WO2013024398A3 - Improved method for quantitative determination of linezolid - Google Patents

Improved method for quantitative determination of linezolid Download PDF

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Publication number
WO2013024398A3
WO2013024398A3 PCT/IB2012/054017 IB2012054017W WO2013024398A3 WO 2013024398 A3 WO2013024398 A3 WO 2013024398A3 IB 2012054017 W IB2012054017 W IB 2012054017W WO 2013024398 A3 WO2013024398 A3 WO 2013024398A3
Authority
WO
WIPO (PCT)
Prior art keywords
linezolid
improved method
quantitative determination
liquids
methanol
Prior art date
Application number
PCT/IB2012/054017
Other languages
French (fr)
Other versions
WO2013024398A2 (en
Inventor
Venkatraman JAYARAMAN
Sundara Kalyana BALAJI
Sanjiv DIXIT
Jagadish KADIA
Original Assignee
Alembic Pharmaceuticals Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alembic Pharmaceuticals Limited filed Critical Alembic Pharmaceuticals Limited
Publication of WO2013024398A2 publication Critical patent/WO2013024398A2/en
Publication of WO2013024398A3 publication Critical patent/WO2013024398A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
    • B01D15/166—Fluid composition conditioning, e.g. gradient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • B01D15/426—Specific type of solvent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials

Abstract

Disclosed are an improved HPLC method for analyzing Linezolid, wherein the mobile phase comprises two or more liquids including buffer and methanol. And the relative concentration of the liquids is varied to a predetermined gradient.
PCT/IB2012/054017 2011-08-12 2012-08-07 An improved method for the quantitative determination of linezolid WO2013024398A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2289MU2011 2011-08-12
IN2289/MUM/2011 2011-08-12

Publications (2)

Publication Number Publication Date
WO2013024398A2 WO2013024398A2 (en) 2013-02-21
WO2013024398A3 true WO2013024398A3 (en) 2013-04-11

Family

ID=47715531

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2012/054017 WO2013024398A2 (en) 2011-08-12 2012-08-07 An improved method for the quantitative determination of linezolid

Country Status (1)

Country Link
WO (1) WO2013024398A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110579556A (en) * 2018-06-08 2019-12-17 天津科伦药物研究有限公司 Detection method of linezolid product
CN109265407B (en) * 2018-10-23 2020-05-29 扬子江药业集团北京海燕药业有限公司 Synthesis method of bislinezolid
CN113244169A (en) * 2021-05-20 2021-08-13 石家庄四药有限公司 Linezolid sodium chloride injection and preparation method thereof
CN113588848B (en) * 2021-07-21 2023-06-06 江苏吴中医药集团有限公司 Pretreatment solution, pretreatment method and detection method of linezolid glucose solution
CN115047117B (en) * 2022-07-18 2023-06-16 北京云鹏鹏程医药科技有限公司 Detection method for simultaneously determining 3 genetic toxin impurities in linezolid

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1713924A (en) * 2000-08-22 2005-12-28 法马西亚公司 Solution composition of an oxazolidinone antibiotic drug having enhanced drug loading
US20070197529A1 (en) * 2005-12-01 2007-08-23 Viviana Braude Isolated desfluoro-linezolid, preparation thereof and its use as a reference marker and standard

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1713924A (en) * 2000-08-22 2005-12-28 法马西亚公司 Solution composition of an oxazolidinone antibiotic drug having enhanced drug loading
US20070197529A1 (en) * 2005-12-01 2007-08-23 Viviana Braude Isolated desfluoro-linezolid, preparation thereof and its use as a reference marker and standard

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
C. M. TOBIN ET AL.: "A simple, isocratic high-performance liquid chromatography assay for linezolid in human serum.", JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY., vol. 48, 2001, pages 605 - 608 *

Also Published As

Publication number Publication date
WO2013024398A2 (en) 2013-02-21

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