WO2013036053A3 - Solid dispersion comprising tacrolimus and method for preparing the same - Google Patents

Solid dispersion comprising tacrolimus and method for preparing the same Download PDF

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Publication number
WO2013036053A3
WO2013036053A3 PCT/KR2012/007195 KR2012007195W WO2013036053A3 WO 2013036053 A3 WO2013036053 A3 WO 2013036053A3 KR 2012007195 W KR2012007195 W KR 2012007195W WO 2013036053 A3 WO2013036053 A3 WO 2013036053A3
Authority
WO
WIPO (PCT)
Prior art keywords
tacrolimus
solid dispersion
preparing
same
prepared
Prior art date
Application number
PCT/KR2012/007195
Other languages
French (fr)
Other versions
WO2013036053A2 (en
Inventor
Kyung-Hee Kim
Su-Jong Hwang
Jun-Seok Hwang
Chaul-Min Pai
Original Assignee
Samyang Biopharmaceuticals Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samyang Biopharmaceuticals Corporation filed Critical Samyang Biopharmaceuticals Corporation
Publication of WO2013036053A2 publication Critical patent/WO2013036053A2/en
Publication of WO2013036053A3 publication Critical patent/WO2013036053A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to a tacrolimus solid dispersion prepared by hot melting and a method for preparing the same, and more particularly to a tacrolimus solid dispersion and a method for preparing the same, where the solid dispersion is prepared from tacrolimus, a polymer melt base, and a surfactant by hot melting in order to improve the bioavailability of tacrolimus used as an immunosuppressive drug.
PCT/KR2012/007195 2011-09-09 2012-09-06 Solid dispersion comprising tacrolimus and method for preparing the same WO2013036053A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020110092112A KR20130028824A (en) 2011-09-09 2011-09-09 Solid dispersant comprising tacrolimus and a method for preparing the same
KR10-2011-0092112 2011-09-09

Publications (2)

Publication Number Publication Date
WO2013036053A2 WO2013036053A2 (en) 2013-03-14
WO2013036053A3 true WO2013036053A3 (en) 2013-05-02

Family

ID=47832716

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/007195 WO2013036053A2 (en) 2011-09-09 2012-09-06 Solid dispersion comprising tacrolimus and method for preparing the same

Country Status (2)

Country Link
KR (1) KR20130028824A (en)
WO (1) WO2013036053A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005020994A1 (en) * 2003-08-29 2005-03-10 Lifecycle Pharma A/S Solid dispersions comprising tacrolimus
WO2006080778A1 (en) * 2005-01-25 2006-08-03 Gl Pharmtech Corp. Solid dispersion comprising tacrolimus and enteric-coated macromolecule
US20060177500A1 (en) * 2003-07-09 2006-08-10 Hee-Jong Shin Solid dispersion of tacrolimus
US20100086592A1 (en) * 2007-03-29 2010-04-08 Panacea Biotec Limited. Modified dosage forms of tacrolimus

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060177500A1 (en) * 2003-07-09 2006-08-10 Hee-Jong Shin Solid dispersion of tacrolimus
WO2005020994A1 (en) * 2003-08-29 2005-03-10 Lifecycle Pharma A/S Solid dispersions comprising tacrolimus
WO2006080778A1 (en) * 2005-01-25 2006-08-03 Gl Pharmtech Corp. Solid dispersion comprising tacrolimus and enteric-coated macromolecule
US20100086592A1 (en) * 2007-03-29 2010-04-08 Panacea Biotec Limited. Modified dosage forms of tacrolimus

Also Published As

Publication number Publication date
KR20130028824A (en) 2013-03-20
WO2013036053A2 (en) 2013-03-14

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