WO2013074871A3 - Humanin analogs - Google Patents

Humanin analogs Download PDF

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Publication number
WO2013074871A3
WO2013074871A3 PCT/US2012/065426 US2012065426W WO2013074871A3 WO 2013074871 A3 WO2013074871 A3 WO 2013074871A3 US 2012065426 W US2012065426 W US 2012065426W WO 2013074871 A3 WO2013074871 A3 WO 2013074871A3
Authority
WO
WIPO (PCT)
Prior art keywords
humanin
analogs
disclosed
humanin analogs
pharmaceutically acceptable
Prior art date
Application number
PCT/US2012/065426
Other languages
French (fr)
Other versions
WO2013074871A2 (en
Inventor
John J. Nestor
Original Assignee
Cohbar, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cohbar, Inc. filed Critical Cohbar, Inc.
Publication of WO2013074871A2 publication Critical patent/WO2013074871A2/en
Publication of WO2013074871A3 publication Critical patent/WO2013074871A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Disclosed are humanin (HN) analogs, and methods of making and using the humanin analogs. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of a humanin analog of the invention and a pharmaceutically acceptable carrier.
PCT/US2012/065426 2011-11-17 2012-11-16 Humanin analogs WO2013074871A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161561155P 2011-11-17 2011-11-17
US61/561,155 2011-11-17

Publications (2)

Publication Number Publication Date
WO2013074871A2 WO2013074871A2 (en) 2013-05-23
WO2013074871A3 true WO2013074871A3 (en) 2013-07-11

Family

ID=48430352

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/065426 WO2013074871A2 (en) 2011-11-17 2012-11-16 Humanin analogs

Country Status (1)

Country Link
WO (1) WO2013074871A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170216399A1 (en) * 2014-09-12 2017-08-03 Los Angeles Biomedical Research Institute At Harbo-Ucla Medical Center Compositions, methods and uses for protecting white blood cells from suppression or death
US10792331B2 (en) 2015-09-09 2020-10-06 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Methods for reducing cardiotoxicity from chemotherapy by administering humanin analog compositions
WO2017044626A1 (en) * 2015-09-09 2017-03-16 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Humanin compositions, methods and uses for protecting heart from stress and chemotherapy
WO2021030469A1 (en) * 2019-08-12 2021-02-18 Cohbar, Inc. Therapeutic mitochondrial peptides
CN114703154B (en) * 2022-03-30 2024-01-09 云南大学 Polypeptide, protein containing same and application
US12064467B2 (en) 2022-10-28 2024-08-20 Transdermal Biotechnology, Inc. Systems and methods for delivery of humanin or other peptides

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050233413A1 (en) * 2002-05-16 2005-10-20 Ikuo Nishimoto Neuroprotective polypeptides and methods of use
US20100204099A1 (en) * 2007-05-30 2010-08-12 Nir Barzilai Treatment of type 2 diabetes, metabolic syndrome, myocardial injury and neurodegeneration with humanin and analogs thereof
US20110039771A1 (en) * 2008-05-01 2011-02-17 The Regents Of The University Of California Small humanin-like peptides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050233413A1 (en) * 2002-05-16 2005-10-20 Ikuo Nishimoto Neuroprotective polypeptides and methods of use
US20100204099A1 (en) * 2007-05-30 2010-08-12 Nir Barzilai Treatment of type 2 diabetes, metabolic syndrome, myocardial injury and neurodegeneration with humanin and analogs thereof
US20110039771A1 (en) * 2008-05-01 2011-02-17 The Regents Of The University Of California Small humanin-like peptides

Also Published As

Publication number Publication date
WO2013074871A2 (en) 2013-05-23

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