WO2013019762A4

WO2013019762A4 - Filamentous bioresorbable stent

Info

Publication number: WO2013019762A4
Application number: PCT/US2012/048912
Authority: WO
Inventors: Catherine Ann SCANLON
Original assignee: SCANLON, John, James
Priority date: 2011-07-31
Filing date: 2012-07-31
Publication date: 2013-03-21
Also published as: WO2013019762A2; WO2013019762A3

Abstract

Disclosed herein is a high radial strength, filament-reinforced bioresorbable stent comprising extruding a polymer into one or more small diameter filaments; stretching the extruded filaments to an optimum longer length; organizing one or more of the stretched filaments into a tubular shape; thermoforming the tubular shaped filaments to substantially retain a tubular shape; binding the filaments together with one or more bioresorbable polymers to produce a filament-reinforced tube; fabricating a stent from the filament-reinforced tube by cutting a strut pattern in the wall thickness of the tube; covering the stent with coating to delay hydrolysis and/or deliver an active ingredient to minimize the risk of restenosis; crimping the stent onto a balloon catheter assembly; delivering the stent into an anatomical lumen via percutaneous methods to a treatment location; expanding the stent at the treatment location wherein the stent temporarily supports the anatomical lumen; and removing the catheter from the lumen.

Claims

AMENDED CLAIMS

received by the International Bureau on 12 February 2013 (12.02.2013)

Claim 1. An endoprosthesis comprising:

A hollow, elongated, body including a wall thickness formed of at least one layer of one or more filaments positioned on an outer surface of a tubular-shaped mandrel,

Wherein said filaments and mandrel comprise one or more materials of the same or different chemical composition or molecular weight;

Wherein said filament or filaments are positioned in said wall thickness of said body in an axial orientation, a circumferential orientation, an angled orientation or combination thereof orientation relative to the central axis of the body;

Wherein said filament or filaments are of one or more thicknesses,

Wherein said body includes a pattern of openings partially or fully surrounded by interconnecting struts of any repeating or non-repeating geometric pattern;

Wherein said struts comprise multiple filament sections and mandrel sections after inclusion of said openings in said body; and

Wherein said material or materials maintain sufficient strength to hold open an anatomical lumen from the time of deployment of said endoprosthesis until the end of a treatment time, at which time said material or materials undergo degradation resulting in a loss of said strength and with longer time said material is substantially broken down into byproducts that undergo partial or full resorption by a living body.

Claim 2. The endoprosthesis of claim 1 includes one or more coatings of the same or different chemical composition on the endoprosthesis abluminal surface, endoprosthesis luminal surface, endoprosthesis cutting edges, one or more filament surfaces, or combinations thereof.

Claim 3. The endoprosthesis of claim 1 includes at least a partial thermal fusion between said severed filaments at a position near the cutting edges of said struts to at least partially attach the ends of the filaments together near the cutting edges.

Claim 4. The endoprosthesis of claim 1 includes one or more active ingredients of the same or different composition.

Claim 5. The endoprosthesis of claim 1 includes at least one layer of a binding material that connects one or more filaments or layers of filaments wherein the binding material is positioned on the inner surface of a filament layer, outer surface of a filament layer, between filament layers, between adjacent filaments, between adjacent multi-filaments, or combinations thereof.

Claim 6. The endoprosthesis of claim 1 includes an application selected from the group of: coronary vascular stents, carotid stents, peripheral vascular stents, renal stents, iliac stents, superficial femoral artery stents, cerebral stents, urinary stents (urethral and ureteral stents), biliary stents, tracheal stents, gastrointestinal stents, esophageal stents, and drug delivery device.

Claim 7. The endoprosthesis of claim 1 includes a stent-to-anatomical lumen coverage ratio of less than 75 percent. Claim 8. The endoprosthesis of claim 1 includes a strut thickness less than 0.15 mm. Claim 9. The endoprosthesis of claim 1 includes a radial strength of greater than 0.05 MPa^r(400 mmHg).

Claim 10. The endoprosthesis of claim 1 includes filaments organized in said wall thickness by one or more processes selected from the group of: braiding, winding, weaving, crocheting, interlacing, nonwoven, spun bond, fibrillating, flash spun, or knitting said filaments.

Claim 11. The binding material of claim 5 has a thickness ranging from 0.0001 to 0.2000 mm.

ClaimJ2. The filament of claim 1 has a thickness ranging from 0,05 to 150 microns. Claim 13. The filament of claim 1 has a tensile strength greater than 70 MPa (10,500 psi).

Claim 14_* The endoprosthesis of claim 1 includes at least one malleable wire comprised of bioresorbable material.

Claim 15. The endoprosthesis of claim 1 includes filaments that degrade and lose mass at different rates.

Claim 16. The coating of claim 2 delays the onset of degradation of said material by greater than 1 week at physiological conditions.

Claim 17. The coating of claim 2 includes a storage and a delivery of at least one therapeutic drug of the same or different composition to said anatomical lumen. Claim 18. The endoprosthesis of claim 1 includes one or more additives, nano sized additives, or combinations thereof.

Claim 19 (the claim is canceled).

Claim 20 (the claim is cancelled).

Claim 21. The filament or filaments of claim 1 are a straight, curved, bent, or combination thereof shape,

Claim 22. The filament or filaments of claim 1 are positioned on a mandrel comprised of oriented or extended molecular chain material having a solid or porous wall thickness prior to cutting said pattern of openings into said tubular-shaped body.