WO2013052511A3 - Systems and methods for applying and monitoring eye therapy - Google Patents

Systems and methods for applying and monitoring eye therapy Download PDF

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Publication number
WO2013052511A3
WO2013052511A3 PCT/US2012/058500 US2012058500W WO2013052511A3 WO 2013052511 A3 WO2013052511 A3 WO 2013052511A3 US 2012058500 W US2012058500 W US 2012058500W WO 2013052511 A3 WO2013052511 A3 WO 2013052511A3
Authority
WO
WIPO (PCT)
Prior art keywords
eye
force
systems
methods
applying
Prior art date
Application number
PCT/US2012/058500
Other languages
French (fr)
Other versions
WO2013052511A2 (en
Inventor
Marc D. Friedman
David Muller
Evan A. Sherr
Original Assignee
Avedro, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avedro, Inc. filed Critical Avedro, Inc.
Priority to EP12838305.6A priority Critical patent/EP2760397A4/en
Priority to JP2014534642A priority patent/JP2015500670A/en
Publication of WO2013052511A2 publication Critical patent/WO2013052511A2/en
Publication of WO2013052511A3 publication Critical patent/WO2013052511A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/0079—Methods or devices for eye surgery using non-laser electromagnetic radiation, e.g. non-coherent light or microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/16—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring intraocular pressure, e.g. tonometers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/10—Eye inspection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/1015—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for wavefront analysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/102—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for optical coherence tomography [OCT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/13—Ophthalmic microscopes
    • A61B3/135—Slit-lamp microscopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F2009/00844—Feedback systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F2009/00861—Methods or devices for eye surgery using laser adapted for treatment at a particular location
    • A61F2009/00872—Cornea

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Electromagnetism (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Eye Examination Apparatus (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

In systems and methods for generating cross-linking activity in an eye, a feedback system monitors a biomechanical strength of the eye in response to the photoactivation of a cross-linking agent applied to an eye. The feedback system includes a perturbation system that applies a force to the eye and a characterization system that determines an effect of the force on the eye. The effect of the force provides an indicator of the biomechanical strength of the eye. The characterization system determines the effect of the force on the eye by measuring an amount of deformation caused by the force or a rate of recovery from the deformation.
PCT/US2012/058500 2011-10-02 2012-10-02 Systems and methods for applying and monitoring eye therapy WO2013052511A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP12838305.6A EP2760397A4 (en) 2011-10-02 2012-10-02 Systems and methods for applying and monitoring eye therapy
JP2014534642A JP2015500670A (en) 2011-10-02 2012-10-02 System and method for applying and monitoring eye therapy

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161542269P 2011-10-02 2011-10-02
US61/542,269 2011-10-02
US201161550576P 2011-10-24 2011-10-24
US61/550,576 2011-10-24
US201261597137P 2012-02-09 2012-02-09
US61/597,137 2012-02-09

Publications (2)

Publication Number Publication Date
WO2013052511A2 WO2013052511A2 (en) 2013-04-11
WO2013052511A3 true WO2013052511A3 (en) 2013-07-04

Family

ID=47993243

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/058500 WO2013052511A2 (en) 2011-10-02 2012-10-02 Systems and methods for applying and monitoring eye therapy

Country Status (4)

Country Link
US (1) US20130085370A1 (en)
EP (1) EP2760397A4 (en)
JP (1) JP2015500670A (en)
WO (1) WO2013052511A2 (en)

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JP2011508651A (en) 2008-01-02 2011-03-17 アークスキャン インコーポレイテッド Imaging device, ultrasonic arc scanning device, and ultrasonic scanning device
US10531859B2 (en) 2008-01-02 2020-01-14 Arcscan, Inc. Components for a precision ultrasonic scanning apparatus for body parts
WO2011050164A1 (en) 2009-10-21 2011-04-28 Avedro, Inc. Eye therapy
JP6377906B2 (en) * 2010-03-19 2018-08-22 アヴェドロ・インコーポレーテッドＡｖｅｄｒｏ，Ｉｎｃ． System for applying and monitoring eye treatment
US9622911B2 (en) 2010-09-30 2017-04-18 Cxl Ophthalmics, Llc Ophthalmic treatment device, system, and method of use
US9044308B2 (en) 2011-05-24 2015-06-02 Avedro, Inc. Systems and methods for reshaping an eye feature
EP2713849B1 (en) 2011-06-02 2017-02-15 Avedro, Inc. Systems for monitoring time based photo active agent delivery or photo active marker presence
WO2013148895A1 (en) 2012-03-29 2013-10-03 Cxl Ophthalmics, Llc Ocular cross-linking system and method for sealing corneal wounds
WO2013149075A1 (en) 2012-03-29 2013-10-03 Cxl Ophthalmics, Llc Compositions and methods for treating or preventing diseases associated with oxidative stress
EP2830627B1 (en) 2012-03-29 2024-05-01 Epion Therapeutics, Inc. Ocular treatment solutions, delivery devices and delivery augmentation methods
US9597059B2 (en) 2012-05-17 2017-03-21 Arcscan, Inc. Correcting for unintended motion for ultrasonic eye scans
US9320427B2 (en) 2012-07-09 2016-04-26 Arcscan, Inc. Combination optical and ultrasonic imaging of an eye
JP6271541B2 (en) 2012-07-16 2018-01-31 アヴェドロ・インコーポレーテッドＡｖｅｄｒｏ，Ｉｎｃ． System and method for corneal cross-linking by pulsed light
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US9498114B2 (en) 2013-06-18 2016-11-22 Avedro, Inc. Systems and methods for determining biomechanical properties of the eye for applying treatment
WO2014205145A1 (en) 2013-06-18 2014-12-24 Avedro, Inc. Systems and methods for determining biomechanical properties of the eye for applying treatment
US20160151202A1 (en) * 2013-07-19 2016-06-02 The General Hospital Corporation System, method and arrangements for modifying optical and mechanical properties of biological tissues
JP5881083B2 (en) * 2013-08-14 2016-03-09 石根 三井 Contact lenses for straightening corneal cross-linking
US20150057524A1 (en) * 2013-08-22 2015-02-26 Alcon Research, Ltd Systems and methods for intra-operative eye biometry or refractive measurement
EP3073316B1 (en) 2013-11-20 2018-12-26 Iwane Mitsui Contact lens for cornea-correction crosslinking, cornea-correction crosslinking method, and ring-shaped contact lens
EP3753539A1 (en) * 2014-02-04 2020-12-23 AMO Development, LLC System and method for laser corneal incisions for keratoplasty procedures
WO2015127417A1 (en) 2014-02-24 2015-08-27 Arcscan, Inc. Disposable eyepiece system for an ultrasonic eye scanning apparatus
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US9958829B2 (en) * 2014-05-07 2018-05-01 International Business Machines Corporation Sensory holograms
WO2015200817A1 (en) * 2014-06-27 2015-12-30 TECLens, LLC Realtime acoustic dosimetry for corneal collagen crosslinking
JP6644799B2 (en) 2014-10-27 2020-02-12 アヴェドロ・インコーポレーテッドＡｖｅｄｒｏ，Ｉｎｃ． System and method for ocular crosslinking treatment
WO2016077747A1 (en) 2014-11-13 2016-05-19 Avedro, Inc. Multipass virtually imaged phased array etalon
US10258809B2 (en) 2015-04-24 2019-04-16 Avedro, Inc. Systems and methods for photoactivating a photosensitizer applied to an eye
EP3297589A4 (en) 2015-05-22 2019-03-06 Avedro Inc. Systems and methods for monitoring cross-linking activity for corneal treatments
WO2017015471A1 (en) 2015-07-21 2017-01-26 Avedro, Inc. Systems and methods for treaments of an eye with a photosensitizer
DE102015009642A1 (en) * 2015-07-24 2017-01-26 Carl Zeiss Meditec Ag Method for determining the topography of the cornea of an eye
US11426611B2 (en) 2015-10-13 2022-08-30 Arcscan, Inc. Ultrasound therapeutic and scanning apparatus
WO2017066460A1 (en) 2015-10-13 2017-04-20 Arcscan, Inc Ultrasonic scanning apparatus
EP3422954B1 (en) 2016-02-29 2020-05-13 Teclens, LLC Corneal measurement and control of corneal crosslinking
US10342697B2 (en) 2016-04-13 2019-07-09 Avedro, Inc. Systems and methods for delivering drugs to an eye
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WO2018140703A1 (en) * 2017-01-27 2018-08-02 The Uab Research Foundation Common-path phase-sensitive optical coherence tomography
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Also Published As

Publication number Publication date
WO2013052511A2 (en) 2013-04-11
EP2760397A2 (en) 2014-08-06
JP2015500670A (en) 2015-01-08
EP2760397A4 (en) 2015-06-24
US20130085370A1 (en) 2013-04-04

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