WO2013023043A3 - Treatment of advanced solid tumors using combination of anti-erbb3 immunotherapy and selected chemotherapy - Google Patents
Treatment of advanced solid tumors using combination of anti-erbb3 immunotherapy and selected chemotherapy Download PDFInfo
- Publication number
- WO2013023043A3 WO2013023043A3 PCT/US2012/050124 US2012050124W WO2013023043A3 WO 2013023043 A3 WO2013023043 A3 WO 2013023043A3 US 2012050124 W US2012050124 W US 2012050124W WO 2013023043 A3 WO2013023043 A3 WO 2013023043A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- solid tumors
- erbb3
- treatment
- immunotherapy
- combination
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2012294326A AU2012294326A1 (en) | 2011-08-10 | 2012-08-09 | Treatment of advanced solid tumors using combination of anti-ErbB3 immunotherapy and selected chemotherapy |
Applications Claiming Priority (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161522063P | 2011-08-10 | 2011-08-10 | |
US61/522,063 | 2011-08-10 | ||
US201161530935P | 2011-09-02 | 2011-09-02 | |
US61/530,935 | 2011-09-02 | ||
US201161535303P | 2011-09-15 | 2011-09-15 | |
US61/535,303 | 2011-09-15 | ||
US201261616902P | 2012-03-28 | 2012-03-28 | |
US61/616,902 | 2012-03-28 | ||
US201261638611P | 2012-04-26 | 2012-04-26 | |
US61/638,611 | 2012-04-26 | ||
FR1255209 | 2012-06-05 | ||
FR1255209 | 2012-06-05 | ||
FR1256174 | 2012-06-28 | ||
FR1256174 | 2012-06-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2013023043A2 WO2013023043A2 (en) | 2013-02-14 |
WO2013023043A3 true WO2013023043A3 (en) | 2013-04-18 |
Family
ID=47669228
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2012/050124 WO2013023043A2 (en) | 2011-08-10 | 2012-08-09 | Treatment of advanced solid tumors using combination of anti-erbb3 immunotherapy and selected chemotherapy |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2012294326A1 (en) |
WO (1) | WO2013023043A2 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2544680T3 (en) * | 2010-03-11 | 2015-04-27 | Merrimack Pharmaceuticals Inc | USE OF ErbB3 INHIBITORS IN TREATMENT OF TRIPLE-NEGATIVE BREAST CANCER |
CN104159924B (en) * | 2011-12-05 | 2018-03-16 | 诺华股份有限公司 | The antibody of EGF-R ELISA 3 (HER3) |
TW201601753A (en) * | 2013-09-30 | 2016-01-16 | 第一三共股份有限公司 | Protein biomarker and uses thereof |
US20150152508A1 (en) * | 2013-09-30 | 2015-06-04 | Daiichi Sankyo Company, Limited | Nucleic acid biomarker and use thereof |
WO2015100459A2 (en) | 2013-12-27 | 2015-07-02 | Merrimack Pharmaceuticals, Inc. | Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies |
KR20170137886A (en) * | 2015-04-17 | 2017-12-13 | 메리맥 파마슈티컬즈, 인크. | Therapeutic combination therapy |
US10184006B2 (en) | 2015-06-04 | 2019-01-22 | Merrimack Pharmaceuticals, Inc. | Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors |
JP2019508428A (en) | 2016-03-15 | 2019-03-28 | メリマック ファーマシューティカルズ インコーポレーティッド | Methods for treating ER +, HER2-, HRG + breast cancer using combination therapy comprising an anti-ERBB3 antibody |
CN111647074B (en) * | 2020-06-01 | 2023-12-19 | 皖南医学院 | HER3 dimerization interface antigen peptide, recombinant antigen peptide, encoding gene and application thereof |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070117815A1 (en) * | 2005-11-04 | 2007-05-24 | James Pluda | Method of treating cancers with SAHA and pemetrexed |
US20090082295A1 (en) * | 2005-11-11 | 2009-03-26 | Pfizer Inc. | Combinations and methods of using an immunomodulatory oligodeoxynucleotide |
US20090214562A1 (en) * | 2005-05-03 | 2009-08-27 | Karel Steven J | Combination of a beta-glucan and an egf receptor antagonist for the treatment of cancer and infection |
US20100056761A1 (en) * | 2007-02-16 | 2010-03-04 | Merrimack Pharmaceuticals, Inc. | Antibodies against erbb3 and uses thereof |
US20110027291A1 (en) * | 2008-08-15 | 2011-02-03 | Merrimack Pharmaceuticals, Inc. | Methods, systems and products for predicting response of tumor cells to a therapeutic agent and treating a patient according to the predicted response |
US20110189092A1 (en) * | 2009-03-30 | 2011-08-04 | Scott Eliasof | Polymer-agent conjugates, particles, compositions, and related methods of use |
-
2012
- 2012-08-09 AU AU2012294326A patent/AU2012294326A1/en not_active Abandoned
- 2012-08-09 WO PCT/US2012/050124 patent/WO2013023043A2/en active Application Filing
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090214562A1 (en) * | 2005-05-03 | 2009-08-27 | Karel Steven J | Combination of a beta-glucan and an egf receptor antagonist for the treatment of cancer and infection |
US20070117815A1 (en) * | 2005-11-04 | 2007-05-24 | James Pluda | Method of treating cancers with SAHA and pemetrexed |
US20090082295A1 (en) * | 2005-11-11 | 2009-03-26 | Pfizer Inc. | Combinations and methods of using an immunomodulatory oligodeoxynucleotide |
US20100056761A1 (en) * | 2007-02-16 | 2010-03-04 | Merrimack Pharmaceuticals, Inc. | Antibodies against erbb3 and uses thereof |
US7846440B2 (en) * | 2007-02-16 | 2010-12-07 | Merrimack Pharmaceuticals, Inc. | Antibodies against ErbB3 and uses thereof |
US20110027291A1 (en) * | 2008-08-15 | 2011-02-03 | Merrimack Pharmaceuticals, Inc. | Methods, systems and products for predicting response of tumor cells to a therapeutic agent and treating a patient according to the predicted response |
US20110189092A1 (en) * | 2009-03-30 | 2011-08-04 | Scott Eliasof | Polymer-agent conjugates, particles, compositions, and related methods of use |
Also Published As
Publication number | Publication date |
---|---|
WO2013023043A2 (en) | 2013-02-14 |
AU2012294326A1 (en) | 2013-03-21 |
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