WO2012170614A3 - Dna methylation markers in non-small cell lung cancer and methods of using the same - Google Patents
Dna methylation markers in non-small cell lung cancer and methods of using the same Download PDFInfo
- Publication number
- WO2012170614A3 WO2012170614A3 PCT/US2012/041228 US2012041228W WO2012170614A3 WO 2012170614 A3 WO2012170614 A3 WO 2012170614A3 US 2012041228 W US2012041228 W US 2012041228W WO 2012170614 A3 WO2012170614 A3 WO 2012170614A3
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- WO
- WIPO (PCT)
- Prior art keywords
- lung cancer
- small cell
- cell lung
- methods
- same
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
Abstract
Provided herein are unique sets of genes that are regulated by methylation in non-small cell lung cancer ("NSCLC") that are useful as a biomarker or in an assay for determining, diagnosing or subtyping lung cancer and/or the outcome of certain drug therapies.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161494142P | 2011-06-07 | 2011-06-07 | |
US61/494,142 | 2011-06-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012170614A2 WO2012170614A2 (en) | 2012-12-13 |
WO2012170614A3 true WO2012170614A3 (en) | 2013-04-04 |
Family
ID=47296727
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2012/041228 WO2012170614A2 (en) | 2011-06-07 | 2012-06-07 | Dna methylation markers in non-small cell lung cancer and methods of using the same |
Country Status (1)
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WO (1) | WO2012170614A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20140227694A1 (en) * | 2013-02-08 | 2014-08-14 | Zymo Research Corporation | Epigenetic markers of pluripotency |
CA2926215A1 (en) * | 2013-10-06 | 2015-04-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modified pseudomonas exotoxin a |
CN108680745B (en) * | 2018-01-03 | 2021-06-15 | 湖州市中心医院 | Application method of serum lipid biomarker in early diagnosis of NSCLC |
CN115772565B (en) * | 2021-09-08 | 2023-09-05 | 广州市基准医疗有限责任公司 | Methylation site for auxiliary detection of lung cancer somatic EGFR gene mutation and application thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080241842A1 (en) * | 2005-07-09 | 2008-10-02 | Lovelace Respiratory Research Institute | Gene Methylation as a Biomarker in Sputum |
WO2009023172A2 (en) * | 2007-08-09 | 2009-02-19 | The Johns Hopkins University | Predictions of responsiveness to egfr inhibitors |
-
2012
- 2012-06-07 WO PCT/US2012/041228 patent/WO2012170614A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080241842A1 (en) * | 2005-07-09 | 2008-10-02 | Lovelace Respiratory Research Institute | Gene Methylation as a Biomarker in Sputum |
WO2009023172A2 (en) * | 2007-08-09 | 2009-02-19 | The Johns Hopkins University | Predictions of responsiveness to egfr inhibitors |
Non-Patent Citations (3)
Title |
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GOTO, Y. ET AL.: "Epigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma", CANCER RES., vol. 69, no. 23, 1 December 2009 (2009-12-01), pages 9073 - 9082 * |
GU, J. ET AL.: "Aberrant promoter methylation profile and association with survival in patients with non-small cell lung cancer", CLIN. CANCER RES., vol. 12, no. 24, 15 December 2006 (2006-12-15), pages 7329 - 38 * |
KIM, B. ET AL.: "Clinical validity of the lung cancer biomarkers identified by bioinformatics analysis of public expression data", CANCER RES., vol. 67, no. 15, 1 August 2007 (2007-08-01), pages 7431 - 7438 * |
Also Published As
Publication number | Publication date |
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WO2012170614A2 (en) | 2012-12-13 |
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