WO2013021398A3 - A process for preparation of mivacurium chloride - Google Patents

A process for preparation of mivacurium chloride Download PDF

Info

Publication number
WO2013021398A3
WO2013021398A3 PCT/IN2012/000540 IN2012000540W WO2013021398A3 WO 2013021398 A3 WO2013021398 A3 WO 2013021398A3 IN 2012000540 W IN2012000540 W IN 2012000540W WO 2013021398 A3 WO2013021398 A3 WO 2013021398A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
octene
bis
methyl
chloride
Prior art date
Application number
PCT/IN2012/000540
Other languages
French (fr)
Other versions
WO2013021398A2 (en
Inventor
Mahalinga Manjathuru
Anil Narayan MAYEKAR
Yogeesh Derambala
Pejakala Kakrannaya Vasudeva
Thangavel Arulmoli
Gautam Kumar Das
Original Assignee
Sequent Scientific Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sequent Scientific Limited filed Critical Sequent Scientific Limited
Publication of WO2013021398A2 publication Critical patent/WO2013021398A2/en
Publication of WO2013021398A3 publication Critical patent/WO2013021398A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention discloses a novel, cost-effective process for preparation of [R-[R*,R*-(E)]]-2,2'-(l,8-dioxo-4-octene-l,8-diyl) bis(oxy- 3, 1-propanediyl) bis(l,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-l-[(3,4,5- trimethoxyphenyl)- methyl] isoquinolinium) dichloride, commonly known as mivacurium chloride, which avoids the conversion of (E)-4-octene-l,8-dioic acid to its acid chloride and use of non-ionic polymeric adsorbent resin to get a highly pure product.
PCT/IN2012/000540 2011-08-05 2012-08-03 A process for preparation of mivacurium chloride WO2013021398A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2693/CHE/2011 2011-08-05
IN2693CH2011 2011-08-05

Publications (2)

Publication Number Publication Date
WO2013021398A2 WO2013021398A2 (en) 2013-02-14
WO2013021398A3 true WO2013021398A3 (en) 2013-03-14

Family

ID=47669030

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2012/000540 WO2013021398A2 (en) 2011-08-05 2012-08-03 A process for preparation of mivacurium chloride

Country Status (1)

Country Link
WO (1) WO2013021398A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103373959A (en) * 2013-06-14 2013-10-30 安徽省先锋制药有限公司 Preparation method of cis-benzyl isoquinoline compound and application thereof
CN108375644B (en) * 2016-12-07 2021-11-30 四川科瑞德制药股份有限公司 Analysis method of neuromuscular blocker intermediate
CN108929269B (en) * 2017-05-26 2024-01-23 四川科瑞德制药股份有限公司 Benzisoquinoline non-depolarizing muscle relaxant and preparation method and application thereof
CN110698398B (en) * 2019-10-31 2021-08-03 武汉嘉诺康医药技术有限公司 Purification method of mikui ammonium chloride
CN111471013B (en) * 2020-05-26 2021-04-30 朗天药业(湖北)有限公司 Mickura ammonium chloride and preparation method of injection thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4491665A (en) * 1979-10-19 1985-01-01 Burroughs Wellcome Co. Method of preparing isomers of bis isoquinolinium compounds
US4761418A (en) * 1984-07-18 1988-08-02 Burroughs Wellcome Co. Novel compounds
US20070293534A1 (en) * 2006-06-20 2007-12-20 Farmabios S.P.A. Process for the preparation of mivacurium chloride

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4491665A (en) * 1979-10-19 1985-01-01 Burroughs Wellcome Co. Method of preparing isomers of bis isoquinolinium compounds
US4761418A (en) * 1984-07-18 1988-08-02 Burroughs Wellcome Co. Novel compounds
US20070293534A1 (en) * 2006-06-20 2007-12-20 Farmabios S.P.A. Process for the preparation of mivacurium chloride

Also Published As

Publication number Publication date
WO2013021398A2 (en) 2013-02-14

Similar Documents

Publication Publication Date Title
JOP20180102A1 (en) Pharmaceutical composition
WO2011138281A3 (en) Process for the preparation of dithiine tetracarboxydiimides
MX2010007587A (en) Compounds comprising a cyclobutoxy group.
CA2830549C (en) Methods and compositions for preparing noribogaine from voacangine
WO2011138678A3 (en) Compositions, gels and foams with rheology modulators and uses thereof
MX2011008864A (en) Sulfonylated tetrahydroazolopyrazines and their use as medicinal products.
WO2013067349A9 (en) Novel chemistry used in biosensors
WO2011084848A3 (en) Prodrugs of heteraromatic compounds
WO2011157722A3 (en) Solid ivabradine-containing composition
WO2013021398A3 (en) A process for preparation of mivacurium chloride
JO3154B1 (en) Trpv4 antagonists
MX2012013855A (en) Oligo-benzamide compounds and their use.
WO2011015882A3 (en) Anhydrate of triotropium bromide
HRP20181437T1 (en) Method for the preparation of (3s,3s') 4,4'-disulfanediylbis (3-aminobutane 1-sulfonic acid)
WO2013121279A3 (en) Process to prepare ertapenem
TN2011000531A1 (en) 5- alkynyl - pyridines
HK1215244A1 (en) Process for the preparation of (1s,4s,5s)-4-bromo-6- oxabicyclo[3.2.1]octan-7-one (1s4s5s)-4--6-[321]-7-
WO2011107967A3 (en) Improved polymer membranes, processes for production thereof and use thereof
WO2012130674A3 (en) Alkoxysilyl-containing adhesive sealants having an increased rupture stress
MX2014004210A (en) 2-oxo-piperidinyl derivatives.
WO2012159704A8 (en) Stable crystal modifications of dotap chloride
WO2012150607A3 (en) Oral liquid composition comprising divalproex sodium and process for preparing thereof
JO2857B1 (en) Phenyl-alkylpiperazines with tnf-modulating activity
IT1401698B1 (en) CATALYST FOR THE DECOMPOSITION OF DANGEROUS PROSTOSIS.
WO2014096300A3 (en) Antibacterial compounds

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12821805

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 12821805

Country of ref document: EP

Kind code of ref document: A2