WO2013032230A3 - Pharmaceutical angiogenic composition including a microrna-382 activator - Google Patents

Pharmaceutical angiogenic composition including a microrna-382 activator Download PDF

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Publication number
WO2013032230A3
WO2013032230A3 PCT/KR2012/006909 KR2012006909W WO2013032230A3 WO 2013032230 A3 WO2013032230 A3 WO 2013032230A3 KR 2012006909 W KR2012006909 W KR 2012006909W WO 2013032230 A3 WO2013032230 A3 WO 2013032230A3
Authority
WO
WIPO (PCT)
Prior art keywords
microrna
activator
pharmaceutical
angiogenic composition
composition including
Prior art date
Application number
PCT/KR2012/006909
Other languages
French (fr)
Korean (ko)
Other versions
WO2013032230A2 (en
Inventor
이유미
Original Assignee
경북대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 경북대학교 산학협력단 filed Critical 경북대학교 산학협력단
Priority to US14/240,530 priority Critical patent/US9051620B2/en
Priority claimed from KR1020120094792A external-priority patent/KR20130024830A/en
Publication of WO2013032230A2 publication Critical patent/WO2013032230A2/en
Publication of WO2013032230A3 publication Critical patent/WO2013032230A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C12N2310/141—MicroRNAs, miRNAs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to an angiogenic composition, and more particularly, to a pharmaceutical angiogenic composition including a microRNA-382 activator. The inventors of the present invention have confirmed that microRNA-382, the expression of which is elevated in stomach cancer cells in a low oxygen environment, affects the promotion of angiogenesis. Therefore, provided in the present invention is the pharmaceutical angiogenic composition which includes the microRNA-382 activator, which is angiogenic and thus promotes cell proliferation, and can be valuably used in treating injuries, ischemic myocardial infarctions, or foot ischemia.
PCT/KR2012/006909 2011-08-30 2012-08-29 Pharmaceutical angiogenic composition including a microrna-382 activator WO2013032230A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US14/240,530 US9051620B2 (en) 2011-08-30 2012-08-29 Pharmaceutical angiogenic composition including a microRNA-382 activator

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2011-0086986 2011-08-30
KR20110086986 2011-08-30
KR10-2012-0094792 2012-08-29
KR1020120094792A KR20130024830A (en) 2011-08-30 2012-08-29 Pharmaceutical composition comprising microrna-382 activator for promoting angiogenic activity

Publications (2)

Publication Number Publication Date
WO2013032230A2 WO2013032230A2 (en) 2013-03-07
WO2013032230A3 true WO2013032230A3 (en) 2013-05-10

Family

ID=47757053

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/006909 WO2013032230A2 (en) 2011-08-30 2012-08-29 Pharmaceutical angiogenic composition including a microrna-382 activator

Country Status (1)

Country Link
WO (1) WO2013032230A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008014008A2 (en) * 2006-07-28 2008-01-31 The Johns Hopkins University Compositions and methods for modulating angiogenesis
KR20100009268A (en) * 2008-07-18 2010-01-27 국립암센터 Anti-cancer composition comprising microrna molecules

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008014008A2 (en) * 2006-07-28 2008-01-31 The Johns Hopkins University Compositions and methods for modulating angiogenesis
KR20100009268A (en) * 2008-07-18 2010-01-27 국립암센터 Anti-cancer composition comprising microrna molecules

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KIM, MIN JEONG: "The roles of microRNA-382 induced by hypoxia in angiogenesis", MASTER'S THESIS, KYUNKPOOK NATIONAL UNIVERSITY GRADUATE SCHOOL, June 2010 (2010-06-01) *
SUAREZ ET AL.: "MicroRNAs as novel regulators of angiogenesis", CIRCULATION RESEARCH, vol. 104, 2009, pages 442 - 454, XP008108165, DOI: doi:10.1161/circresaha.108.191270 *

Also Published As

Publication number Publication date
WO2013032230A2 (en) 2013-03-07

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