patent/WO2013090567A3/en

Links

Classifications

    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/80—Analysis of captured images to determine intrinsic or extrinsic camera parameters, i.e. camera calibration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00594—Quality control, including calibration or testing of components of the analyser
    • G01N35/00603—Reinspection of samples
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10024—Color image
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10056—Microscopic image
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30024—Cell structures in vitro; Tissue sections in vitro

Abstract

A method for validating an immunohistochemical slide. The slide is pre-treated and stained in accordance with an immunohistochemical protocol and includes a validation portion with at least one control group. The at least one control group is configured to validate at least one parameter directed to at least one of the pre-treatment or of the staining of the slide. The method includes capturing an image of the slide and measuring a value of the at least one parameter for the control group from the image. The measured value of the at least one parameter is compared to an acceptable value. Based on this comparison, an indication of the validity of the IHC slide is generated.
PCT/US2012/069499 2011-12-13 2012-12-13 Immunohistochemical validation devices and methods WO2013090567A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161570037P 2011-12-13 2011-12-13
US61/570,037 2011-12-13

Publications (2)

Publication Number Publication Date
WO2013090567A2 WO2013090567A2 (en) 2013-06-20
WO2013090567A3 true WO2013090567A3 (en) 2013-10-10

Family

ID=47459176

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/069499 WO2013090567A2 (en) 2011-12-13 2012-12-13 Immunohistochemical validation devices and methods

Country Status (1)

Country Link
WO (1) WO2013090567A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102342993B1 (en) * 2017-06-15 2021-12-27 션전 피알에스 리미티드 Process recording slides for immunohistochemical staining
JP7440411B2 (en) * 2017-06-15 2024-02-28 シンセン ピーアールエス リミテッド Method of scale extrapolation for IHC antigen imaging
US10921223B2 (en) * 2018-10-12 2021-02-16 Shenzhen Prs Limited Process record slide for staining and method of using the same
EP4076756A4 (en) * 2019-12-20 2024-01-24 Roche Diagnostics Hematology Inc Linearity control compositions and methods of use
GB202006260D0 (en) * 2020-04-28 2020-06-10 Leeds Teaching Hospitals Nhs Trust Stain Assessment

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001046671A1 (en) * 1999-12-20 2001-06-28 Veracel Inc. Apparatus and method for image analysis quality control and assurance
US20070037138A1 (en) * 2003-02-27 2007-02-15 Lars Winther Standard for immunohistochemistry, immunocytochemistry and molecular cytogenetics

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001046671A1 (en) * 1999-12-20 2001-06-28 Veracel Inc. Apparatus and method for image analysis quality control and assurance
US20070037138A1 (en) * 2003-02-27 2007-02-15 Lars Winther Standard for immunohistochemistry, immunocytochemistry and molecular cytogenetics

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
OLE FELDBALLE RASMUSSEN: "Immunohistochemical staining methods", DAKO EDUCATION GUIDES, 2 December 2009 (2009-12-02), pages 127 - 130, XP055056959, Retrieved from the Internet <URL:http://www.dako.com/08002_03aug09_ihc_guidebook_5th_edition_chapter_19.pdf> [retrieved on 20130318] *
VON BUEREN ERICO ET AL: "Analysis of HER2 Peptide-Based Analyte Control Slides", JOURNAL OF HISTOTECHNOLOGY, DOWNERS GROVE, IL, US, vol. 33, no. 4, 1 December 2010 (2010-12-01), pages 153 - 156, XP009167914, ISSN: 0147-8885 *

Also Published As

Publication number Publication date
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