WO2012166705A3 - Nanofibres et hydrogels supramoléculaires à base de conjugués acide aminé-nucléobase-glucoside - Google Patents
Nanofibres et hydrogels supramoléculaires à base de conjugués acide aminé-nucléobase-glucoside Download PDFInfo
- Publication number
- WO2012166705A3 WO2012166705A3 PCT/US2012/039821 US2012039821W WO2012166705A3 WO 2012166705 A3 WO2012166705 A3 WO 2012166705A3 US 2012039821 W US2012039821 W US 2012039821W WO 2012166705 A3 WO2012166705 A3 WO 2012166705A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nucleobase
- amino acid
- supramolecular
- hydrogels based
- glycoside conjugates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L31/129—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing macromolecular fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
L'invention concerne des promoteurs d'hydrogel qui comportent une nucléobase, un acide aminé et un glucoside. Ces promoteurs d'hydrogel présentent une résistance accrue aux protéases et peuvent former par auto-assemblage des nanofibres ou des hydrogels supramoléculaires. Ces structures supramoléculaires peuvent être utilisées pour favoriser la croissance de cellules ou pour délivrer une substance à une cellule.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/093,974 US10093674B2 (en) | 2011-05-31 | 2013-12-02 | Supramolecular nanofibers and hydrogels based on nucleic acids functionalized with nucleobases |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161491544P | 2011-05-31 | 2011-05-31 | |
US61/491,544 | 2011-05-31 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2012/039822 Continuation-In-Part WO2012166706A2 (fr) | 2011-05-31 | 2012-05-29 | Nanofibres et hydrogels supramoléculaires à base d'oligopeptides fonctionnalisés par des nucléobases |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012166705A2 WO2012166705A2 (fr) | 2012-12-06 |
WO2012166705A3 true WO2012166705A3 (fr) | 2013-02-28 |
Family
ID=47260243
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2012/039821 WO2012166705A2 (fr) | 2011-05-31 | 2012-05-29 | Nanofibres et hydrogels supramoléculaires à base de conjugués acide aminé-nucléobase-glucoside |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2012166705A2 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014138367A1 (fr) * | 2013-03-06 | 2014-09-12 | Brandeis University | Inhibition de la croissance tumorale avec des agrégats de petites molécules |
WO2015116242A1 (fr) | 2014-02-03 | 2015-08-06 | Brandeis University | Hydrogel supramoléculaire de molécules à base de fmlf et son utilisation |
US10857243B2 (en) | 2014-04-09 | 2020-12-08 | Brandeis University | Enzymatically responsive magnetic particles and their use |
EP3310396A4 (fr) | 2015-06-16 | 2019-02-27 | The Johns Hopkins University | Hydrogels thérapeutiques à base de nanofibres pour le traitement local des maladies liées au cerveau |
WO2019035928A1 (fr) | 2017-08-15 | 2019-02-21 | Brandeis University | Formation rapide d'hydrogels supramoléculaires par un peptide court et de petites molécules bioactives |
WO2019055988A1 (fr) | 2017-09-18 | 2019-03-21 | Brandeis University | Peptides ramifiés pour assemblage enzymatique et administration de médicament à des mitochondries |
US11834517B2 (en) | 2017-09-18 | 2023-12-05 | Brandeis University | Branched peptides for enzymatic assembly and mitochondria drug delivery |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5278284A (en) * | 1992-05-14 | 1994-01-11 | Miller Brewing Company | Protein purification method |
US20020081726A1 (en) * | 2000-09-25 | 2002-06-27 | Brenda Russell | Microfabrication of membranes for the growth of cells |
US20080057005A1 (en) * | 2005-03-24 | 2008-03-06 | Jean-Marie Lehn | Hydrogels for the controlled release of bioactive materials |
-
2012
- 2012-05-29 WO PCT/US2012/039821 patent/WO2012166705A2/fr active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5278284A (en) * | 1992-05-14 | 1994-01-11 | Miller Brewing Company | Protein purification method |
US20020081726A1 (en) * | 2000-09-25 | 2002-06-27 | Brenda Russell | Microfabrication of membranes for the growth of cells |
US20080057005A1 (en) * | 2005-03-24 | 2008-03-06 | Jean-Marie Lehn | Hydrogels for the controlled release of bioactive materials |
Non-Patent Citations (2)
Title |
---|
LI, X. ET AL.: "Multifunctional, Biocompatible Supramolecular Hydrogelators Consist Only for Nucleobase, Amino Acid, and Glycoside", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 133, 19 September 2011 (2011-09-19), pages 17513 - 17518 * |
YANG, Z. ET AL.: "Supramolecular hydrogels based on biofunctional nanofibers of self-assembled small molecules", JOURNAL OF MATERIALS CHEMISTRY, vol. 17, 2007, pages 2385 - 2393 * |
Also Published As
Publication number | Publication date |
---|---|
WO2012166705A2 (fr) | 2012-12-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2012166705A3 (fr) | Nanofibres et hydrogels supramoléculaires à base de conjugués acide aminé-nucléobase-glucoside | |
EP2325896A4 (fr) | Electrode frontale pour pile solaire permettant de réduire la perte de puissance, et pile solaire comprenant cette électrode | |
WO2010088633A3 (fr) | Nouvelles lignées cellulaires et procédés | |
WO2010030598A3 (fr) | Formulations pharmaceutiques comprenant du pemetrexed | |
EP3539380A3 (fr) | Composition améliorée de cellules et son procédé de fabrication | |
WO2010102116A3 (fr) | Pile solaire ayant plusieurs donneurs d'électrons | |
EP2315810B8 (fr) | Polyuréthanes antistatiques ou électroconducteurs et procédé de production | |
EP3049116A4 (fr) | Administration de gènes médiée par des nanoparticules, édition génomique et modification ciblée par un ligand dans diverses populations de cellules | |
WO2013029013A8 (fr) | Souches de bacillus produisant une enzyme | |
WO2011160021A3 (fr) | Dérivés de fullerènes | |
WO2010129288A3 (fr) | Marqueurs d'évènement comestibles à haute fiabilité et leurs procédés d'utilisation | |
EP2605314A4 (fr) | Ensemble d'électrodes ayant des structures en forme de fibres, et batterie le comprenant | |
WO2015047484A3 (fr) | Systèmes électrochimiques et procédés pour récupérer de l'énergie thermique | |
EP2503635A4 (fr) | Ensemble paire d'électrodes bipolaires/membrane de séparation, batterie bipolaire le comprenant, et son procédé de production | |
WO2010111659A8 (fr) | Cellules initiatrices de tumeur et procédés pour les utiliser | |
EP2544279A4 (fr) | Matériau actif d'électrode positive pour batterie au lithium-ion, électrode positive pour batterie au lithium-ion, et batterie au lithium-ion | |
EP2327119A4 (fr) | Accumulateur bipolaire, procédé de fabrication de l accumulateur bipolaire, électrode bipolaire, procédé de fabrication de l électrode bipolaire et batterie assemblée | |
FR2957360B1 (fr) | Electrolyseur a haute temperature (eht) comprenant une pluralite de cellules, a fonctionnement ameliore en cas de casse d'au moins une cellule et en veillissement | |
WO2012148569A3 (fr) | Ensemble électrode sensible au profil | |
WO2009102569A3 (fr) | Nouvelles lignées cellulaires et méthodes associées | |
WO2012068441A3 (fr) | Sels d'intedanib et leurs formes à l'état solide | |
EP3316376A4 (fr) | Plaque bipolaire, cadre de cellules, empilement de cellules et batterie à flux redox | |
WO2010047489A3 (fr) | Dispositif d'interconnexion pour ensembles d'éléments de batterie | |
WO2012076230A3 (fr) | Conducteur d'ions sodium à base de titanate de sodium | |
WO2012162494A3 (fr) | Appareil et procédés comprenant un transistor bipolaire à jonctions couplé à une chaîne de cellules de mémoire |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 12792966 Country of ref document: EP Kind code of ref document: A2 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 12792966 Country of ref document: EP Kind code of ref document: A2 |