WO2012178184A3 - Removable protective shell for imaging agents and bioactive substances - Google Patents
Removable protective shell for imaging agents and bioactive substances Download PDFInfo
- Publication number
- WO2012178184A3 WO2012178184A3 PCT/US2012/044052 US2012044052W WO2012178184A3 WO 2012178184 A3 WO2012178184 A3 WO 2012178184A3 US 2012044052 W US2012044052 W US 2012044052W WO 2012178184 A3 WO2012178184 A3 WO 2012178184A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- imaging agents
- nanoparticles
- protective shell
- removable protective
- bioactive substances
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1878—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles the nanoparticle having a magnetically inert core and a (super)(para)magnetic coating
- A61K49/1881—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles the nanoparticle having a magnetically inert core and a (super)(para)magnetic coating wherein the coating consists of chelates, i.e. chelating group complexing a (super)(para)magnetic ion, bound to the surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides nanoparticles for delivery of imaging agents, drugs, and other molecules, such as genetic material. The nanoparticles have a core structure comprising the imaging agent and/or drug, and a shell structure that allows for water solubility. The shell structure further provides a barrier with limited water permeability that protects the core. The nanoparticles can be induced to release their cargo by treatment with ultrasound. Methods of delivering drugs and imaging agents are also provided, whereby the nanoparticles are delivered to tissues of interest in a substantially inert form, then activated using ultrasound to release the drugs or imaging agents.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161500585P | 2011-06-23 | 2011-06-23 | |
US61/500,585 | 2011-06-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012178184A2 WO2012178184A2 (en) | 2012-12-27 |
WO2012178184A3 true WO2012178184A3 (en) | 2014-05-08 |
Family
ID=47423269
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2012/044052 WO2012178184A2 (en) | 2011-06-23 | 2012-06-25 | Removable protective shell for imaging agents and bioactive substances |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2012178184A2 (en) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6559644B2 (en) * | 2001-05-30 | 2003-05-06 | Insightec - Txsonics Ltd. | MRI-based temperature mapping with error compensation |
US20050214379A1 (en) * | 2004-01-02 | 2005-09-29 | Sandro Mecozzi | Encapsulation of chemical compounds in fluorous-core and fluorous-inner-shell micelles formed from semifluorinated-block or fluorinated-block copolymers |
US20060293396A1 (en) * | 2005-01-14 | 2006-12-28 | Eastman Kodak Company | Amine polymer-modified nanoparticulate carriers |
US20070243259A1 (en) * | 2006-04-17 | 2007-10-18 | Hsing-Wen Sung | Nanoparticles for protein/peptide delivery and delivery means |
US20080044746A1 (en) * | 1998-11-20 | 2008-02-21 | Anderson Richard R | Permanent, removable tissue markings |
US20100068522A1 (en) * | 2008-08-07 | 2010-03-18 | Nanoco Technologies Limited | Surface Functionalised Nanoparticles |
-
2012
- 2012-06-25 WO PCT/US2012/044052 patent/WO2012178184A2/en active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080044746A1 (en) * | 1998-11-20 | 2008-02-21 | Anderson Richard R | Permanent, removable tissue markings |
US6559644B2 (en) * | 2001-05-30 | 2003-05-06 | Insightec - Txsonics Ltd. | MRI-based temperature mapping with error compensation |
US20050214379A1 (en) * | 2004-01-02 | 2005-09-29 | Sandro Mecozzi | Encapsulation of chemical compounds in fluorous-core and fluorous-inner-shell micelles formed from semifluorinated-block or fluorinated-block copolymers |
US20060293396A1 (en) * | 2005-01-14 | 2006-12-28 | Eastman Kodak Company | Amine polymer-modified nanoparticulate carriers |
US20070243259A1 (en) * | 2006-04-17 | 2007-10-18 | Hsing-Wen Sung | Nanoparticles for protein/peptide delivery and delivery means |
US20100068522A1 (en) * | 2008-08-07 | 2010-03-18 | Nanoco Technologies Limited | Surface Functionalised Nanoparticles |
Also Published As
Publication number | Publication date |
---|---|
WO2012178184A2 (en) | 2012-12-27 |
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