WO2013017690A3 - Troponin based rule in and rule out algorithm of myocardial infarction - Google Patents

Troponin based rule in and rule out algorithm of myocardial infarction Download PDF

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Publication number
WO2013017690A3
WO2013017690A3 PCT/EP2012/065266 EP2012065266W WO2013017690A3 WO 2013017690 A3 WO2013017690 A3 WO 2013017690A3 EP 2012065266 W EP2012065266 W EP 2012065266W WO 2013017690 A3 WO2013017690 A3 WO 2013017690A3
Authority
WO
WIPO (PCT)
Prior art keywords
myocardial infarction
rule
sample
out algorithm
present
Prior art date
Application number
PCT/EP2012/065266
Other languages
French (fr)
Other versions
WO2013017690A2 (en
Inventor
Jochen Jarausch
Sylvie Menassanch-Volker
Christian Müller
Tobias Reichlin
Wilma Verhagen-Kamerbeek
Silvia Weiser
Christian Zaugg
Original Assignee
Roche Diagnostics Gmbh
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP11176486A external-priority patent/EP2554995A1/en
Priority claimed from US13/197,470 external-priority patent/US20130035603A1/en
Application filed by Roche Diagnostics Gmbh, F. Hoffmann-La Roche Ag filed Critical Roche Diagnostics Gmbh
Publication of WO2013017690A2 publication Critical patent/WO2013017690A2/en
Publication of WO2013017690A3 publication Critical patent/WO2013017690A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to a method for diagnosing myocardial infarction in a subject presenting with chest pain. The method is based on the determination the amount of a cardiac Troponinin a first sample from the subject obtained at presentation to a physician, and in a second sample obtained within one hour after the first sample. Moreover, the present invention envisages a method for ruling in myocardial infarction and a method for ruling out myocardial infarction. The said methods are also based on the determination the amount of a cardiac Troponinin a first sample from the subject obtained at presentation to a physician, and in a second sample obtained within one hour after the first sample. The present invention also relates to a system for performing a diagnosis, rule in, or rule of myocardial infarction as disclosed herein and to reagents and kits used in performing the methods disclosed herein.
PCT/EP2012/065266 2011-08-03 2012-08-03 Troponin based rule in and rule out algorithm of myocardial infarction WO2013017690A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP11176486.6 2011-08-03
EP11176486A EP2554995A1 (en) 2011-08-03 2011-08-03 Troponin based rule in and rule out algorithm of myocardial infarction
US13/197,470 US20130035603A1 (en) 2011-08-03 2011-08-03 Troponin based rule-in and rule-out algorithm of myocardial infarction
US13/197,470 2011-08-03

Publications (2)

Publication Number Publication Date
WO2013017690A2 WO2013017690A2 (en) 2013-02-07
WO2013017690A3 true WO2013017690A3 (en) 2013-03-28

Family

ID=46601842

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2012/065266 WO2013017690A2 (en) 2011-08-03 2012-08-03 Troponin based rule in and rule out algorithm of myocardial infarction

Country Status (1)

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WO (1) WO2013017690A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017500547A (en) * 2013-11-15 2017-01-05 オタゴ イノベーション リミテッド Biomarkers for heart failure

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
E. GIANNITSIS ET AL: "Analytical Validation of a High-Sensitivity Cardiac Troponin T Assay", CLINICAL CHEMISTRY, vol. 56, no. 2, 1 February 2010 (2010-02-01), pages 254 - 261, XP055011464, ISSN: 0009-9147, DOI: 10.1373/clinchem.2009.132654 *
EISENMAN ARIE: "Troponin assays for the diagnosis of myocardial infarction and acute coronary syndrome: where do we stand?", EXPERT REVIEW OF CARDIOVASCULAR THERAPY, EXPERT REVIEWS LTD, GB, vol. 4, no. 4, 1 July 2006 (2006-07-01), pages 509 - 514, XP009153834, ISSN: 1744-8344 *
FRED S: "Edging Closer to Early Optimal Patient Management With High-Sensitivity Cardiac Troponin Assay", CIRCULATION, LIPPINCOT WILLIAMS AND WILKINS, BALTIMORE, US, vol. 124, 12 July 2011 (2011-07-12), pages 127 - 129, XP007919695, ISSN: 1524-4539, DOI: 10.1161/CIRCULATIONAHA.111.038851 *
M. REITER ET AL: "Early diagnosis of acute myocardial infarction in the elderly using more sensitive cardiac troponin assays", EUROPEAN HEART JOURNAL, vol. 32, no. 11, 1 June 2011 (2011-06-01), pages 1379 - 1389, XP055011691, ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehr033 *
REICHLIN T ET AL: "Clinical use of a high-sensitive cardiac troponin assay in patients with suspected myocardial infarction", INTERNET CITATION, 3 May 2011 (2011-05-03), pages 1, XP007919708, Retrieved from the Internet <URL:http://spo.escardio.org/AbstractDetails.aspx?id=89878&eevtid=40> [retrieved on 20111107] *
TOBIAS REICHLIN ET AL: "Utility of Absolute and Relative Changes in Cardiac Troponin Concentrations in the Early Diagnosis of Acute Myocardial Infarction", CIRCULATION, LIPPINCOT WILLIAMS AND WILKINS, BALTIMORE, US, vol. 124, 1 January 2011 (2011-01-01), pages 136 - 145, XP007919690, ISSN: 1524-4539, [retrieved on 20110627], DOI: 10.1161/CIRCULATIONAHA.111.023937 *

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