WO2013026852A3 - Derivatives of mecamylamine - Google Patents
Derivatives of mecamylamine Download PDFInfo
- Publication number
- WO2013026852A3 WO2013026852A3 PCT/EP2012/066285 EP2012066285W WO2013026852A3 WO 2013026852 A3 WO2013026852 A3 WO 2013026852A3 EP 2012066285 W EP2012066285 W EP 2012066285W WO 2013026852 A3 WO2013026852 A3 WO 2013026852A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- mecamylamine
- derivatives
- hypertensive
- demise
- nachr
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
- C07C209/14—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups
- C07C209/16—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
- C07C211/38—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
Abstract
Mecamylamine is a general nicotinic acetylcholine receptor (nAChR) antagonist that was one of the first anti-hypertensive agents. Since its demise as an anti-hypertensive drug, mecamylamine has been shown to aid smoking cessation (in humans), reduce cue induced craving in human cocaine addicts and heavy drinkers. The present invention provides for novel derivatives of mecamylamine and inventive synthetic routes to these compounds.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11178258 | 2011-08-22 | ||
EP11178258.7 | 2011-08-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2013026852A2 WO2013026852A2 (en) | 2013-02-28 |
WO2013026852A3 true WO2013026852A3 (en) | 2013-04-11 |
Family
ID=46704684
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2012/066285 WO2013026852A2 (en) | 2011-08-22 | 2012-08-21 | Derivatives of mecamylamine |
Country Status (1)
Country | Link |
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WO (1) | WO2013026852A2 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8809397B2 (en) * | 2010-05-27 | 2014-08-19 | Targacept, Inc. | Nicotinic receptor non-competitive antagonists |
CN103402971A (en) * | 2011-01-07 | 2013-11-20 | 塔加西普特公司 | Nicotinic receptor non-competitive antagonists |
WO2014004417A1 (en) * | 2012-06-26 | 2014-01-03 | Targacept, Inc. | Nicotinic receptor non-competitive antagonists |
US11840495B2 (en) | 2020-12-23 | 2023-12-12 | The Broad Institute, Inc. | Compositions and methods related to di-substituted bicyclo[2.2.1] heptanamine-containing compounds |
GB202203728D0 (en) | 2022-03-17 | 2022-05-04 | Univ Oxford Innovation Ltd | Treatments and methods for increasing dopamine |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999015492A1 (en) * | 1997-09-23 | 1999-04-01 | Poli Industria Chimica S.P.A. | Method for preparing bicycloheptan-amine compounds |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US804879A (en) | 1904-03-08 | 1905-11-21 | William A Parrish | Detachable link. |
GB804879A (en) | 1955-06-06 | 1958-11-26 | Merck & Co Inc | Isocamphane compounds and processes for preparing them |
US2831027A (en) | 1955-06-06 | 1958-04-15 | Merck & Co Inc | Isocamphane compounds and processes for preparing the same |
US2885428A (en) | 1958-01-08 | 1959-05-05 | Rohm & Haas | 2-isothiocyanatoisocamphane |
WO2005067909A1 (en) | 2004-01-06 | 2005-07-28 | Yale University | Combination therapy with mecamylamine for the treatment of mood disorders |
-
2012
- 2012-08-21 WO PCT/EP2012/066285 patent/WO2013026852A2/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999015492A1 (en) * | 1997-09-23 | 1999-04-01 | Poli Industria Chimica S.P.A. | Method for preparing bicycloheptan-amine compounds |
Non-Patent Citations (2)
Title |
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ERICH DWORAN ET AL: "Eine neue Totalsynthese von Epifenchon und Dehydrocamphenilon", CHEMISCHE BERICHTE, vol. 114, no. 6, 1 June 1981 (1981-06-01), pages 2357 - 2359, XP055042078, ISSN: 0009-2940, DOI: 10.1002/cber.19811140632 * |
SUCHOCKI J A ET AL: "Synthesis of 2-exo- and 2-endo-mecamylamine analogs. Structure-activity relationships for nicotinic antagonism in the central nervous system", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 34, 1 January 1991 (1991-01-01), pages 1003 - 1010, XP002218706, ISSN: 0022-2623, DOI: 10.1021/JM00107A019 * |
Also Published As
Publication number | Publication date |
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WO2013026852A2 (en) | 2013-02-28 |
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