WO2012170098A3 - Arbovirus inhibitors and uses thereof - Google Patents

Arbovirus inhibitors and uses thereof Download PDF

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Publication number
WO2012170098A3
WO2012170098A3 PCT/US2012/029634 US2012029634W WO2012170098A3 WO 2012170098 A3 WO2012170098 A3 WO 2012170098A3 US 2012029634 W US2012029634 W US 2012029634W WO 2012170098 A3 WO2012170098 A3 WO 2012170098A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibitors
arbovirus
present
arboviruses
discovery
Prior art date
Application number
PCT/US2012/029634
Other languages
French (fr)
Other versions
WO2012170098A2 (en
Inventor
Scott Larsen
Janice Sindac
Scott Barraza
David J. Miller
Original Assignee
The Regents Of The University Of Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of Michigan filed Critical The Regents Of The University Of Michigan
Publication of WO2012170098A2 publication Critical patent/WO2012170098A2/en
Publication of WO2012170098A3 publication Critical patent/WO2012170098A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

Abstract

The present invention relates to chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides compounds as inhibitors of arboviruses.
PCT/US2012/029634 2011-03-31 2012-03-19 Arbovirus inhibitors and uses thereof WO2012170098A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161470038P 2011-03-31 2011-03-31
US61/470,038 2011-03-31

Publications (2)

Publication Number Publication Date
WO2012170098A2 WO2012170098A2 (en) 2012-12-13
WO2012170098A3 true WO2012170098A3 (en) 2013-01-31

Family

ID=46928024

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/029634 WO2012170098A2 (en) 2011-03-31 2012-03-19 Arbovirus inhibitors and uses thereof

Country Status (2)

Country Link
US (1) US8846684B2 (en)
WO (1) WO2012170098A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2927023C (en) * 2013-10-10 2022-08-02 The Regents Of The University Of Michigan Deubiquitinase inhibitors and methods for use of the same
EP3215150B1 (en) * 2014-11-07 2022-07-20 The Regents of The University of Michigan Inhibitors of myocardin-related transcription factor and serum response factor (mrtf/srf)-mediated gene transcription and methods for use of the same
UY38434A (en) * 2018-11-02 2020-05-29 Aicuris Gmbh & Co Kg NEW 6,7-DIHYDRO-4H-PYRAZOLE [1,5-A] PIRAZIN INDOL-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)
CA3150147A1 (en) * 2019-09-05 2021-03-11 Guimin ZHANG Magl inhibitor, preparation method and use thereof
US20240059688A1 (en) * 2020-12-22 2024-02-22 Luxembourg Institute Of Health (Lih) Conolidine analogues as selective ackr3 modulators for the treatment of cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070155761A1 (en) * 2006-01-05 2007-07-05 Caterina Bissantz Indol-3-yl-carbonyl-spiro-piperidine derivatives
US20080200491A1 (en) * 2005-06-22 2008-08-21 Thuy-Anh Tran 1,2-Dihydro-Spiro[3H-Indole-3,4'-Piperidine] Compounds, as Modulators of the Mas Receptor Novel

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2647596C (en) 2006-04-04 2012-06-12 Fibrogen, Inc. Pyrrolo- and thiazolo-pyridine compounds as hif modulators

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080200491A1 (en) * 2005-06-22 2008-08-21 Thuy-Anh Tran 1,2-Dihydro-Spiro[3H-Indole-3,4'-Piperidine] Compounds, as Modulators of the Mas Receptor Novel
US20070155761A1 (en) * 2006-01-05 2007-07-05 Caterina Bissantz Indol-3-yl-carbonyl-spiro-piperidine derivatives

Also Published As

Publication number Publication date
US20120252807A1 (en) 2012-10-04
US8846684B2 (en) 2014-09-30
WO2012170098A2 (en) 2012-12-13

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