WO2013072686A3 - Self-assembling peptides and hydrogels comprising them - Google Patents

Self-assembling peptides and hydrogels comprising them Download PDF

Info

Publication number
WO2013072686A3
WO2013072686A3 PCT/GB2012/052830 GB2012052830W WO2013072686A3 WO 2013072686 A3 WO2013072686 A3 WO 2013072686A3 GB 2012052830 W GB2012052830 W GB 2012052830W WO 2013072686 A3 WO2013072686 A3 WO 2013072686A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptides
hydrogels
self
assembling peptides
amino acids
Prior art date
Application number
PCT/GB2012/052830
Other languages
French (fr)
Other versions
WO2013072686A2 (en
Inventor
Janice Anson
Agnieszka MILEWSKA-ZUK
Alberto Saiani
Claire TANG
Robyn WALKER
Original Assignee
Reckitt & Colman (Overseas) Limited
The University Of Manchester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reckitt & Colman (Overseas) Limited, The University Of Manchester filed Critical Reckitt & Colman (Overseas) Limited
Publication of WO2013072686A2 publication Critical patent/WO2013072686A2/en
Publication of WO2013072686A3 publication Critical patent/WO2013072686A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

Abstract

The present invention is directed to peptide-based hydrogels in which the peptides coalesce such that they 'self-assemble' to form a hydrogel. Such hydrogels can be used to deliver pharmaceutically active compounds through mucosal tissue. The peptides have 2- 20 amino acids. Preferred peptides have 6 - 10 amino acids. The peptides have been found to adhere well to mucosal tissue allowing for good delivery of pharmaceutically active compounds.
PCT/GB2012/052830 2011-11-18 2012-11-15 Self-assembling peptides WO2013072686A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1119910.6A GB2496654A (en) 2011-11-18 2011-11-18 Self-assembling peptides
GB1119910.6 2011-11-18

Publications (2)

Publication Number Publication Date
WO2013072686A2 WO2013072686A2 (en) 2013-05-23
WO2013072686A3 true WO2013072686A3 (en) 2013-08-15

Family

ID=45475354

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2012/052830 WO2013072686A2 (en) 2011-11-18 2012-11-15 Self-assembling peptides

Country Status (2)

Country Link
GB (1) GB2496654A (en)
WO (1) WO2013072686A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10526371B2 (en) 2015-07-13 2020-01-07 Universiteit Gent Hydrogel-forming peptides
EP3419642B1 (en) * 2016-02-16 2023-10-04 Vrije Universiteit Brussel Hydrogel-forming composition comprising a peptide hydrogelator for controlled release
CN111647044B (en) * 2020-06-05 2022-02-08 东北农业大学 Antibacterial peptide rich in phenylalanine as well as preparation method and application thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999004764A1 (en) * 1997-07-23 1999-02-04 Perio Products Ltd. Tannic acid-polymer compositions for controlled release of pharmaceutical agents, particularly in the oral cavity
US20020160471A1 (en) * 2001-02-06 2002-10-31 John Kisiday Peptide scaffold encapsulation of tissue cells and uses thereof
WO2004052915A2 (en) * 2002-12-06 2004-06-24 Adaptive Therapeutics, Inc. Novel cyclic peptides comprising alpha-, beta- and gamma- amino acids
WO2006116524A1 (en) * 2005-04-25 2006-11-02 Massachusetts Institute Of Technology Compositions and methods for promoting hemostasis and other physiological activities
US20100221341A1 (en) * 2009-02-27 2010-09-02 Drexel University Alanine-Based Peptide Hydrogels

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955343A (en) 1992-12-28 1999-09-21 Massachusetts Institute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
US5670483A (en) 1992-12-28 1997-09-23 Massachusetts Insititute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
US7713923B2 (en) 2003-06-25 2010-05-11 Massachusetts Institute Of Technology Self-assembling peptides incorporating modifications and methods of use thereof
US7846891B2 (en) * 2003-10-17 2010-12-07 Massachusetts Institute Of Technology Self-assembling peptides for regeneration and repair of neural tissue
EP4023240A1 (en) * 2004-07-06 2022-07-06 3D Matrix, Inc. Purified amphiphilic peptide compositions and uses thereof
US20070148246A1 (en) * 2005-08-11 2007-06-28 Dan Luo Nucleic Acid-Based Matrixes
EP2066697A2 (en) * 2006-09-26 2009-06-10 Massachusetts Institute of Technology Modified self-assembling peptides
US20110117195A1 (en) * 2009-11-18 2011-05-19 National Cheng Kung University Method for improving myocardial infarction by intramyocardial or transendocardial injection of peptide nanofibers
WO2011116072A1 (en) * 2010-03-16 2011-09-22 Escape Therapeutics, Inc. Hybrid hydrogel scaffold compositions and methods of use

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999004764A1 (en) * 1997-07-23 1999-02-04 Perio Products Ltd. Tannic acid-polymer compositions for controlled release of pharmaceutical agents, particularly in the oral cavity
US20020160471A1 (en) * 2001-02-06 2002-10-31 John Kisiday Peptide scaffold encapsulation of tissue cells and uses thereof
WO2004052915A2 (en) * 2002-12-06 2004-06-24 Adaptive Therapeutics, Inc. Novel cyclic peptides comprising alpha-, beta- and gamma- amino acids
WO2006116524A1 (en) * 2005-04-25 2006-11-02 Massachusetts Institute Of Technology Compositions and methods for promoting hemostasis and other physiological activities
US20100221341A1 (en) * 2009-02-27 2010-09-02 Drexel University Alanine-Based Peptide Hydrogels

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "Hydrolyzed collagen From Wikipedia", INTERNET CITATION, 28 March 2013 (2013-03-28), XP002698422, Retrieved from the Internet <URL:http://en.wikipedia.org/wiki/Hydrolyzed_collagen> [retrieved on 20130607] *
MASLOVSKIS, A., SAIANI, A., MILLER, A.F.: "Thermoresponsive hydrogels from physical mixtures of self-assembling peptide and its conjugate with PNIPAAm", MACROMOLECULAR SYMPOSIA, vol. 296, 2010, Weinheim, pages 248 - 253, XP002694022 *
SAIANI A ET AL: "Self-assembly and gelation properties of [alpha]-helix versus [beta]-sheet forming peptides", SOFT MATTER, R S C PUBLICATIONS, GB, vol. 5, no. 1, 1 January 2009 (2009-01-01), pages 193 - 202, XP009155196, ISSN: 1744-683X, [retrieved on 20081016], DOI: 10.1039/B811288F *

Also Published As

Publication number Publication date
GB2496654A (en) 2013-05-22
GB201119910D0 (en) 2012-01-04
WO2013072686A2 (en) 2013-05-23

Similar Documents

Publication Publication Date Title
AU2018201997B2 (en) Peptides which inhibit activated receptors and their use in cosmetic or pharmaceutical compositions
WO2016004093A3 (en) Therapeutic compositions including galectin-3 inhibitors and uses thereof
WO2015183963A3 (en) Therapeutic compositions including redox-active parabenzoquinones and uses thereof
WO2010100477A3 (en) Amino acid and peptide carbamate prodrugs of tapentadol and uses thereof
EP2365796A4 (en) Fusogenic properties of saposin c and related proteins and peptides for application to transmembrane drug delivery systems
EP3428182A3 (en) Anti-inflammatory peptides and composition comprising the same
EP3428181A3 (en) Anti-inflammatory peptides and composition comprising the same
AU2019376660A8 (en) 2,5-dioxopiperazine lipids with intercalated ester, thioester, disulfide and anhydride moieities
WO2011048390A3 (en) Gadd45beta targeting agents
WO2012158962A3 (en) Improved peptide pharmaceuticals
WO2012054500A3 (en) Compositions for drug administration
WO2013084000A3 (en) Exosomes for delivery of biotherapeutics
WO2008021088A3 (en) Salicylanilides enhance oral delivery of therapeutic peptides
WO2015183995A3 (en) Therapeutic compositions including frataxin, lactoferrin, and mitochondrial energy generating enzymes, and uses thereof
WO2014104974A3 (en) Self-assembling ultrashort peptides modified with bioactive agents by click chemistry
WO2018067217A3 (en) Compositions comprising pedf-derived short peptides and uses thereof
GB2502716A (en) Fluorocarbon-linked peptide formulation
WO2011156453A3 (en) Therapeutic peptides
WO2013004716A9 (en) Peptide beads
WO2013120058A3 (en) Novel sp-b &amp; sp-c peptides, synthetic lung surfactants, and use thereof
WO2013072686A3 (en) Self-assembling peptides and hydrogels comprising them
EP2598158A4 (en) Pharmaceutical compositions for the treatment of left ventricular diastolic dysfunction comprising an apolipoprotein peptide/phospholipid complex
WO2018215525A8 (en) Mic-1 compounds and uses thereof
WO2014006502A8 (en) Protozoan variant-specific surface proteins (vsp) as carriers for oral drug delivery
WO2013051938A3 (en) Cyclic analogs of glp-1 and glp-1 related peptides and uses thereof

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12790947

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 12790947

Country of ref document: EP

Kind code of ref document: A2