WO2013074727A2 - Accommodative intraocular lenses using pupil miosis - Google Patents

Accommodative intraocular lenses using pupil miosis Download PDF

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Publication number
WO2013074727A2
WO2013074727A2 PCT/US2012/065167 US2012065167W WO2013074727A2 WO 2013074727 A2 WO2013074727 A2 WO 2013074727A2 US 2012065167 W US2012065167 W US 2012065167W WO 2013074727 A2 WO2013074727 A2 WO 2013074727A2
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WO
WIPO (PCT)
Prior art keywords
pupil
intraocular lens
eye
iol
miosis
Prior art date
Application number
PCT/US2012/065167
Other languages
French (fr)
Other versions
WO2013074727A3 (en
Inventor
Geunyoung Yoon
Original Assignee
University Of Rochester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Rochester filed Critical University Of Rochester
Publication of WO2013074727A2 publication Critical patent/WO2013074727A2/en
Publication of WO2013074727A3 publication Critical patent/WO2013074727A3/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1613Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1624Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
    • A61F2/1629Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing longitudinal position, i.e. along the visual axis when implanted

Definitions

  • the present invention is directed to treatment of presbyopia and more particularly to such treatment using an intraocular lens (IOL).
  • IOL intraocular lens
  • Fig. 1 shows the reduction in accommodation with age.
  • the present invention uses pupil miosis, that is, pupil constriction with accommodation.
  • Pupil miosis is the change in pupil diameter under different conditions, such as different levels of illumination. It also occurs with accommodation, even in presbyopia.
  • An intraocular lens will be implanted; that can be done using conventional surgical techniques. While typical IOL's are implanted in the capsular bag, the lens according to the present invention in at least some embodiments will be mounted around the edge of the pupil. The pupil miosis which occurs when accommodation is stimulated will cause axial movements of the lens, thereby producing different optical powers.
  • Fig. 1 is a plot showing the deterioration of accommodation with age
  • FIGs. 2A and 2B show an IOL implanted in an eye in accordance with the preferred embodiment
  • Figs. 3A and 3B show the induced dioptric power versus IOL movement
  • Figs. 4A and 4B show examples of the forward movement of the IOL and the optical power induced as functions of the pupil miosis in diameter.
  • FIGs. 2A and 2B show a patient's eye E, including its iris /, which defines a pupil P.
  • An intraocular lens (IOL) 102 is implanted in the eye E and attached to the iris / at the edge of the pupil P using haptic elements 104.
  • Fig. 2A shows the pupil P expanded for distance focus
  • Fig. 2B shows the pupil P contracted for near focus.
  • the change in size of the pupil P pulls on the haptic elements 104, thus repositioning the IOL 102.
  • the pupil miosis pulls the IOL 102 forward.
  • Figs. 3A and 3B show the above in greater detail.
  • the accommodation power P accommodation relative to the IOL power P IOL is given by the following known formula:
  • the haptics can have the appropriate mechanical designs, e.g., the hinge of the haptics for the IOL to move axially and features to mount this IOL onto the pupil.
  • the designs can vary in accordance with whether the IOL is to be mounted in front of or behind the pupil plane.
  • Fig. 4A shows an example of the forward movement of the IOL as a function of pupil miosis.
  • Fig. 4B shows the optical power induced as a function of pupil miosis for IOL's having powers of 10, 20 and 30 diopters.

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

An intraocular lens is mounted around the edge of the pupil. The pupil miosis that occurs when accommodation is stimulated will cause axial movements of the lens, thereby producing different optical powers.

Description

ACCOMMODATIVE INTRAOCULAR LENSES USING PUPIL MIOSIS
Reference to Related Application
[0001] The present application claims the benefit of U.S. Provisional Patent Application No.
61/559,987, filed November 15, 2011. Related information is disclosed in U.S. Provisional Patent Application No. 61/414,111, filed November 16, 2010. The disclosures of the above- referenced applications are hereby incorporated by reference in their entireties into the present disclosure.
Field of the Invention
[0002] The present invention is directed to treatment of presbyopia and more particularly to such treatment using an intraocular lens (IOL).
Description of Related Art
[0003] The amplitude of human lens accommodation, the eye's ability to change optical power dynamically, decreases with aging, and at the age of 60, very limited accommodation is available. That age-related lack of accommodation is called "presbyopia." Fig. 1 shows the reduction in accommodation with age.
[0004] Since that happens to everybody at some point in life, there is a huge demand for therapeutic tools. Increasing depth of focus using multifocal contact or intraocular lenses is one of the options to overcome the presbyopic problem. Those lenses, however, have to compromise retinal image quality in distant vision to enhance the image quality of a near object. Summary of the Invention
[0005] It is therefore an object of the invention to have a dynamic power change induced by accommodative effort, just as normal young eyes always do.
[0006] It is another object of the invention to provide well-focused image quality at different object distances.
[0007] To achieve the above and other objects, the present invention uses pupil miosis, that is, pupil constriction with accommodation. Pupil miosis is the change in pupil diameter under different conditions, such as different levels of illumination. It also occurs with accommodation, even in presbyopia.
[0008] An intraocular lens will be implanted; that can be done using conventional surgical techniques. While typical IOL's are implanted in the capsular bag, the lens according to the present invention in at least some embodiments will be mounted around the edge of the pupil. The pupil miosis which occurs when accommodation is stimulated will cause axial movements of the lens, thereby producing different optical powers.
Brief Description of the Drawings
[0009] A preferred embodiment will be set forth in detail with reference to the drawings, in which:
[0010] Fig. 1 is a plot showing the deterioration of accommodation with age;
[0011] Figs. 2A and 2B show an IOL implanted in an eye in accordance with the preferred embodiment;
[0012] Figs. 3A and 3B show the induced dioptric power versus IOL movement; and
[0013] Figs. 4A and 4B show examples of the forward movement of the IOL and the optical power induced as functions of the pupil miosis in diameter.
Detailed Description of the Preferred Embodiment
[0014] A preferred embodiment of the invention will be set forth with reference to the drawings, in which like reference numerals refer to like elements or steps throughout.
[0015] Figs. 2A and 2B show a patient's eye E, including its iris /, which defines a pupil P. An intraocular lens (IOL) 102 is implanted in the eye E and attached to the iris / at the edge of the pupil P using haptic elements 104.
[0016] Fig. 2A shows the pupil P expanded for distance focus, while Fig. 2B shows the pupil P contracted for near focus. As shown, the change in size of the pupil P pulls on the haptic elements 104, thus repositioning the IOL 102. During near focus, the pupil miosis pulls the IOL 102 forward.
[0017] Figs. 3A and 3B show the above in greater detail. As the pupil diameter changes from Distance to Dnear, the distance between the iris / and the IOL 102 changes from Hdistance to Elnear- The accommodation power P accommodation relative to the IOL power PIOL is given by the following known formula:
[0018] P accommodation ~ PlOL (Hdistance ~
Figure imgf000005_0001
[0019] The haptics can have the appropriate mechanical designs, e.g., the hinge of the haptics for the IOL to move axially and features to mount this IOL onto the pupil. The designs can vary in accordance with whether the IOL is to be mounted in front of or behind the pupil plane.
[0020] Fig. 4A shows an example of the forward movement of the IOL as a function of pupil miosis. Fig. 4B shows the optical power induced as a function of pupil miosis for IOL's having powers of 10, 20 and 30 diopters.
[0021] While a preferred embodiment of the invention has been set forth in detail, those skilled in the art who have reviewed the disclosure will readily appreciate that other embodiments can be realized within the scope of the invention. For example, numerical values are illustrative rather than limiting. Also, human and veterinary applications are contemplated. Therefore, the present invention should be construed as limited only by the appended claims.

Claims

I claim:
1. A method for treatment of presbyopia in an eye of a patient, the method comprising:
(a) implanting an intraocular lens into the eye; and
(b) attaching the intraocular lens to the iris of the eye such that pupil miosis changes a position of the intraocular lens in the eye.
2. The method of claim 1, wherein step (b) comprises attaching the intraocular lens to an edge of the pupil using haptic members.
3. The method of claim 2, wherein the haptic members comprise hinges.
4. The method of claim 1, wherein step (b) comprises attaching the intraocular lens to the iris of the eye such that the intraocular lens is situated behind a pupil plane.
5. An optical element for treatment of presbyopia in an eye of a patient, the optical element comprising:
an intraocular lens; and
an attachment element configured to attach the intraocular lens to the iris of the eye such that pupil miosis changes a position of the intraocular lens in the eye.
6. The optical element of claim 5, wherein the attachment element comprises haptic members for attaching the intraocular lens to an edge of the pupil.
7. The optical element of claim 6, wherein the haptic members comprise hinges.
8. The optical element of claim 5, wherein the attachment element is configured to attach the intraocular lens to the iris of the eye such that the intraocular lens is situated behind a pupil plane.
PCT/US2012/065167 2011-11-15 2012-11-15 Accommodative intraocular lenses using pupil miosis WO2013074727A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161559987P 2011-11-15 2011-11-15
US61/559,987 2011-11-15

Publications (2)

Publication Number Publication Date
WO2013074727A2 true WO2013074727A2 (en) 2013-05-23
WO2013074727A3 WO2013074727A3 (en) 2013-07-11

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3975779A (en) * 1975-04-09 1976-08-24 American Optical Corporation Artificial intraocular lens and supporting system therefor
US5192319A (en) * 1991-05-20 1993-03-09 Worst Jan G F Intraocular refractive lens
US20030033011A1 (en) * 2001-08-08 2003-02-13 Singer Jack A. Intraocular lens for vision correction and cataract prevention
US6800091B2 (en) * 1997-08-20 2004-10-05 Thinoptx, Inc. Method of using a small incision lens
US20070142911A1 (en) * 2001-01-30 2007-06-21 Willis Timothy R Refractive intraocular implant lens and method

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3975779A (en) * 1975-04-09 1976-08-24 American Optical Corporation Artificial intraocular lens and supporting system therefor
US5192319A (en) * 1991-05-20 1993-03-09 Worst Jan G F Intraocular refractive lens
US6800091B2 (en) * 1997-08-20 2004-10-05 Thinoptx, Inc. Method of using a small incision lens
US20070142911A1 (en) * 2001-01-30 2007-06-21 Willis Timothy R Refractive intraocular implant lens and method
US20030033011A1 (en) * 2001-08-08 2003-02-13 Singer Jack A. Intraocular lens for vision correction and cataract prevention

Also Published As

Publication number Publication date
WO2013074727A3 (en) 2013-07-11

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